JP7360944B2 - ポリマー繊維から形成された医療装置 - Google Patents
ポリマー繊維から形成された医療装置 Download PDFInfo
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- JP7360944B2 JP7360944B2 JP2019535792A JP2019535792A JP7360944B2 JP 7360944 B2 JP7360944 B2 JP 7360944B2 JP 2019535792 A JP2019535792 A JP 2019535792A JP 2019535792 A JP2019535792 A JP 2019535792A JP 7360944 B2 JP7360944 B2 JP 7360944B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
- A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Polymers & Plastics (AREA)
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Description
上記実施形態のいずれか1つに代替的にまたは追加的に、第1のポリマーは、ポリグリコール酸とポリカプロラクトンからなるブロックポリマーを含んでなる。
上記実施形態のいずれか1つに代替的にまたは追加的に、ブロックポリマーは、約60%以上のポリ-L-乳酸を含む。
上記実施形態のいずれか1つに代替的にまたは追加的に、第2のポリマーは、ポリカプロラクトンを含む。
上記実施形態のいずれか1つに代替的にまたは追加的に、植込式医療装置は、ステントからなる。
上記実施形態のいずれか1つに代替的にまたは追加的に、複数の融点を有するフィラメントを形成する工程は、第1のポリマーと第2のポリマーの混合物を押し出す工程からなる
上記実施形態のいずれか1つに代替的にまたは追加的に、押し出す工程は、第1の融点またはそれ以上の温度で押し出すことを含む。
上記実施形態のいずれか1つに代替的にまたは追加的に、第2のポリマーは、ポリカプロラクトンを含んでなる。
上記実施形態のいずれか1つに代替的にまたは追加的に、第1のブロックポリマーは、生分解性である。
上記実施形態のいずれか1つに代替的に又は追加的に、医療装置本体は、複数の融点を有するポリマー繊維からなる。
全ての数値は、明示の有無にかかわらず、「約」という用語で修飾されると想定される。「約」という用語は、一般に当業者が記載されている値に均等であると考える数値範囲のことをいう(例えば、同一の機能または結果を奏する)。多くの場合において、「約」の用語には、最も近い有効数字に四捨五入される複数の数値が含まれる。
この明細書と添付の請求項で使用するように、「a」、「an」、「the」には、反対のことを明示しない限り複数の対象物が含まれる。この明細書および添付の請求項で使用するように、「or(または)」は、反対のことを明示しない限り、「and/or(および/または)」を含む意味で一般に用いる。
Claims (11)
- ブロックポリマーである第1のポリマーと、第2のポリマーとからなる混合物を押し出し成形することによって複数の融点を有する繊維を形成する工程であって、前記混合物は、第1の融点と、前記第1の融点より低い第2の融点とを有する、前記複数の融点を有する繊維を形成する工程と、
前記繊維を製織、編立、または編組することによって前記繊維を管状の植込式医療用ステントに形成する工程と、
前記繊維を管状の植込式医療用ステントに形成した後、前記繊維を、前記第2の融点から10℃の範囲内で、且つ前記第1の融点より低い温度でヒートセットする工程であって、前記管状の植込式医療用ステントが所望の形状を保持するように、前記ポリマーの混合物に更なる配向及び結晶化のうちの少なくともいずれか一方を誘導する、前記繊維をヒートセットする工程と、
を備える、医療用ステントの製造方法。 - 前記第1のポリマーは、ポリグリコール酸とポリカプロラクトンからなるブロックポリマーを含んでなる、請求項1に記載の方法。
- 前記第1のポリマーは、ポリ-L-乳酸とポリカプロラクトンからなるブロックポリマーを含んでなる、請求項1に記載の方法。
- 前記ブロックポリマーは、60%以上のポリ-L-乳酸を含む、請求項3に記載の方法。
- 前記ブロックポリマーは、70%以上のポリ-L-乳酸を含む、請求項3に記載の方法。
- 前記第2のポリマーは、ポリカプロラクトンを含んでなる、請求項1~5のいずれか一項に記載の方法。
- 前記第1のポリマーは、生分解性ポリマーを含んでなる、請求項1~6のいずれか一項に記載の方法。
- 前記押し出し成形することは、前記第1の融点以上の温度で押し出すことからなる、請求項1に記載の方法。
- 押し出し成形することによって形成された複数の融点を有するポリマー繊維を、製織、編立、または編組することによって形成された管状体を備え、
前記複数の融点を有するポリマー繊維はそれぞれ、第1のブロックポリマーと第2のポリマーからなるポリマーの混合物から形成され、
前記ポリマーの混合物は、第1の融点と、前記第1の融点より低い第2の融点とを有し、
前記管状体が形成された後、前記管状体が、前記ポリマーの混合物に更なる配向及び結晶化のうちの少なくともいずれか一方を誘導して所望の形状を保持するために、前記第2の融点から10℃の範囲内で、且つ前記第1の融点よりも低い温度でヒートセットされている、医療用ステント。 - 前記第1のブロックポリマーは、ポリ-L-乳酸とポリカプロラクトンからなるブロックポリマーを含んでなる、請求項9に記載の医療用ステント。
- 前記第2のポリマーは、ポリカプロラクトンを含んでなる、請求項10に記載の医療用ステント。
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JP2021123523A JP7280317B2 (ja) | 2016-12-29 | 2021-07-28 | ポリマー繊維から形成された医療装置 |
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US201662440229P | 2016-12-29 | 2016-12-29 | |
US62/440,229 | 2016-12-29 | ||
PCT/US2017/068162 WO2018125794A1 (en) | 2016-12-29 | 2017-12-22 | Medical devices formed from polymer filaments |
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US (2) | US10966848B2 (ja) |
EP (1) | EP3562527B1 (ja) |
JP (2) | JP7360944B2 (ja) |
CN (1) | CN110366436A (ja) |
AU (1) | AU2017387027B2 (ja) |
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KR101728319B1 (ko) * | 2015-04-15 | 2017-04-19 | 주식회사 엠아이텍 | 스텐트 제조방법 |
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- 2017-12-22 CN CN201780087580.4A patent/CN110366436A/zh active Pending
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AU2017387027A1 (en) | 2019-07-04 |
EP3562527B1 (en) | 2020-11-18 |
JP7280317B2 (ja) | 2023-05-23 |
JP2021180869A (ja) | 2021-11-25 |
JP2020513916A (ja) | 2020-05-21 |
AU2017387027B2 (en) | 2020-04-23 |
US20180185181A1 (en) | 2018-07-05 |
WO2018125794A1 (en) | 2018-07-05 |
US10966848B2 (en) | 2021-04-06 |
CN110366436A (zh) | 2019-10-22 |
EP3562527A1 (en) | 2019-11-06 |
US20210161690A1 (en) | 2021-06-03 |
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