CA3087079A1 - Use of ambroxol to improve skin barrier function - Google Patents

Use of ambroxol to improve skin barrier function Download PDF

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Publication number
CA3087079A1
CA3087079A1 CA3087079A CA3087079A CA3087079A1 CA 3087079 A1 CA3087079 A1 CA 3087079A1 CA 3087079 A CA3087079 A CA 3087079A CA 3087079 A CA3087079 A CA 3087079A CA 3087079 A1 CA3087079 A1 CA 3087079A1
Authority
CA
Canada
Prior art keywords
skin
ceramide
ambroxol
stratum
decreasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3087079A
Other languages
English (en)
French (fr)
Inventor
Stephen Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuere LLC
Original Assignee
Neuere LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuere LLC filed Critical Neuere LLC
Publication of CA3087079A1 publication Critical patent/CA3087079A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3087079A 2018-01-26 2019-01-25 Use of ambroxol to improve skin barrier function Pending CA3087079A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622375P 2018-01-26 2018-01-26
US62/622,375 2018-01-26
PCT/US2019/015137 WO2019147931A1 (en) 2018-01-26 2019-01-25 Use of ambroxol to improve skin barrier function

Publications (1)

Publication Number Publication Date
CA3087079A1 true CA3087079A1 (en) 2019-08-01

Family

ID=65363412

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3087079A Pending CA3087079A1 (en) 2018-01-26 2019-01-25 Use of ambroxol to improve skin barrier function

Country Status (6)

Country Link
US (3) US10894008B2 (https=)
EP (1) EP3743039A1 (https=)
JP (1) JP7369716B2 (https=)
CN (1) CN111655223A (https=)
CA (1) CA3087079A1 (https=)
WO (1) WO2019147931A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3654960A1 (en) * 2017-07-16 2020-05-27 Neuere, LLC Ambroxol to improve and/or extend healthspan, lifespan and/or mental acuity
JP7369716B2 (ja) * 2018-01-26 2023-10-26 ノイレ， エルエルシー 皮膚バリア機能を改善するためのアンブロキソールの使用
WO2022098366A1 (en) * 2020-11-09 2022-05-12 Redwood Ip Holding, Llc Skincare compositions for preventing transepidermal water loss
JPWO2023145735A1 (https=) * 2022-01-25 2023-08-03
CN121127451A (zh) * 2023-05-02 2025-12-12 启威公司 一种用于医疗用途的改良型氨溴索

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533379A (ja) * 1998-12-23 2002-10-08 イデア アクチェンゲゼルシャフト 生体内における局所的に非侵襲性である用途のための改善された製剤
MXPA04002066A (es) 2001-09-04 2005-02-17 Techno Network Shinoku Co Ltd Farmacos contra influenza.
DE10332487A1 (de) 2003-07-16 2005-02-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol für die Behandlung von chronisch nozizeptiven Schmerzen
DE102004021992A1 (de) 2004-05-03 2005-11-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Topische Zubereitung enthaltend Ambroxol
JP2008520630A (ja) * 2004-11-22 2008-06-19 シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト 皮膚損傷に有効なセラミド及び／又は偽セラミドと（α−）ビサボロールを含む製剤
ES2641272T3 (es) * 2006-04-28 2017-11-08 Children's Hospital Medical Center Composiciones que comprenden proteínas o polipéptidos fusogénicos derivados de la prosaposina para aplicación en sistemas de suministro de fármacos transmembrana
WO2008021829A2 (en) * 2006-08-09 2008-02-21 Lipo Chemicals Inc. Topical ceramide compositions and methos of use
JP5337405B2 (ja) 2007-09-17 2013-11-06 ザ・ホスピタル・フォー・シック・チルドレン ゴーシェ病の治療方法
US20110294833A1 (en) 2010-05-26 2011-12-01 Scripps Health Methods for Healthy Aging
JP5938193B2 (ja) * 2011-11-10 2016-06-22 ポーラ化成工業株式会社 抗老化剤のスクリ−ニング方法
BR112014012858B1 (pt) * 2011-11-30 2019-02-26 Ibr - Israeli Biotechnology Research Ltd. Extrato de jojoba útil em melhorar as funções de barreira da pele
JP2013241398A (ja) * 2012-04-27 2013-12-05 Fujifilm Corp β−グルコセレブロシダーゼ活性増強剤、セラミド産生増強剤及び皮膚バリア機能改善剤
TW201422246A (zh) * 2012-12-11 2014-06-16 Avon Prod Inc 藉由調節ｗｉｐｉ－１改善皮膚老化外觀之方法
US20180296464A1 (en) 2017-04-17 2018-10-18 W Skincare, LLC Autophagy activation nutrient complex, compositions and methods
US10179095B2 (en) 2017-06-07 2019-01-15 Dr. Raymond Laboratories Autophage activating resveratrol topical composition for skin improvement and treatment
EP3654960A1 (en) * 2017-07-16 2020-05-27 Neuere, LLC Ambroxol to improve and/or extend healthspan, lifespan and/or mental acuity
JP7369716B2 (ja) * 2018-01-26 2023-10-26 ノイレ， エルエルシー 皮膚バリア機能を改善するためのアンブロキソールの使用

Also Published As

Publication number Publication date
EP3743039A1 (en) 2020-12-02
CN111655223A (zh) 2020-09-11
JP2021511388A (ja) 2021-05-06
JP7369716B2 (ja) 2023-10-26
WO2019147931A1 (en) 2019-08-01
US12390409B2 (en) 2025-08-19
US20210128438A1 (en) 2021-05-06
US11730690B2 (en) 2023-08-22
US10894008B2 (en) 2021-01-19
US20200060955A1 (en) 2020-02-27
US20230346671A1 (en) 2023-11-02

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