JP7360784B2 - pharmaceutical composition - Google Patents

Description

The present invention relates to a pharmaceutical composition in which the unpleasant odor of herbal medicines is reduced.

In modern society, poor blood circulation (blood flow) often becomes a problem due to various factors such as autonomic nerve dysfunction due to lack of exercise and stress. This poor blood flow (reduction in blood flow) causes various symptoms such as headaches, stiff shoulders, irregular menstruation, sensitivity to cold, swelling, and rough skin, so from a health perspective, increase blood flow and improve blood flow. There is a need for measures to do so.

To improve physical condition due to poor blood flow, it is desirable to use herbal medicines and other herbal medicines that gradually increase the body's natural healing power, based on ideas from ancient Oriental medicine. Examples of crude drug combination preparations that improve blood flow include, for example, Patent Document 1, which describes oral blood preparations containing crushed products, powders, extracts, or crudely purified products or purified products of Viburnum dilatatum of the family Lonicerae, genus Viburnum. A glidant is described, and Patent Document 2 describes one or more ingredients selected from the group consisting of Bamboo Bush Ginseng or its extract, Heshu Karasu or its extract, pantothenyl ethyl ether, menthol, and hinokitiol. A blood flow promoter as an active ingredient is described.

In addition, in general, crude drug combination preparations are required to be taken continuously for a long period of time, but they are difficult to swallow due to their unique flavors such as unpleasant odors and bitterness, making it difficult to maintain compliance. For example, it is known as a method of masking the flavor of crude drug combination preparations to incorporate large amounts of sweeteners such as honey, sucrose, and high-intensity sweeteners. As a masking method using ingredients other than sweeteners, for example, Patent Document 3 describes a method of masking the unpleasant and irritating properties of Hibusei Habue Pill extract by blending gelatin-containing granules in a lozenge. , Patent Document 4 describes a method of reducing the bitterness or odor of Bofu Tsushosan by using Bofutsushosan together with capsaicin or a capsaicin-containing substance.

JP2006-347898A Japanese Patent Application Publication No. 2005-213214 Japanese Patent Application Publication No. 05-070359 JP2009-084213A

The present inventor investigated a crude drug combination preparation that is effective as a blood flow improving agent, and came up with a crude drug composition that contains Angelica cucumber, Peony, Nemonicum, and Ginseng and is not a simultaneous extract of multiple crude drugs. However, this crude drug composition had a unique unpleasant odor and faced the problem of being very difficult to take.

The present invention provides a pharmaceutical composition that reduces the characteristic unpleasant odor of a mixture of herbal medicines in a pharmaceutical composition containing a herbal medicine composition that is not a simultaneous extract of multiple herbal medicines and contains Angelica quince, peony, nebula, and ginseng. The purpose is to

As a result of extensive studies, the present inventors have found that a crude drug composition containing Angelica quince, Peony, Namiki, and Carrot, which is not a simultaneous extract of multiple crude drugs, as well as Botanpi, Keihi, Bukuriyo, Licorice, Goshitsu, Sandalwood, Koubushi, It has been found that the unpleasant odor characteristic of the crude drug composition can be reduced by incorporating a crude drug selected from the group consisting of Kouka, Goshuyu, Hange, Rhubarb, Rhubarb, and Rhubarb. The present invention was completed through further studies based on this knowledge.

That is, the present invention provides the inventions of the following aspects.
Item 1. (A) Angelica and/or its sole extract, Peony and/or its sole extract, Nebula and/or its sole extract, and Carrot and/or its sole extract;
(B) Botanpi and its sole extract, cinnamon bark and its sole extract, licorice and its sole extract, licorice and its sole extract, sandalwood and its sole extract, sandalwood and its sole extract, korubushi and its sole extract selected from the group consisting of Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Sojutsu and its sole extract, and Rhubarb and its sole extract. A pharmaceutical composition comprising at least one of
Item 2. The pharmaceutical composition according to claim 1, wherein the content of the component (A) in the total herbal medicine components is 30 to 98% by weight.
Item 3. Item 3. The pharmaceutical composition according to item 1 or 2, wherein the component (A) is a Chinese angelica, a peony, a nebula, and a carrot.
Item 4. Items 1 to 3, wherein the component (B) is at least one member selected from the group consisting of botanpi, keihi, bukuryo, licorice, goshitsu, sandalwood, kobushi, koka, goshuyu, hange, rhubarb, sojutsu, and rhubarb. The pharmaceutical composition according to any one of the above.
Item 5. Item 5. The pharmaceutical composition according to any one of Items 1 to 4, which is a blood flow improving agent.
Item 6. (A) Pharmaceutical compositions containing Angelica and/or its sole extract, Peony and/or its sole extract, Nebula and/or its sole extract, and ginseng and/or its sole extract (however, nectar Component (A), together with (B) botanpi and its sole extract, cinnamon bark and its sole extract, bukuriyo and its sole extract, licorice and its sole extract, goshitsu and its sole extract. Extracts, Sandalwood and its sole extract, Koubushi and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Soju and its sole extract 1. A method for reducing unpleasant odor of a pharmaceutical composition, which comprises blending at least one selected from the group consisting of R. spp.

According to the pharmaceutical composition of the present invention, in a pharmaceutical composition containing a herbal medicine composition that is not a simultaneous extract of multiple herbal medicines and which contains Angelica cucumber, peony, nebula, and ginseng, the characteristic unpleasant odor of the herbal medicine mixture is reduced. Since the drug formulation is provided, it is possible to obtain good dosing properties that allow the drug to be taken continuously without difficulty.

1. Pharmaceutical Composition The pharmaceutical composition of the present invention comprises (A) Angelica and/or its sole extract, Peony and/or its sole extract, Nebula and/or its sole extract, and Carrot and/or its sole extract. (hereinafter also referred to as component (A)); (B) botanpi and its sole extract, cinnamon bark and its sole extract, bukuriyo and its sole extract, licorice and its sole extract, goshitsu and its sole extract Sandalwood and its sole extract, Koubushi and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Soju and its sole extract , and at least one member selected from the group consisting of dioxonia and its sole extract (also referred to as component B). Hereinafter, the pharmaceutical composition of the present invention will be explained in detail.

(A) Ingredient The pharmaceutical composition of the present invention contains, as the (A) ingredient, Angelica and/or its sole extract, Peony and/or its sole extract, Nebula and/or its sole extract, and Carrot and/or its sole extract. or its sole extract.

Ingredient (A) may be a mixture of four types of herbal medicines (Episodes trifoliata, peony, nebula, and ginseng), a mixture of individual extracts of each of the four types of herbal medicines, or a combination of herbal medicines and herbal medicines. It may be a mixture with a single extract of. Although such a mixture of four kinds of herbal medicines and/or their individual extracts has a unique unpleasant odor, the pharmaceutical composition of the present invention can reduce such unpleasant odor. Therefore, even if component (A) contains a herbal medicine with a large degree of unpleasant odor, especially a mixture of four kinds of herbal medicines (Japanese trumpet, peony, nebula, and ginseng), the pharmaceutical composition of the present invention It can effectively reduce unpleasant odors.

Touki is the root of Angelica acutiloba Kitagawa, a member of the Umbelliferae family, or other related plants, and is usually blanched.It is used as a herbal medicine (Japanese Pharmacopoeia) for women's medicine, medicine for cold sensitivity, and health care. It is used in the formulation of tonics, psychotropic drugs, and drugs for urinary tract disorders. Touki is commercially available from Maruzen Pharmaceutical Co., Ltd., Mikuni Co., Ltd., Ichimaru Falcos Co., Ltd., etc.

The sole extract of Angelica canker is known as Angelica root extract, as it is indicated in Japanese Pharmaceutical Standards, Standards for Quasi-drug Ingredients, etc. Specifically, the sole extract of Angelica can be obtained by extracting the roots of Angelica or other related plants using an extraction solvent after removing the soluble portion of n-hexane and/or n-butanol as necessary. It can be obtained by processing. Examples of extraction solvents used in the single extraction treatment of Japanese Angelica include: water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as mixtures thereof. Water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof are preferred. Angelica extract is commercially available from, for example, Maruzen Pharmaceutical Co., Ltd., Alps Yakuhin Kogyo Co., Ltd., etc.

Peony (peony) is the root of Paeonia lactiflora Pallas or other related plants of the Paeoniaceae family, and is used as a herbal medicine (Japanese Pharmacopoeia) mainly as an analgesic antispasmodic (gastrointestinal medicine), a women's medicine, a medicine for cold sensitivity, Used for cold medicine, etc. Incidentally, peony is both a crude drug name (Japanese Pharmacopoeia) and a botanical name. Peonies are commercially available from Maruzen Pharmaceutical Co., Ltd., Mikuni Co., Ltd., Ichimaru Falcos Co., Ltd., etc.

A single extract of a peony is listed as a peony extract in the Quasi-drug Ingredients Standards and is well known. Specifically, a single extract of peony can be obtained by extracting roots of peony or other related plants using an extraction solvent. Extraction solvents used in the single extraction treatment of peonies include, for example, water; lower alcohols such as ethanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as mixtures thereof, preferably. Water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Peony extract is commercially available from, for example, Maruzen Pharmaceutical Co., Ltd., Ichimaru Falcos Co., Ltd., Alps Yakuhin Kogyo Co., Ltd., etc.

Cnidium officinale Makino, a member of the Umbelliferae family, is usually made by blanching the rhizome of Cnidium officinale Makino, and is used as a herbal medicine (Japanese Pharmacopoeia) mainly for purposes such as blood vessel reinforcement and women's medicine. Ru. Incidentally, Senkyu is both a crude drug name (Japanese Pharmacopoeia) and a botanical name. Senkyu is commercially available from Nippon Powder Yakuhin Co., Ltd., Tochimoto Tenkaido Co., Ltd., etc.

A single extract of Nebula chinensis is listed in the Standards for Quasi-drug Ingredients as Nebula nigra extract, and is well known. Specifically, a single extract of Nebula can be obtained by extracting the rhizome of Nebula with an extraction solvent. Extraction solvents used for single extraction treatment of nebula include, for example, water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; ketones such as acetone; diethyl ether, dioxane, Examples include esters such as acetonitrile and ethyl acetate; xylene; benzene; chloroform; and mixed solvents thereof, preferably water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. The nebula extract is commercially available from, for example, Maruzen Pharmaceutical Co., Ltd., Alps Yakuhin Kogyo Co., Ltd., and the like.

Panax ginseng C. ginseng belongs to the family Araliaceae. A. Meyer (Panax schinseng Nees) root with the fine roots removed or lightly blanched.It is used as a herbal medicine (Japanese Pharmacopoeia) mainly as a tonic tonic, a digestive stimulant, an anti-diarrheal drug, a tranquilizer, and a hypoglycemic agent. It is used for medicine, cardiotonic, heat-retaining, anti-fatigue, etc. Note that ginseng is both a crude drug name (Japanese Pharmacopoeia) and a botanical name. Carrots are commercially available from Nippon Powder Yakuhin Co., Ltd., Tochimoto Tenkaido Co., Ltd., and others.

The sole extract of carrot is described as carrot extract in the Quasi-drug Ingredients Standards and is well known. Specifically, a single extract of carrot can be obtained by extracting fine roots of carrot using an extraction solvent. Extraction solvents used for the single extraction treatment of carrots include, for example, water; lower alcohols such as ethanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as mixtures thereof, preferably. Water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Carrot extract is commercially available from, for example, Matsuura Pharmaceutical Co., Ltd., Alps Yakuhin Kogyo Co., Ltd., and the like.

In the pharmaceutical composition of the present invention, the content of component (A) in all herbal drug components is not particularly limited and may be set appropriately depending on the efficacy to be exhibited, etc., but the total amount When the amount is 30 to 98% by weight, preferably 30 to 85% by weight, the effect of reducing the unpleasant odor characteristic of component (A) by component (B) can be particularly remarkable. In the pharmaceutical composition of the present invention, the component (B) has an excellent effect of reducing the unpleasant odor characteristic of the component (A), so even if the component (A) in the total herbal medicine components is relatively large, it is effective. Unpleasant odors can be reduced. From this point of view, in the pharmaceutical composition of the present invention, the content of the component (A) in all the herbal drug components is more preferably 35 to 85% by weight, and even more preferably 40 to 85% by weight in terms of the original herbal drug. 85% by weight, particularly preferably 43 to 85% by weight.

The content of all herbal drug components (the total amount of component (A), component (B), and other crude drug components blended as necessary) in the entire pharmaceutical composition of the present invention is 30 to 98% by weight. , preferably 40 to 95% by weight.

(A) The proportion of Angelica and/or its single extract in the ingredient is not particularly limited and may be set as appropriate depending on the efficacy to be exhibited, etc., but for example, the proportion of (A) 25 to 35% by weight, preferably 28 to 32% by weight of the total components.

(A) The proportion of peony and/or its single extract in the ingredient is not particularly limited and may be set as appropriate depending on the efficacy to be exhibited, etc., but for example, as the amount equivalent to the crude drug, (A) 25 to 35% by weight, preferably 28 to 32% by weight of the total components.

(A) The proportion of nebula and/or its single extract in the ingredient is not particularly limited and may be set as appropriate depending on the efficacy to be exerted, but for example, as the amount equivalent to the original herbal medicine, (A) 15 to 25% by weight, preferably 18 to 22% by weight of the total components.

(A) The proportion of carrot and/or its single extract in the ingredient is not particularly limited and may be set as appropriate depending on the efficacy to be exhibited, etc., but for example, as the amount equivalent to the crude drug, (A) 15 to 25% by weight, preferably 18 to 22% by weight of the total components.

(B) Ingredient The pharmaceutical composition of the present invention contains, as the (B) ingredient, botanpi and its sole extract, cinnamon bark and its sole extract, bukryo and its sole extract, licorice and its sole extract, goshitsu and its sole extract. Extracts, Sandalwood and its sole extract, Koubushi and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Soju and its sole extract The composition contains at least one selected from the group consisting of 1, 2, 3, 3, 3, 3, 3, 3, 4, 5, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 4, 5, 1, 2, 3, 3, 3, 3, 3, and a single extract thereof.

In the present invention, component (A) has a unique unpleasant odor, but by blending component (B) with component (A), the unique unpleasant odor of component (A) can be reduced. (B) The masking effect of the ingredient is to mask the unique unpleasant odor caused by the composition of the ingredient (A) by using a specific herbal medicine, and the masking mechanism is to offset the individual flavors of the specific herbal medicines. This is due to Therefore, the masking effect using component (B), which is a specific crude drug, is a unique effect obtained with component (A). Furthermore, since the pharmaceutical composition of the present invention performs masking using crude drug components, the efficacy of the masking component (component (B)) itself can be expected.

Ingredients (B) include botanpi and its sole extract, cinnamon bark and its sole extract, licorice and its sole extract, licorice and its sole extract, sandalwood and its sole extract, and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Sojutsu and its sole extract, and Rhubarb and its sole extract. One type of crude drug component may be used alone, or a plurality of crude drug components may be used in combination.

In addition, from the viewpoint of further reducing the unpleasant odor of the component (A), the component (B) includes cinnamon bark and its sole extract, Bukryō and its sole extract, licorice and its sole extract, sandalwood and its sole extract. , Kobushu and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Soju and its sole extract, and Rhubarb and its sole extract Preferably, it contains one or more selected from the group consisting of; It is more preferable to contain one or more selected from the group consisting of the sole extract thereof, Kouka and the sole extract thereof, and Hange and the sole extract thereof; It is more preferable that the composition contains a single extract, and one or more types selected from the group consisting of licorice and its single extract.

Furthermore, from the viewpoint of more efficiently reducing the unpleasant odor of component (A), component (B) is preferably a crude drug itself rather than an independent extract. That is, the component (B) is preferably one or more selected from the group consisting of botanpi, keihi, bukuryo, licorice, goshitsu, sandalwood, kobushi, koka, goshuyu, hange, rhubarb, sojutsu, and rhubarb. ; It is more preferable that it contains one or more species selected from the group consisting of Keihi, Bukryō, Licorice, Sandalwood, Koubushi, Kouka, Goshuyu, Hange, Rhubarb, Sojutsu, and Zhiou; Keihi, Bukryō, Licorice, Sandalwood More preferably, it contains one or more species selected from the group consisting of , Koubushi, Kouka, and Hange; It further preferably contains one or more species selected from the group consisting of Keihi, Bukuryo, and Licorice. Particularly preferred.

Botanpi (peony bark) is the root bark of Paeonia suffruticosa Andrews (Paeonia moutan Sims) of the Paeoniaceae family, and is used as a crude drug (Japanese Pharmacopoeia) mainly for purposes such as women's medicine. Botanpi is commercially available from Tochimoto Tenkaido Co., Ltd., Takasago Pharmaceutical Co., Ltd., etc.

A single extract of Botanpi can be obtained by extracting the root bark of Botanpi using an extraction solvent. Extraction solvents used for single extraction of Botanpi include, for example, water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as mixtures thereof. Water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof are preferred. A single extract of Botanpi is commercially available from, for example, Alps Yakuhin Kogyo Co., Ltd.

Cinnamomum cassia Blum is the peeled bark of the thick trunk of Cinnamomum cassia Blum, a member of the Lauraceae family, or other plants of the same genus, and is used as a herbal medicine (Japanese Pharmacopoeia) mainly as an aromatic stomachic medicine. be done. Keihi is commercially available from Nippon Powder Yakuhin Co., Ltd., Tochimoto Tenkaido Co., Ltd., etc.

The sole extract of cinnamon bark is known as a cinnamon bark extract, as it is indicated in the standards for raw materials for quasi-drugs. Specifically, the sole extract of cinnamon bark can be obtained by extracting the bark of cinnamon bark or other congenerous plants using an extraction solvent. Extraction solvents used for the sole extraction treatment of cinnamon bark include, for example, water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as mixtures thereof. Water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof are preferred. Cinnabar extract is commercially available from, for example, Maruzen Pharmaceutical Co., Ltd., Nippon Powdered Yakuhin Co., Ltd., and the like.

Poria cocos is the sclerotium of Wolfiporia cocos Ryvarden et Gilbertson (Poria cocos Wolf), a member of the Polyporaceae family, and is usually removed from most of the outer layer, and is used as a crude drug (Japanese Pharmacopoeia). Mainly as a sedative , used for purposes such as diuretics. Bukuryo is commercially available from Takasago Pharmaceutical Co., Ltd., Tochimoto Tenkaido Co., Ltd., etc.

A single extract of Lamium chinensis is listed in the Standards for Quasi-drug Ingredients as Lamium chinensis extract, and is well known. Specifically, a single extract of Prunus japonicus can be obtained by extracting sclerotia of Prunus japonicus using an extraction solvent. Extraction solvents used for single extraction treatment of nebula include, for example, water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; ketones such as acetone; diethyl ether, dioxane, Examples include esters such as acetonitrile and ethyl acetate; xylene; benzene; chloroform; and mixed solvents thereof, preferably water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Bukryo extract is commercially available, for example, from Maruzen Pharmaceutical Co., Ltd., Alps Yakuhin Kogyo Co., Ltd., and the like.

Licorice (licorice) is the root and stolone of Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne, which belongs to the Fabaceae family (Leguminosae). Used for medicine, stomach ulcer medicine, etc. Licorice is commercially available from Nippon Powder Yakuhin Co., Ltd., Takasago Pharmaceutical Co., Ltd., Tochimoto Tenkaido Co., Ltd., etc.

The sole extract of licorice is listed as licorice extract in the Quasi-drug Ingredients Standards and is well known. Specifically, the sole extract of licorice extract can be obtained by extracting the roots or stolons of Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne using an extraction solvent. Extraction solvents used for the sole extraction of licorice include, for example, water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; ketones such as acetone; diethyl ether, dioxane, Examples include esters such as acetonitrile and ethyl acetate; xylene; benzene; chloroform; and mixed solvents thereof, preferably water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Licorice extract is commercially available from, for example, Maruzen Pharmaceutical Co., Ltd., Nippon Powder Yakuhin Co., Ltd., Alps Yakuhin Kogyo Co., Ltd., etc.

Goshitsu (Cow's knee) is the root of Achyranthes fauriei Leveille et Vaniot or Achyranthes bidentata Blume, which belongs to the Amaranthaceae family, and is mainly used as a diuretic and a gynecologist as a herbal medicine (Japanese Pharmacopoeia). Used for medicine, etc. . Goshitsu is commercially available from Nippon Powder Yakuhin Co., Ltd., Mikuni Co., Ltd., Maechu Co., Ltd., and others.

A single extract of Goshitsu can be obtained by extracting the root of Kojitsu chinensis using an extraction solvent. Extraction solvents used for the sole extraction treatment of Goshitsu include, for example, water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; ketones such as acetone; diethyl ether, dioxane, Examples include esters such as acetonitrile and ethyl acetate; xylene; benzene; chloroform; and mixed solvents thereof, preferably water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Goshitsu extract is commercially available, for example, from Nippon Powder Yakuhin Co., Ltd., Maechu Co., Ltd., and the like.

Sandalwood is the rhizome of Atractylodes japonica Koidzumi ex Kitamura or Atractylodes ovata De Candolle of the Compositae family, and is used as an herbal medicine. (Japanese Pharmacopoeia) and is mainly used as a stomachic medicine, laxative, etc. . Sandalwood is commercially available from Tochimoto Tenkaido Co., Ltd., Konishi Pharmaceutical Co., Ltd., etc.

A single extract of Sandalwood can be obtained by extracting the rhizomes of Okera or Opera oleracea using an extraction solvent. Extraction solvents used for the sole extraction treatment of sandalwood include, for example, water; lower alcohols such as ethanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as mixtures thereof, preferably. Water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. A single extract of Sandalwood can be obtained commercially from, for example, Alps Yakuhin Kogyo Co., Ltd.

Koubushi (Koubusi) is the rhizome of Cyperus rotundus Linne, a member of the Cyperaceae family, and is used as a herbal medicine (Japanese Pharmacopoeia) mainly for purposes such as analgesics. Koubushi is commercially available from Tochimoto Tenkaido Co., Ltd. and others.

A single extract of Kobushu can be obtained by extracting the rhizomes of A. japonica using an extraction solvent. Extraction solvents used for the sole extraction treatment of Kobusi include, for example, water; lower alcohols such as ethanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as mixtures thereof. Preferably, Water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Koubushi extract is commercially available, for example, from Nippon Powder Yakuhin Co., Ltd.

Kouka (safflower) is the tubular flower of Carthamus tinctorius Linne, a member of the Compositae family, either as it is or with most of the yellow pigment removed, and sometimes pressed into a plate shape. It is mainly used as a gynecological medicine. Kouka is commercially available from Tochimoto Tenkaido Co., Ltd. and others.

A single extract of Kouka is known as a safflower extract and is indicated in the Japanese Pharmaceutical Standards and the like outside the Japanese Pharmacopoeia. Specifically, a single extract of Kouka can be obtained by extracting tubular flowers of Safflower or those from which most of the yellow pigment has been removed using an extraction solvent. Extraction solvents used for the sole extraction treatment of Kouka include, for example, water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; ketones such as acetone; diethyl ether, dioxane, Examples include esters such as acetonitrile and ethyl acetate; xylene; benzene; chloroform; and mixed solvents thereof, preferably water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Safflower extract is commercially available from, for example, Maruzen Pharmaceutical Co., Ltd., Nippon Powdered Pharmaceutical Co., Ltd., and the like.

Euodia ruticarpa Hooker filius et Thomson (Evodia rutaecarpa Bentham), Euodia officiali, belongs to the Rutaceae family. It is the fruit of s Dode (Evodia officialis Dode) or Euodia bodinieri Dode (Evodia bodinieri Dode), and is used as a herbal medicine ( (Japanese Pharmacopoeia) and is mainly used as an analgesic and a gastric medicine. Goshuyu is both a crude drug name (Japanese Pharmacopoeia) and a botanical name. Goshuyu is commercially available from Nippon Powder Yakuhin Co., Ltd.

A single extract of Goshuyu can be obtained by extracting Goshuyu fruit using an extraction solvent. Extraction solvents used for the single extraction treatment of goshuyu include, for example, water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; ketones such as acetone; diethyl ether, dioxane, Examples include esters such as acetonitrile and ethyl acetate; xylene; benzene; chloroform; and mixed solvents thereof, preferably water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. Goshuyu extract is commercially available from, for example, Alps Yakuhin Kogyo Co., Ltd.

Hange (Hange) is a tuber of Pinellia ternata Breitenbach from the family Araceae, from which the cork layer has been removed, and is used as a herbal medicine (Japanese Pharmacopoeia) mainly as an antiemetic and an expectorant. Hange is commercially available from Tochimoto Tenkaido Co., Ltd. and others.

A single extract of P. japonica can be obtained by extracting the tuber of P. japonica from which the cork layer has been removed using an extraction solvent. Extraction solvents used for the single extraction treatment of Hange include, for example, water; lower alcohols such as ethanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as a mixture thereof. Preferably, Water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof. A single extract of Hange is commercially available, for example, from Alps Pharmaceutical Industries Co., Ltd. and the like.

Rheum palmatum L. is a member of the Polygonaceae family. , Rheum tanguticum Maximowicz, Rheum officinale Baillon, Rheum coreanum Nakai or their interspecific hybrids, and are usually rhizomes, and are mainly used as herbal medicines (Japanese Pharmacopoeia) for stomachic medicines and laxatives. Rhubarb is commercially available from Sanwa Herbal Medicine Co., Ltd., Tochimoto Tenkaido Co., Ltd., etc.

The sole extract of rhubarb is Rheum palmatum L. , Rheum tanguticum Maximowicz, Rheum officinale Baillon, Rheum coreanum Nakai, or their interspecific hybrids, by extracting the rhizomes using an extraction solvent. Extraction solvents used for the sole extraction treatment of rhubarb include, for example, water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as mixtures thereof. Water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof are preferred. A single extract of rhubarb is commercially available from, for example, Alps Yakuhin Kogyo Co., Ltd.

Sojutsu is the rhizome of Atractylodes lancea De Candolle or Atractylodes chinensis Koidzumi, which belongs to the Compositae family, and is mainly used as a herbal medicine (Japanese Pharmacopoeia) for stomach health. used for. Soujutsu is commercially available from Tochimoto Tenkaido Co., Ltd., Yoshimi Pharmaceutical Co., Ltd., etc.

A single extract of Sojutsu can be obtained by extracting the rhizome of Hosobaokera using an extraction solvent. Extraction solvents used for the sole extraction treatment of Sojutsu include, for example, water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as mixtures thereof. Water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof are preferred. Single extracts of Soju are commercially available, for example, from Alps Yakuhin Kogyo Co., Ltd. and the like.

Rehmannia glutinosa Liboschitz var. Rehmannia glutinosa belongs to the family Scrophulariaceae. It is the root of purpurea Makino or Rehmannia glutinosa Liboschitz (dried rhubarb) or its steamed product (mature rhubarb), and is used as a crude drug (Japanese Pharmacopoeia) mainly for antidiarrheal and diuretic purposes. Zi-O is commercially available from Tochimoto Tenkaido Co., Ltd., Nippon Powdered Yakuhin Co., Ltd., etc.

A single extract of Rhododendron can be obtained by extracting the roots of Rhododendron alba with an extraction solvent. Extraction solvents used for the sole extraction treatment of dioxium include, for example, water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as mixtures thereof. Water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof are preferred. A single extract of Rhododendron is commercially available from, for example, Nippon Powder Yakuhin Co., Ltd.

In the pharmaceutical composition of the present invention, the content of component (B) in all the herbal drug components is not particularly limited, but may be, for example, 2 to 70% by weight in total in terms of the original herbal drug. Component (B) has an excellent masking effect against the unpleasant odor peculiar to component (A), so even if component (B), which is a masking agent, is not used in large excess in all herbal medicine components, Unpleasant odors can be effectively reduced. From this point of view, in the pharmaceutical composition of the present invention, the content of the component (B) in all herbal drug components is preferably 2 to 65% by weight, more preferably 2 to 60% by weight in terms of the original herbal drug. % by weight, more preferably 2 to 57% by weight. Furthermore, from the viewpoint of obtaining an even better masking effect against the unpleasant odor of component (A), the amount is preferably 15 to 57% by weight.

In the pharmaceutical composition of the present invention, the ratio of component (A) to component (B) is determined depending on the amount of each component described above, but from the viewpoint of more preferably reducing the unpleasant odor peculiar to component (A). Therefore, the total amount of component (B) per 1 part by weight of component (A) in terms of the crude drug is 0.02 parts by weight to 2.3 parts by weight. Component (B) has an excellent masking effect against the unpleasant odor peculiar to component (A), so it effectively reduces unpleasant odors even if it is not used in large excess relative to component (A). can be done. From this point of view, in the pharmaceutical composition of the present invention, the amount of component (B) per 1 part by weight of component (A) in terms of the original drug is preferably 0.1 to 1.9 parts by weight, and more It is preferably 0.1 to 1.5 parts by weight, more preferably 0.1 to 1.3 parts by weight. Furthermore, from the viewpoint of obtaining an even better masking effect against the unpleasant odor of component (A), the amount is preferably 0.2 to 1.3 parts by weight.

Other Components In addition to the above-mentioned components (A) and (B), the pharmaceutical composition of the present invention may further contain additives and bases depending on the formulation form. Additives and bases are not particularly limited as long as they are pharmaceutically acceptable, but include excipients, binders, disintegrants, lubricants, tonicity agents, plasticizers, dispersants, emulsifiers, Solubility aids, wetting agents, stabilizers, suspending agents, adhesives, coating agents, brightening agents, water, oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, water-soluble Polymers, surfactants, metallic soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, ultraviolet inhibitors, preservatives, flavoring agents, fragrances, powders, thickeners, pigments , chelating agents, and the like. These additives may be used alone or in combination of two or more. Further, the contents of these additives and bases are appropriately set depending on the types of additives and bases used, the formulation form of the pharmaceutical composition of the present invention, and the like.

Examples of additives and bases include starch, lactose, carmellose calcium, light anhydrous silicic acid, magnesium stearate, synthetic aluminum silicate, magnesium aluminate metasilicate, calcium silicate, magnesium silicate, synthetic Examples include hydrotalcite, anhydrous calcium hydrogen phosphate, carmellose, croscarmellose sodium, sodium starch glycolate, crospovidone, and preferably carmellose calcium, light anhydrous silicic acid, magnesium stearate, and synthetic aluminum silicate. Can be mentioned. Examples of the starch include potato starch, corn starch, etc., with corn starch being preferred. The contents of these additives and base material are appropriately set depending on the types of additives and base material used.

When the pharmaceutical composition of the present invention further contains an additive or a base in addition to the above-mentioned components (A) and (B), the amounts of the additive and base in the entire pharmaceutical composition are as follows: The total amount may be 2 to 70% by weight, preferably 5 to 60% by weight.

Moreover, the pharmaceutical composition of the present invention may further contain nutritional components and pharmacological components other than component (A), if necessary. Such nutritional and pharmacological ingredients are not particularly limited as long as they are pharmaceutically acceptable, but include, for example, antacids, stomachic agents, digestive agents, intestinal regulation agents, antispasmodics, mucosal repair agents, anti-inflammatory agents, and antiemetics. agents, antitussives, expectorants, anti-inflammatory enzymes, sedative-hypnotics, antihistamines, caffeine, cardiac diuretics, antibacterial agents, vasoconstrictors, vasodilators, local anesthetics, herbal medicines and/or herbal medicine extracts, vitamins etc. These nutritional components and pharmacological components may be used alone or in combination of two or more. Further, the contents of these components are appropriately set depending on the types of components used. In addition, when crude drugs and/or crude drug extracts are included as other nutritional ingredients or pharmacological ingredients, the content of all crude drug ingredients in the entire pharmaceutical composition, together with the content of the above-mentioned components (A) and (B). The amount is, for example, 30 to 98% by weight, preferably 40 to 95% by weight, as described above.

Formulation The form of the pharmaceutical composition of the present invention is not particularly limited as long as it can be administered orally and is not a honey pill, but examples include powders, fine granules, granules, tablets, troches, and chewables. Solid preparations such as tablets, capsules (soft capsules, hard capsules), pills (excluding honey pills); Semi-solid preparations such as jellies; solutions, suspensions, syrups Examples include liquid preparations such as. Among these formulation forms, solid formulations are preferred from the viewpoints of stability of contained ingredients, portability, and the like. In addition, the pharmaceutical composition of the present invention has a reduced unpleasant odor peculiar to component (A), so it provides a good feeling when taking it even if it is in a formulation that does not contain a large amount of a known masking agent such as a sweetener. Obtainable. From this point of view, more preferred formulation forms include powders, fine granules, granules, tablets, capsules, and pills (excluding honey pills), and more preferably, Examples include powders, fine granules, granules, and tablets.

Manufacturing method The method for manufacturing the pharmaceutical composition of the present invention is to prepare a conventional formulation employed in the pharmaceutical field using the above-mentioned (A) component and the above-mentioned (B) component, and other components blended as necessary. It may be formulated according to the chemical method.

Applications The pharmaceutical composition of the present invention may be used in any application in which the efficacy of the crude drug constituting the component (A) and the component (B) is expected. Preferably, it is suitably used as a blood flow improving agent due to the efficacy of the crude drug constituting the component (A). By improving blood flow, it is expected that various physical ailments caused by an imbalance between female hormones and autonomic nerves, for example, can be alleviated, so it is more suitable for use as a women's health drug.

Dosage/Administration The pharmaceutical composition of the present invention is used by oral administration. The dosage of the pharmaceutical composition of the present invention is appropriately set depending on the purpose of administration, the age, sex, constitution, degree of symptoms, etc. of the person to be administered. It may be taken 1 to 3 times a day, preferably 2 or 3 times a day, in an amount of 1.5 to 7 g, preferably 2.0 to 6 g, in terms of the original herbal medicine. The timing of administration is not particularly limited and may be taken before meals, after meals, or between meals, but preferably after meals.

2. Method for Reducing Unpleasant Odor of Pharmaceutical Compositions As mentioned above, botanpi and its sole extract, cinnamon bark and its sole extract, licorice and its sole extract, licorice and its sole extract, goshitsu and its sole extract, sandalwood and its sole extract. its sole extract, Kobushi and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, rhubarb and its sole extract, Rhubarb and its sole extract, and Rhubarb and its sole extract; Component (B), which is at least one selected from the group consisting of and a single extract thereof, is a Japanese angelica and/or a single extract thereof, a peony and/or a single extract thereof, a nebula and/or a single extract thereof, Furthermore, the characteristic unpleasant odor of component (A), which is carrot and/or its sole extract, can be reduced. Therefore, the present invention further includes (A) Angelica and/or its sole extract, Peony and/or its sole extract, Nemthena and/or its sole extract, and Carrot and/or its sole extract. In a pharmaceutical composition (excluding the case of honey pills), together with the component (A), (B) botanpi and its sole extract, cinnamon bark and its sole extract, bud lily and its sole extract, licorice and its sole extract. Single extract, Goshuyu and its sole extract, Sandalwood and its sole extract, Kobushu and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract Provided is a method for reducing the unpleasant odor of a pharmaceutical composition, which comprises blending at least one member selected from the group consisting of a soybean extract, a sole extract thereof, and a rhubarb extract and a sole extract thereof.

In the method for reducing unpleasant odor of a pharmaceutical composition, the types and amounts of the components used, the form of the pharmaceutical composition, etc. are as shown in the column of "1. Pharmaceutical composition" above.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to Examples, but the present invention is not limited to these Examples.

Pharmaceutical compositions having the compositions listed in Tables 1 to 4 were prepared. The degree of reduction in unpleasant odor in the prepared pharmaceutical composition was evaluated based on the following criteria.

5: Unpleasant odor was extremely reduced 4: Unpleasant odor was greatly reduced 3: Unpleasant odor was reduced 2: Unpleasant odor was slightly reduced 1: Unpleasant odor was only slightly reduced 0: Unpleasant Odor is similar to Comparative Example 1 -1: The feeling of taking the drug worsened due to an increase in unpleasant odor or the addition of another unpleasant taste.

The results are shown in Tables 1 to 4. As is clear from Tables 1 and 2, the unpleasant odor in the pharmaceutical composition (Comparative Example 1) containing only the component (A) containing powdered chili powder, powdered peony powder, powdered nebula powder, and powdered ginseng powder was found in It is reduced by blending the component (B) selected from the group consisting of licorice powder, licorice powder, sandalwood powder, kobushi powder, kouka powder, goshuyu powder, hange powder, rhubarb powder, sojutsu powder, and rhubarb powder. Ta. Furthermore, as is clear from Table 3, even when component (B) is added to a pharmaceutical composition containing a herbal drug component (component (a)) other than component (A), the effect of reducing unpleasant odors cannot be obtained. There wasn't. In particular, when compounded in a pharmaceutical composition containing Oren Agyoto, rhubarb powder, scutellariae powder, and oren powder as the component (a) (Comparative Examples 3, 4, 5, 6, 7, 9, 10), Even when component (B) was added, the feeling of taking the drug actually worsened. In other words, it was shown that the masking effect of component (B) is a unique effect exerted on pharmaceutical compositions containing component (A). Furthermore, as is clear from Table 4, even when a crude drug component (component (b)) other than component (B) was added to component (A), no effect of reducing unpleasant odor could be obtained. In particular, when forsythia powder, forsythia powder, ephedra powder, and bellflower powder were blended as the component (b) (Comparative Examples 11, 12, 13, and 15), the feeling of taking the drug rather worsened. In other words, it was shown that the masking effect exerted on the pharmaceutical composition containing component (A) is an effect unique to component (B).

Claims (6)

(A) Angelica and/or its sole extract, Peony and/or its sole extract, Nebula and/or its sole extract, and Carrot and/or its sole extract;
(B) Botanpi and its sole extract, cinnamon bark and its sole extract, licorice and its sole extract, licorice and its sole extract, sandalwood and its sole extract, sandalwood and its sole extract, korubushi and its sole extract selected from the group consisting of Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Sojutsu and its sole extract, and Rhubarb and its sole extract. and at least one species of
A pharmaceutical composition in which all the herbal medicine components are the above-mentioned (A) component and the above-mentioned (B) component (excluding the case where it is a honey pill). The pharmaceutical composition according to claim 1, wherein the content of the component (A) in the total herbal medicine components is 30 to 98% by weight. The pharmaceutical composition according to claim 1 or 2, wherein the component (A) is a Chinese angelica, a peony, a nebula, and a carrot. Component (B) is at least one species selected from the group consisting of botanpi, keihi, bukuryo, licorice, goshitsu, sandalwood, kobushi, koka, goshuyu, hange, rhubarb, sojutsu, and rhubarb. 3. The pharmaceutical composition according to any one of 3. The pharmaceutical composition according to any one of claims 1 to 4, which is a blood flow improving agent. (A) Pharmaceutical compositions containing Angelica and/or its sole extract, Peony and/or its sole extract, Nebula and/or its sole extract, and ginseng and/or its sole extract (however, nectar A method for reducing unpleasant odors ( except in cases where
The pharmaceutical composition further includes: (B) botanpi and its sole extract, cinnamon bark and its sole extract, licorice and its sole extract, licorice and its sole extract, goshitsu and its sole extract, sandalwood and its sole extract; Extracts, Kobushu and its sole extract, Kouka and its sole extract, Goshuyu and its sole extract, Hange and its sole extract, Rhubarb and its sole extract, Rhubarb and its sole extract, and Rhubarb and its sole extract. Blending at least one selected from the group consisting of single extracts ,
The method described above, wherein all the herbal medicine components contained in the pharmaceutical composition further containing the component (B) consist of the component (A) and the component (B).