JPH0614746A - Health beverage - Google Patents

Abstract

PURPOSE:To provide a health beverage capable of promoting alcohol metabolism to mitigate its burden on human body, thus effective for preventing overdrunkenness, drunken sickness, and hangover attendant upon drinking, containing, as active ingredients, a glycoside of quercetin, divalent metallic ion and licorice extract. CONSTITUTION:A composition containing, as the essential ingredients, (A) a component with a glycoside of water-soluble quercetin (e.g. rutin) included by a cyclodextrin, (B) divalent metallic ions (e.g. of calcium, magnesium, zinc) and (C) a third component with a glycyrrhizin-contg. licorice extract included by a cyclodextrin, and, as necessary, incorporated with vitamin C, citric acid, oyster extract, etc., is dissolved in purified water to give the objective safe health beverage which can easily be taken before or after drinking. This beverage has alcohol metabolism-promotive activity, hepatopathy-suppressive activity, and other suppressive activity for lesions due to ethanol and acetaldehyde, being effective for preventing overdrunkenness, drunken sickness, and hangover.

Description

Detailed Description of the Invention

[0001]

The present invention relates to quercetin glycosides and 2
It is a health drink that contains valent metal ions and licorice extract as essential ingredients, promotes alcohol metabolism function in the liver during drinking, and keeps the ion balance of the living body normal, resulting in excessive sickness, sickness, and hangover associated with drinking The present invention relates to a health drink effective for prevention and prevention of

[0002]

2. Description of the Related Art Rutin, which is a quercetin glycoside, is contained in Enju and buckwheat. This rutin is mainly used for the treatment of capillarity bleeding, and it is also associated with hypertension, telangiectasia, and various other vulnerable defects. It is said to be effective in treating bleeding.

Mineral components such as calcium, magnesium and zinc are constituent components of bones and teeth, and become components of organic compounds in the body, and also maintain osmotic pressure of body fluid ions, acid-alkali balance, and stimulation of muscle nerves. It is a substance that regulates physiology such as transmission, and is an important substance for the living body.

By the way, the relationship between alcohol and the human body caused by drinking, especially the sickness and hangover caused by drinking, is something that anyone who enjoys drinking is sure to experience it. For this sickness and hangover, by eating food before drinking and at the same time as drinking, due to effects such as protecting the stomach wall and delaying absorption of alcohol,
It is known to be somewhat mitigated, but it cannot be a sufficient countermeasure.

Alcohol is finally decomposed into carbon dioxide gas and water in the body, during which time acetaldehyde, which is said to be the cause of hangover and sickness, is involved, and its involvement in electrolyte balance and prostaglandins. It has been pointed out that it influences various aspects such as lipid metabolism, amino acid protein metabolism, digestive organs, cranial nerves, etc.

[0006] Further, in general, when drinking alcohol, meals are reduced due to gastrointestinal burden, or meals are neglected, resulting in a heavy burden on digestive organs such as stomach and intestines. As a result, recovery of physical strength takes a long time. It has been pointed out that various problems have been pointed out, that is, it causes a hangover, imbalances nutritional balance.

[0007] As a food or medicine for the prevention of hangover and sickness, and for the purpose of improving the deterioration of the functions of the stomach and intestines associated with drinking, gastrointestinal drugs, yeast foods, oyster meat, which are expected to have stomachic and intestinal function Extracts, persimmon tannins, etc. have been proposed.

[0008] Sports drinks and health drinks for the purpose of nourishing and toning, which are added with various components such as various minerals, vitamins and other crude drugs, are also widely consumed.

Further, there is also provided a medicine containing a licorice extract as a component for the purpose of enhancing and protecting liver function.

[0010]

However, the above problems have the following problems. That is, in the above, by ingesting yeast foods, oyster meat extract, persimmon tannin, etc., alcohol metabolism is promoted and the burden of alcohol is alleviated, but for some effects such as hangover and hangover Is not enough.

The above-mentioned sports drinks and health drinks have the effect of replenishing various minerals and adjusting their physical condition, but they are not intended to cope with drinking and are not expected to have their effects, and also to prevent hangovers and hangovers. On the other hand, no effect can be expected.

[0012] The above is one in which glycyrrhizin contained in licorice produces glucuronic acid in the body and exhibits an action such as detoxification, protects the liver and promotes metabolism of alcohol, and has some effect on drinking alcohol. I can expect it, but it was not enough.

The present invention has been completed in view of the above technical problems. That is, the present inventor, the functional food containing young leaves of buckwheat as an active ingredient, is very effective against drunkenness due to drinking, hangover and hangover,
Carefully researching the components of young leaves of buckwheat, and its components rutin and minerals such as calcium and magnesium work synergistically with licorice extract containing glycyrrhizin, and it is effective in preventing and responding to drunkenness, hangover and hangover It was discovered that there was.

Then, these active ingredients are made into an aqueous solution,
Of this useful ingredient when drinking in response to drinking,
Rutin and glycyrrhizin are poorly soluble components in water, and there is a problem in making them a health drink for drinking.

Therefore, the present inventor is said to be effective for the treatment of capillary bleeding and various bleeding and for high blood pressure, and further contains a glycoside of quercetin which has an antioxidant effect, and further Among the minerals that affect retention and electrolyte balance such as acid-alkali equilibrium, and are physiological function-regulating substances such as muscular nerve stimulation transmission, divalent divalent compounds that interact with quercetin glycosides to form complexes We examined substances containing the metal ions calcium, magnesium, and zinc, and these minerals are indispensable to the living body, but in particular, they play an important role in recovering the modulation of various functions of the living body by drinking alcohol. I have found that I can do it.

According to the present invention, a licorice extract, which is a safe food additive containing a quercetin glycoside, a divalent metal ion and glycyrrhizin, is an essential component, and the licorice extract promotes alcohol metabolism. To relieve the burden, and to suppress liver damage and microsomal metabolic enzymes,
Or, it acts on cell membranes and the like to suppress damage caused by ethanol and acetaldehyde, and by the synergistic effect with calcium, magnesium, zinc, etc., which are divalent metal ions, prevention of excessive sickness, sickness, and hangover associated with drinking It is an object of the present invention to provide a healthy beverage that is effective for prevention and is safe, and that can be easily consumed at any time before, immediately before or after drinking.

Further, in the present invention, it is an object of the present invention to provide a useful health drink by using a water-soluble component as each active ingredient or solubilizing each active ingredient in water. The amount of each active ingredient required to be ingested is extremely small as compared with the usual dose as a usual drug, and the effect of preventing or preventing excessive sickness, sickness and hangover associated with drinking is expressed.

[0018]

In order to achieve the above object, the health drink of the present invention has the following technical means.

That is, in the health drink of the present invention, quercetin glycoside, divalent metal ion and licorice extract are essential components. Hereinafter, the present invention will be described in detail.

The glycoside of quercetin used in the present invention is not particularly limited, but the glycoside of water-soluble quercetin, that is, water-soluble rutin or quercetin included by cyclodextrin. Examples include glycosides.

As the glycoside of quercetin, as water-soluble rutin, α-glucosyl rutin to which a sugar having a plurality of glucose is added can be mentioned. Also, an inclusion compound of rutin cyclodextrin obtained by a conventional method may be used.

By the way, rutin, which is a glycoside of quercetin, is contained in Enju, buckwheat, and citrus fruits, and is extremely safe.

In the health drink of the present invention, the quercetin glycoside, the divalent metal ion and the licorice extract are essential components.

The divalent metal ion includes at least one of calcium, magnesium and zinc.

In the present invention, calcium, magnesium or zinc is not particularly limited as long as it can exist in the form of ions in health drinks, but those generally used as foods are safe. It is preferable from the point.

That is, the calcium compound is not particularly limited as long as it has a solubility of 0.1 g / 100 ml or more, and specifically, for example, calcium lactate,
Calcium gluconate, calcium pantothenate, calcium sulphate, calcium chloride, calcium propionate, calcium hydroxide, calcium phosphate, as well as ionized water sources such as bone meal, shellfish and egg shells, which are natural sources of calcium. Is mentioned.

The magnesium compound is not particularly limited as long as it has a solubility of 0.1 g / 100 ml or more, and specific examples thereof include magnesium chloride, magnesium sulfate, magnesium oxide and magnesium stearate. Can be mentioned.

Further, as a zinc compound, the solubility is 0.1.
It is not particularly limited as long as it is g / 100 ml or more, and specific examples thereof include extract of shellfish such as zinc sulfate, zinc gluconate, and oyster meat extract containing zinc, and extract of seaweed. To be

Further, plant-derived extracts such as buckwheat leaves and barley leaves, especially extracts of these young leaves, contain calcium and magnesium and can be usefully utilized.

In the health drink of the present invention, it is said that it has useful actions such as strengthening peripheral blood vessels, high blood pressure and antioxidant, and is a highly safe glycoside of quercetin, Interactions such as formation of complexes with quercetin glycosides among minerals that affect the retention of osmotic pressure of body fluids and electrolyte balance such as acid-alkali equilibrium, and are substances that regulate physiological functions such as stimulus transmission of muscle nerves Calcium, magnesium, which is a divalent metal ion having
In addition to those containing zinc, in addition to promoting alcohol metabolism to alleviate the burden, and also to suppress liver damage and microsomal metabolic enzymes, or cell membranes and other damages caused by ethanol or acetaldehyde. When the licorice extract containing the so-called glycyrrhizin is contained,
Surprisingly, the interaction of these components can effectively prevent or prevent excessive sickness, sickness, and hangover from drinking.

By the way, licorice is a perennial of the legume family that grows naturally in northern China and uses roots. However, because it has a special sweetness, it has long been used as a corrigent or sweetener, including related plants. It is a highly safe product that has been widely used in the food field as a sweetener for miso and soy sauce, and as a flavoring agent and sweetener for various other foods, and also in the pharmaceutical field for other purposes such as a flavoring agent, a sweetener, and the like. is there.

What is used in the present invention is a licorice extract extracted from this licorice by various methods. Particularly, an extract whose quality is secured by the content of glycyrrhizin as a main component is easy to use and preferred.

Further, since glycyrrhizin is in a free form, it is hardly soluble in water in normal health drinks. Therefore, it is preferable to use glycyrrhizin which is solubilized by inclusion with cyclodextrin by a known method. It is preferable.

This glycyrrhizin hydrolyzes one molecule in the body to produce two molecules of glucuronic acid, which prevents detoxification, that is, the adverse effect of the toxin on the body by strongly forming a conjugate with the toxin. In addition, it enhances adrenocortical hormones, decholesterolemia and arteriosclerosis, promotes metabolism and disappearance of alcohol, and further improves liver function and protects the liver.

As described above, when a healthy drink comprising a quercetin glycoside, a licorice extract containing divalent metal ions and glycyrrhizin is consumed, the amount of each component ingested by the interaction between them is small. Even so, surprisingly, it is possible to prevent excessive sickness, sickness, and hangover, and if you take it before or just before drinking, it will be drastically less drastic than the state when drinking before, and drunken drastically It was found that the condition was improved, and moreover that there was no change in the taste of sake.

The health drink of the present invention contains the above-mentioned components as essential components. However, if desired, various water-soluble additives may be added to improve the taste and sensation during drinking and further enhance nutrition. Is also good.

For this purpose, for example, sucrose, fructose, glucose, oligosaccharides, fructooligosaccharides, maltose, stevia, honey, sodium chloride, potassium chloride, glycerin, dextrin, CMC, alginic acid, alagia gum powder, amino acids, vitamins, shiitake mushrooms. Extract, gardenia extract, plum extract, citrus extract such as lemon, flavoring agents, sweeteners, flavoring agents, solvents, thickeners, flavoring agents, preservatives, surfactants, health enhancers, liver It may contain a water-soluble additive such as a natural product useful for the function.

The health drink of the present invention is to be drunk for drinking, but it is possible to easily understand a single dose.
It is extremely convenient to divide it into small parts and seal them in a container such as a light-shielding glass bottle, and at the same time, it is possible to prevent alteration by blocking the outside air. In this case, a dose of 25 to 100 ml is generally used as a single dose.

In the health drink of the present invention, the blending ratio of each component is not particularly limited as long as it is a desired ratio to exert the effect.

The health drink of the present invention contains 0.005 to 1% by weight of quercetin glycoside (A) in terms of rutin and 0.02% of divalent metal ion (B) in the above drink.
It is useful that the licorice extract (C) is glycyrrhizin as an active ingredient in an amount of 0. 01 to 1% by weight and 0.005 to 0.5% by weight.

The content of the component (A) is 0.005% by weight.
If it is less than, the synergistic effect of the components of the health drink may not be able to be fully utilized, and the effect becomes poor,
On the other hand, if it is 1% by weight or more, the balance with the above-mentioned components (B) and (C) is disturbed, the synergistic effect becomes poor, and the effect on sickness, hangover, etc. may become poor, which is not preferable. For these reasons, the content of the component (A) is preferably 0.01 to 0.5% by weight in terms of rutin.

Here, the rutin conversion is used to determine the component (A) blending ratio for the following reason. That is, in quercetin glycosides, the molecular weight varies depending on the type of sugar in the glycoside, and these sugars provide quercetin glycoside as a water-soluble component to health drinks, and The quercetin glycoside of is also decomposed into quercetin and sugar in the body, which is the most representative component as the quercetin glycoside, and it is the purpose of the present invention to convert it based on rutin which is widely used. Because they match.

Further, in the above (B), when the content of the divalent metal ion is less than 0.001% by weight, the significance of blending becomes small and the interaction with the above component (A) cannot be expected. There is a risk that the effect on sickness and hangover may be poor, while if it exceeds 1% by weight, it will be an excessive amount for the purpose of the health drink of the present invention, it is uneconomical, and these metal ions cause the components in the health drink to be contained. It is not preferable because it may affect precipitation and cause precipitation, or the flavor of a healthy beverage may be deteriorated.

For these reasons, the content of the component (B) is preferably in the range of 0.002 to 0.5% by weight.

Further, in the content of the component (C), when the content of glycyrrhizin which is the effective component thereof is less than 0.005% by weight, the effect of glycyrrhizin itself becomes poor, or the above (A) and (B). As a result, the balance with the ingredients is lost and the interaction becomes poor, so there is a risk that the effects on sickness, hangover, etc. may not be expected. On the other hand, when it exceeds 0.5% by weight, the balance with the above-mentioned components (A) and (B) Is not preferable because not only the value of the beverage as a health drink decreases, such as the deterioration of flavor and the flavor, but also cloudiness such as precipitation may occur.

Therefore, the content of glycyrrhizin which is the effective component of the above component (C) is as follows:
Particularly, 0.01 to 0.3% by weight is desirable.

As described above, in this health drink,
In determining the blending ratio of the component (C), the ratio of glycyrrhizin, which is the active ingredient, is used for the following reasons.

That is, since licorice is a natural product, there are various grades of glycyrrhizin, which is an active ingredient, of about 2 to 5% by weight, and various components are mixed in the extract derived from licorice. To do. Therefore, the use of glycyrrhizin, which is the active ingredient thereof, as an indicator substance is extremely important in achieving the object of the present invention.

In the above health drink of the present invention, a water-soluble form can be used in which rutin is included in cyclodextrin in place of the water-soluble quercetin glycoside.

That is, a health drink is generally acidic as an aqueous solution thereof for the purpose of preventing deterioration and refreshing the taste, while rutin is hardly soluble in the acidic aqueous solution. In order to effectively use rutin, which is the most readily available glycoside and is widely used, it is desirable to use the soluble form as described above.

A known method may be used as a method of incorporating rutin with cyclodextrin.

Further, glycyrrhizin, which is an active ingredient of licorice extract, is an acidic substance, exists as a free acid in an acidic aqueous solution, and is poor in solubility. Can be used.

As a method for incorporating the licorice extract with cyclodextrin, a known method may be used.

The health drink of the present invention includes those containing the above-mentioned various additives as components of the drink, and the mixing ratio of the additives is a desired amount for achieving the mixing purpose. This is good, and this makes it possible to improve the flavor of healthy drinks, make them easier to drink, and improve their functions.

Furthermore, by subdividing the above-mentioned healthy drink into small containers and sealing them in a container such as a light-shielding glass bottle, the outside air can be shut off and the influence of ultraviolet rays can be prevented to prevent deterioration. It is extremely convenient because you can easily know the dose of one dose.

In the present invention, quercetin glycoside (A)
In addition, a divalent metal ion (B) and a licorice extract (C) containing vitamin C and / or an organic acid (D) as essential components are particularly useful.

In the present invention, the above-mentioned health drink contains vitamin C and / or organic acid, and the components (A), (B) and (C) used here are the above-mentioned health drinks. Since it is the same as the beverage, it is omitted to avoid redundant explanation.

As described above, when vitamin C among component (D) is contained in the above-mentioned health drink, stability and absorbability of quercetin glycoside in the health drink are improved, and quercetin glycoside is improved. The effect of strengthening peripheral blood vessels and the like is further improved.

Further, vitamin C promotes a diuretic action,
It has the function of releasing the toxin in the living body to the outside of the body early to restore the normal activity of the living body.

Further, in the health drink containing the organic acid among the components (D) in the health drink, the organic acid is contained in the health drink,
And, if the pH is 3 to 5, the stability and absorbability of the quercetin glycoside in the health drink are improved, and it is absorbed to promote cell activation, and the presence of an organic acid further The stability of quercetin glycosides and vitamin C is enhanced.

The organic acid used here is not particularly limited as long as it is an organic acidic substance which can be used for food, and specific representative examples thereof include citric acid, malic acid, tartar liquor and the like. These may be used alone or in combination of two or more.

Of these organic acids, citric acid is particularly preferable because it decomposes lactic acid, pyrogluconic acid and the like in the body to prevent acidification of blood.

Also, this health drink is similar to the above case,
By including various additives, it is possible to improve the flavor of health drinks, make them easier to drink, and improve their functions.

Further, as in the above case, it is preferable to take measures such as subdividing the light-shielding bottle to prevent alteration.

In the health drink of the present invention, the compounding ratio of each component is not particularly limited as long as it is a desired ratio exhibiting an effect.

In the health drink of the present invention, the blending ratio of each component in the above drink is 0.005 to 1% by weight of the quercetin glycoside (A) in terms of rutin and 0.2% of the divalent metal ion (B).
001 to 1% by weight, licorice extract (C) as an active ingredient, glycyrrhizin 0.005 to 0.5% by weight, and vitamin C and / or organic acid (D) 0.01 to 2% by weight. What is done is extremely useful.

In the health drink of the present invention, the above (A),
The reason why the components (B) and (C) are specified is the same as in the case of the health drink described above, and therefore the description thereof is omitted to avoid redundant description.

The reason why the component (D) is specified here is as follows. That is, as described above, among the components of (D) above, vitamin C improves the stability and absorbability of quercetin glycosides in health drinks, and the effects of quercetin glycosides such as strengthening of peripheral blood vessels are further improved. And, in addition,
It promotes the diuretic action, releases toxins in the living body out of the body at an early stage, and restores the functions of the living body that have been reduced by alcohol to normal.

On the other hand, when the organic acid is contained in the component (D), the stability and absorbability of the quercetin glycoside in the health drink are improved, and at the same time, it is absorbed to promote cell activation. Furthermore, the presence of organic acids enhances the stability of quercetin glycosides and vitamin C.

However, in the health drink of the present invention,
If the content of vitamin C and / or organic acid in the component (D) is less than 0.01% by weight, the stability and absorptivity of quercetin glycoside may be insufficient and the synergistic effect may be poor. In some cases, it may not be possible to promote the cell activation action, and other problems such as a healthy beverage not being able to obtain a desired acidity, while vitamin C and / or organic acids exceeding 2% by weight (A ), (B) and (C) are out of balance with other ingredients such as flavor and drinkability to reduce the value as a beverage, and the acidity becomes too strong, resulting in precipitation of ingredients and beverages. It is not preferable because it may cause turbidity.

Therefore, the content of the component (D) is preferably 0.05 to 1% by weight of vitamin C and / or organic acid.

In the present invention, the above-mentioned health drink includes those containing the above-mentioned various additives in the health drink, but the description is omitted because it is the same as above. The container is also the same as described above, and will be omitted.

[0073]

The health drink of the present invention has the above-mentioned constitution and contains quercetin glycoside, divalent metal ion and licorice extract as essential components. Rutin, which is a typical component of quercetin glycosides, is a component contained in buckwheat, etc. Soba has been eaten in a wide area for a long time since ancient times, and licorice and extracts derived from licorice are also included. It has been widely used as a corrigent and a sweetener for foods and pharmaceuticals, and all are extremely safe.

Further, quercetin glycosides are said to be effective for the treatment of capillary bleeding and various bleeding and are said to have an antioxidant effect. It protects peripheral blood vessels against the rise in blood pressure and the circulation of blood and body fluids, and also affects the retention of osmotic pressure of body fluids and the electrolyte balance such as acid-alkaline balance, and stimulation of muscle nerves. Calcium, which is a divalent metal ion that is a physiological regulator of transmission, and further has an interaction such as forming a complex with quercetin glycoside,
By containing at least one of magnesium and zinc, the recovery of biological functions due to drinking is promoted, and by containing licorice extract, the active ingredient glycyrrhizin promotes the metabolism of alcohol. The glucuronic acid produced by the decomposition of glycyrrhizin in the body is toxin and toxin, which alleviates the burden and suppresses the damage caused by ethanol and aldehyde by acting on liver damage suppression and microsomal metabolic enzymes, or cell membranes. By forming a conjugate or the like, detoxification is expressed, alcohol metabolism and disappearance are promoted, and detoxification and liver function improvement and protection are shown, and bile secretion is promoted. The synergistic effects of the ingredients effectively prevent and prevent excessive sickness, sickness, and hangovers associated with drinking, and Safe anywhere at any time, it has a function that may correspond to hangovers, etc. and drinking with ease in response to the well drinking before drinking.

When the health drink of the present invention further contains vitamin C and / or an organic acid, the vitamin C
Not only enhances the absorption and stability of quercetin glycosides, but also interacts with quercetin glycosides to exert synergistic effects in the digestive and circulatory organs. Is promoted to prevent excessive sickness, sickness, and hangover due to drinking, and by containing the organic acid, quercetin glycosides and vitamin C can be further stabilized and cell activation can be achieved. In particular, citric acid has the action of promoting the action of decomposing lactic acid and pyrogluconic acid in the body to prevent acidification of blood.

As described above, surprisingly, in the health drink of the present invention, if it is drunk before drinking, it is completely different from the conventional drinking state, and even if the amount of each component is small, it causes sickness. In addition to the fact that the drunkenness is significantly improved, it has the effect of further preventing and preventing excessive sickness, sickness and hangover due to drinking.

[0077]

EXAMPLES The present invention will now be described in detail based on examples, but the present invention is not limited thereto. Example 1 α-Glycosyl rutin 0.1% by weight Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Cyclodextrin inclusion body of licorice extract 1.5% by weight Vitamin C 0.2% by weight Citric acid 0. 1% by weight Purified water 97.8% by weight

The α-glycosyl rutin, that is, the water-soluble rutin, had a content of 40% by weight in terms of rutin. This is a mixture of rutin with 1 to 4 glucose added.

The cyclodextrin inclusion body of the licorice extract used had a glycyrrhizin content of 4.2% by weight.

Example 2 Cyclodextrin inclusion body of rutin 0.3% by weight Calcium lactate 0.2% by weight Magnesium sulfate 0.15% by weight Oyster meat extract 5.0% by weight Cyclodextrin inclusion body of licorice extract 1.5 % By weight Vitamin C 0.2% by weight Purified water 92.65% by weight

As the cyclodextrin inclusion body of rutin, one having a rutin content of 10% by weight was used. The zinc content in the oyster meat extract was 0.065% by weight.

The cyclodextrin inclusion body of the licorice extract used had a glycyrrhizin content of 4.2% by weight.

Example 3 Cyclodextrin inclusion body of rutin 0.3% by weight Calcium gluconate 0.2% by weight Magnesium chloride 0.15% by weight Zinc gluconate 0.1% by weight Sodium chloride 0.1% by weight Licorice extract Cyclodextrin inclusion body 1.5% by weight Citric acid 0.2% by weight Potassium chloride 0.1% by weight Taurine 1.0% by weight Sodium benzoate 0.001% by weight Honey 3.0% by weight Stevia 0.05% by weight Purified water 93.299% by weight

As the cyclodextrin inclusion body of rutin, one having a rutin content of 10% by weight was used.

The cyclodextrin inclusion body of the licorice extract used had a glycyrrhizin content of 4.2% by weight.

Example 4 α-Glycosyl rutin 0.1% by weight Water extract of buckwheat leaf 2.0% by weight Cyclodextrin inclusion body of licorice extract 0.8% by weight Vitamin C 0.2% by weight Citric acid 0 .1% by weight Purified water 96.8% by weight

The α-glycosyl rutin, that is, the water-soluble rutin, had a content of 40% by weight in terms of rutin. This is a mixture of rutin with 1 to 4 glucose added.

The water extract of buckwheat leaf is 1000 ml of water.
To 100 g of dried buckwheat leaf powder was added, and the mixture was leached at 30 ° C. for 2 days with occasional stirring, and the aqueous extract solution obtained by vacuum filtration was concentrated under reduced pressure to 200 ml and filtered again. The solution was concentrated to obtain 50 ml of water extract. This extract contained 3.6% by weight of calcium and 1.7% by weight of magnesium, but rutin was not detected.

The cyclodextrin inclusion body of the licorice extract used had a glycyrrhizin content of 4.2% by weight.

Example 5 α-Glycosyl rutin 0.3% by weight Calcium lactate 0.2% by weight Licorice extract 3.0% by weight Glycerin 8.0% by weight Sucrose 2.0% by weight Purified water 86.5% by weight

The α-glycosyl rutin, that is, the water-soluble rutin, had a content of 40% by weight in terms of rutin. This is a mixture of rutin with 1 to 4 glucose added.

The licorice extract has a glycyrrhizin content of 3.
5% by weight was used.

Example 6 0.3% by weight of α-glycosyl rutin Magnesium chloride 0.2% by weight Licorice extract 1.5% by weight Glycerin 8.0% by weight Sucrose 1.0% by weight Purified water 89.0% by weight

The α-glycosyl rutin, that is, the water-soluble rutin, had a content of 40% by weight in terms of rutin. This is a mixture of rutin with 1 to 4 glucose added.

The licorice extract has a glycyrrhizin content of 3.
5% by weight was used.

Comparative Example 1 α-Glycosyl rutin 0.3% by weight Magnesium chloride 0.2% by weight Calcium lactate 0.2% by weight Glycerin 8.0% by weight Sucrose 1.0% by weight Purified water 90.3% by weight

The α-glycosyl rutin, that is, the water-soluble rutin, had a content of 40% by weight in terms of rutin. This is a mixture of rutin with 1 to 4 glucose added.

Comparative Example 2 Magnesium chloride 0.2% by weight Calcium lactate 0.2% by weight Cyclodextrin inclusion body of licorice extract 1.5% by weight Glycerin 8.0% by weight Sucrose 1.0% by weight Purified water 89.1 weight%

The cyclodextrin inclusion body of the licorice extract used had a glycyrrhizin content of 4.2% by weight.

Comparative Example 3 α-Glycosyl rutin 0.3% by weight Licorice extract 3.0% by weight Glycerin 8.0% by weight Sucrose 1.0% by weight Purified water 87.7% by weight

The licorice extract has a glycyrrhizin content of 3.
5% by weight was used.

Comparative Example 4 α-Glycosyl rutin 0.3% by weight Cyclodextrin inclusion body of licorice extract 1.5% by weight Glycerin 8.0% by weight Sucrose 1.0% by weight Vitamin C 0.2% by weight Citric acid 0 .1% by weight Purified water 88.9% by weight

The α-glycosyl rutin, that is, the water-soluble rutin, had a content of 40% by weight in terms of rutin. This is a mixture of rutin with 1 to 4 glucose added.

As the cyclodextrin inclusion body of the licorice extract, one having a glycyrrhizin content of 4.2% by weight was used.

The above-mentioned examples and comparative examples were used.
The content of glycyrrhizin in the licorice extract and cyclodextrin inclusion bodies of the licorice extract was measured by high performance liquid chromatography.

Using the health drink of Example 1 above, 38 to 5
Fifteen 6-year-old boys drank 50 g (50 ml) immediately before drinking.

In this case, it was a monthly banquet and an opportunity to drink a relatively large amount of sake. The evaluation was made on the occasion of similar drinking until now, and the result of comparison with the situation when drinking the same amount or more of alcohol was used as the evaluation of voluntary declaration.

As a result, up to 12 out of 15 people evaluated that the state of sickness was much less than before, and the mental state was not so drunk, and 3 were more than ever. They evaluated that they had less sickness, and even one of them reported that they felt a little less sick, but did not understand.

Further, 15 persons evaluated that the frequency of urination was high, and no one said that the taste of sake was particularly bad.

The next morning, all reported that they had no hangover and were well awake.

Further, in the following month, the same member evaluated the effect on drinking in Comparative Example 1 in the same manner. When we drunk about the same amount as the previous month, we evaluated that 10 people had no difference from the state of sickness when they drank the same amount, and 5 people evaluated that they were slightly sick. It was

Also, the next morning, there were 3 people who experienced so-called hangover headaches, and there is a feeling that alcohol remains. There were three people who reported feeling unwell and tired.

Furthermore, 50 g (5%) of the health drinks of Examples 2-6 were prepared.
20 ml each, total of 100 bottles are produced, 20 panelists are provided with 5 healthy beverages per person at random, and 1 drink is taken 30 minutes to 1 hour before drinking.
I drank a book and asked for a self-report on the effect.

Here, it was assumed that those who took healthy drinks had a lot of drinking opportunities and had a hangover experience.

Similarly, 50 g (50 g) of the beverages of Comparative Examples 1 to 4 were prepared.
20 bottles each, totaling 80 bottles, and randomly providing 4 beverages per person to the 20 panelists.
At the time of one drinking, similarly, one bottle was drunk 30 minutes to 1 hour before drinking, and the self-report of the effect was requested.

The panelist is a boy 1 aged from 31 to 65 years.
There are 5 women and 5 girls aged 42 to 55 years old, who are the ones whose business is to entertain drinking.

The results are summarized in Tables 1 and 2.

[0118]

[Table 1]

In Table 1, the state of sickness and the frequency of urine were evaluated by the following methods. State of sickness A: I have very few sickness and I have a clear awareness. B I have little sickness. C Feels like you have less sickness. D No change. I do not understand. Frequency of urine A When drinking alcohol, the frequency of urine is high and the amount is high. B It is the same as when drinking alcohol. I do not understand.

[0120]

[Table 2]

In Table 2, State 1 and State 2 of the next day were evaluated by the following methods. State of the next day 1 A Awakens better than when drinking alcohol all the time. B It is the same as when drinking alcohol. I do not understand. State 2 on the next day (One person evaluated multiple items in duplicate.) A: The physical condition is good. B: I feel tired when I am tired of drinking. C I feel like alcohol remains. D I have a headache. E My stomach is not feeling well.

That is, the healthy beverages of Examples 2 to 4 had an excellent effect in preventing and preventing excessive sickness, hangover, etc. due to drinking, and in Examples 5 and 6, those drinking Effective, but Comparative Example 1
It was found that the beverages of Nos. 5 to 5 had no effect, or even if they had an effect, they were not sufficient.

[0123]

The health drink of the present invention has the above constitution,
As described above, the beverage is extremely safe. or,
Quercetin glycosides are said to be effective in the treatment of capillary bleeding and various bleeding, and have an antioxidant effect, but the quercetin glycosides increase blood pressure and enhance circulation of body fluids by drinking alcohol. On the other hand, it protects peripheral blood vessels, affects the retention of osmotic pressure of body fluids, the electrolyte balance such as acid-alkali balance, and is a physiological regulator of muscular nerve stimulation transmission. By containing at least one of divalent metal ions, calcium, magnesium and zinc, which have an interaction such as forming a complex with a sugar, it promotes recovery of the function of the living body by drinking. Furthermore, by containing a licorice extract, glycyrrhizin, an active ingredient, promotes the metabolism of alcohol to alleviate the burden, and suppresses liver damage and microzoa. It acts on metabolic enzymes of the system, cell membranes, etc. to suppress damages caused by ethanol and aldehydes, and glucuronic acid produced by decomposition of glycyrrhizin in the body forms a conjugate with a toxin to detoxify. It is expressed, promotes metabolism and disappearance of alcohol, exhibits detoxification and liver function improvement and protection, and promotes bile secretion. Due to the synergistic effect of these components, it is well-known for drinking. , Sickness,
It has the effect of effectively preventing and preventing a hangover, and, in addition, before and after drinking alcohol, it can be easily consumed in response to drinking and can be used to cope with hangover.

When the health drink of the present invention further contains vitamin C and / or an organic acid, the vitamin C
Not only improves the absorption and stability of quercetin glycosides, but also interacts with quercetin glycosides to exert a synergistic effect on the digestive and circulatory organs, which further improves alcohol metabolism. It is promoted to prevent excessive sickness, sickness and hangover caused by drinking, and when the organic acid is contained, quercetin glycosides and vitamin C can be further stabilized and cell activation can be promoted. In particular, the use of citric acid has the effect of decomposing lactic acid, pyrogluconic acid and the like in the body and preventing acidification of blood.

As described above, surprisingly, in the health drink of the present invention, if it is taken before drinking, it is completely different from the conventional drinking state, and even if the amount of each component is small, it causes a sickness. In addition, the drunkenness is significantly improved, and it is possible to prevent and prevent excessive sickness, sickness and hangover caused by drinking.

As described above, the health drink of the present invention is a highly safe drink, can be easily taken at any time, and is extremely useful in responding to drinking due to its combined action and effect.

Claims (7)

[Claims] 1. A health drink comprising a quercetin glycoside, a divalent metal ion and a licorice extract as essential components. 2. The health drink according to claim 1, wherein the glycoside of quercetin is water-soluble. 3. The health drink according to claim 1, wherein the glycoside of quercetin is included by cyclodextrin. 4. The health drink according to claim 1, wherein the divalent metal ion is at least one selected from calcium, magnesium and zinc. 5. The health drink according to claim 1, wherein the licorice extract contains glycyrrhizin. 6. The health drink according to claim 1, wherein the licorice extract is included in cyclodextrin. 7. The health drink according to claim 7, wherein the organic acid contains at least one of vitamin C, citric acid, malic acid and tartar liquor.