JPH09194356A - Internal liquid preparation compounded with iron compound - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject internal liquid preparation having reduced unpleasant taste attributable to iron, free from a metallic taste of calcium, etc., extremely pleasantly drinkable and useful for prophylax is of anaemia, etc., by compounding an organic iron compound with an organic acid and adjusting pH to a specific range. SOLUTION: This internal liquid preparation is obtained by compounding (A) an organic iron compound (preferably, ferric ammonium citrate) with (B) one or more kinds of organic acids in an amount of 0.05-2.0wt.% so that the organic acid(s) is 3-300 pts.wt. based on the 1 pt.wt. of the iron component in the component A, and the pH is adjusted to 2.5-5.0. Further, it is preferable that (C) 0.001-1.0wt.% of a calcium component is further added so that the content of the calcium component (preferably, calcium glucuronate) is 1-49 pts.wt. based on 1 pt.wt. of iron component in the component A, and the component B is an acid selected from citric acid, malic acid, fumaric acid, tartaric acid, lactic acid and succinic acid.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an iron compound-containing oral solution containing a reduced iron-derived metallic taste,
It can be applied to the field of food.

[0002]

2. Description of the Related Art Iron contains about 3 g in an adult body,
It is mainly contained in hemoglobin of red blood cells in blood, myoglobin of muscle and ferritin of liver, and part of it is a trace metal element widely distributed in cells throughout the body. The physiological actions of iron include the following. The iron in hemoglobin carries oxygen, and the iron in myoglobin takes oxygen in the blood into cells. Iron in each cell is involved in the activation of oxygen,
Helps burn nutrients. As described above, iron is an indispensable metal in the living body, but due to its unique taste, solid agents mainly composed of tablets that are not so much affected by taste are mainly used.

[0003]

[Problems to be Solved by the Invention] Conventionally, iron has not been suitable for oral supplementation with an aqueous solution because of its unique taste derived from iron. An object of the present invention is to provide an iron supplement oral liquid which masks unpleasant taste derived from iron and is extremely effective for prevention of anemia and the like.

[0004]

As a result of intensive studies, the present inventors have added an organic iron compound and one or more organic acids, and have a pH of 2.5 to 5.0, preferably pH
The inventors have found that an iron compound-containing oral solution adjusted to 3.0 to 4.5 can solve the problems, and completed the present invention. Examples of the organic iron compound used in the present invention include iron citrate, ammonium iron citrate, sodium iron citrate,
Examples thereof include ferrous gluconate and iron lactate, with ammonium iron citrate being preferred. The intake of organic iron compounds is
0.5-18m / day converted to iron component in organic iron compound
g.

Examples of the organic acid include citric acid, malic acid, fumaric acid, tartaric acid, lactic acid and succinic acid. The organic acids can also be formulated in salt form, for example sodium citrate. The amount of them is 0.05 to 2% by weight because the masking becomes better as the sourness increases, but conversely the sourness becomes too strong and it is difficult to take.
Is preferable. Further, it is preferable to add 3 to 300 parts by weight to 1 part by weight of the iron component in the organic iron compound. When the organic acid is blended in the form of a salt, the blending amount is determined in terms of the organic acid.

In the present invention, it is preferable to add a calcium compound, and the amount thereof is 0.001 to
The amount is 1.0% by weight and 1 to 40 parts by weight of calcium component per 1 part by weight of iron component in the organic iron compound. When the amount of calcium component is less than 0.001% by weight,
When the compounding amount of the organic acid is small, the taste masking effect of the iron component is deteriorated, and when it exceeds 1.0% by weight, a metallic taste of calcium occurs, which is not preferable. In addition, when the said calcium compound is mix | blended, the compounding quantity of an organic acid may be 0.01-2.0 weight%. As the calcium compound, calcium ascorbate, calcium chloride, calcium citrate, calcium glycerophosphate,
Although calcium gluconate, calcium carbonate, calcium lactate, calcium pantothenate, calcium hydrogen phosphate, etc. can be used, calcium gluconate is particularly preferable.

In addition, the oral liquid preparation of the present invention also contains other components such as vitamins, minerals, amino acids and salts thereof,
Crude drug, sweetener, preservative, royal jelly, caffeine,
γ-oryzanol, civet, panthenol, sodium copper chlorophyllin, sodium chondroitin sulfate,
Fragrances and the like can be added within a range that does not impair the effects of the present invention. Examples of vitamins include vitamin B ₁ or a derivative thereof or a salt thereof, vitamin B ₂ or a derivative thereof or a salt thereof, vitamin B ₆ or a derivative thereof or a salt thereof, vitamin C or a derivative thereof or a salt thereof, vitamin E or a derivative thereof, nicotine. Acid amide,
Examples thereof include folic acid and thioctic acid.

Examples of minerals include zinc compounds, magnesium compounds, copper compounds, sodium compounds and potassium compounds. Amino acids or salts thereof include aminoethyl sulfonic acid, L-leucine,
L-isoleucine, L-lysine, L-methionine, L-
Examples thereof include phenylalanine, L-threonine, L-tryptophan, L-valine, L-histidine, L-aspartic acid, magnesium L-aspartate, and L-arginine hydrochloride.

Herbal medicines include Epimedium, Eleuthero,
Examples include kaijin, guarana, licorice, kokushi, sycamore, dio, hump, bukuro, daikon, carrot, yokinin, muirapuama and the like. As the sweetener, sugar, fructose, glucose, liquid sugar, sorbitol, xylitol, maltitol, erythritol,
Examples thereof include trehalose, inositol, reduced maltose syrup, stevia extract and aspartame.
Examples of the preservatives include parabens such as nipamethyi, nipaethi, nipapro and nipabuti, benzoic acid or salts thereof, edetic acid or salts thereof, and the like.

As the fragrance, orange, grapefruit, lemon, lime, tangerine, yuzu, citrus unshiu, natsumikan, grape, strawberry, pineapple,
Fruit flavors such as banana, peach, melon, watermelon, plum, cherry, pair, apricot, currant, plum, mango, mangosteen, guava, raspberry, blueberry, green tea, wrapped tea, tea, cocoa, chocolate, coffee, almond. , Maple, vanilla, whiskey, brandy, rum, wine, liqueur, cocktail, and the like, and these can be used alone or in combination of two or more kinds.

[0011]

INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to provide a very easy-to-drink oral compound containing an iron compound in which the unpleasant taste derived from iron is reduced and the metallic taste of calcium is not present.
Therefore, it can be used for prevention of anemia and the like.

[0012]

EXAMPLES Next, the present invention will be described in more detail with reference to Examples, Comparative Examples and Test Examples. Comparative Example 1 Ammonium iron citrate 40 mg Purified water Total amount 200 ml (Production method) A prescribed amount of ammonium iron citrate was dissolved in 200 ml of purified water (pH = 6.1).

Comparative Example 2 Ammonium iron citrate 240 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Comparative Example 1 (pH =
5.9).

Comparative Example 3 Ammonium iron citrate 40 mg Malic acid 24 mg Sodium hydroxide Suitable amount Purified water Total amount 200 ml (Production method) The prescribed amounts of the above components were dissolved in purified water 200 ml, and the pH was adjusted to 4.0 with sodium hydroxide. I adjusted.

Example 1 Ammonium iron citrate 40 mg Citric acid 140 mg Purified water Total amount 200 ml (Production method) The prescribed amount of the above components were dissolved in purified water 100 ml, and purified water was added to make the total amount 200 ml (pH = 3). .0).

Example 2 Ammonium iron citrate 40 mg Sodium citrate 80 mg Citric acid 156 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 3 Ammonium iron citrate 240 mg Citric acid 256 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
3.0).

Example 4 Ammonium iron citrate 240 mg Sodium citrate 80 mg Citric acid 124 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 5 Ammonium iron citrate 240 mg Monosodium fumarate 80 mg Sodium malate 200 mg Tartaric acid 128 mg Purified water Total amount 200 ml (Production method) Prepared by the same method as in Example 1 (pH =
4.0).

Example 6 Ammonium iron citrate 240 mg Sodium malate 80 mg Malic acid 92 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 7 Ammonium iron citrate 240 mg Monosodium fumarate 80 mg Sodium malate 200 mg Lactic acid 204 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 8 Ammonium iron citrate 40 mg Calcium gluconate 80 mg Malic acid 24 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 9 Ammonium iron citrate 240 mg Calcium gluconate 480 mg Malic acid 104 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 10 Ammonium iron citrate 240 mg Calcium gluconate 8000 mg Malic acid 632 mg Purified water Total amount 200 ml (Production method) Prepared in the same manner as in Example 1 (pH =
4.0).

Example 11 Calcium gluconate 800 mg Ammonium iron citrate 72 mg Sodium riboflavin phosphate 10 mg Pyridoxine hydrochloride 20 mg Anhydrous caffeine 200 mg Aminoethyl sulfonic acid 2000 mg Sugar 32000 mg Sodium benzoate 60 mg Citrate 620 mg Tropical fruit flavor Total amount of purified water 200 ml ( Manufacturing method) A prescribed amount of sugar is stirred and dissolved in 100 ml of purified water, and then other components are sequentially added while stirring to confirm dissolution, and then purified water is added to make a total amount of 200 ml. The pH at that time was 3.5. This preparation was filtered using a filter device in which diatomaceous earth was thinly and uniformly layered on a filter paper. Then, the filtrate was sterilized by using a sterilizer at 95 ° C. for 60 seconds, then filled in a bottle and capped.

Example 12 Calcium gluconate 800 mg Ammonium iron citrate 80 mg Magnesium L-aspartate 400 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 20 mg Anhydrous caffeine 200 mg Aminoethyl sulfonic acid 2000 mg Yokuinin 2400 mg Reduced maltose starch syrup 10000 mg Isomerized sugar 30,000 mg Benzoic acid Sodium 60mg Sodium citrate 100mg Citric acid 600mg Malic acid Appropriate amount Cherry brandy flavor Trace amount Purified water Total amount 200ml (Manufacturing method) Dissolve a prescribed amount of sugar with stirring in 100ml of purified water, and then add other ingredients sequentially with stirring to dissolve After checking, add purified water to make the total volume 200 ml. After adjusting the pH to 3.5 by adding an appropriate amount of malic acid,
This preparation was filtered using a filter device in which diatomaceous earth was thinly and uniformly layered on a filter paper. Then, the filtrate was sterilized by using a sterilizer at 95 ° C. for 60 seconds, then filled in a bottle and capped.

Example 13 Calcium gluconate 800 mg Ammonium iron citrate 80 mg Magnesium L-aspartate 400 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 20 mg Anhydrous caffeine 200 mg Aminoethyl sulfonic acid 2000 mg Yokuinin 2400 mg Stevia extract 30 mg Sugar 26000 mg Sodium benzoate 60 mg Sodium malate 100 mg Malic acid 600 mg Citric acid Suitable amount Mixed fruit flavor Trace amount Purified water Total amount 200 ml (Production method) Production was carried out in the same manner as in Example 12 (pH
= 4.0).

Example 14 Calcium gluconate 5000 mg Ammonium ferric citrate 120 mg Magnesium L-aspartate 2400 mg Fursultiamine hydrochloride 20 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 20 mg Anhydrous caffeine 200 mg Aminoethylsulfonic acid 2000 mg Yokuinin 2400 mg Reduced maltose starch syrup 10000 mg Saccharified sugar 30000 mg Sodium benzoate 60 mg Monosodium fumarate 100 mg Malic acid 400 mg Tartaric acid Appropriate amount Lemon liqueur flavor Small amount of purified water Total amount 200 ml (Production method) Produced by the same method as in Example 12 (pH).
= 4.0).

Example 15 Calcium Gluconate 1000 mg Ammonium Iron Citrate 100 mg Magnesium L-Aspartate 500 mg Dicethiamine 20 mg Riboflavin Sodium Phosphate 10 mg Pyridoxine Hydrochloride 20 mg Anhydrous Caffeine 200 mg Aminoethyl Sulfonic Acid 2000 mg Yokuinin 2400 mg Dioce 600 mg Carrot 2000 mg Royal Jelly Stevia extract 30 mg Sugar 26000 mg Sodium benzoate 60 mg Sodium malate 100 mg Citric acid 600 mg Malic acid Appropriate amount Mix flavor Small amount of purified water Total amount 200 ml (Production method) Produced by the same method as in Example 12 (pH
= 3.5).

Test Example A sensory test was performed on the aqueous solutions prepared by mixing the 18 types of ammonium iron citrate prepared in the above Examples and Comparative Examples. The evaluation method is as follows. 22 specialized panels
A total of 16 men, eight men and eight women aged 39 to 39 were used. For the evaluation of flavor, 10 ml of the sample was taken and the iron taste was evaluated absolutely. After evaluating one sample,
The inside of the oral cavity was washed with hot water and the following samples were evaluated after 30 minutes. The results are shown in Table 1.

[0031]

[Table 1]

Continuation of the front page (51) Int.Cl. ⁶ Identification number Reference number within the agency FI Technical indication location A61K 31:70) (72) Inventor Taku Mizutani 3-24-1 Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. Within

Claims (6)

[Claims] 1. An organic iron compound and one or more organic acids in an amount of 0.05 to 2.0% by weight and 3 to 300 parts by weight per 1 part by weight of the iron component in the organic iron compound. An oral solution containing an iron compound, which is formulated to have a pH of 2.5 to 5.0. 2. The iron compound-containing oral administration according to claim 1, wherein the calcium component is 0.001 to 1.0% by weight, and 1 to 40 parts by weight of the calcium compound is contained per 1 part by weight of the iron component in the organic iron compound. Liquid agent. 3. A compounding amount of one or more kinds of organic acids is 0.01 to 2.0% by weight and 2 to 60 parts by weight with respect to 1 part by weight of the iron component in the organic iron compound. Item 3. An iron compound-containing oral liquid preparation according to item 2. 4. The iron compound-containing oral liquid preparation according to claim 3, wherein the organic iron compound is ammonium iron citrate. 5. The iron compound-containing oral liquid preparation according to claim 2, wherein the calcium compound is calcium gluconate. 6. The one or more kinds of organic acids are “one or more kinds of compounds selected from the group consisting of citric acid, malic acid, fumaric acid, tartaric acid, lactic acid and succinic acid”. The oral liquid preparation containing the iron compound according to any one of 1 to 5.