JP2006028051A - Ameliorant for exhausted feeling at time of rising, composition for ameliorating exhausted feeling at time of rising, and food and beverage for ameliorating exhausted feeling at time of rising, containing them - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an ameliorant for exhausted feeling at the time of rising, which improves sleeping qualities, makes a user feel removal of exhausted feeling at the time of rising by internal use, a composition for ameliorating exhausted feeling at the time of rising, and a food and beverage for ameliorating exhausted feeling at the time of rising, containing them. <P>SOLUTION: The ameliorant for exhausted feeling at the time of rising comprises a component derived from a plant of the genus Withania of the family Solanaceae as an active ingredient. The composition for ameliorating exhausted feeling at the time of rising comprises the ameliorant for exhausted feeling at the time of rising and a recovery agent from fatigue composed of an animal or plant-derived component as an active ingredient. The food and beverage for ameliorating exhausted feeling at the time of rising contains either the ameliorant for exhausted feeling at the time of rising or the composition for ameliorating exhausted feeling at the time of rising. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an agent for improving fatigue at wake-up, a composition for improving fatigue at wake-up, and a wake-up comprising the same, which can improve the quality of sleep and allow the user to experience the relief of fatigue when waking up (at awakening). It relates to food and drink for improving fatigue. In the present invention, food and drink refer to general foods, health foods, health functional foods, quasi drugs, and pharmaceuticals that are taken orally.

In recent years, many problems related to sleep, such as sleep disorders and insomnia, have been taken up.
According to the 2000 Health and Welfare Trend Survey conducted by the Ministry of Health, Labor and Welfare for 32,000 Japanese people over the age of 12, it was found that about 1 out of 5 people have problems with sleep. Among them, the most common answer is “I don't feel a good sleep when I wake up in the morning (24.2%)”, then “I wake up early in the morning (22.0%)”, “ “Wake up (19.5%)”. In addition, at the symposium of the Japanese Society of Sleep in 2002, 49.4% of 1424 people surveyed based on responses based on the Athens Insomnia Scale (Soldatos et al .: Journal of Psychosomatic Research 48: 555-560, 2000). It was found that there was a suspicion of insomnia.

A variety of products for solving such problems related to sleep have been developed and marketed, and can be roughly classified into two types based on the mechanism of action.
One is a product group that assists falling asleep or awakening or obtains a sleep improvement effect by applying stimuli such as sound, light, and fragrance from outside the body (see Patent Documents 1 and 2). However, there are differences among individuals in response to stimuli, and there are differences in the effects that can be obtained depending on the degree of problems related to sleep and the attitude to accept stimuli. .

  The other is a product group that seeks to improve sleep by orally ingesting (taking) drinks (such as herbal tea), foods (such as health foods), and pharmaceuticals (such as sleeping pills) containing active ingredients. It is. For example, a composition for insomnia containing valerian extract (see Patent Document 3), a health food for sleep that includes ginseng extract, ginkgo biloba extract, etc., and a composition for promoting sleep containing steroids (see Patent Documents 4 to 6) Patent Document 7), a composition that improves sleep disorders including theanine (see Patent Document 8), and the like, and a composition that provides a sleep-inducing effect and a restful sleep by improving stress and fatigue that induce sleep disorders. Has been proposed. However, these compositions often have a characteristic odor and may prevent continuous and active intake.

  On the other hand, for drugs such as sleeping pills, although there are OTC drugs, resistance to sleeping pills is generally strong. In addition to the necessity of a doctor's diagnosis and prescription, there is a problem that the risk of side effects cannot be excluded when taken.

  By the way, it is very important to be able to experience a feeling of deep sleep and a refreshing feeling when getting up and to start a day's activities comfortably. In addition, a truly meaningful improvement in sleep is an improvement in sleep quality, that is, the recovery of mental and physical fatigue through sleep, and the ability to experience it.

  However, all of the previous proposals have the main purpose of removing sleep-causing factors and promoting the effects of sleep onset. There is no disclosure of the effect of being eliminated.

  Therefore, it is easy to take orally, improves the quality of sleep, and gives a refreshing feeling and a deep sleep feeling when you get up, especially when you get up and get tired when you get up. The present situation is that the improvement composition and the food for improving fatigue feeling at the time of waking up which contain these have not been provided yet, and development of these is earnestly desired.

JP-A-9-187512 WO01 / 058435 JP 2003-183174 A JP-A-9-23849 Japanese Patent Laid-Open No. 9-23850 Japanese Patent Laid-Open No. 9-23851 JP-A-11-35596 JP 2000-247878 A

An object of the present invention is to solve the conventional problems and achieve the following objects.
That is, the present invention is easy to take orally, improves the quality of sleep, and when taken, a refreshing feeling and a deep sleep feeling can be obtained, and in particular, an agent for improving a feeling of waking up when waking up can be experienced, An object of the present invention is to provide a composition for improving a feeling of getting up at fatigue, and a food and drink for improving the feeling of getting up at fatigue, including these compositions.

  As a result of intensive studies by the present inventors in order to solve the above-mentioned problems, it has been found that a component derived from a plant belonging to the genus Whitania belongs to the use of a plant belonging to the genus Withania, which is useful for improving the feeling of fatigue when waking up, and the mind and body (particularly the brain Etc.), the inventor has obtained a new finding that the effect of improving fatigue feeling upon waking up can be obtained by ingesting a composition comprising a combination of a fatigue recovery agent comprising an animal and plant-derived component having a fatigue recovery action.

This invention is based on the said knowledge by this inventor, and as a means for solving the said subject, it is as follows. That is,
<1> An agent for improving fatigue at wake-up, comprising a component derived from a plant belonging to the genus Wisania of the solanaceous family as an active ingredient.
<2> The agent for improving fatigue during waking according to <1> above, which contains, as an active ingredient, an extract obtained by extracting a rhizome part of a plant belonging to the genus Withania in an eggplant with an aqueous solvent.
<3> The agent for improving fatigue at wake-up according to any one of <1> to <2>, wherein the plant belonging to the genus Withania is a Wizania somnifera Dunal .
<4> (A) comprising the wake-up fatigue improvement agent according to any one of <1> to <3>, and (B) a fatigue recovery agent comprising an animal or plant-derived component as an active ingredient. It is a composition for improving a feeling of fatigue when waking up.
<5> The fatigue recovery agent (B) comprising an animal or plant-derived ingredient as an active ingredient contains at least one material or extract selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg. The composition for improving a feeling of fatigue when waking up according to the above <4>.
<6> Phosphorus recovery agent (B) comprising an animal or plant-derived ingredient as an active ingredient is extracted from at least one material selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg The composition for improving fatigue feeling upon waking according to any one of <4> to <5>, wherein the composition comprises at least one of fatidylserine, γ-aminobutyric acid, taurine, tryptophan, and theanine.
<7> The composition for improving a feeling of fatigue when waking up according to any one of <4> to <6>, comprising any one of an amino acid and vitamins.
<8> A food / drink for improving fatigue at waking, comprising the agent for improving fatigue at waking up according to any one of <1> to <3>.
<9> A food / drink for improving fatigue at wake-up, comprising the composition for improving fatigue at wake-up according to any one of <4> to <7>.

With respect to the physiological and pharmacological effects of the plant belonging to the genus Witiania, in particular, the plant extract of Withania somnifera Dunal , nourishing tonic, tonic, anti-stress, and It is known about antirheumatic action and the like (for example, JP-A-2002-145794). However, it has not been known at all that the component derived from the plant belonging to the genus Wisania of the solanaceous family improves sleep and exerts an effect of improving fatigue feeling when waking up by taking it. It is knowledge.

  According to the present invention, it is easy to take orally, improves the quality of sleep, and when taken, a refreshing feeling and a deep sleep feeling can be obtained. It is possible to provide a time fatigue sensation improving composition and a food and drink for improving fatigue sensation when waking up.

(Wake-up fatigue improvement agent)
The wake-up fatigue sensation-improving agent of the present invention comprises a component derived from a plant belonging to the genus Widonia, as an active ingredient. The wake-up fatigue ameliorating agent may be used in combination with other components appropriately selected as necessary.
The details of the substance that shows the effect of improving fatigue at the time of waking up, which is a component derived from the plant belonging to the genus Wisonia of the solanaceae family, are not known. Examples include a diluted solution of the liquid, a dried product obtained by drying the extract, a roughly purified product, and a purified product.

  As the solanaceous wisnia genus plant, wisonia somnifera dunal is preferable. The Wizania somnifera dunal is an evergreen shrub of the plant belonging to the genus Uzaniaaceae, which grows naturally in dry subtropics such as western India, Pakistan, Sri Lanka, and South Africa, and includes Ashwagandha and Winter Cherry. ) Is also called a plant.

As the extract of the plant belonging to the genus Widonia, which is used in the present invention, an extract obtained by extracting the rhizome part with an aqueous solvent is preferable.
The extract obtained by extracting the rhizome part with an aqueous solvent can be obtained by drying the rhizome part as it is or by pulverizing it with a crusher and using it in an aqueous solvent.
There is no restriction | limiting in particular as a method of drying the said rhizome part, A well-known method can be suitably selected according to the objective.
In addition, there is no restriction | limiting in particular as a method of obtaining the said extract, A well-known extraction method can be suitably selected according to the objective.

  As the aqueous solvent, it is preferable to use water, a hydrophilic organic solvent, and a mixture thereof at a temperature from room temperature to the boiling point of the solvent.

  Examples of the water include pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, and those subjected to various treatments. Examples of the treatment applied to water include purification, heating, sterilization, sterilization, filtration, ion exchange, adjustment of osmotic pressure, buffering, and the like. Therefore, the water that can be used as the extraction solvent in the present invention includes purified water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered saline, and the like.

  Examples of the hydrophilic organic solvent include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; 1,3-butylene glycol, propylene glycol, Examples thereof include C2-C5 polyhydric alcohols such as propylene glycol and glycerin, and a mixed solvent of these hydrophilic organic solvents and water can be used. In the case of using a mixed solvent of water and a hydrophilic organic solvent, 1 to 90 parts by mass with respect to 10 parts by mass of water in the case of a lower alcohol, and 10 parts by mass of water in the case of a lower aliphatic ketone. On the other hand, in the case of 1 to 40 parts by mass, in the case of polyhydric alcohol, it is preferable to add 10 to 90 parts by mass with respect to 10 parts by mass of water.

  In order to obtain a diluted or concentrated solution of the extracted solution, a dried product of the extracted solution, or a crudely purified product or purified product thereof, the extract is subjected to treatment such as dilution, concentration, drying and purification according to a conventional method. You may give it.

  In addition, it is possible to perform purification for the purpose of decolorization, deodorization, etc. within a range that does not cause a decrease in the fatigue improvement effect at the time of waking up, but there is no practical problem even if it is not purified. Specifically, purification can be performed by activated carbon treatment, adsorption resin treatment, ion exchange resin treatment, or the like.

The extract can be used as it is as a wake-up fatigue sensation improver as it is, but is preferably a concentrated solution or a dried product from the viewpoint of taking or preparing the composition.
In obtaining a dried product of the extract, a carrier such as dextrin or cyclodextrin may be added to improve hygroscopicity.
Moreover, since the said extract has a bitter taste, the taste at the time of ingesting the method (refer Unexamined-Japanese-Patent No. 2002-218936) which adds a galactomannan degradation product can be improved. In addition, a method of encapsulating (see Japanese Patent Application Laid-Open No. 2003-55219) or the like may mask the taste at the time of ingestion and may be stably absorbed in the digestive organs.

There is no restriction | limiting in particular as a method of formulating the said fatigue-relieving composition at the time of waking, and it can select suitably according to the objective. There is no restriction | limiting in particular as a dosage form of the said wake-up fatigue feeling improvement agent, According to the objective, it can select suitably, For example, a solid agent, a liquid agent, etc. are mentioned.
Examples of the solid agent include tablets, capsules, granules, powders, fine granules, and enteric coating agents by a coating method. As said solid agent, the additive used at the time of manufacture of an oral solid formulation can be mix | blended suitably in the range which does not impair the effect of this invention. Examples of the additive include potassium salt, acetic acid, excipient, binder, disintegrant, lubricant, flavoring agent, extender, coating agent, acidulant / pH adjuster, quality improver, thickener. Stabilizers, preservatives and the like can be mentioned.
The liquid agent is not particularly limited and may be appropriately selected depending on the intended purpose. For example, a solution obtained by dissolving and dispersing the solanaceous wizania plant-derived component in water using an emulsifier, ethyl alcohol And the like dissolved in a water-soluble solvent, and then dissolved in water.

  There is no restriction | limiting in particular as a usage method of the said fatigue sensation agent at the time of awakening, Although it can select suitably according to the objective, For example, it can be used as a pharmaceutical, a quasi-drug, health food, etc. In addition, it can be used as a component of a composition for improving a feeling of getting up at the time of waking up, which is formed by blending other components that enhance the effect of improving the feeling of getting up at the time of fatigue, and will be described later by being contained in a general food or a general beverage. It can be suitably used as a component of food and drink for improving the feeling of fatigue when waking up.

  The intake amount of the wake-up fatigue sensation-improving agent can be appropriately selected according to the level of sleep troubles. The dry matter weight of the rhizome extract is preferably 1 to 5000 mg / day, and 10 to 1000 mg. / Day is more preferable.

  The agent for improving fatigue at wake-up of the present invention can be taken orally on a daily basis, and the quality of sleep is improved by the action of the above-mentioned plant belonging to the plant belonging to the genus Widonia, so that a feeling of deep sleep and a refreshing sensation can be obtained. In particular, the fatigue can be eliminated.

(Composition to improve fatigue when getting up)
The composition for improving fatigue at wakeup of the present invention comprises (A) the above-mentioned fatigue amelioration agent at wake-up and (B) a fatigue recovery agent comprising an animal or plant-derived component as an active ingredient, and other components appropriately selected. But it ’s okay.

As the fatigue recovery agent comprising the above-mentioned (B) animal and plant-derived ingredients as active ingredients, Rahan fruit ( Momordicae grosvenori Swingle , Siraitia grosvenorii (Swingle) ), ginger (genus Zingiber), soybean ( Glycine max (L.) Merrill ), rice ( Oryza sativa), cherry (Prunus spp.), tea (tea: Camellia sinensis (L.) O. kuntze , China species:. var sinensis, Assam species:. var assamica), oyster (Crassostrea gigas), milk, and eggs from At least one material or extract selected is preferred.
Examples of the form of the material include a pulverized product, a dried product, and a dried pulverized product. Examples of the extract include an extract, an extract, a dried product obtained by drying the extract, and a rough product thereof. Examples include purified products, purified products, and fermentation metabolites.

  In addition, the fatigue recovery agent comprising (B) an animal and plant-derived component as an active ingredient is a phosphine extracted from at least one material selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg. It preferably contains at least one of fatidylserine, γ-aminobutyric acid, taurine, tryptophan, and theanine. These substances may be derived from the above materials and may be fermentation metabolites.

  The amount of the material and the substance is not particularly limited and can be appropriately selected depending on the purpose. For example, during the daily intake of the composition for improving fatigue at wakeup of the present invention, It is preferable that the amount shown in Table 1 below is included as the weight. Moreover, the said raw material and substance can mix | blend 1 type (s) or 2 or more types.

Furthermore, other components can be blended in the composition for improving a feeling of fatigue when waking up for the purpose of enhancing the effect of improving the feeling of fatigue when waking up.
Other components include, for example, amino acids, vitamins, bifidobacteria, oligosaccharides, lactic acid bacteria, hyaluronic acid, polyphenol, DHA (docosahexaenoic acid), EPA (eicosapentanoic acid), squalane, chitosan, propolis, lactoferrin, chlorella raw material Powder, Spirulina bulk powder, St. John's wort extract, and minerals (zinc, calcium, magnesium, etc.). Among these, amino acids and vitamins are particularly preferable.

The amino acid is preferably an essential amino acid, and examples include tryptophan, methionine, lysine, phenylalanine, leucine, isoleucine, valine, threonine, and histidine. Among these, tryptophan is preferable.
Examples of the vitamins include water-soluble vitamins, fat-soluble vitamins, vitamin-like substances (vitamin P, vitamin Q, vitamin U, inositol, etc.) and provitamins. Among these, vitamins A, vitamin B group, vitamin C, vitamin E, and combinations thereof are preferable. Add fat-soluble vitamins to the extent that they do not cause harmful effects of excessive intake.

In addition, there is no restriction | limiting in particular in the mixing | blending method of the said (A) said tiredness improvement agent at the time of rising, and (B) animal and plant origin component, Manufacturing of the extract of each component which can be suitably selected according to the objective. You may mix | blend beforehand in a step and may mix | blend separately.
The amount of (A) the wake-up fatigue sensation-improving agent and (B) the animal and plant-derived component is the daily intake amount, and (A) is 1 to 5000 mg as the dry matter weight of the rhizome part, As long as each component of (B) is contained so as to satisfy the amount shown in Table 1, it is not particularly limited.

  The method for using the composition for improving fatigue at the time of waking up is not particularly limited and may be appropriately selected depending on the intended purpose. For example, it may be used as a health food such as pharmaceuticals, quasi drugs, and supplements. Can do. Moreover, by making it contain in a general food and a general drink, it can be conveniently used as a component of the food for improving the feeling of fatigue when waking up, which will be described later.

There is no restriction | limiting in particular as a method of formulating the said wake-up fatigue feeling improvement composition in a solid agent, a liquid agent, etc., According to the objective, it can select suitably.
Examples of the solid agent include tablets, capsules, granules, powders, fine granules, enteric coating agents by a coating method, and the like. As said solid agent, the additive used at the time of manufacture of an oral solid formulation can be mix | blended suitably in the range which does not impair the effect of this invention. Examples of the additive include potassium salt, acetic acid, excipient, binder, disintegrant, lubricant, flavoring agent, extender, coating agent, acidulant / pH adjuster, quality improver, thickener. Stabilizers, preservatives and the like can be mentioned.
As the liquid agent, for example, the components of the composition for improving fatigue feeling upon waking up are dissolved and dispersed in water using an emulsifier, dissolved in a soluble solvent such as ethyl alcohol, and then dissolved in water. And so on.

  The composition for improving fatigue at the time of waking up of the present invention can be taken orally on a daily basis, and the function of the component derived from the plant belonging to the genus Widonia belonging to the solanaceous family and the recovery from fatigue contained in the composition for improving the feeling of fatigue at waking up With the ingredients, the quality of sleep is improved, and a deep sleep feeling and a refreshing feeling can be obtained when waking up.

(Food and drink for improving fatigue when waking up)
The food and drink for improving the feeling of waking up of the present invention contains any one of the agent for improving the feeling of waking up when fatigued and the composition for improving the feeling of waking up when waking up, and other components appropriately selected as necessary. It contains.

  The food and drink to which the agent for improving fatigue at wake-up and the composition for improving fatigue at wake-up can be applied are not particularly limited, but those that do not significantly affect the calories obtained in a normal diet are preferred. In particular, as a food / drink taken before going to bed, the calorie content of the above-mentioned food for improving fatigue when waking up is preferably 0-100 kcal, more preferably 0-50 kcal, so as not to cause obesity. 10 kcal is more preferable.

  Examples of the food for improving fatigue when waking up include beverages such as soft drinks, carbonated drinks, nutritive drinks, fruit drinks, and lactic acid drinks; candy, candy, gum, chocolate, tablet confectionery, snack confectionery, biscuits, jelly, jam Confectionery such as ice cream, ice sherbet and shaved ice; seasonings such as sauce, sauce and spices; dairy products such as processed milk and fermented milk; salad oil, tempura oil, margarine, Fats and oils and processed foods such as mayonnaise, shortening, whipped cream, dressing; noodles such as buckwheat, udon, harusame, gyoza skin, cucumber skin, Chinese noodles, instant noodles; crab, salmon, clams, tuna, sardines, shrimp , Bonito, mackerel, whale, oyster, saury, squid, red scallop, scallop, abalone, sea urchin, salmon roe, tocobushi Seafood products such as kamaboko, ham, sausage, processed fishery products such as kamaboko, ham, sausage; curry, stew, oyakodon, rice bowl, miscellaneous food, Chinese rice bowl, and rice bowl, tempura, eel rice, hayashi rice, oden, mabodorf, beef bowl, meat sauce, egg Retort pouch foods such as soup, omelet rice, dumplings, shumai, hamburger, meatballs; various forms of health and nutritional supplements, etc., added with auxiliary ingredients and additives normally used in the production of these can do.

Examples of the other components include auxiliary raw materials or additives that are usually used in producing the food and drink.
The raw material or additive is not particularly limited and may be appropriately selected depending on the intended purpose.For example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, rubusoside, corn syrup, lactose, citric acid, Tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, gum arabic , Carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinamide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances, preservatives, and the like.

  The amount of addition of the wake-up fatigue sensation-improving agent of the present invention and the wake-up fatigue sensation improving composition in the food for improving wake-up fatigue sensation varies depending on the type of food or drink to be used, and is generally defined. However, it may be added within a range that does not impair the original taste of food and drink, and is usually preferably 10 ppm to 50% and more preferably 100 ppm to 30% with respect to various foods and drinks. Moreover, in the case of foods and drinks in the form of granules, tablets or capsules, usually 0.1 to 100% by mass is preferable, and 5 to 100% by mass is more preferable.

  The wake-up fatigue improvement food and drink of the present invention can be taken orally on a daily basis, and by the action of the added wake-up fatigue amelioration agent and the wake-up fatigue amelioration composition, The quality is improved and a feeling of deep sleep and a refreshing feeling can be obtained when waking up.

Hereinafter, although the Example of this invention is described, this invention is not limited to this Example at all.
[Production Example 1]
-Capsule containing composition for improving fatigue at waking-
A capsule containing a composition for improving fatigue at wake-up having the following composition was produced by a conventional method. As the capsule, No. 1 hard gelatin capsule was used.
<Blend ingredients and their amount (in 4 capsules)>
・ Withernia Somnifera dunar rhizome extract dry powder 300.0mg
・ Rice-derived gamma aminobutyric acid 100.0mg
・ Rakan fruit extract 20.0mg
・ Vitamin B6 1.5mg
・ Excipient (cellulose) 200.0mg
However, the said compounding quantity showed the quantity in 4 capsules as a daily intake.

[Comparative Production Example 1]
As a placebo of the capsule containing the composition for improving fatigue at wake-up produced in Production Example 1, a capsule having the following composition was produced by a conventional method. As the capsule, No. 1 hard gelatin capsule was used.
<Blend ingredients and their amount (in 4 capsules)>
・ Vitamin B6 1.5mg
・ Excipient (cellulose) 620.0mg
However, the said compounding quantity showed the quantity in 4 capsules as a daily intake. The appearance of the produced capsule was the same as that of the capsule of Production Example 1.

(Example 1 and Comparative Example 1)
As a result of the Athenian insomnia scale, 30 people who were suspected of having insomnia (6 points or more) or who had trouble with sleep and were not diagnosed or administered by a doctor were examined. It was.
(1) Sample taking The 30 subjects were divided into 2 groups of 15 subjects, and the test was conducted for 15 days according to the following schedule.
-Group 1: 5 days of taking a sample, 5 days of non-dosing, 5 days of taking a placebo-Group 2: 5 days of taking a placebo, 5 days of taking no sample, 5 days of taking a sample Note that in the case of taking a sample (Example 1), the above production example For taking 1 capsule of 4 capsules in placebo (Comparative Example 1), 4 capsules of Comparative Production Example 1 were each taken once a day, 30 to 60 minutes before going to bed.

(2) Evaluation method-Evaluation on feeling of sleep-
The subject was asked to answer a questionnaire based on the OSA sleep evaluation form (MA version) before starting the test and when getting up during the test.
The questionnaire is a four-limb selection answer system composed of 16 questions. The items of the question are “(I) sleepiness when waking up”, “(II) falling asleep and sleep maintenance (sleep quality)”, “(III) dreaming (sleep disturbance due to nightmares and frequent dreams)”, “ (IV) Fatigue recovery feeling (refreshing feeling when waking up) "and" (V) Sleep feeling prolonged feeling (feeling of having slept for a long time) ". Each question item has a scale value (Zc) weighted by the reaction frequency, and based on this, the results are tabulated for each factor (brain and psychiatry, 10: 401-409 (1999)). If each factor has a high score, it is judged that sleep is good.
Table 2 shows the number of subjects who showed improvement of 5 points or more compared with the score before the test.
Moreover, a score is shown in Table 3 and FIG. 1 about the result at the time of sample taking (Example 1) in a test, and the result at the time of taking a placebo (Comparative Example 1).

被験者間の得点のばらつきが大きかったため、平均得点で評価した場合、実施例１と比較例１との得点差が小さいが、いずれの因子の平均得点も実施例１が高く、サンプル摂取により睡眠が良化されていることがわかった。

Since the score variation between subjects was large, when evaluated by average score, the score difference between Example 1 and Comparative Example 1 is small, but the average score of any factor is high in Example 1, and sleep is caused by sample intake. It turns out that it is improving.

-Evaluation of sensation when getting up-
The subjects were asked to freely answer the sensation of getting up every time.
In response to the above free answers, (1) the total number of subjects who answered that they showed some improvement in sleep during the test period, and (2) the items pointed out in the answers were classified, and multiple items were listed The responses were divided and tabulated for the number of specific sleep improvements. With regard to (2), for example, the answer that “I hardly woke up until morning, so I could sleep well” was “I did not get up until morning (= almost no awakening)”, “I slept well (= It was assumed that the improvement was recognized for each of the two items, “A feeling of deep sleep” was counted.
As a result, at the time of taking the sample (Example 1), the number of subjects who experienced some improvement in sleep was 10 out of 15 (66.7%). The number of cases showing concrete improvement in sleep, such as “Improved quality of sleep” and “Relieved fatigue when waking up” was 38 cases.
On the other hand, at the time of taking a placebo (Comparative Example 1), 2 subjects out of 15 (13.3%) responded that they experienced the improvement of sleep. The number of cases shown was seven.

-Evaluation of mood when getting up-
The subjects were asked to evaluate the mood at the time of waking up on the fifth day after taking the sample and the fifth day after taking the placebo in the following five stages. An evaluation of “feeling good” indicates a subjective feeling or feeling such as “has a refreshing feeling” or “no feeling of fatigue”. Responses were obtained that included relative evaluations such as eliminating fatigue. The results are shown in Table 4.
<Evaluation>
5 ... Feels very good 4 ... Feels slightly good 3 ... Not good 2 ... Feels a little bad 1 ... Feels very bad

表４から、サンプル摂取により、起床時の気分が改善されることがわかった。

From Table 4, it was found that the mood at the time of waking up was improved by ingesting the sample.

(Example 2 and Comparative Example 2)
As a result of the Athenian Insomnia Scale, 10 subjects who were determined to have insomnia (6 points or more) or who had troubles related to sleep and were not diagnosed or administered by a doctor It was.
(1) Sample taking Ten subjects were divided into two groups of five, and the test was conducted for 10 weeks according to the following schedule.
Group 1: 4 weeks of sample taking, 2 weeks of non-dosing, 4 weeks of taking placebo Group 2: 4 weeks of taking placebo, 2 weeks of non-dosing, 4 weeks of taking sample In addition, in the sample taking (Example 2), the above production example In the case of taking 1 capsule of 4 capsules in placebo (Comparative Example 2), 4 capsules of Comparative Production Example 1 were each taken once a day, 30 to 60 minutes before going to bed.

(2) Evaluation method-Evaluation on feeling of sleep-
In the same manner as in Example 1, the subjects were asked to answer a questionnaire based on the OSA sleep evaluation vote (MA version), and this was totaled.
Table 5 and FIGS. 2 to 6 show the scores obtained every week for the results of taking the sample during the test (Example 2) and the results of taking the placebo (Comparative Example 2).

表５の結果から、実施例２ではいずれの因子においても、平均得点が比較例２よりも高く、サンプル摂取により睡眠が良化され、特に、総合的な睡眠に対する満足度が高くなることがわかった。

From the results of Table 5, it can be seen that in any of the factors in Example 2, the average score is higher than in Comparative Example 2, and sleep is improved by taking the sample, and in particular, the satisfaction with total sleep is increased. It was.

-Evaluation of sensation when getting up-
The test subjects were asked to freely answer the sensation of getting up each time, and counting was performed in the same manner as in Example 1.
As a result, when taking the sample (Example 2), the number of subjects who experienced some kind of sleep improvement was 6 out of 10 (60%). There were 14 specific cases of sleep improvement, such as “I woke up in the morning” and “I was relieved of my fatigue when waking up”.
On the other hand, at the time of taking a placebo (Comparative Example 2), 2 out of 10 subjects (20%) responded that they experienced the improvement of sleep, and the number of subjects showing a specific improvement of sleep. There were 5 cases.

-Evaluation of mood when getting up-
The subjects were evaluated in the same manner as in Example 1 after 4 weeks after taking the sample and 4 weeks after taking the placebo. The results are shown in Table 6.

表６から、サンプル摂取により、起床時の気分が改善されることがわかった。

From Table 6, it was found that the mood at the time of waking up was improved by ingesting the sample.

  The composition for improving fatigue at the time of waking up of the present invention can be easily taken orally, the quality of sleep is improved, and a feeling of deep sleep and a refreshing feeling can be obtained at the time of waking up. I knew it was possible. Hereinafter, the manufacture example of the food-drinks for improving the feeling of fatigue at the time of rising containing the composition for improving the feeling of fatigue at the time of rising of the present invention is described.

[Production Example 2]
-Capsule containing composition for improving fatigue at waking-
The capsule composition containing the composition for improving fatigue at wake-up having the following composition was produced by a conventional method. As the capsule, No. 1 hard gelatin capsule was used.
Compounding ingredients Compounding amount
-Withania Somnifera dunar rhizome extract 25% by mass
・ GABA extract 5% by mass
・ Ginger extract 1% by mass
・ Tryptophan 4% by mass
・ Phosphatidylserine 8% by mass
・ Arhat extract 2% by mass
・ Arginine 2% by mass
・ Lysine 2% by mass
・ Vitamin B6 0.2% by mass
・ Vitamin C 20% by mass
・ Excipient (cellulose) balance
The produced capsules can be easily taken orally with almost no odor or bitterness that impedes intake, improve sleep after intake, and improve the feeling of fatigue when waking up.

[Production Example 3]
-Tablets containing composition for improving fatigue at wake-up-
A tablet containing the composition for improving fatigue at wake-up having the following composition was produced by a conventional method.
Compounding ingredients Compounding amount
・ Capsule with wizzania somnifera dunal extract ^{(* 1)} 30% by mass
・ GABA extract 10% by mass
・ Ginger extract 2% by mass
・ Phosphatidylserine 5% by mass
・ Arhat extract 5% by mass
・ Vitamin B group mixture ^{(* 2)} 1.5% by mass
・ Niacin 5% by mass
・ Β-Carotene 0.3% by mass
・ Corn starch 10% by mass
・ Hydroxypropylcellulose 10% by mass
・ Lactose balance
* 1: The above-mentioned Capsule with Withania Somnifera Dunal Extract is a cyclodextrin capsule prepared by a conventional method containing 5% of Withania Somnifera Dunal Extract.
* 2: Vitamin B1 / Vitamin B2 / Vitamin B6 / Vitamin B12 = 450/500/670/1
The manufactured tablets can be easily taken orally with almost no odor or bitterness that hinders intake, improve sleep after intake, and improve the feeling of fatigue when waking up.

[Production Example 4]
-A jelly containing a composition for improving fatigue when waking up-
A jelly composition containing a composition for improving fatigue at wake-up having the following composition was produced by a conventional method.
Compounding ingredients Compounding amount
・ Capsule with wizzania somnifera dunal extract ^(*) 3% by mass
・ GABA extract 1% by mass
・ Ginger juice 1% by mass
・ Phosphatidylserine 1% by mass
・ Arhat extract 2% by mass
・ Gelatin 1.5% by mass
・ Non-calorie sweetener appropriate amount ・ fragrance (ginger flavor) appropriate amount
・ Water balance
However, the capsule containing the Withania somnifera dunal extract is a cyclodextrin capsule prepared by a conventional method by blending 5% Withania somnifera dunal extract.
The produced jelly can be easily taken orally with almost no odor or bitterness that hinders intake, improves sleep after intake, and improves feeling of fatigue when waking up.

[Production Example 5]
-Cookies containing composition to improve fatigue when getting up-
A wake-up fatigue feeling improving composition-containing cookie having the following composition was produced by a conventional method.
Compounding ingredients Compounding amount
・ Capsule with wizzania somnifera dunal extract ^(*) 3% by mass
-Rahan fruit extract 10% by mass
・ Milk 60% by mass
・ 10% by mass of whole eggs
・ Sugar 5% by mass
・ Corn starch 5% by mass
・ Salt 0.5% by mass
・ Flavor (vanilla essence)
However, the capsule containing the Withania somnifera dunal extract is a cyclodextrin capsule prepared by a conventional method by blending 5% Withania somnifera dunal extract.
The manufactured cookie can be easily taken orally with almost no odor or bitterness that hinders intake, improves sleep after intake, and improves feeling of fatigue when waking up.

[Production Example 6]
-Noodles (Udon) containing a composition for improving fatigue when waking up-
Noodles (udon) containing the composition for improving fatigue at wake-up having the following composition were produced by a conventional method.
Compounding ingredients Compounding amount
・ Withania Somnifera Dunal Extract 0.2% by mass
-Rahan fruit extract 1% by mass
・ 65% by weight of flour
・ Salt 3% by mass
・ Appropriate amount of water
The produced noodles can be easily taken orally with almost no odor or bitterness that hinders intake, improve sleep after intake, and improve the feeling of fatigue when waking up .

  The wake-up fatigue sensation-improving agent and the wake-up fatigue sensation-improving composition have an effect of improving sleep quality, and can be experienced to eliminate fatigue when waking up (at the time of awakening), It is easy to ingest, and can be widely applied to foods and drinks such as general foods, health foods, health functional foods, quasi drugs and pharmaceuticals that are taken orally. In addition, the wake-up fatigue improvement food or drink of the present invention containing either the wake-up fatigue sensation improving agent or the wake-up fatigue sensation improving composition can be suitably used as a health food.

FIG. 1 is a graph showing evaluation results regarding sleep feeling in Example 1 and Comparative Example 1. FIG. 2 is a graph showing (I) an evaluation result regarding sleepiness when waking up among evaluation factors regarding sleep feeling in Example 2 and Comparative Example 2. FIG. 3 is a graph showing (II) evaluation results on sleep onset and sleep maintenance among evaluation factors related to sleep feeling in Example 2 and Comparative Example 2. FIG. 4 is a graph showing the evaluation results regarding (III) dreams among the evaluation factors regarding sleep feeling in Example 2 and Comparative Example 2. FIG. 5 is a graph showing (IV) an evaluation result regarding a feeling of recovery from fatigue among evaluation factors regarding a feeling of sleep in Example 2 and Comparative Example 2. FIG. 6 is a graph showing the evaluation results regarding (V) sleep time prolongation among the evaluation factors regarding sleep feeling of Example 2 and Comparative Example 2.

Claims (9)

  An agent for improving fatigue during waking, comprising a component derived from a plant belonging to the genus Withania, as an active ingredient.   The agent for improving fatigue at wake-up according to claim 1, comprising an extract obtained by extracting a rhizome part of a plant belonging to the genus Withania with an aqueous solvent as an active ingredient. The agent for improving fatigue at wake-up according to any one of claims 1 to 2, wherein the plant belonging to the genus Withania is a Withania somnifera Dunal .   (A) The agent for improving fatigue at wakeup according to any one of claims 1 to 3, and (B) a fatigue recovery agent comprising an animal or plant-derived component as an active ingredient for improving fatigue at wakeup, Composition.   (B) The fatigue recovery agent comprising an animal or plant-derived component as an active ingredient contains at least one material or extract selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg. 2. A composition for improving fatigue feeling upon waking up.   (B) A phosphatidylserine extracted from at least one material selected from rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg The composition for improving fatigue feeling upon waking according to any one of claims 4 to 5, comprising at least one of γ-aminobutyric acid, taurine, tryptophan, and theanine.   The composition for improving fatigue feeling upon waking according to any one of claims 4 to 6, comprising any one of amino acids and vitamins.   A food for improving a feeling of fatigue at waking up, comprising the agent for improving fatigue at waking up according to any one of claims 1 to 3. A food / drink for improving fatigue feeling when waking up, comprising the composition for improving fatigue feeling when waking up according to any one of claims 4 to 7.

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