JP2011153125A - Autonomic control agent containing pseudo-leaf of asparagus as active ingredient - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an autonomic nerve regulator which controls an autonomic nerve safely and effectively to prevent or ameliorate autonomic ataxia, and to ameliorate sleep state effectively, functional foods or food materials which prevent or ameliorate autonomic ataxia, and a method of using the autonomic nerve regulator incorporated in foods or food materials for preventing or ameliorating autonomic ataxia and ameliorating sleep. <P>SOLUTION: Pseudo-leaves of asparagus and processed materials thereof (materials obtained through pulverization, shredding, drying, roasting, extraction, ultrasonic homogenization or freezing, and in addition, materials resulting from the combination of these processes), preferably, dried powder thereof, are used as an active ingredient. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an autonomic nerve regulator comprising asparagus pseudo leaves as an active ingredient, more specifically, an autonomic nerve regulator comprising the asparagus pseudo leaves or a processed product thereof as an active ingredient, prevention of autonomic dysfunction or The present invention relates to an improving agent, a sleep improving agent, a functional food or food material for preventing or improving autonomic dysfunction, and a method for using asparagus pseudo leaves or a processed product thereof.

  The autonomic nervous system is widely distributed in various internal organs, blood vessels, glands, etc., and functions to maintain a certain state homeostasis (homeostasis) for the external internal environment by adjusting each organ concomitantly It is also said to be a plant nervous system. The autonomic nervous system has two systems, a sympathetic nervous system and a parasympathetic nervous system, and the autonomic nervous system is controlled by a balance between the two. That is, when the body is active, sympathetic nerve activity is dominant, and the whole body is in tension. Conversely, when parasympathetic activity predominates, the body becomes tense and relaxed. In addition, it is known that various disabilities occur when disturbance of autonomic nerve activity continues for a long time due to stress. Disturbance of autonomic nervous activity means a state where sympathetic nerve activity is dominant or parasympathetic nerve activity is dominant, but in modern society, health problems due to the persistence of sympathetic nerve activity are a problem. Is being viewed.

  The balance between the exchange and parasympathetic nerves has been found to be closely related to the state of the heart in humans. For example, in a depressed state, the parasympathetic nerve activity, which should be increased when relaxed, is reduced, but when healed, the normal balance in which the parasympathetic nerve predominates when restored is restored. It has also been found that when exposed to excessive stress, parasympathetic nerves do not function well, sympathetic nerve activity continues to increase, and poor physical condition such as insomnia occurs. Other symptoms include headache, dizziness, fatigue, tremor, cold limbs, sweating abnormalities, palpitation, shortness of breath, chest tightness, chest pain, loss of appetite, stomach fullness, constipation, and diarrhea. In recent years, it has been pointed out that decreased parasympathetic nerve activity is an important risk factor for coronary heart disease and sudden death. Various complaints caused by a decrease in the function of the autonomic nervous system are called autonomic dysfunction and have a significant adverse effect on the maintenance and improvement of normal daily life.

  In reality, treatment is performed symptomatically for each symptom or disease, and a method for controlling the autonomic nerve activity itself, which is the root cause, has not been taken. Symptomatic therapy can temporarily improve the condition itself, but it will recur if you stop taking the drug, and if you continue to take it, the autonomic nerve that is the root cause of the disease may be improved. Many other diseases develop due to disturbances in the body and decreased autonomic nervous activity. Therefore, there has been a demand for pharmaceuticals or health foods that control the autonomic nervous activity itself that is the root cause. In other words, by suppressing sympathetic nerve activity or parasympathetic nerve activity that has been increased for some reason, or by increasing decreased sympathetic nerve activity or parasympathetic nerve activity, a state in which sympathetic nerve activity is dominant, a state in which parasympathetic nerve activity is dominant, overall If an active ingredient compound, substance or natural product having an action of recovering a state in which autonomic nerve activity is enhanced or reduced is obtained, the utility value is extremely high from the viewpoint of preventing various diseases.

  Various active ingredient compounds have been proposed in the past for the prevention and treatment of autonomic dysfunction, anxiety and depression, and naturally derived substances give a sense of security to humans and have been widely used as crude drugs in the past. Are known. As derived from animals and plants, by extracting from a natural material by an ordinary method from a stress symptom-recovering agent associated with autonomic dysfunction, comprising a crude saponin of medicinal carrot as an active ingredient Known sympathetic excitation inhibitors containing phospholipids containing n-3 polyunsaturated fatty acids such as docosahexaenoic acid and / or eicosapentaenoic acid as constituents are known (see, for example, Patent Document 2). ing.

  Further, a composition for anti-stress and relaxation containing one or two or more selected from the group consisting of theanine (an extract from tea) and herbs, GABA and palatinose (for example, see Patent Document 3), carnosine And a functional food having a learning function improving effect and an anxiolytic effect (for example, see Patent Document 4), an extract of pine (jasmin sambac), 3-methyloctano-4- There is known an autonomic nerve regulator comprising one or more selected from lactone, bornyl acetate, and thymus vulgaris steam distillate as active ingredients (see, for example, Patent Document 5).

  Furthermore, as drinking water which has a relaxing effect, the drinking water which has a relaxing effect containing the water of hardness 60-2000 (for example, refer patent document 6) is known.

  On the other hand, as a technique using asparagus stems and artificial leaves, powdered tea made from asparagus obtained by drying, pulverizing, and roasting green asparagus stems, or asparagus A blended tea blended with powdered leaf tea obtained by similarly drying, crushing, and roasting artificial leaves (see, for example, Patent Document 7), and Asparagus genus containing rutin and at least 100 mg of sugar per 1 g dry weight A dry powder of a pseudo-leaf tissue of a plant (for example, see Patent Document 8) is known.

  On the other hand, there are no known autonomic nerve regulators containing asparagus pseudo leaves as active ingredients, preventive or ameliorating agents for autonomic dysfunction, sleep improving agents, and the like.

Japanese Examined Patent Publication No. 62-44526 JP 2004-67537 A JP 2005-232045 A International Publication No. 2007-116987 Japanese Unexamined Patent Publication No. 2009-233501 JP 2009-274980 A JP-A 63-273462 International Publication No. 2006-22338

  The present invention is capable of adjusting an autonomic nerve safely and effectively, preventing or improving autonomic dysfunction, an autonomic nerve adjusting agent capable of effectively improving sleep state, and a function for preventing or improving autonomic dysfunction Food or food material, a method for using the autonomic nerve modifier in food or food material for prevention or improvement of autonomic dysfunction and for sleep improvement, and prevention or improvement of autonomic dysfunction, and sleep improvement Provided for use in the production of food or food ingredients for use.

  In Hokkaido, where asparagus is actively cultivated, the present inventors have discarded a large amount of stems 25 cm or less from the tip and leaves grown on green asparagus (pseudo leaves) after harvesting asparagus. In particular, the pseudo leaves have been known to have a high rutin content for some time, but as a result of intensive studies to develop an effective use of the asparagus pseudo leaves, Or the results of further research since the treated symptoms were administered to people diagnosed with mild depression, those with indefinite complaints, those who reported insomnia, etc. The inventors have found that the present invention is effective in preventing and improving diseases in the autonomic nervous system such as autonomic insufficiency and insomnia, and have completed the present invention.

  That is, the present invention relates to (1) an autonomic nerve regulator characterized by comprising asparagus pseudo-leaf as an active ingredient, and (2) autonomic dysfunction characterized by comprising asparagus pseudo-leaf as an active ingredient. The present invention relates to a preventive or ameliorating agent and (3) a sleep improving agent characterized by using asparagus pseudo-leaf as an active ingredient.

  The present invention also includes (4) a functional food or food material for preventing or ameliorating autonomic dysfunction characterized by containing asparagus pseudo-leaf as an active ingredient, or (5) asparagus. The present invention relates to the use of gas mimetic leaves in the production of functional foods or food materials for preventing or improving autonomic dysfunction or for improving sleep.

  The autonomic nerve modifier of the present invention, an agent for preventing or improving autonomic dysfunction, a sleep improving agent, a functional food or food material for preventing or improving autonomic dysfunction, has no side effects in its use, and is sensitive to individuals. It is possible to adjust the autonomic nerves statically without being influenced by taste and preference, and for those who have an excessive balance of sympathetic nerves due to the balance of the autonomic nerves, anorexia, high blood pressure, headache, stiff shoulders, hot flashes It is possible to improve safely and effectively against various symptoms caused by autonomic dysfunction such as irritation and insomnia. In addition, the present invention contributes to ecological measures without affecting the natural environment in terms of effective use of asparagus pseudo-leaf waste and reduction of waste.

Shows the sleep sensation score when waking up for each sample taken. Sample A shows the dextrin of the comparative example, and Sample B shows the asparagus pseudo-leaf powder that is the autonomic nervous regulator of the present invention.

  The autonomic nerve adjusting agent, the autonomic dysfunction prevention or improving agent, and the sleep improving agent of the present invention are not particularly limited as long as they contain an asparagus pseudo-leaf as an active ingredient. There are physical symptoms such as tiredness, fatigue, insomnia, head sensation, sweating, etc. as a function of the conditioning agent, but there are few psychological symptoms such as anxiety, and it is improved against symptoms that are not enough to use anti-anxiety drugs Although autonomic ataxia has individual differences, the balance of the autonomic nerves is disturbed, and the autonomic nervous system (each organ, such as the head, ears, mouth, throat, heart / vasculature, There are many types of subjective symptoms in the respiratory system, digestive organs, hands, feet, skin, urinary organs, genital organs, autonomic nervous system in muscles and joints), specifically headache, tinnitus, palpitation, stuffy breath, nausea, hyperhidrosis Numbness of hands, cold feet , Frequent urination, stiff shoulders, joint pain, and other general symptoms such as fatigue, ease of fatigue, dizziness, hot flashes, loss of appetite, etc. There are symptoms such as depression, anger, lack of concentration, motivation, decreased memory and attention, and the present invention prevents or improves these symptoms. The sleep improving agent improves symptoms such as inability to sleep, waking up immediately, and difficulty in getting up.

  Asparagus pseudo-leaf is a stalk that branches after the edible young shoots grow, and it makes nutrients by photosynthesis instead of leaves. In open-season cultivation, most of the young stems are harvested around May and June, but some are left as they are to store the nutrients in the roots for the next year and grown into pseudo leaves. The application object in the present invention is this pseudo-leaf whose tip is shaped like a pine needle, which appears by growing.

  Asparagus plants are perennials of the lily family, originating from southern Europe and Ukraine, and widely distributed in Europe, Africa and Asia. Asparagus officinalis, commonly referred to as "asparagus" and used as food, is also A.asparagoides (A. asparagus), A. asparagus. Cochinchinensis, A.plumosus, A.myrioclaudus, etc. are used for food, foliage, and Kampo. As an asparagus pseudo leaf in the present invention, a pseudo leaf of Asparagus officinalis can be preferably exemplified.

  Asparagus young stems contain functional substances such as rutin, saponin, fructooligosaccharides and dietary fiber. It is known that some of these substances have an antioxidant action and an antitumor activity. In addition, the rutin content of asparagus pseudo leaves is 100 to 200 times that of ordinary buckwheat, and there is no worry of buckwheat allergy, and it has a clean green color like matcha and a light asparagus flavor with a subtle sweetness. It is also known that it can be used as a food and drink material.

  The asparagus pseudo leaves in the present invention include the pseudo leaves themselves and processed products thereof. The processed products include asparagus pseudo leaf pulverized processed products, shredded processed products, dried processed products, roasted processed products, extracted processed products, ultrasonic homogenized processed products, frozen processed products, and combinations of these processes. The processed material obtained by this can be mentioned. For example, a method for producing asparagus puree is as follows. After removing the adhering earth and sand, soot, etc. after washing the artificial leaves that have been cultivated until late summer, shred it with a food cutter, add water to this shredded product, and use an electric stone mortar etc. The resulting pasty solution is concentrated with a low-temperature concentrator. This concentrate (pure) exhibits a dark green cocoon-like state, or as it is or in combination with other excipients, the autonomic nerve regulator of the present invention, an agent for preventing or improving autonomic dysfunction, sleep improvement It can be suitably used as an agent or a functional food or food material for preventing or improving autonomic dysfunction.

  Moreover, the manufacturing method of the dry pulverized processed product of asparagus pseudo leaves is as follows. Asparagus pseudo leaves are shredded with a food cutter, and the shredded pseudo leaves are dried under mild conditions using a dryer selected from freeze dryer, vacuum dryer, ventilation dryer, etc. The resulting dried asparagus pseudo leaves are pulverized with a pulverizer according to the application. Furthermore, it can also be finely powdered using a fine pulverizer such as a turbo mill (Turbo Industry Co., Ltd.). The dry powder can be used as it is or in combination with other excipients, the autonomic nerve regulator of the present invention or the preventive or ameliorating agent for autonomic dysfunction, a functional food for preventing or improving autonomic dysfunction, or It can be suitably used as a raw material for food materials. The dry powder can be applied in many fields as compared with the puree.

  Examples of other processed asparagus pseudo leaves include those obtained by chopping pseudo asparagus pseudo leaves, or dried products thereof, liquid asparagus pseudo leaves (juice), or dry products thereof. These can be used as they are or in combination with other excipients, etc., the autonomic nerve regulator of the present invention or the preventive or ameliorating agent of autonomic dysfunction, the functional food for the prevention or improvement of autonomic dysfunction Or it can be used as a food material.

  Examples of the dosage form of the autonomic nerve adjusting agent, autonomic dystaxia preventive or ameliorating agent, and sleep improving agent of the present invention include powders, tablets, capsules, granules, powders, liquids, etc. It is administered orally as a pharmaceutical composition. Moreover, these dosage forms can be manufactured by the conventional formulation method known conventionally. For example, it is molded by mixing with carriers, excipients, fragrances, emulsifiers, preservatives, dispersants and the like that are permitted in the preparation of the preparation. Moreover, another active ingredient can also be mix | blended as needed. Examples of the excipient include lactose, dextrose, cellulose, methylcellulose, starch and the like.

  As a functional food or food material for preventing or ameliorating autonomic dysfunction of the present invention, or for improving sleep, asparagus pseudoleaf itself or a processed product of the asparagus pseudoleaf as an active ingredient, It is not particularly limited as long as it can be distinguished from other asparagus fake leaf-containing foods or food materials in terms of prevention or improvement of autonomic dysfunction, or sleep improvement. Examples that can be distinguished include the presence or absence of a display indicating that the food or food material packaging has a function for preventing or improving autonomic dysfunction or for improving sleep. As a method for producing such a functional food or food material, for example, chopped asparagus pseudo leaves, or dried product thereof, asparagus pseudo leaves liquefied (pure, juice, etc.), Alternatively, it is possible to add a dry product or a powdered asparagus pseudo-leaf to a food or a food material, or a method of adding and blending after a production process or after production. The food object is not particularly limited, baked confectionery such as cookies, bread, cakes, rice crackers, tablet confectionery such as ramune confectionery, Japanese confectionery such as mutton, frozen confectionery such as pudding, jelly, ice cream, Sweets such as chewing gum and candy, snacks such as crackers and chips, noodles such as udon and soba, fish paste products such as kamaboko, ham and fish sausage, dairy products such as cheese and butter, miso and soy sauce , Dressings, mayonnaise, sweeteners, and other tofu, konjac, other boiled dishes, dumplings, croquettes, salads, soups, stews, etc., yogurt, drink yogurt, juice, milk, soy milk, alcohol Specific examples include various drinks such as black tea, sencha, oolong tea, and sports drinks.

  The dosage of the autonomic nerve adjusting agent, autonomic dystaxia preventive or ameliorating agent of the present invention, sleep improving agent varies depending on age, therapeutic effect and disease state, and is not particularly limited, but the asparagus pseudo leaves are dried per day. What is necessary is just to adjust a compounding quantity etc. so that 1-300g as a weight, Preferably 2-10g can be ingested. Asparagus pseudo leaves can be taken in various dosage forms and added to various foods, beverages, etc., as described above. Especially when taking in the form of beverages, matcha flavor when taken with water. However, it may be taken together with sports drinks, milk, soy milk or the like according to preference.

  EXAMPLES Hereinafter, although an Example demonstrates this invention more concretely, the technical scope of this invention is not limited to these illustrations.

(Preparation of asparagus pseudoleaf puree)
The harvested asparagus pseudo-leaf contaminants were removed, washed, drained, and shredded into 2 to 3 cm with a food cutter (Slicer OV type, manufactured by Archer). Three times the amount of water was added to the shredded product, and it was ground twice with an electric stone mill (mass colloider, manufactured by Masuko Sangyo Co., Ltd.) until a predetermined particle size was obtained. The paste-like solution was put into a low-temperature concentrator (Evapor, manufactured by Okawara Seisakusho), concentrated to a liquid temperature of 35 ° C. and about Bx15, and further heated at 55 ° C. for 15 minutes to prepare an asparagus pseudoleaf concentrate. The product was dark green and contained rutin and sugar suitable for water content. The yield was 150%. This concentrated solution can be used as it is, or filled in a bottle, can, paper container or the like as the autonomic nervous regulator of the present invention. Moreover, it can mix | blend as a raw material of a foodstuff or a foodstuff material for the prevention or improvement of an autonomic dysfunction, and a sleep improvement. Cryopreservation is also possible.

(Preparation of freeze-dried asparagus pseudo-leaf powder)
The harvested asparagus pseudo-leaf contaminants were removed, washed, drained, and shredded into 2 to 3 cm with a food cutter (Slicer OV type, manufactured by Archer). The shredded product was pre-frozen at −40 ° C., and further freeze-dried using a vacuum freeze dryer (manufactured by Kyowa Vacuum Technology Co., Ltd.) at a shelf heating temperature of 30 ° C. and a drying time of 48 hours. The yield was 24%. The dried asparagus pseudo leaves were pulverized with a turbo mill (Turbo Industry Co., Ltd.) to form a powder. This powder can be used as it is or filled in a bottle, a can, a paper container, or the like, as an autonomic nerve adjusting agent of the present invention, or in various dosage forms.

[Granule (Hereinafter, the blending ratio is expressed by mass%)]
(1) Sucralose 0.1
(2) Autonomic nerve regulator (dry powder of Example 2) 0.5
(3) Flavoring 5.0
(4) Excipient (Theolus) 10.0
(5) Maltitol residual

[Tablets (chewable type)]
(1) Inositol 11.0
(2) Maltitol 15.0
(3) Sucrose 0.5
(4) White coconut extract (DNA Na) 0.1
(5) Yeast extract 0.1
(6) Autonomic nerve regulator (dried powder of Example 2) 0.5
(7) Flavoring 5.0
(8) Excipient residue

[Tablet]
(1) Lubricants (sucrose fatty acid esters, etc.) 1.0
(2) Gum arabic aqueous solution (5%) 2.0
(3) Acidulant 1.0
(4) Coloring agent appropriate amount (5) Autonomic nerve modifier (dried powder of Example 2) 1.0
(6) Carbohydrate (powdered sugar or sorbitol, etc.) Residue

[Candy]
(1) Sugar 57.5
(2) Minamata 40.0
(3) Organic acid 2.0
(4) Autonomic nerve regulator (dried powder of Example 2) 0.5

[Gum]
(1) Sugar 33.0
(2) Gum base 30.0
(3) Glucose 10.0
(4) Minamata 16.0
(5) Autonomic nerve regulator (dry powder of Example 2) 1.0

(Sleep improvement experiment by human monitor test)
(Target)
1) Do not take drugs related to autonomic dysfunction 2) During the study period, take an autonomic nerve regulator (asparagus pseudo-leaf dry powder of Example 2) every day and fill the questionnaire when waking up Nine persons satisfying these two conditions were selected as subjects.
(Test sample)
As test samples, sample A (dextrin) and sample B (autonomic nerve regulator: asparagus pseudo-leaf dry powder of Example 2) are prepared, and the color tone of these two types of test samples is distinguished from the appearance. Each unfilled capsule was packed to 250 mg / grain.

(Test method)
The subjects who were divided into two groups by random numbers were not allowed to take any test sample as the non-taking period from the 0th day to the 7th day of the test, and the test sample as the first taking period from the 8th day to the 21st day A or B was taken 8 times a day, with water or hot water within 30 minutes after dinner. From the 22nd to the 28th day from the start of the test, the non-taking period is set as the second taking period from the 29th to the 42nd day, and the test sample B is given to the group of subjects who took the test sample A in the first taking period. A group of subjects who took the test sample B had the test sample A taken in the same manner.
The test was performed so that the subject and the data analyst did not know whether the test sample A or B was taken by the subject during the first dose period or the second dose period, thus maintaining the fairness of the data.

  Sleeping, getting up, sleeping time, amount of drinking, names of drugs taken, and 5 items related to the feeling of sleep when waking up, extracted from the sleep feeling survey table when waking up. (1) Getting tired when waking up. (2) Sleeping well. Create a survey table that describes the situation of (3) clear heading, (4) good sleep, and (5) did not wake up during sleep. During the test period, I was asked to fill in the situation immediately after waking up every morning. For the five items related to the feeling of sleep when waking up, ○ was given to the corresponding part of the five-step evaluation.

(Sleep improvement effect by taking)
In a five-stage evaluation of five items related to the feeling of sleep when waking up, the sleep feeling during the period was quantified with 10 points being the most comfortable and -10 points being the most uncomfortable. For each subject, the sleep sensation score during the dosing period was averaged.
Table 1 shows the result of sleep feeling score of each subject.

  An average score between the first and second dose periods was compared and a significant difference test was performed. FIG. 1 shows the number of sleep sensation points when waking up for each sample. In the sample A (dextrin) dosing period and sample B (autonomic nerve regulator) dosing period, a significant improvement in sleep sensation was observed in the sample B dosing period of the asparagus pseudo-leaf dry powder of Example 2 (p = 0.0134).

(Symptoms: Mild depression, age 28, female)
He was diagnosed with mild depression and treated for nearly 2 years. Currently, he is being treated with 20 mg / tablet of paroxetine hydrochloride on a daily basis. Instead of the prescribed dose, I took two weeks of medicine in about three weeks, and I wanted to stop taking the medicine. As a method for taking asparagus pseudo leaves, 2 g / day of asparagus pseudo leaves (dried powder of Example 2) was dissolved and suspended in 500 ml of soft drink. About one week later, my body became much easier, and after about two weeks, when I took over-the-counter paroxetine hydrochloride, I felt abnormally dull and drowsy, so I stopped taking over-the-counter paroxetine hydrochloride. The drug was completely discontinued after about a month, and now there are signs of recovery while taking 6 tablets containing asparagus fake leaves and oyster extract.

(Symptoms: insomnia, anxiety, loss of appetite, 33 years old, male)
I have been unable to sleep for about 2 or 3 years, I have a sudden feeling of anxiety, no appetite, and I visited a psychosomatic medicine department. Currently, milnacipran hydrochloride 15 mg 2 tablets / day, commercially available brotizolam 1 tablet / day, commercially available Although taking cloxazolam 1 mg 1 tablet / day and being stable as such, she still had anxiety during the day, so she was taking diazepam 0.3 g / day as needed. By taking 1 g or 2 times a day of asparagus pseudo leaves (dry powder of Example 2) 2 g / day and 4 g of commercially available nutritional and multivitamin preparations dissolved and suspended in 500 ml of soft drinks, about a week later I haven't had any dreams during my sleep, so I feel a natural appetite in about two weeks. The asparagus fake leaves and vitamins have been taken for about 2 months, and the physical condition and sleep state are good even though the drug is hardly taken.

(Symptoms: loss of appetite, depression, age 32, female)
Commercially used fluvoxamine maleate 25 mg 2 tablets / day, commercially available cloxazolam 1 mg 1 tablet / day, but asparagus pseudo leaves (dry powder of Example 2) 2 g / day dissolved and suspended in 500 ml of soft drink When I took, I returned to my appetite and motivation, decreased my medication, and is not taking it now.

(Symptoms: Diarrhea, loss of appetite, 38 years old, male)
Anorexia, sluggishness, lack of motivation, thought to have some kind of gastrointestinal illness. Even if you take psychiatric prescription drugs, it will only improve your sleepiness, but it will not improve. Every day you used 6 tablets of ERABU and 6 tablets of commercially available nutritional and multivitamins and herbal medicines (sleep, stabilizer). I was having a hard time in anxiety. In parallel with the administration, 2 g / day of asparagus pseudo leaves (dry powder of Example 2) dissolved and suspended in 500 ml of soft drinks was taken, and the body became comfortable in one week.

(Symptoms: Diarrhea, loss of appetite, age 26, female)
Due to the stress caused by the brothers' company management, they are frustrated all day, their appetite is poor, their bodies are sluggish and they don't feel like doing anything. He was diagnosed with some kind of gastrointestinal illness and visited the internal medicine department. However, if I really want to go to Mt. Fuji with my university friends a week later, this week, the meal will be about one meal a day, or about the amount of porridge. I took 6 vitamin tablets and oyster extract-containing tablets. Asparagus pseudo leaves (dried powder of Example 2) 2 g dissolved and suspended in 500 ml of soft drink from 1 week before climbing / After taking 3/4 of the day and herbal medicine (Beef Yellow Spirit), the appetite immediately emerged, and at Mt. Fuji, everyone was able to climb to the summit only when everyone retired due to bad weather. I came.

(Symptoms: Diarrhea, loss of appetite, 30s, male)
Diagnosis of diarrhea, abdominal pain, stomach pain, etc., it was judged that there was no abnormality even after examination with a stomach camera or colon fiber. I had a bad sleep at night and I was lying down forever in the morning. A combination of a commercially available nutritional / multivitamin preparation, 2 g / day of asparagus pseudo-leaf (dried powder of Example 2) dissolved and suspended in 500 ml of soft drink, and 3 commercially available enteric medicines / day It will be fine in a week. Diarrhea became loose stool, and the frequency decreased to about once. My stomach ache has faded and my appetite has come out. If I noticed it at night, I went to sleep and started eating in the morning.

Claims (5)

An autonomic nervous regulator comprising asparagus pseudo-leaf as an active ingredient. A preventive or ameliorating agent for autonomic dysfunction, comprising asparagus pseudo-leaf as an active ingredient. A sleep improving agent comprising asparagus pseudo leaves as an active ingredient. A functional food or food material for preventing or improving autonomic dystaxia or for improving sleep, comprising asparagus pseudo-leaf as an active ingredient. Use of asparagus pseudo-leaf in the production of functional foods or food materials for prevention or improvement of autonomic dysfunction or sleep improvement.