JP7382716B2 - 非アルコール性脂肪性肝疾患（ｎａｆｌｄ）の予防または治療用医薬の調製におけるトリアセチル－３－ヒドロキシフェニルアデノシンの使用 - Google Patents

非アルコール性脂肪性肝疾患（ｎａｆｌｄ）の予防または治療用医薬の調製におけるトリアセチル－３－ヒドロキシフェニルアデノシンの使用 Download PDF

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JP7382716B2
JP7382716B2 JP2018533743A JP2018533743A JP7382716B2 JP 7382716 B2 JP7382716 B2 JP 7382716B2 JP 2018533743 A JP2018533743 A JP 2018533743A JP 2018533743 A JP2018533743 A JP 2018533743A JP 7382716 B2 JP7382716 B2 JP 7382716B2
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nafld
alcoholic fatty
fatty liver
liver disease
treatment
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海波 朱
会杰 史
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Beijing Gushen Life Health Technology Co Ltd
Institute of Materia Medica of CAMS and PUMC
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Institute of Materia Medica of CAMS and PUMC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Veterinary Medicine (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2018533743A 2015-12-31 2016-12-28 非アルコール性脂肪性肝疾患（ｎａｆｌｄ）の予防または治療用医薬の調製におけるトリアセチル－３－ヒドロキシフェニルアデノシンの使用 Active JP7382716B2 (ja)

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Application Number Priority Date Filing Date Title
CN201511034199.0 2015-12-31
CN201511034199 2015-12-31
PCT/CN2016/112623 WO2017114413A1 (zh) 2015-12-31 2016-12-28 三乙酰基-3-羟基苯基腺苷在制备预防或者治疗非酒精性脂肪肝药物中的应用

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JP2019500379A5 JP2019500379A5 (https=) 2020-02-13
JP7382716B2 true JP7382716B2 (ja) 2023-11-17

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US (1) US11058703B2 (https=)
EP (1) EP3398604A4 (https=)
JP (1) JP7382716B2 (https=)
KR (1) KR102676056B1 (https=)
CN (2) CN118178446A (https=)
AU (1) AU2016383376B2 (https=)
CA (1) CA3010097C (https=)
HK (1) HK1255689A1 (https=)
RU (1) RU2759916C2 (https=)
WO (1) WO2017114413A1 (https=)
ZA (1) ZA201805080B (https=)

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Publication number Priority date Publication date Assignee Title
CN107334775A (zh) * 2016-03-14 2017-11-10 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷在制备治疗动脉粥样硬化药物中的应用
CA3102404A1 (en) 2018-06-05 2019-12-12 Flagship Pioneering Innovations V, Inc. Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
CN111821313A (zh) * 2019-04-17 2020-10-27 江苏天士力帝益药业有限公司 三乙酰基-3-羟基苯基腺苷在制备抑制心脏纤维化的药物中的应用
CN114869901B (zh) * 2022-05-06 2023-10-27 安徽医科大学 马鞭草苷在治疗酒精性肝损伤药物中的应用
CN117599076A (zh) * 2023-11-15 2024-02-27 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷在制备运动模拟药物中的应用

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JP2005132812A (ja) 2003-10-08 2005-05-26 Kobayashi Pharmaceut Co Ltd シイタケ菌糸体抽出物の分画物およびその用途
JP2007210926A (ja) 2006-02-08 2007-08-23 Tokyo Univ Of Pharmacy & Life Science ピラジンカルボン酸化合物からなる薬剤、及び食餌
JP2011196874A (ja) 2010-03-19 2011-10-06 Kanazawa Univ 肝保護作用を有するタンパク質、肝障害予防・保護用化合物のスクリーニング方法
JP2012519714A (ja) 2008-10-06 2012-08-30 中国医学科学院葯物研究所 トライアシル−３−ヒドロキシフェニルアデノシン及びその血中脂肪の調節用途

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CN100427534C (zh) * 2004-03-19 2008-10-22 四川大学 聚合物型含磷阻燃剂及其制备方法和用途
CN102125580A (zh) 2011-01-17 2011-07-20 泰山医学院 三乙酰基-3-羟基苯基腺苷thpa在制药中的应用
AU2012245996B2 (en) * 2011-04-22 2016-09-01 Pfizer Inc. Pyrazolospiroketone derivatives for use as acetyl-CoA carboxylase inhibitors
AU2013204500A1 (en) 2012-09-21 2014-04-10 Barbara Jane Badenoch-Jones Novel AMPK agonist compositions and methods of use
CN103191145A (zh) 2013-03-27 2013-07-10 南京理工大学 腺苷及其衍生物在防治药物性肝损伤中的应用
CN104211747B (zh) * 2013-05-29 2018-09-25 中国医学科学院药物研究所 5’-磷酸-n6-（3-羟基苯基）腺苷的制备及医药用途
US9827222B2 (en) 2013-07-01 2017-11-28 Emory University Treating or preventing nephrogenic diabetes insipidus
CN104546887B (zh) * 2013-10-09 2018-10-30 中国医学科学院药物研究所 虫草素衍生物治疗炎症疾病的用途
CN105663152A (zh) * 2014-11-19 2016-06-15 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷在制备改善胰岛素抵抗及相关疾病中的应用
CN107334775A (zh) * 2016-03-14 2017-11-10 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷在制备治疗动脉粥样硬化药物中的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005132812A (ja) 2003-10-08 2005-05-26 Kobayashi Pharmaceut Co Ltd シイタケ菌糸体抽出物の分画物およびその用途
JP2007210926A (ja) 2006-02-08 2007-08-23 Tokyo Univ Of Pharmacy & Life Science ピラジンカルボン酸化合物からなる薬剤、及び食餌
JP2012519714A (ja) 2008-10-06 2012-08-30 中国医学科学院葯物研究所 トライアシル−３−ヒドロキシフェニルアデノシン及びその血中脂肪の調節用途
JP2011196874A (ja) 2010-03-19 2011-10-06 Kanazawa Univ 肝保護作用を有するタンパク質、肝障害予防・保護用化合物のスクリーニング方法

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Ｌｉｐｉｄｓ ｉｎ Ｈｅａｌｔｈ ａｎｄ Ｄｉｓｅａｓｅ， ２０１１， １０， ｐ．６７（ｈｔｔｐ：／／ｗｗｗ．ｌｉｐｉｄｗｏｒｌｄ．ｃｏｍ／ｃｏｎｔｅｎｔ／１０／１／６７）
ＰＬｏＳ Ｏｎｅ， ２０１２， ７（３）， ｅ３２１１５
日本消化器病学会雑誌、２０１４年、１１１巻１号、４～１３頁
肝臓、１９８１年、２２巻１号、１２３頁

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KR20180100152A (ko) 2018-09-07
CN106943420A (zh) 2017-07-14
KR102676056B1 (ko) 2024-06-19
HK1255689A1 (en) 2019-08-23
CA3010097A1 (en) 2017-07-06
AU2016383376B2 (en) 2022-07-28
US11058703B2 (en) 2021-07-13
EP3398604A1 (en) 2018-11-07
RU2018126158A (ru) 2020-01-31
WO2017114413A1 (zh) 2017-07-06
ZA201805080B (en) 2019-10-30
CN118178446A (zh) 2024-06-14
CA3010097C (en) 2023-08-22
RU2759916C2 (ru) 2021-11-18
US20190022120A1 (en) 2019-01-24
JP2019500379A (ja) 2019-01-10
RU2018126158A3 (https=) 2020-03-11
EP3398604A4 (en) 2019-06-19
AU2016383376A1 (en) 2018-07-12

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