JP7368670B2 - 破傷風毒素に対する完全天然型ヒト中和モノクロナル抗体及びその応用 - Google Patents

破傷風毒素に対する完全天然型ヒト中和モノクロナル抗体及びその応用 Download PDF

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JP7368670B2
JP7368670B2 JP2020555284A JP2020555284A JP7368670B2 JP 7368670 B2 JP7368670 B2 JP 7368670B2 JP 2020555284 A JP2020555284 A JP 2020555284A JP 2020555284 A JP2020555284 A JP 2020555284A JP 7368670 B2 JP7368670 B2 JP 7368670B2
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seq
amino acid
monoclonal antibody
set forth
neutralizing monoclonal
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JP2021508495A (ja
JP2021508495A5 (enExample
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ホアシン リャオ
ユエミン ワン
シアオホイ ユアン
ウェイホン チョン
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チューハイ トリノマブ ファーマシューティカル カンパニー，リミティド
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Priority claimed from CN201711482969.7A external-priority patent/CN108218984B/zh
Priority claimed from CN201711486732.6A external-priority patent/CN108314731B/zh
Priority claimed from CN201711486693.XA external-priority patent/CN108314730B/zh
Priority claimed from CN201810420730.5A external-priority patent/CN108623681B/zh
Application filed by チューハイ トリノマブ ファーマシューティカル カンパニー，リミティド filed Critical チューハイ トリノマブ ファーマシューティカル カンパニー，リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020555284A 2017-12-29 2018-12-28 破傷風毒素に対する完全天然型ヒト中和モノクロナル抗体及びその応用 Active JP7368670B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN201711482969.7A CN108218984B (zh) 2017-12-29 2017-12-29 一种抗破伤风毒素的全人源中和抗体
CN201711486732.6A CN108314731B (zh) 2017-12-29 2017-12-29 一种针对破伤风毒素的全人源单克隆中和抗体及其应用
CN201711482969.7 2017-12-29
CN201711486693.X 2017-12-29
CN201711486732.6 2017-12-29
CN201711486693.XA CN108314730B (zh) 2017-12-29 2017-12-29 抗破伤风毒素中和抗体及其制备与应用
CN201810420730.5 2018-05-04
CN201810420730.5A CN108623681B (zh) 2018-05-04 2018-05-04 一种抗破伤风毒素的中和抗体及应用
PCT/CN2018/124958 WO2019129214A1 (zh) 2017-12-29 2018-12-28 针对破伤风毒素的全人源单克隆中和抗体及其应用

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JP2021508495A JP2021508495A (ja) 2021-03-11
JP2021508495A5 JP2021508495A5 (enExample) 2023-05-30
JP7368670B2 true JP7368670B2 (ja) 2023-10-25

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US (1) US11725046B2 (enExample)
EP (3) EP4786004A2 (enExample)
JP (1) JP7368670B2 (enExample)
AU (1) AU2018395100B2 (enExample)
BR (1) BR112020013094A2 (enExample)
WO (1) WO2019129214A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN118139879A (zh) * 2021-09-07 2024-06-04 生物医学研究院 结合破伤风毒素的抗体及其用途
CN114044819B (zh) * 2021-09-29 2024-07-12 上海儒克生物科技有限公司 全羊源单克隆抗体的高通量制备方法
CN119700969A (zh) * 2023-09-27 2025-03-28 珠海泰诺麦博制药股份有限公司 一种抗破伤风毒素抗体在预防或治疗破伤风中的应用
CN118812707B (zh) * 2024-09-20 2024-12-31 北京科兴中维生物技术有限公司 抗破伤风毒素抗体及应用
CN120829503B (zh) * 2025-09-18 2025-12-26 北京科兴中维生物技术有限公司 抗破伤风毒素抗体及其制备方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001299360A (ja) 2000-04-28 2001-10-30 Morihiro Matsuda ヒト型抗破傷風毒素一本鎖組換え抗体フラグメント
CN1634991A (zh) 2003-12-30 2005-07-06 龚小迪 人源抗破伤风毒素单克隆抗体及其制备方法和用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2627076B2 (ja) * 1988-08-19 1997-07-02 森永製菓株式会社 抗破傷風毒素ヒト型モノクローナル抗体、それを利用した破傷風毒素中和剤及びヒト型モノクローナル抗体産生ハイブリドーマ
US6657103B1 (en) * 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
DK0562132T3 (da) 1992-03-23 1999-03-22 Schweiz Serum & Impfinst Monoklonale antistoffer mod tetanustoksin og farmaceutiske præparater indeholdende dem
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
CN101220096B (zh) * 2003-12-30 2010-09-29 龚小迪 人源抗破伤风毒素单克隆抗体的制备和应用
CN105153305B (zh) * 2015-06-26 2019-03-01 安泰吉（北京）生物技术有限公司 一种全人源抗破伤风毒素单克隆抗体及其衍生物制备方法和应用
CN108623681B (zh) * 2018-05-04 2019-05-24 珠海泰诺麦博生物技术有限公司 一种抗破伤风毒素的中和抗体及应用
CN108314730B (zh) * 2017-12-29 2019-01-08 珠海泰诺麦博生物技术有限公司 抗破伤风毒素中和抗体及其制备与应用
CN108218984B (zh) 2017-12-29 2018-10-26 珠海泰诺麦博生物技术有限公司 一种抗破伤风毒素的全人源中和抗体
CN108314731B (zh) * 2017-12-29 2019-02-12 珠海泰诺麦博生物技术有限公司 一种针对破伤风毒素的全人源单克隆中和抗体及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001299360A (ja) 2000-04-28 2001-10-30 Morihiro Matsuda ヒト型抗破傷風毒素一本鎖組換え抗体フラグメント
CN1634991A (zh) 2003-12-30 2005-07-06 龚小迪 人源抗破伤风毒素单克隆抗体及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biologicals，2003年03月，Vol.31, No.1，pp.45-53

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JP2021508495A (ja) 2021-03-11
EP3733699A4 (en) 2022-06-08
EP3733699A1 (en) 2020-11-04
AU2018395100B2 (en) 2025-01-23
WO2019129214A1 (zh) 2019-07-04
EP3733699B1 (en) 2026-06-24
EP4786003A2 (en) 2026-08-05
AU2018395100A1 (en) 2020-07-23
US11725046B2 (en) 2023-08-15
US20210002356A1 (en) 2021-01-07
BR112020013094A2 (pt) 2021-03-30
EP4786004A2 (en) 2026-08-05

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