JP7369716B2 - 皮膚バリア機能を改善するためのアンブロキソールの使用 - Google Patents

皮膚バリア機能を改善するためのアンブロキソールの使用 Download PDF

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JP7369716B2
JP7369716B2 JP2020561603A JP2020561603A JP7369716B2 JP 7369716 B2 JP7369716 B2 JP 7369716B2 JP 2020561603 A JP2020561603 A JP 2020561603A JP 2020561603 A JP2020561603 A JP 2020561603A JP 7369716 B2 JP7369716 B2 JP 7369716B2
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skin
ceramide
cer
increasing
appearance
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JPWO2019147931A5 (https=
JP2021511388A5 (https=
JP2021511388A (ja
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スティーブン アンダーソン，
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ノイレ， エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020561603A 2018-01-26 2019-01-25 皮膚バリア機能を改善するためのアンブロキソールの使用 Active JP7369716B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622375P 2018-01-26 2018-01-26
US62/622,375 2018-01-26
PCT/US2019/015137 WO2019147931A1 (en) 2018-01-26 2019-01-25 Use of ambroxol to improve skin barrier function

Publications (4)

Publication Number Publication Date
JP2021511388A JP2021511388A (ja) 2021-05-06
JPWO2019147931A5 JPWO2019147931A5 (https=) 2022-01-12
JP2021511388A5 JP2021511388A5 (https=) 2022-01-12
JP7369716B2 true JP7369716B2 (ja) 2023-10-26

Family

ID=65363412

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020561603A Active JP7369716B2 (ja) 2018-01-26 2019-01-25 皮膚バリア機能を改善するためのアンブロキソールの使用

Country Status (6)

Country Link
US (3) US10894008B2 (https=)
EP (1) EP3743039A1 (https=)
JP (1) JP7369716B2 (https=)
CN (1) CN111655223A (https=)
CA (1) CA3087079A1 (https=)
WO (1) WO2019147931A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3654960A1 (en) * 2017-07-16 2020-05-27 Neuere, LLC Ambroxol to improve and/or extend healthspan, lifespan and/or mental acuity
JP7369716B2 (ja) * 2018-01-26 2023-10-26 ノイレ， エルエルシー 皮膚バリア機能を改善するためのアンブロキソールの使用
WO2022098366A1 (en) * 2020-11-09 2022-05-12 Redwood Ip Holding, Llc Skincare compositions for preventing transepidermal water loss
JPWO2023145735A1 (https=) * 2022-01-25 2023-08-03
CN121127451A (zh) * 2023-05-02 2025-12-12 启威公司 一种用于医疗用途的改良型氨溴索

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520630A (ja) 2004-11-22 2008-06-19 シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト 皮膚損傷に有効なセラミド及び／又は偽セラミドと（α−）ビサボロールを含む製剤
JP2009137933A (ja) 2007-09-17 2009-06-25 Hospital For Sick Children ゴーシェ病の治療方法
JP2013099305A (ja) 2011-11-10 2013-05-23 Pola Chemical Industries Inc 抗老化剤のスクリ−ニング方法
JP2013241398A (ja) 2012-04-27 2013-12-05 Fujifilm Corp β−グルコセレブロシダーゼ活性増強剤、セラミド産生増強剤及び皮膚バリア機能改善剤
US20140161916A1 (en) 2012-12-11 2014-06-12 Avon Products, Inc. Method of Improving Aging Appearance of Skin by Modulation of WIPI-1
JP2016121165A (ja) 2006-04-28 2016-07-07 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533379A (ja) * 1998-12-23 2002-10-08 イデア アクチェンゲゼルシャフト 生体内における局所的に非侵襲性である用途のための改善された製剤
MXPA04002066A (es) 2001-09-04 2005-02-17 Techno Network Shinoku Co Ltd Farmacos contra influenza.
DE10332487A1 (de) 2003-07-16 2005-02-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol für die Behandlung von chronisch nozizeptiven Schmerzen
DE102004021992A1 (de) 2004-05-03 2005-11-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Topische Zubereitung enthaltend Ambroxol
WO2008021829A2 (en) * 2006-08-09 2008-02-21 Lipo Chemicals Inc. Topical ceramide compositions and methos of use
US20110294833A1 (en) 2010-05-26 2011-12-01 Scripps Health Methods for Healthy Aging
BR112014012858B1 (pt) * 2011-11-30 2019-02-26 Ibr - Israeli Biotechnology Research Ltd. Extrato de jojoba útil em melhorar as funções de barreira da pele
US20180296464A1 (en) 2017-04-17 2018-10-18 W Skincare, LLC Autophagy activation nutrient complex, compositions and methods
US10179095B2 (en) 2017-06-07 2019-01-15 Dr. Raymond Laboratories Autophage activating resveratrol topical composition for skin improvement and treatment
EP3654960A1 (en) * 2017-07-16 2020-05-27 Neuere, LLC Ambroxol to improve and/or extend healthspan, lifespan and/or mental acuity
JP7369716B2 (ja) * 2018-01-26 2023-10-26 ノイレ， エルエルシー 皮膚バリア機能を改善するためのアンブロキソールの使用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520630A (ja) 2004-11-22 2008-06-19 シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト 皮膚損傷に有効なセラミド及び／又は偽セラミドと（α−）ビサボロールを含む製剤
JP2016121165A (ja) 2006-04-28 2016-07-07 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
JP2009137933A (ja) 2007-09-17 2009-06-25 Hospital For Sick Children ゴーシェ病の治療方法
JP2013099305A (ja) 2011-11-10 2013-05-23 Pola Chemical Industries Inc 抗老化剤のスクリ−ニング方法
JP2013241398A (ja) 2012-04-27 2013-12-05 Fujifilm Corp β−グルコセレブロシダーゼ活性増強剤、セラミド産生増強剤及び皮膚バリア機能改善剤
US20140161916A1 (en) 2012-12-11 2014-06-12 Avon Products, Inc. Method of Improving Aging Appearance of Skin by Modulation of WIPI-1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAORAN Tai, et al.，Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence，Autophagy，2017年，Vol.13, No.1，page.99-113

Also Published As

Publication number Publication date
EP3743039A1 (en) 2020-12-02
CA3087079A1 (en) 2019-08-01
CN111655223A (zh) 2020-09-11
JP2021511388A (ja) 2021-05-06
WO2019147931A1 (en) 2019-08-01
US12390409B2 (en) 2025-08-19
US20210128438A1 (en) 2021-05-06
US11730690B2 (en) 2023-08-22
US10894008B2 (en) 2021-01-19
US20200060955A1 (en) 2020-02-27
US20230346671A1 (en) 2023-11-02

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