JP2000169385A - Internal liquid pharmaceutical preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an internal liquid pharmaceutical preparation that is readily takable, while its metallic taste originating from iron is masked, and is useful for treatment and prevention of anemia, poor circulation or the like by using iron components, rehmanniae radix (a kind of Chinese medicine) and xylitol. SOLUTION: This internal liquid pharmaceutical preparation includes (A) an iron component, preferably iron citrate, ammonium iron citrate, sodium iron citrate or the like, (B) rehmanniae radix and (C) xylitol. In a preferred embodiment, the amount of the component (A) is 0.05-50 mmol/L calculated as iron, that of the component (B) is 40-2,000 mg every dose calculated as the original herb, and that of the component (C) is >=20 mmol per 1 mmol of the iron in the component (A). This liquid preparation can be applied to internal liquid of drugs and quasi drugs, for example, drinkable preparation, syrups, and the like and a variety of beverages, for example, health drinks or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid preparation containing an iron component and ground yellow in which the metallic taste derived from iron is reduced, and is applicable to the fields of medicine and food.

[0002]

2. Description of the Related Art Iron is widely distributed in living organisms, such as hemoglobin in blood, myoglobin in muscle, and ferritin in liver. If iron is insufficient, it causes symptoms such as anemia and malaise. In addition, ground yellow has a blood glucose lowering action, an anti-intravascular coagulation action, a blood flow improving effect, and the like, and is a crude drug that is effective in improving coldness and the like. Anemia, chilliness and the like are symptoms that are common in women. Therefore, a drug containing iron and ground yellow at the same time is particularly useful as a medicine for women. However,
When an iron component is incorporated into an oral solution, there is a drawback that it is difficult to take due to its unique metallic taste.

[0003] As a method of improving such metallic taste derived from iron, a method of blending fruit juice (Japanese Patent Application Laid-Open No.
JP-A-4-86858), a method of blending an alcohol component (JP-A-4-27369), and a method of blending a fragrance are known, but are not necessarily sufficient.

On the other hand, ground yellow has an effect of masking metallic taste to itself, and it is useful to mix ground yellow with an oral solution containing an iron component. However, there is a problem that even if the liquid preparation containing an iron component at a low concentration is useful, a sufficient masking effect cannot always be obtained at a high concentration.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to mix an iron component and ground yellow to mask the metallic taste derived from iron.
It is an object of the present invention to provide an oral solution which is extremely effective for treating or preventing anemia and chilliness.

[0006]

Means for Solving the Problems The present inventors have made intensive studies to achieve the above object, and as a result, have solved the problem by adding a new xylitol to an oral solution containing an iron component and ground yellow. And completed the present invention. That is, the present invention is an oral liquid preparation characterized by containing an iron component, ground yellow and xylitol.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, iron components are iron citrate, iron ammonium citrate, iron sodium citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, and sulfuric acid. There is no particular limitation as long as it is an iron-containing compound, such as ferrous iron or ferric chloride, which can be blended in the oral liquid, but the present invention is more preferable with iron citrate, iron ammonium citrate and sodium iron citrate, and ferrous gluconate. And the effect of the present invention is further exhibited by ammonium iron citrate. Although the effect of the present invention is exhibited when the iron component is blended at a rate of 50 mmol / L or less as the iron content, masking is possible regardless of the present invention in a thin region where the iron content is 0.05 mmol / L or less. In a dark area, the effect is low. Preferably, it is in the range of 0.1 to 30 mmol / L.

[0008] The ground yellow used in the present invention is dough yellow, fresh ground yellow, dry ground yellow, mature ground yellow, etc., and dry extracts, soft extracts, flow extracts, and extracts prepared from the raw materials by the usual methods. Commercially available ones can also be used. The amount of ground yellow is 10 to 40 as a crude drug equivalent, since it has a medicinal effect and a masking effect by itself.
00 mg, preferably 40-2000 mg, can be formulated as a single dose. If the amount is less than 10 mg, the effect cannot be expected, and if it exceeds 4000 mg, the ground yellow itself has a strong taste and the flavor is impaired.

Xylitol can mask a metallic taste derived from iron in a mixture of iron and ground yellow by adding 20 mmol or more of xylitol to 1 mmol of iron, but is preferably 30 mmol or more. In addition, since xylitol has a laxative effect, a single dose is preferably 20 g or less.

The oral liquid preparation of the present invention also contains vitamins, for example, water-soluble vitamins such as vitamin B group and vitamin C, and fat-soluble vitamins such as vitamin A, vitamin D and vitamin E. But it is good. One or more of these vitamins can be used.

The pH of the liquid preparation of the present invention is usually about 2 to 7, preferably about 2.5 to 6. PH of oral solution
Can be adjusted using a conventional pH adjuster. Examples of the pH adjuster include organic acids and salts thereof such as citric acid, malic acid, tartaric acid, fumaric acid, lactic acid, succinic acid, ascorbic acid, and acetic acid; and inorganic acids and salts thereof such as hydrochloric acid and phosphoric acid. No. One or more of these pH adjusters can be used.

The oral liquid preparation of the present invention generally contains, as other components, minerals, amino acids and salts thereof, crude drugs and crude drug extracts, sweeteners, preservatives, flavoring agents, flavoring agents, coloring agents and the like. The components used can be blended.

The liquid preparation for internal use according to the present invention can be prepared by a conventional method, and the method is not particularly limited. Usually, each component is mixed with a specified amount or less of purified water, and the volume is adjusted to the specified amount. It is obtained by performing filtration and sterilization as appropriate. When a fat-soluble vitamin is contained, the fat-soluble vitamin may be emulsified or solubilized with a commonly used surfactant or solubilizer, or may be suspended with a dispersant.

The oral liquid preparation of the present invention is, for example, a drink preparation,
The present invention can be applied to various kinds of beverages such as medicines such as syrups, oral liquids of quasi-drugs, and health drinks.

[0015]

According to the present invention, it has been found that, by further mixing xylitol in an oral solution containing an iron component and ground yellow, an oral solution which can effectively reduce the metallic taste derived from iron and is easy to take can be provided.

[0016]

Next, the present invention will be described in detail with reference to examples and test examples. Example 1 Ammonium iron citrate 40 mg Ground yellow extract 200 mg (equivalent to crude drug) Xylitol 2000 mg Purified water (total) 100 mL (about 1.2 mmol / L as iron) The above components were mixed and dissolved to obtain a liquid preparation.

Example 2 Ammonium iron citrate 40 mg Ground yellow extract 200 mg (converted to crude drug) Xylitol 2000 mg Malic acid Suitable amount (pH 4) Purified water (total amount) 100 mL (about 1.2 mmol / L as iron) Were mixed and dissolved to obtain a liquid preparation.

Example 3 Ammonium iron citrate 100 mg Ground yellow extract 500 mg (equivalent to crude drug) Xylitol 10,000 mg Purified water (total amount) 100 mL (about 3.0 mmol / L as iron amount) Obtained.

Example 4 Ammonium iron citrate 100 mg Ground yellow extract 400 mg (converted to crude drug) Xylitol 6000 mg Malic acid Suitable amount (pH 4) Purified water (total amount) 100 mL (about 3.0 mmol / L as iron) Were mixed and dissolved to obtain a liquid preparation.

Example 5 Ammonium iron citrate 60 mg Ground yellow extract 200 mg (converted to crude drug) Thiamine nitrate 5 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 10 mg Aminoethylsulfonic acid 1500 mg Magnesium L-aspartate 1200 mg Gluconic acid Calcium 2500 mg Nicotinamide 20 mg Inositol 100 mg Anhydrous caffeine 50 mg Yokuinin flow extract 2000 mg (converted to crude drug) Xylitol 5000 mg Sugar 5000 mg Erythritol 1000 mg Sodium benzoate 70 mg Butyl benzoate Propyl benzoate 5 mg Propyl paraoxybenzoate 5 mg DL-malic acid 500 mg Citric acid Appropriate amount (pH 4) Mixed fruit flavor Trace amount Purified water (Total amount) ) 100 mL (1.8 mmol / L as iron amount) The above components were mixed and dissolved to obtain a liquid preparation.

Comparative Example 1 Ammonium iron citrate 20 mg Ground yellow extract 100 mg (in terms of crude drug) Purified water (total amount) 100 mL (about 0.6 mmol / L as iron amount) The above components were mixed and dissolved to obtain a liquid preparation.

Comparative Example 2 Ammonium iron citrate 40 mg Ground yellow extract 200 mg (converted to crude drug) Malic acid Suitable amount (pH 4) Purified water (total amount) 100 mL (about 1.8 mmol / L as iron amount) A solution was obtained.

Test Examples The liquids containing the six iron components of Examples 1 to 4 and Comparative Examples 1 and 2 were organoleptically evaluated for the degree of metallic taste by 20 panelists. In addition, the evaluation of metal taste was performed by the following six-step evaluation, and the average score was calculated for each.

Evaluation 1: Metallic taste is strongly felt (5 points) Evaluation 2: Metallic taste is strongly felt (4 points) Evaluation 3: Metallic taste is somewhat strong (3 points) Evaluation 4: Metallic taste is felt (2 points) Evaluation 5: Metallic taste is slightly weakened (1 point) Evaluation 6: Metallic taste is not felt (0 point).

The results are shown in Table 1. As is clear from Table 1, it was proved that the addition of xylitol significantly reduced the metallic taste derived from iron.

[0026]

[Table 1]

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 47/10 A61K 47/10 LF term (Reference) 4C076 AA12 BB01 CC11 CC14 CC21 DD30E DD38T DD41A DD43A EE58T FF52 4C086 AA01 AA02 GA13 HA11 HA20 MA03 MA05 MA17 MA52 NA09 ZA36 ZA54 ZA55 ZC21 ZC35 4C088 AB37 AC13 BA08 MA02 MA17 MA52 NA09 ZA36 ZA54 ZA55 ZC21 ZC35 4C206 AA01 AA02 CA05 DB03 DB27 JB11 KA13 MA03 Z0537

Claims (4)

[Claims] 1. An oral solution containing an iron component, ground yellow and xylitol. 2. The iron content is 0.05 to 5% in terms of iron content.
The oral liquid preparation according to claim 1, wherein the amount is 50 mmol / L. 3. The method according to claim 1, wherein the iron component comprises at least 20 mmol of xylitol per 1 mmol of iron.
Or the oral liquid preparation according to 2. 4. The oral liquid preparation according to claim 1, wherein the iron component is at least one selected from iron citrate, iron ammonium citrate, sodium iron citrate and ferrous gluconate.