JPH111436A - Iron-containing liquid agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject agent useful as a medicine or food obviating such symptoms as anemia and feeling of fatigue by including an iron component and an extract such as of Rehmannia glutinosa followed by adjustment to a sepcific pH so as to improve unpleasant flavor unique to the iron component subject to increase with the lapse of time. SOLUTION: This liquid agent is obtained by including (A) an iron component such as ferric ammonium citrate, ferric sodium citrate, ferric chloride or ferrous sulfate and (B) at least one kind of extract selected from Rehmannia glutinosa and analogs as crude drugs. The contents of the above active ingredients are as follows: the component A: 0.0005-0.05 mol/L in terms of iron; the component B: 40-4,000 mg in terms of orginal crude drug based on the component A corresponding to 0.01 mol. of iron. This liquid agent is adjusted to pH 2.0-4.5.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an iron-containing liquid having an improved flavor.

[0002]

2. Description of the Related Art Iron is an essential component of living organisms, and when it is deficient, symptoms such as anemia and malaise occur. Therefore, in order to eliminate iron deficiency, drugs and foods containing iron have recently been put on the market. However, the oral liquid formulation containing iron has a unique flavor such as iron so-called iron odor, and has a drawback that the unique flavor increases with time.

[0003] As a method for improving such a unique flavor of iron, a method of blending fruit juice (JP-A-64
JP-A-86858), a method of blending an alcohol component (JP-A-4-27369), and a method of blending a fragrance are known, but none of these methods has sufficiently improved the unpleasant flavor that increases with time. .

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to improve the iron-specific unpleasant taste which increases with time in an iron-containing solution.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted various studies to achieve the above object. As a result, when an extract of ground yellow or mature ground yellow is added to a solution containing iron and adjusted to a specific pH, The present inventors have found that an increase in the unpleasant flavor peculiar to iron, which increases with time, is suppressed, and that the flavor does not deteriorate even after a long period of time, thereby completing the present invention.

[0006] That is, the present invention is an iron-containing liquid formulation containing an iron component and an extract of ground yellow or mature ground yellow, and having a pH of 2 to 4.5.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, iron content is ferric chloride, iron citrate, iron ammonium citrate, iron sodium citrate, ferrous gluconate, iron lactate, ferrous pyrphosphate and ferrous pyrophosphate. There is no particular limitation as long as it is an iron-containing compound that can be blended in an oral liquid, such as ferrous sulfate and ferrous sulfate.
From the viewpoint of the flavor improving effect, ammonium iron citrate, sodium iron citrate, ferric chloride, ferrous sulfate and the like are preferable, and the most preferable one is ammonium ferric citrate.

[0008] The compounding amount of iron is 0.00
The effect of the present invention is remarkably exhibited when blended at a ratio of from 0.05 to 0.05 mol / l. If it is less than 0.0005 mol / l, the flavor can be improved without using the present invention.
If the amount is more than 0.05 mol / l, the improvement of flavor cannot be satisfied even by the present invention.

[0009] The extract of earthy yellow or mature earth yellow used in the present invention is an extract produced by a usual method or a dried extract, and commercially available ones can also be used.

The amount of the extract of ground yellow or mature ground yellow is 40 to 40% in terms of the amount of a crude drug per 0.01 mol of iron.
It is 4000 mg, preferably 80-2300 mg. If the amount is less than 40 mg, the effect of improving the unique flavor of iron is not sufficient. If the amount exceeds 4000 mg, the taste of the crude drug itself becomes conspicuous and the flavor of the whole liquid preparation is impaired.

[0011] The iron-containing solution of the present invention must be adjusted to have a pH in the range of 2 to 4.5 from the viewpoint of flavor improving effect.
The preferred pH is in the range of 3-4.

The iron-containing solution of the present invention can be produced by a usual method for producing a solution. In addition, as long as the flavor is not impaired, sweeteners (erythritol, maltitol, mannitol, xylitol, sorbitol, glucose, sucrose, fructose, lactose, stevia, thaumatin, sucralose, etc.), pH regulators (citric acid, malic acid, tartaric acid) ,
Ascorbic acid, succinic acid, etc., surfactants (polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymers, polysorbates, sodium lauryl sulfate, macro Galls, sucrose fatty acid esters, etc.), preservatives (parabens, benzoates, etc.), fragrances (orange, grapefruit, lemon, lime, tangerine, yuzu, unshiu mandarin, nuts orange, grape, strawberry, pineapple, banana, peach) , Melon, watermelon, plum, cherry, pair, apricot, currant, plum, mango, mangosteen, guava, raspberry, blueberry and other fruit flavors, green tea, wrapped tea, black tea, cocoa, tea Cholate, can be blended coffee, almond, maple, vanilla, whiskey, brandy, rum, wine, liqueur, cocktail, normal components blended in solution in such mix flavors).

[0013]

According to the present invention, it has become possible to provide a flavorful iron-containing solution.

[0014]

The present invention will be described in more detail with reference to the following Examples and Test Examples.

Example 1 Iron ammonium citrate 600 mg Ripe ground yellow extract 1 g (equivalent to crude drug) Taurine 10 g Magnesium aspartate 10 g Calcium gluconate 20 g Vitamin B2 100 mg Vitamin B6 100 mg Caffeine 1 g Inositol 1 g Nicotinamide 1 g Prescription and isomerization 150 g of sugar, 36 g of D-sorbitol and 6 g of citric acid were dissolved in purified water. After adjusting the pH to 2.5 with sodium citrate, purified water was added to obtain a 1-liter solution (iron concentration: 0.00625 mol / l).

Example 2 Ferric citrate 21.6 g Jiwang extract 600 g (equivalent to crude drug) Muirapuama extract 60 g (equivalent to crude drug) Taurine 120 g Calcium carbonate 60 g Magnesium carbonate 100 g Fursultiamine hydrochloride 1.2 g Vitamin B12 12 mg Biotin 1 0.2g Vitamin C 600g Carnitine chloride 1.2g Vitamin B2 1.2g Vitamin B6 1.2g Folic acid 120mg Anhydrous caffeine 24g The above formula and isomerized sugar 7.2kg, Stevia 18g
And 120 g of citric acid were dissolved in purified water. After adjusting the pH to 3.5 with sodium citrate, purified water was added,
A 60-liter solution (iron concentration 0.0038 mol / l) was used.

Example 3 6 mg of iron citrate 20 mg of ground yellow extract (in terms of crude drug) Magnesium aspartate 400 mg Potassium aspartate 400 mg Taurine 400 mg Dicetiamine hydrochloride 5 mg Vitamin B2 20 mg Vitamin B6 20 mg Vitamin C 2 g Vitamin E 100 mg Vitamin D3 2000 I.U. Calcium acid 200mg The above formulation, sucrose 14g, D-sorbitol 2.
5 g, Nikkor HCO60 (trade name) 50 mg and citric acid 50 mg were dissolved in purified water. Thereafter, the pH was adjusted to 4.0 with sodium citrate, and purified water was added to the solution.
The solution was a 00 ml liquid (iron concentration 0.000625 mol / l).

Example 4 Ammonium iron citrate 24 g Inositol 2 g Arginine 200 g Ripe ground yellow extract 560 g (converted to crude drug) Yokuinin 50 g (converted to crude drug) Ginseng 20 g (converted to crude drug) Royal jelly 100 g Taurine 400 g Calcium gluconate 100 g Magnesium aspartate 200 g Vitamin B1 6g Vitamin B2 2g Vitamin B6 2g Vitamin B12 200mg Vitamin E 20g Biotin 1mg Anhydrous caffeine 14g The above formula and sucrose 1000g, erythritol 4
00g, sodium malate 40g and Nikkor H
50 g of CO60 (trade name) was dissolved in purified water. Then, after adjusting the pH to 4.5 with citric acid, purified water was added to obtain a 10 l solution (iron concentration 0.0125 mol / l).

Example 5 Ammonium iron citrate 240 mg Ripe ground yellow extract 20 g Aspartic acid K / Mg mixture 20 g Calcium carbonate 10 g Taurine 10 g Nicotinamide 5 g Biotin 1 mg Vitamin B2 200 mg Vitamin B6 200 mg Vitamin C 5 g Vitamin D3 5000 I.U. And 800 g of isomerized sugar, xylitol 20
0 g, malic acid 10 g and citric acid 15 g were dissolved in purified water. The pH was adjusted to 2.0 with sodium citrate and made up to 5 l with purified water (iron concentration 0.05 mol / l).

Test Example (Test Method) When the sample of Example 1 was left at room temperature for 3 years to test the unpleasant taste of iron in a modified product,
Since an iron flavor equivalent to that left for a period of one day was obtained, a sample left at 65 ° C. for three days was used for the flavor test.

As a comparison, a formulation containing only an iron component (formulation 1) and a formulation containing a peach flavor which is known to have an effect of improving iron flavor (formulation 2) were used, and the unpleasant flavor of the iron component which increased with time was increased. The effect reduced by the present invention was tested.

As a subject, prescription 1: 0.00625mo
l / l iron citrate compound aqueous solution, prescription 2: 0.00625m
ol / l iron citrate + 0.4 wt% peach flavored aqueous solution,
Formulation 3: 0.00625 mol / l iron citrate + ground yellow extract (crude drug 400 mg) added aqueous solution, Formulation 4: 0.0062
5mol / l iron citrate + ripened ground yellow extract (400mg of crude drug)
Four types of the aqueous solution were used. The pH of each formulation was adjusted to 3.5 with citric acid to prepare a test solution.

As a test method, each subject after standing at 65 ° C. for 3 days was taken by 10 specialized panelists, and the degree of iron taste was 5: taking a very strong iron taste. Difficult 4: Strong irony can be taken 3: Irony but can be taken 2: Somewhat irony but can be taken 1: No irony And asked them to answer the questionnaire on a five-point scale.

The results are shown in Table 1.

[0025]

[Table 1]

Claims (6)

[Claims] 1. An iron-containing liquid formulation comprising an extract of iron and at least one extract of a crude drug selected from ground yellow and mature ground yellow, and having a pH of 2.0 to 4.5. 2. The iron content is 0.000 as iron content.
2. The iron-containing liquid preparation according to claim 1, wherein the amount is 5 to 0.05 mol / l. 3. The iron-containing liquid preparation according to claim 1, wherein the iron content is one or more selected from ammonium iron citrate, sodium iron citrate, ferric chloride and ferrous sulfate. 4. An amount of at least one crude drug selected from the earthy yellow and the matured earthy yellow with respect to the iron content of 0.01 mol of iron.
The iron-containing liquid preparation according to any one of claims 1 to 3, wherein 40 to 4000 mg of a seed extract is added in terms of a crude drug. 5. An iron content of 0.0005 to 0.05 mol /
1. An iron-containing liquid preparation, characterized in that at least one extract of a crude drug selected from ground yellow and ripened ground yellow is added to the liquid preparation containing 1) iron. 6. An extract of ground yellow or mature ground yellow, wherein p
A method for improving the flavor of an iron-containing solution by adjusting H to a range of 2 to 4.5.