JP2009284900A - Beverage - Google Patents
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- JP2009284900A JP2009284900A JP2009110279A JP2009110279A JP2009284900A JP 2009284900 A JP2009284900 A JP 2009284900A JP 2009110279 A JP2009110279 A JP 2009110279A JP 2009110279 A JP2009110279 A JP 2009110279A JP 2009284900 A JP2009284900 A JP 2009284900A
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- beverage
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- extract
- saden
- licorice
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- 235000013361 beverage Nutrition 0.000 title claims abstract description 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 47
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 14
- 241000202807 Glycyrrhiza Species 0.000 claims description 13
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 13
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 13
- 229940010454 licorice Drugs 0.000 claims description 13
- 239000012676 herbal extract Substances 0.000 claims description 12
- 235000017803 cinnamon Nutrition 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 8
- 235000019634 flavors Nutrition 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims 3
- 239000000284 extract Substances 0.000 abstract description 27
- 239000003814 drug Substances 0.000 abstract description 20
- 229940079593 drug Drugs 0.000 abstract description 15
- 241001125048 Sardina Species 0.000 abstract description 5
- 235000019512 sardine Nutrition 0.000 abstract description 5
- 241000544270 Angelica acutiloba Species 0.000 abstract description 3
- 241000987738 Gloydius blomhoffii Species 0.000 abstract description 3
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract description 2
- 235000021511 Cinnamomum cassia Nutrition 0.000 abstract description 2
- 240000008917 Glycyrrhiza uralensis Species 0.000 abstract description 2
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 abstract description 2
- 241000411851 herbal medicine Species 0.000 description 12
- 235000013305 food Nutrition 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000723347 Cinnamomum Species 0.000 description 8
- 244000269722 Thea sinensis Species 0.000 description 8
- 235000013376 functional food Nutrition 0.000 description 8
- 235000013616 tea Nutrition 0.000 description 8
- 230000000873 masking effect Effects 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 241000251468 Actinopterygii Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000019688 fish Nutrition 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 4
- VEYJKJORLPYVLO-RYUDHWBXSA-N Val-Tyr Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 VEYJKJORLPYVLO-RYUDHWBXSA-N 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 108010009962 valyltyrosine Proteins 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 108090000145 Bacillolysin Proteins 0.000 description 1
- 108091005658 Basic proteases Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- 240000007154 Coffea arabica Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 108091005507 Neutral proteases Proteins 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 229940006423 chondroitin sulfate sodium Drugs 0.000 description 1
- 235000020230 cinnamon extract Nutrition 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002892 effect on hypertension Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000008924 yoghurt drink Nutrition 0.000 description 1
Landscapes
- Non-Alcoholic Beverages (AREA)
Abstract
Description
本発明は、飲料に関し、更に詳細には、サーデンペプチドを配合する保健機能食品、食品、医薬品および医薬部外品の分野に応用しうる飲料に関するものである。 The present invention relates to a beverage, and more particularly to a beverage that can be applied to the fields of health functional foods, foods, pharmaceuticals, and quasi drugs containing a saden peptide.
サーデンペプチド(イワシペプチド)は、すぐれた血圧降下作用を有するものであり、これを含む製品が血圧が高めの方向けの保健機能食品として認可され、錠剤、顆粒剤、カプセル剤、散剤、ドリンク剤等種々の形態で発売されている(特許文献1)。また、サーデンペプチドには、カルシウム吸収促進効果(特許文献2)や、カルシウムチャンネル阻害ないし抑制効果(特許文献3)等の効果も知られている。 Sarden Peptide (Sardine Peptide) has excellent blood pressure lowering action, and products containing it are approved as health functional foods for people with high blood pressure, and tablets, granules, capsules, powders, drinks It is marketed in various forms such as an agent (Patent Document 1). In addition, effects such as calcium absorption promotion effect (Patent Document 2) and calcium channel inhibition or suppression effect (Patent Document 3) are also known for saden peptides.
しかし、サーデンペプチドはそもそも魚臭がするため、これを特に飲料として提供するには商品性に問題があった。このため、従来販売されているサーデンペプチドを配合した飲料では、ミックスフルーツ等の風味にすることで魚臭のマスキングを試みているものの、嗅覚で感じる魚臭のマスキング効果は満足できるものではなかった。 However, since the Sarden peptide has a fishy odor in the first place, there is a problem in merchantability to provide this as a drink. For this reason, in the beverages containing the sadden peptide sold in the past, we tried to mask the fish odor by making it flavored with mixed fruits, but the fish odor masking effect felt by the sense of smell is not satisfactory. It was.
一方、ペプチド類を含有する飲料の風味改善技術としては、没食子酸誘導体、フラボノイド類等の酸化防止剤を配合することによるペプチド臭の抑制技術(特許文献4)等が知られているが、この技術で全てのペプチド類を含有する飲料の風味を改善できるわけではなかった。 On the other hand, as a technique for improving the flavor of a beverage containing peptides, a technique for suppressing peptide odor by adding an antioxidant such as a gallic acid derivative or a flavonoid (Patent Document 4) is known. The technology has not been able to improve the flavor of beverages containing all peptides.
また、他の一般的なマスキング技術として、シクロデキストリンによる苦味のマスキング、香料によるチアミン由来の不快臭のマスキング等があるが(特許文献5、6)、これらは飲料中のサーデンペプチドに対する効果は十分でなく、サーデンペプチドに特に効果のあるマスキング技術は知られていないのが現状である。 In addition, as other general masking techniques, there are masking of bitter taste by cyclodextrin, masking of unpleasant odor derived from thiamine by a fragrance, etc. (Patent Documents 5 and 6). It is not sufficient, and there is no known masking technique that is particularly effective for sadden peptides.
従って、本発明はサーデンペプチドを配合した飲料において、サーデンペプチドに固有の不快臭を抑制したサーデンペプチド配合飲料を提供することを課題とする。 Therefore, this invention makes it a subject to provide the saden peptide mixing | blending drink which suppressed the unpleasant odor peculiar to a saden peptide in the drink which mix | blended the saden peptide.
本発明者らは、上記課題を解決すべく、近年の需用者の自然志向にも鑑み、天然物質、特に生薬中からサーデンペプチドに固有の不快臭を抑制できる素材を探索したところ、特定の生薬の抽出物は、サーデンペプチドを配合する飲料中で十分なマスキング効果を奏し、単なる服用性向上のみならず自然志向の期待に応えられることを見出し、本発明を完成するに至った。 In order to solve the above-mentioned problems, the present inventors searched for a natural substance, particularly a material capable of suppressing an unpleasant odor inherent in a saden peptide from herbal medicines in view of the natural orientation of consumers in recent years. It has been found that the herbal extract of the present invention has a sufficient masking effect in a beverage containing a saden peptide, and can meet not only the improvement of ingestibility but also the expectation of natural orientation, and has completed the present invention.
すなわち、本発明は、サーデンペプチドと、当帰、反鼻、桂皮および甘草からなる群から選ばれる生薬の抽出物の1種以上を含有することを特徴とする飲料である。 That is, the present invention is a beverage characterized by containing a saden peptide and one or more herbal extracts selected from the group consisting of Toki, antinasal, cinnamon and licorice.
また、本発明は、当帰、反鼻、桂皮および甘草からなる群から選ばれる生薬の抽出物の1種以上を有効成分として含有することを特徴とするサーデンペプチドを配合した飲料の風味改善剤である。 In addition, the present invention provides a flavor improvement of a beverage containing a sadden peptide characterized by containing as an active ingredient at least one herbal extract selected from the group consisting of Toki, antinasal, cinnamon and licorice It is an agent.
更に、本発明は、サーデンペプチドを配合した飲料において、当帰、反鼻、桂皮および甘草からなる群から選ばれる生薬の抽出物の1種以上を配合することを特徴とする該飲料の不快臭を低減させる方法である。 Further, the present invention provides a beverage blended with a saden peptide, comprising at least one herbal extract selected from the group consisting of Toki, antinasal, cinnamon, and licorice, wherein the beverage is unpleasant. This is a method of reducing odor.
本発明によれば、サーデンペプチドに起因する魚臭(不快臭)を抑制した風味良好な飲料を得ることができる。また、この飲料は生薬の抽出物を配合しているため単なる服用性向上のみならず自然志向の期待に応えられる優れたものである。 ADVANTAGE OF THE INVENTION According to this invention, the drink with favorable flavor which suppressed the fishy odor (unpleasant odor) resulting from a sadden peptide can be obtained. In addition, since this beverage contains an extract of a herbal medicine, it is excellent in that it can meet not only an improvement in taking but also a nature-oriented expectation.
従って、この飲料はサーデンペプチドの有する血圧降下作用等の生理活性を得るための各種保健機能食品(特定保険用食品、機能性食品)、病者用食品、各種医薬品、医薬部外品および食品等に利用することができる。 Therefore, this beverage has various health functional foods (specific insurance foods, functional foods), sick foods, various pharmaceuticals, quasi-drugs and foods for obtaining physiological activities such as blood pressure lowering action of the sadden peptide. Etc. can be used.
本発明の飲料に配合されるサーデンペプチドは、魚肉、特に好ましくはイワシから採肉機(デボーナー等)で肉質を分離して得たタンパク質を酵素等で分解して得られる、アミノ酸が2〜10個程度つながったオリゴペプチドを主成分とし、バリルチロシンを含有するペプチド組成物である。このサーデンペプチドは、例えば、魚肉を熱変性した後、中性ないしアルカリ性プロテアーゼ処理して加水分解し、酵素を失活せしめた後、分離処理して粗ペプチドを得、この粗ペプチドの水溶液をペプチド吸着樹脂に供してペプチドを該樹脂に吸着せしめた後、エタノール水溶液で溶出することにより製造することができる。このようなサーデンペプチドとしては前記のようにして製造されるものの他に、市販品も利用できる。市販品としては、サーデンペプチドY−2(商品名:仙味エキス株式会社製)等が挙げられる。本発明の飲料におけるサーデンペプチドの含有量は、高血圧に対する効果を期待する場合は、1回あたりの服用量がバリルチロシンとして0.1〜1mgになる量が好ましく、0.3〜0.5mgになる量がさらに好ましい。 The sadden peptide blended in the beverage of the present invention is obtained by decomposing a protein obtained by separating meat quality from fish meat, particularly preferably a sardine with a meat collecting machine (Deboner, etc.) with an enzyme or the like. It is a peptide composition comprising as a main component about 10 oligopeptides and containing valyltyrosine. This saden peptide is, for example, heat-denatured fish meat, hydrolyzed by neutral or alkaline protease treatment to deactivate the enzyme, and then separated to obtain a crude peptide. It can be produced by subjecting the peptide adsorption resin to adsorption of the peptide onto the resin and then elution with an aqueous ethanol solution. In addition to those produced as described above, commercially available products can also be used as such sadden peptides. Examples of commercially available products include Sarden Peptide Y-2 (trade name: manufactured by Senmi Extract Co., Ltd.). The content of the saden peptide in the beverage of the present invention is preferably such that the dose per dose is 0.1 to 1 mg as valyltyrosine when expected to have an effect on hypertension, and 0.3 to 0.5 mg. More preferred is an amount of
また、本発明の飲料には、上記サーデンペプチドと共に、当帰、反鼻、桂皮および甘草からなる群から選ばれる生薬の抽出物の1種以上が添加、配合される。 In addition, the beverage of the present invention is mixed with one or more extracts of herbal medicines selected from the group consisting of Toki, antinasal, cinnamon and licorice along with the above-mentioned sadden peptide.
抽出物の原料である生薬のうち、当帰とは、トウキ(学名:A.acutiloba Kitagawa)またはホッカイトウキ(学名:A.acutiloba Kitagawa var. sugiyamae Hikino)の根を湯通し、乾燥させたものである。また、反鼻とは、マムシ(学名:Agkistrodon halys blomhoffi)の皮および臓腑を除き、乾燥させたものであり、桂皮とは、シナモン(学名:Cinnamomum cassia Blume(Lauranceae))の樹脂又は周皮の一部を乾燥させたものである。更に甘草とは、甘草(学名:Glycyrrhiza uralensis Fischer又はGlycyrrhiza glabra Linne(Leguminosae))の根およびストロンを乾燥させたものあるいは甘草の周皮を除き、乾燥させたもの(皮去カンゾウ)である。 Among herbal medicines that are the raw materials of the extract, Toki means that the roots of Toki (scientific name: A.acutiloba Kitagawa) or Hokkaitouki (scientific name: A.acutiloba Kitagawa var. Sugiyamae Hikino) are boiled and dried. . Antinasal is dried except for the skin and viscera of mamushi (scientific name: Agkistrodon halys blomhoffi), and cinnamon is cinnamon (scientific name: Cinnamomum cassia Blume (Lauranceae)). A part is dried. Licorice is licorice (scientific name: Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne (Leguminosae)) roots and strons that have been dried or licorice pericarp and dried (peeled licorice).
これら生薬のうち、当帰、桂皮および甘草については第15改正日本薬局方に収載されているものである。反鼻については第15改正日本薬局方への収載はないが食品、医薬品、医薬部外品等では使用実績、前例に基づいて配合されているものである。 Of these herbal medicines, Toki, cinnamon and licorice are listed in the 15th revision Japanese Pharmacopoeia. The anti-nasal is not listed in the 15th revised Japanese Pharmacopoeia, but it is formulated based on the actual use and precedents in foods, pharmaceuticals, quasi drugs and the like.
本発明の飲料に配合される生薬の抽出物としては、上記生薬から常法に従い、適切な抽出溶媒を用いて適当な温度(低温や加温条件等)で抽出される液状抽出物や、当該液状抽出物の希釈物、濃縮物、乾固物等が挙げられる。すなわち、本発明に使用する生薬の抽出物としては、第15改正日本薬局方に収載の乾燥エキス、軟エキス、流エキス、チンキに準じたものがいずれも利用できる。 As an extract of herbal medicine blended in the beverage of the present invention, according to a conventional method from the above herbal medicine, a liquid extract extracted at an appropriate temperature (low temperature, heating conditions, etc.) using an appropriate extraction solvent, Examples of the liquid extract include a diluted product, a concentrated product, and a dried product. That is, as the herbal extract used in the present invention, any of the extracts according to the 15th revised Japanese Pharmacopoeia according to the dry extract, soft extract, flow extract and tincture can be used.
上記生薬の抽出物の飲料中への配合量は、サーデンペプチドのマスキングができる濃度であれば特に制限はないが、一般には、原生薬換算で10mg/L以上、好適には100mg/L以上である。より具体的に、生薬抽出物として当帰抽出物を用いる場合であれば原生薬換算で150mg/L以上、好適には300mg/L以上である。また、桂皮抽出物であれば原生薬換算で15mg/L以上、好適には150mg/L以上である。更に、甘草抽出物であれば原生薬換算で50mg/L以上、好適には500mg/L以上である。また更に、反鼻抽出物であれば原生薬換算で10mg/L以上、好適には100mg/L以上である。 The blending amount of the above crude drug extract in the beverage is not particularly limited as long as it is a concentration capable of masking the saden peptide, but is generally 10 mg / L or more, preferably 100 mg / L or more in terms of crude drug. It is. More specifically, in the case of using the Toki extract as the crude drug extract, it is 150 mg / L or more, preferably 300 mg / L or more in terms of crude drug. Moreover, if it is a cinnamon extract, it is 15 mg / L or more, preferably 150 mg / L or more in terms of a crude drug. Furthermore, if it is a licorice extract, it is 50 mg / L or more, preferably 500 mg / L or more in terms of crude drug. Furthermore, if it is an antinasal extract, it is 10 mg / L or more, preferably 100 mg / L or more in terms of the active ingredient.
上記したサーデンペプチドおよび生薬の抽出物を配合した本発明の飲料は、一般的な飲料の製造方法に準じ、各成分を混合することにより製造することができる。例えば、通常の飲料であれば、サーデンペプチド、生薬の抽出物およびその他成分を規定量以下の精製水にて混合した後、pHを調整し、更に精製水にて規定量に容量調整し、必要に応じて濾過、滅菌処理をすることにより得られる。なお、飲料中に脂溶性成分を含むときは、通常用いられる界面活性剤又は可溶化剤により乳化又は可溶化してもよく、また、分散剤を用いて懸濁させてもよい。また、お茶飲料であれば、植物の加工物(例えば、茶葉、茶葉醗酵物等)に10倍〜30倍量の熱水を加え、数分程度保持して得られる茶抽出物に、サーデンペプチド、生薬の抽出物およびその他の成分を混合し、更に上記と同様にして容量調整、滅菌処理等を行うことにより得られる。また、茶抽出物としては、植物の加工物に粉砕等の処理をし、これが0.5〜1.5質量%程度の量となるように熱水を加え、数分間程度保持して得られるものを用いても良い。 The beverage of the present invention in which the above-mentioned sadden peptide and herbal medicine extract are blended can be produced by mixing each component according to a general method for producing a beverage. For example, if it is a normal beverage, after mixing the saden peptide, the extract of herbal medicine and other components with purified water of a specified amount or less, adjust the pH, further adjust the volume to the specified amount with purified water, Obtained by filtration and sterilization as necessary. In addition, when a fat-soluble component is contained in the beverage, it may be emulsified or solubilized with a commonly used surfactant or solubilizer, or may be suspended using a dispersant. In addition, if it is a tea drink, add 10 to 30 times the amount of hot water to a processed plant product (for example, tea leaves, tea leaf fermented product, etc.) and hold it for several minutes. It can be obtained by mixing a peptide, a herbal extract and other components, and further performing volume adjustment, sterilization treatment and the like in the same manner as described above. In addition, the tea extract is obtained by subjecting a processed plant product to pulverization and the like, adding hot water so that the amount is about 0.5 to 1.5% by mass, and holding for about several minutes. A thing may be used.
また、本発明の飲料には、上記必須成分の他に、本発明の効果を損なわない程度に、一般の飲料または製剤に一般に使用される任意成分を適宜配合することができる。このような任意成分としては、水、アルコール、ビタミンおよびその塩類、ミネラル、アミノ酸およびその塩類、ハーブおよびハーブエキス、生薬および生薬抽出物、ローヤルゼリー、カフェイン、コンドロイチン硫酸ナトリウム、甘味剤、矯味剤、pH調整剤、保存剤、抗酸化剤、着色剤等が挙げられる。 Moreover, in the drink of this invention, the arbitrary component generally used for a general drink or a formulation can be suitably mix | blended to the grade which does not impair the effect of this invention other than the said essential component. Such optional ingredients include water, alcohol, vitamins and salts thereof, minerals, amino acids and salts thereof, herbs and herbal extracts, herbal medicines and herbal extracts, royal jelly, caffeine, chondroitin sulfate sodium, sweeteners, flavoring agents, Examples include pH adjusters, preservatives, antioxidants, and colorants.
更に、本発明の飲料のpHに特に限定はないが、飲料としての観点からは、pH2.0〜7.0の範囲が好ましく、飲み心地の観点からは、pH2.5〜4.5の範囲の酸性飲料であることが好ましい。更に、本発明の飲料を茶抽出物と組み合わせた茶飲料とする場合は、そのpHは、4.5〜6.5であることが好ましい。 Furthermore, the pH of the beverage of the present invention is not particularly limited, but from the viewpoint of a beverage, a range of pH 2.0 to 7.0 is preferable, and from the viewpoint of drinking comfort, a range of pH 2.5 to 4.5. It is preferable that this is an acidic beverage. Furthermore, when making the drink of this invention into the tea drink combined with the tea extract, it is preferable that the pH is 4.5-6.5.
上記のようにして製造された本発明の飲料は、瓶(無色又は有色ガラス製)、缶(アルミニウム製、スチール製等)、ポリエチレンテレフタレート製ボトル等の容器に封入して流通させることができる。 The beverage of the present invention produced as described above can be circulated in a container such as a bottle (made of colorless or colored glass), a can (made of aluminum, steel, etc.), a bottle made of polyethylene terephthalate or the like.
斯くして得られる本発明の飲料は、各種保健機能食品(特定保険用食品、機能性食品)、病者用食品、各種医薬品、医薬部外品等とすることができる。より具体的には、サーデンペプチドと生薬の抽出物を他の食品素材と組み合わせることにより、一般に、茶、ウーロン茶、コーヒー、紅茶、酢含飲料、炭酸飲料、果汁や果汁入り飲料、カクテルやチューハイ等のアルコール飲料、ニアウォーター、スポーツドリンク、ヨーグルトドリンク等と認識される飲料とすることができる。また、サーデンペプチドと生薬の抽出物を他の医薬品素材と組み合わせることにより、ドリンク剤、液剤等の経口製剤とすることができる。 The beverages of the present invention thus obtained can be various health functional foods (specific insurance foods, functional foods), sick foods, various pharmaceuticals, quasi drugs and the like. More specifically, by combining the extract of saden peptide and herbal medicine with other food ingredients, generally, tea, oolong tea, coffee, tea, vinegar-containing beverages, carbonated beverages, fruit juices and juices, cocktails and chuhai Alcohol beverages such as alcohol, near water, sports drinks, yogurt drinks and the like. Moreover, it can be set as oral preparations, such as a drink and a liquid agent, by combining the extract of a saden peptide and a crude drug with another pharmaceutical raw material.
以下に、実施例および比較例を挙げ、本発明をさらに詳細に説明するが、本発明はこれらの実施例等に何ら制約されるものではない。 Hereinafter, the present invention will be described in more detail with reference to examples and comparative examples, but the present invention is not limited to these examples and the like.
実 施 例 1
飲料の製造(1):
表1に示す処方の飲料を製造した。まず、生薬の抽出物を表1に示す原生薬換算量で精製水に添加した。次に、精製水にサーデンペプチドY−2(商品名:仙味エキス株式会社製:バリルチロシンを約150mg/100g含む)を0.15%(w/v)の濃度で添加した。これらを50ml容のガラス容器に充填し、キャップを施し、飲料(実施品1〜4)とした。
Example 1
Manufacture of beverages (1):
Beverages having the formulations shown in Table 1 were produced. First, the crude drug extract was added to purified water in the amount equivalent to the drug substance shown in Table 1. Next, Sarden Peptide Y-2 (trade name: manufactured by Semen Extract Co., Ltd .: containing about 150 mg / 100 g of valyltyrosine) was added to purified water at a concentration of 0.15% (w / v). These were filled in a 50 ml glass container, capped, and used as beverages (practical products 1 to 4).
これら飲料を65℃の恒温槽にて1日保管後、開栓し、専門パネル4名により、下記の評価基準にて官能評価した。結果を表1に示した。 These beverages were stored in a thermostatic bath at 65 ° C. for 1 day, then opened, and subjected to sensory evaluation by the following four evaluation panels using four specialist panels. The results are shown in Table 1.
<官能評価の基準>
( 内 容 ) (評価)
不快臭を非常に感じる :0点
不快臭をかなり感じる :1点
不快臭を感じる :2点
不快臭をやや感じる :3点
不快臭を僅かに感じる :4点
不快臭を感じない :5点
<Criteria for sensory evaluation>
(Contents) (Evaluation)
Very unpleasant odor: 0 points Unpleasant odor: 1 point Unpleasant odor: 2 points Unpleasant odor is slightly felt: 3 points Unpleasant odor is slightly felt: 4 points Unpleasant odor is not felt: 5 points
表1の官能評価の結果より明らかなように、生薬(当帰、反鼻、桂皮、甘草)抽出物の添加により、サーデンペプチドを配合した飲料の不快臭は顕著に軽減されることが確認された。 As is clear from the results of sensory evaluation in Table 1, it was confirmed that the unpleasant odor of beverages containing a saden peptide was remarkably reduced by the addition of herbal extracts (Toki, antinasal, cinnamon, licorice). It was done.
比 較 例 1
飲料の製造(2):
表2の処方に従い、各成分を精製水中に混合溶解し、飲料を得た。これらをガラス容器に充填し、キャップを施し、飲料(比較品1〜17)とした。
Comparative Example 1
Manufacture of beverages (2):
According to the formulation in Table 2, each component was mixed and dissolved in purified water to obtain a beverage. These were filled into a glass container, capped, and used as beverages (Comparative products 1 to 17).
これら飲料を65℃恒温槽にて1日保管後、専門パネル4名により、実施例1と同様の評価基準にて評価した。結果を表2に示した。 These beverages were stored in a 65 ° C. constant temperature bath for one day, and then evaluated by the same four evaluation panels as in Example 1 by four specialist panels. The results are shown in Table 2.
表2より明らかなように、上記の添加物を配合した飲料は本発明の生薬の抽出物を添加していないため、サーデンペプチド由来の不快臭を感じ、風味改善効果は限られたものだった。なお、生薬でもオウギ流エキス、オイセイ流エキス、サンヤク流エキスおよびブクリョウ流エキスの風味改善効果は不十分であった。
As is clear from Table 2, the beverage containing the above-mentioned additives does not contain the extract of the herbal medicine of the present invention, so it feels an unpleasant odor derived from the saden peptide and has a limited flavor improving effect. It was. In addition, the flavor improvement effect of an ogi-style extract, a oisei-style extract, a sanyaku-style extract, and a bukuryo-style extract was insufficient even with crude drugs.
本発明の飲料は、サーデンペプチドの不快臭を有効にマスキングできるものであるため、サーデンペプチドの有する血圧降下作用等の各種生理活性を簡単に得るための各種保健機能食品(特定保険用食品、機能性食品)、病者用食品、各種医薬品、医薬部外品および食品等に有利に利用することができる。
以 上
Since the beverage of the present invention can effectively mask the unpleasant odor of the sadden peptide, various health functional foods (food for specified insurance) for easily obtaining various physiological activities such as blood pressure lowering action of the sadden peptide. , Functional foods), foods for patients, various pharmaceuticals, quasi-drugs and foods.
more than
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Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60103960A (en) * | 1983-11-11 | 1985-06-08 | 山陽国策パルプ株式会社 | Deodorizing method |
JPS60176572A (en) * | 1984-02-23 | 1985-09-10 | Ueno Seiyaku Kk | Method for preservation of food against decay |
JPH01317372A (en) * | 1988-06-17 | 1989-12-22 | Nisshin Oil Mills Ltd:The | Production of fishery paste product |
JPH06133730A (en) * | 1992-10-27 | 1994-05-17 | Teruaki Shimazu | Health food and its production |
JPH07236418A (en) * | 1994-02-25 | 1995-09-12 | Kanegafuchi Chem Ind Co Ltd | Antioxidant smell correcting agent for docosahexaenoic acid and enicosapentaenoic acid |
JP2001178429A (en) * | 1999-12-23 | 2001-07-03 | Chinko Sai | Functional antidiabetic drink |
JP2002104987A (en) * | 2000-09-26 | 2002-04-10 | Takeda Chem Ind Ltd | Deodorizing agent and its use |
JP2003252786A (en) * | 2002-03-01 | 2003-09-10 | Sanpo Kk | Antiallergic substance, method for producing the same, antiallergic agent and health food |
JP2005110649A (en) * | 2003-10-03 | 2005-04-28 | Sansho Kk | Beverage added with peptide |
JP2005278601A (en) * | 2004-03-31 | 2005-10-13 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Chlorella food |
JP2006067874A (en) * | 2004-09-01 | 2006-03-16 | Sanei Gen Ffi Inc | Peptide-containing beverage |
JP2006199661A (en) * | 2005-01-24 | 2006-08-03 | Sunstar Inc | Coaggregation inhibitor |
JP2008050349A (en) * | 2006-07-25 | 2008-03-06 | Taisho Pharmaceutical Co Ltd | Beverage comprising branched-chain amino acid formulated therein |
-
2009
- 2009-04-30 JP JP2009110279A patent/JP5359527B2/en not_active Expired - Fee Related
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60103960A (en) * | 1983-11-11 | 1985-06-08 | 山陽国策パルプ株式会社 | Deodorizing method |
JPS60176572A (en) * | 1984-02-23 | 1985-09-10 | Ueno Seiyaku Kk | Method for preservation of food against decay |
JPH01317372A (en) * | 1988-06-17 | 1989-12-22 | Nisshin Oil Mills Ltd:The | Production of fishery paste product |
JPH06133730A (en) * | 1992-10-27 | 1994-05-17 | Teruaki Shimazu | Health food and its production |
JPH07236418A (en) * | 1994-02-25 | 1995-09-12 | Kanegafuchi Chem Ind Co Ltd | Antioxidant smell correcting agent for docosahexaenoic acid and enicosapentaenoic acid |
JP2001178429A (en) * | 1999-12-23 | 2001-07-03 | Chinko Sai | Functional antidiabetic drink |
JP2002104987A (en) * | 2000-09-26 | 2002-04-10 | Takeda Chem Ind Ltd | Deodorizing agent and its use |
JP2003252786A (en) * | 2002-03-01 | 2003-09-10 | Sanpo Kk | Antiallergic substance, method for producing the same, antiallergic agent and health food |
JP2005110649A (en) * | 2003-10-03 | 2005-04-28 | Sansho Kk | Beverage added with peptide |
JP2005278601A (en) * | 2004-03-31 | 2005-10-13 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Chlorella food |
JP2006067874A (en) * | 2004-09-01 | 2006-03-16 | Sanei Gen Ffi Inc | Peptide-containing beverage |
JP2006199661A (en) * | 2005-01-24 | 2006-08-03 | Sunstar Inc | Coaggregation inhibitor |
JP2008050349A (en) * | 2006-07-25 | 2008-03-06 | Taisho Pharmaceutical Co Ltd | Beverage comprising branched-chain amino acid formulated therein |
Non-Patent Citations (2)
Title |
---|
JPN6013023856; "医薬品ミニドリンク剤「ゼナF-IIalpha」新発売",[online],2004年10月29日,大正製薬,[平成25年5月14 * |
JPN6013023857; "説明文書 チオビタ鵬玉精S",2001年8月,大鵬薬品工業株式会社,[平成25年5月14日検索],インターネッ * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020002043A (en) * | 2018-06-27 | 2020-01-09 | 小林製薬株式会社 | Pharmaceutical composition |
JP7360784B2 (en) | 2018-06-27 | 2023-10-13 | 小林製薬株式会社 | pharmaceutical composition |
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