JP4216916B2 - Drinking liquid composition - Google Patents

Description

【００２８】
実施例１２
塩酸ジセチアミン １０ ｍｇ
リン酸リボフラビンナトリウム １０ ｍｇ
塩酸ピリドキシン １０ ｍｇ
アスコルビン酸 ２００ ｍｇ
タウリン １０００ ｍｇ
Ｌ−アスパラギン酸マグネシウム ２００ ｍｇ
クエン酸鉄アンモニウム ３０ ｍｇ
グルコン酸カルシウム １０００ ｍｇ
グルコン酸亜鉛 １００ ｍｇ
Ｌ−塩酸アルギニン ３００ ｍｇ
ニコチン酸アミド ５０ ｍｇ
イノシトール ５０ ｍｇ
無水カフェイン ５０ ｍｇ
砂糖 １００００ ｍｇ
Ｄ−ソルビトール液 １０００ ｍｇ
粉末還元麦芽糖水飴 １０００ ｍｇ
キシリトール １０００ ｍｇ
エリスリトール １０００ ｍｇ
安息香酸ナトリウム ７０ ｍｇ
ＰＯＥ−ＰＯＰ−Ｇ ４００ ｍｇ
ポリオキシエチレン硬化ヒマシ油 ２５０ ｍｇ
クエン酸ナトリウム １０ ｍｇ
ＤＬ−リンゴ酸ナトリウム ２０ ｍｇ
クエン酸 適量
乳酸 ５０ ｍｇ
氷酢酸 ５ ｍｇ
ＤＬ−リンゴ酸 ５０ ｍｇ
ＤＬ−酒石酸 ５０ ｍｇ
Ｌ−メントール １ ｍｇ
フルーツミックスフレーバー １００ ｍｇ
精製水 （全量） １００ ｍｌ
ｐＨ４
【００２９】
【発明の効果】
本発明の飲用液組成物は、ビタミンＢ₁ 誘導体の特異な苦味が有効に軽減されており、苦痛なく服用できる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a drinking liquid composition in which the bitterness and / or aftertaste of a vitamin B ₁ derivative is reduced, and can be applied to the fields of medicine and food.
[0002]
[Prior art]
Vitamin B ₁ derivatives are generally water-soluble and are widely used for internal liquids. However, the vitamin B ₁ derivative has a very strong bitter taste and has the specificity that the bitter taste remains in the mouth after taking. A drinking liquid composition containing such a vitamin B ₁ derivative exhibits a significant bitter taste when taken and is accompanied by pain.
[0003]
Therefore, various studies have been made to mask the bitter taste of vitamin B ₁ derivatives. For example, sweeteners (sugars such as sugar, glucose, fructose, sugar alcohols such as sorbitol, natural or artificial sweeteners, etc.), edible organic acids (citric acid, malic acid, tartaric acid, etc.) and the like are added, and vitamin B ₁ Masks the bitterness of the derivative. However, such a bitter taste masking method gently masks a drug having a bitter taste, but it is extremely difficult to sufficiently suppress the specific bitter taste of the vitamin B ₁ derivative.
[0004]
In JP-A-60-246325, citric acid and an alkali metal salt thereof are added to an aqueous solution containing a bitter component such as fursultiamine to reduce the bitterness, and the pH is adjusted to 2.5 to 5.5. A method is disclosed. This bitter component-containing aqueous solution requires 70 to 150 parts by weight of citric acid and its alkali metal salt in terms of citric acid per 1 part by weight of the bitter component, and a large amount of citric acid and its alkali metal salt are present. However, since the sour taste unique to citric acid becomes considerably strong, the ingestibility is inferior.
[0005]
JP-A-5-146253 discloses a beverage containing a coffee extract and / or coffee flavor and a vitamin B group active substance. In this beverage, the amount of coffee extract and / or coffee flavor added is in a range that exhibits a coffee taste, and a relatively large amount of coffee extract and coffee flavor is required.
Furthermore, JP-A-7-95867 discloses a beverage composition that reduces the bitter taste of vitamin B ₁ derivatives by the bitter taste of herbal extracts having a bitter taste. However, this beverage has not solved the bitterness peculiar to crude drugs, and has a problem in terms of ingestion.
[0006]
[Problems to be solved by the invention]
An object of the present invention, was masked the bitter taste derived from vitamin B ₁ derivatives is to provide potable liquid composition having excellent taking ability.
[0007]
[Means for Solving the Problems]
The present inventors have, for suppressing the bitter taste of vitamin B ₁ derivatives, a result of intensive studies, menthol and / or polyoxyethylene vitamin B ₁ derivatives - polyoxypropylene - by the addition of glycol, of vitamin B ₁ derivatives The present invention was completed by finding out that bitterness can be reduced.
That is, the present invention includes a vitamin B ₁ derivatives, menthol and polyoxyethylene - a drinkable liquid composition comprising at least one glycol - polyoxypropylene.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
The vitamin B ₁ derivative used in the present invention refers to various thiol-type vitamin B ₁ derivatives, such as asymmetric disulfide type vitamin B ₁ derivatives, symmetric disulfide type vitamin B ₁ derivatives, and S-acyl type vitamin B ₁ derivatives. . Examples of asymmetric disulfide-type vitamin B ₁ derivatives include prosultiamine (thiaminepropyl disulfide), fursultiamine (thiaminetetrahydrofurfuryl disulfide), octothiamine (thiamine 8- (methyl 6-acetyldihydrothiooctate) disulfide), Arithiamine (thiamine allyl disulfide) and salts thereof (for example, acid addition salts such as hydrochloride, nitrate, phosphate, sulfate, etc.) and the like can be mentioned. Examples of the symmetric disulfide type vitamin B ₁ derivative include thiamine disulfide, O-benzoylthiamine disulfide, thiamine monophosphate disulfide and salts thereof (for example, acid addition salts such as hydrochloride, nitrate, phosphate, sulfate, etc.). Can be mentioned. Examples of the S-acyl type vitamin B ₁ derivative include O, S-dibenzoylthiamine, S-benzoylthiamine, benhotiamine (S-benzoylthiamine monophosphate), dicetiamine (O, S-dicarboxythiamine), cyclocarbothiamine. And salts thereof (for example, acid addition salts such as hydrochloride, nitrate, phosphate, sulfate, etc.) and the like. These vitamin B ₁ derivatives can be used alone or in combination.
[0009]
As menthol, DL-menthol and / or L-menthol is usually used. Menthol may be added as it is to the aqueous solution, but since it is difficult to dissolve, menthol can be added after dissolving it in a very small amount of alcohol. Menthol can optionally incorporated vitamin B ₁ derivatives amount, menthol 1 part by weight per 0.1 to 1,000 parts by weight normal vitamin B ₁ derivatives, preferably 1 to 100 parts by weight.
[0010]
The polyoxyethylene-polyoxypropylene-glycol used in the present invention is a condensate obtained by addition polymerization of ethylene oxide to polypropylene glycol, and preferably has the following formula:
_{HO (C 2 H 4 O)} n (C 3 H 6 O) m (C 2 H 4 O) n'-H
(In the formula, m, n and n ′ each represent an integer of 3 to 200.)
(US Pat. No. 2,674,619, “New Surfactant” (written by Horiguchi Hiroshi, Sankyo Publishing Co., Ltd.) pp. 670 to 675).
[0011]
In the above formula, the ratio of m to (n + n ′) [m: (n + n ′)] is usually 1: 0.1 to 1: 100, preferably 1: 0.5 to 1:50.
Polyoxyethylene - polyoxypropylene - glycol can also optionally incorporated vitamin B ₁ derivatives amount, polyoxyethylene - polyoxypropylene - glycol 1 part by weight, per vitamin B ₁ derivatives 0.001 to 10 parts by weight, preferably 0.01 to 5 parts by weight.
[0012]
In drinking liquid composition of the present invention, vitamin B ₁ derivatives, menthol, polyoxyethylene - polyoxypropylene - amount of glycol can be suitably selected depending on the type of the liquid composition. The compounding amount of the vitamin B ₁ derivative is usually about 0.0001 to 0.5% by weight, preferably about 0.001 to 0.1% by weight, based on the total amount of the drinking liquid composition. The amount of menthol is usually 0.00001 to 0.01% by weight, preferably 0.00005 to 0.005% by weight, more preferably 0.0001 to 0.001% by weight, based on the total amount of the drinking liquid composition. . The blending amount of polyoxyethylene-polyoxypropylene-glycol is usually 0.001 to 10% by weight, preferably 0.01 to 5% by weight, more preferably 0.05 to 1% by weight, based on the total amount of the drinking liquid composition. It is.
[0013]
The drinking liquid composition of the present invention may contain other vitamins such as water-soluble vitamins such as vitamin B group and vitamin C, fat-soluble vitamins such as vitamin A, vitamin D and vitamin E. . One or more of these vitamins can be used.
[0014]
The vitamin B group includes, for example, vitamin B ₁ such as thiamine hydrochloride, thiamine nitrate, thiamine pyrophosphate, riboflavin, riboflavin phosphate and salts thereof, vitamin B ₂ such as flavin adenine dinucleotide, riboflavin butyrate, pyridoxine, pyridoxal, Vitamin B ₆ such as pyridoxamine, pyridoxine phosphate, pyridoxal phosphate, pyridoxamine phosphate and their salts, etc., vitamin B ₁₂ such as cobalamin, cyanocobalamin, hydroxocobalamin, hydroxocobalamin acetate, mecobalamin, nicotinic acid and its salts, nicotine Examples include acid amide, pantothenic acid and its salts, panthenol, panthetin, folic acid and its salts, biotin and the like. As vitamin C, ascorbic acid and its salts (for example, calcium ascorbate, magnesium ascorbate, sodium ascorbate) or derivatives (for example, magnesium ascorbate phosphate, sodium ascorbate phosphate, glucoside, ascorbate, ascorbine) Acid palmitate).
[0015]
Vitamin A includes etretinate, vitamin A oil, retinol acetate, retinol palmitate, liver oil, and the like. Vitamin D includes cholecalciferol, ergocalciferol, dihydrotaxosterol, alphacalcidol, calcitriol and the like. Vitamin E includes α-tocopherol, tocopherol calcium succinate, tocopherol acetate, tocopherol nicotinate and the like. Vitamins include vitamin Ks such as phytonadione and menatetrenone.
[0016]
The pH of the drinking liquid composition of the present invention is usually about 2 to 7, preferably about 2.5 to 6. The pH of the drinking liquid composition can be adjusted using a commonly used pH adjuster. Examples of the pH adjuster include citric acid, malic acid, tartaric acid, fumaric acid, lactic acid, succinic acid, ascorbic acid, acetic acid and other organic acids and salts thereof, hydrochloric acid and phosphoric acid and other inorganic acids and salts thereof and the like. Can be mentioned. These pH adjusters can be used alone or in combination.
[0017]
In addition, the drinking liquid composition of the present invention includes, as other components, minerals, amino acids or salts thereof, herbal medicines or herbal extracts, royal jelly, caffeine, γ-oryzanol, taurine, saiko (cybet), copper chlorophyllin. Ingredients generally used in pharmaceuticals and foods such as sodium, sodium chondroitin sulfate, sweeteners, preservatives, fragrances, flavoring agents, corrigents, and coloring agents can be blended.
[0018]
Examples of the mineral include zinc compounds such as zinc gluconate, magnesium compounds, calcium compounds such as calcium gluconate, calcium lactate and calcium citrate, iron compounds such as ferrous citrate, ammonium iron citrate and iron gluconate. , Copper compounds such as copper gluconate and copper sulfate, sodium compounds, potassium compounds and manganese compounds.
[0019]
Examples of amino acids or salts thereof include aminoethylsulfonic acid, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-valine, L-histidine, L -Aspartic acid, L-magnesium magnesium aspartate, L-arginine hydrochloride, etc. can be mentioned.
[0020]
Herbal medicines include, for example, Ikariso, Ezokogi, Kaikujin, Guarana, Kanzo, Kokushi, Gooh, Giou, Hampi, Bukuryo, Nikujuyo, Carrot, Yokuinin, Muirapuama, Ogi, Osei, Taiso, Toki, Psycho, Pepper, Rokujo, Examples include Eucommia, Toshishi, Tochu, Sanyaku, Sanshuyu, and Garbage.
[0021]
Examples of the sweetener include sugar, lactose, fructose, glucose, liquid sugar, isomerized sugar, sorbitol, xylitol, maltitol, erythritol, trehalose, inositol, reduced maltose starch syrup, stevia extract, aspartame, thaumatin and the like. it can.
Examples of the preservative include parabens such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate, benzoic acid or a salt thereof, edetic acid or a salt thereof, and the like.
[0022]
Examples of flavors include orange, grapefruit, lemon, apple, lime, tangerine, yuzu, mandarin orange, jujube, grape, strawberry, pineapple, banana, peach, melon, watermelon, plum, cherry, pair, apricot, currant, ume, Fruit flavors such as mango, mangosteen, guava, raspberry, blueberry, green tea, confectionery tea, tea, cocoa, chocolate, coffee, almond, maple, vanilla, whiskey, brandy, rum, wine, liqueur, cocktail, etc. These can be used as one or more mixed flavors.
[0023]
The drinking liquid composition of the present invention can be prepared by a conventional method, and the method is not particularly limited. Usually, each component is mixed with purified water of a specified amount or less, the volume is adjusted to a specified amount, and if necessary. Obtained by filtration and sterilization. In addition, when fat-soluble vitamins are included, they are emulsified or solubilized with a surfactant or solubilizer such as polysorbate 80, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, glycerin fatty acid ester, polyglycerin fatty acid ester, etc. Alternatively, it may be suspended using a dispersing agent such as gum arabic, methylcellulose, carboxymethylcellulose, polyvinylpyrrolidone, pullulan, dextrin, gelatin, crystalline cellulose, xanthan gum, locust bean gum and the like.
The drinking liquid composition of the present invention can be applied to various drinks such as internal liquids such as drinks and syrups, and health drinks.
[0024]
【Example】
EXAMPLES Next, although an Example is given and this invention is demonstrated more concretely, these Examples do not restrict | limit the scope of the present invention at all.
In the following examples, as polyoxyethylene-polyoxypropylene-glycol, Pluronic (following formula: BASF Corp. Ltd.)
_{HO (C 2 H 4 O)} n (C 3 H 6 O) m (C 2 H 4 O) n'-H
, A condensate having m of about 30 and n + n ′ of about 160) (hereinafter referred to as “POE-POP-G”) was used.
The aqueous solution obtained by mixing the following 14 kinds of vitamin B ₁ derivatives, the degree of bitterness was organoleptically evaluated by 20 panelists.
[0025]
Comparative Example 1
Dicetiamine hydrochloride 10 mg
Purified water (total amount) 100 ml
Comparative Example 2
Dicetiamine hydrochloride 10 mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 1
Dicetiamine hydrochloride 10 mg
L-menthol 0.1mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 2
Dicetiamine hydrochloride 10 mg
L-menthol 0.2mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 3
Dicetiamine hydrochloride 10 mg
L-menthol 0.5mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 4
Dicetiamine hydrochloride 10 mg
L-menthol 1 mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 5
Dicetiamine hydrochloride 10 mg
POE-POP-G 10 mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 6
Dicetiamine hydrochloride 10 mg
POE-POP-G 50 mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 7
Dicetiamine hydrochloride 10 mg
POE-POP-G 1000 mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Example 8
Dicetiamine hydrochloride 10 mg
L-menthol 0.2mg
POE-POP-G 250 mg
Phosphoric acid appropriate amount purified water (total amount) 100 ml
pH 3
Comparative Example 3
Dicetiamine hydrochloride 20 mg
Citric acid 500 mg
Sodium hydroxide appropriate amount purified water (total amount) 100 ml
pH 3
Example 9
Dicetiamine hydrochloride 20 mg
L-menthol 1 mg
Citric acid 500 mg
Sodium hydroxide appropriate amount purified water (total amount) 100 ml
pH 3
Example 10
Dicetiamine hydrochloride 20 mg
POE-POP-G 500 mg
Citric acid 500 mg
Sodium hydroxide appropriate amount purified water (total amount) 100 ml
pH 3
Example 11
Dicetiamine hydrochloride 20 mg
L-menthol 0.5mg
POE-POP-G 500 mg
Citric acid 500 mg
Sodium hydroxide appropriate amount purified water (total amount) 100 ml
pH 3
The bitterness was evaluated by the following 6-level evaluation.
[0026]
Evaluation 1: Feel the bitterness quite strongly (5 points)
Evaluation 2: Strong bitterness (4 points)
Evaluation 3: Feel bitterness slightly stronger (3 points)
Evaluation 4: Feeling bitter (2 points)
Evaluation 5: Feel bitterness slightly weak (1 point)
Evaluation 6: I do not feel bitterness (0 points)
The results are shown in Table 1. As is clear from Table 1, it was proved that menthol and / or polyoxyethylene-polyoxypropylene-glycol significantly reduced the specific bitter taste of vitamin B ₁ derivatives.
[0027]
[Table 1]

[0028]
Example 12
Dicetiamine hydrochloride 10 mg
Riboflavin sodium phosphate 10 mg
Pyridoxine hydrochloride 10 mg
Ascorbic acid 200 mg
Taurine 1000 mg
Magnesium L-aspartate 200 mg
Ammonium iron citrate 30 mg
Calcium gluconate 1000 mg
Zinc gluconate 100 mg
L-Arginine hydrochloride 300 mg
Nicotinamide 50 mg
Inositol 50 mg
Anhydrous caffeine 50 mg
10000 mg sugar
D-sorbitol solution 1000 mg
Powdered reduced maltose starch syrup 1000 mg
Xylitol 1000 mg
Erythritol 1000 mg
Sodium benzoate 70 mg
POE-POP-G 400 mg
Polyoxyethylene hydrogenated castor oil 250 mg
Sodium citrate 10 mg
DL-sodium malate 20 mg
Citric acid appropriate amount Lactic acid 50 mg
Glacial acetic acid 5 mg
DL-malic acid 50 mg
DL-tartaric acid 50 mg
L-menthol 1 mg
Fruit mix flavor 100 mg
Purified water (total amount) 100 ml
pH 4
[0029]
【The invention's effect】
In the drinking liquid composition of the present invention, the unique bitterness of the vitamin B ₁ derivative is effectively reduced and can be taken without pain.

Claims (11)

A drinking liquid composition comprising a vitamin B ₁ derivative and polyoxyethylene-polyoxypropylene-glycol . Polyoxyethylene - polyoxypropylene - relative glycol 1 part by weight, drinkable liquid composition of claim 1 wherein the vitamin B ₁ derivatives 0.001 to 10 parts by weight. The drinking liquid composition according to claim 1 or 2, wherein the blending amount of polyoxyethylene-polyoxypropylene-glycol with respect to the total amount of the drinking liquid composition is 0.001 to 10% by weight. Drinkable liquid composition according to any one of claims 1 to 3 amount of vitamin B ₁ derivatives for drinkable solution total composition is 0.0001 to 0.5 wt%. Drinkable liquid composition according to any one of claims 1 to 4 vitamin B ₁ derivative is S- acyl type derivatives. The drinking liquid composition according to claim 5 , wherein the S-acyl type derivative is dicetiamine hydrochloride. The drinking liquid composition according to any one of claims 1 to 6 , wherein the polyoxyethylene-polyoxypropylene-glycol is a condensate obtained by addition polymerization of ethylene oxide to polypropylene glycol. A condensate obtained by addition polymerization of ethylene oxide with polypropylene glycol has the following formula:
_{HO (C 2 H 4 O)} n (C 3 H 6 O) m (C 2 H 4 O) n'-H
(In the formula, m, n and n ′ each represent an integer of 3 to 200.)
The drinking liquid composition according to claim 7 , which is a condensate represented by the formula: The drinking liquid composition according to any one of claims 1 to 8, further comprising menthol. Vitamin B for 1 part by weight of menthol ₁ The drinking liquid composition of Claim 9 containing 0.1-1000 weight part of derivatives. The drinking liquid composition according to claim 9 or 10, wherein the amount of menthol based on the total amount of the drinking liquid composition is 0.00001 to 0.01 wt%.