CN108524356A - A kind of medicated toothpaste and preparation method thereof containing francolin leaf extract - Google Patents
A kind of medicated toothpaste and preparation method thereof containing francolin leaf extract Download PDFInfo
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- CN108524356A CN108524356A CN201810436332.2A CN201810436332A CN108524356A CN 108524356 A CN108524356 A CN 108524356A CN 201810436332 A CN201810436332 A CN 201810436332A CN 108524356 A CN108524356 A CN 108524356A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of medicated toothpaste and preparation method thereof containing francolin leaf extract.Contain francolin leaf extract in the medicated toothpaste.The preparation method includes the following steps：Prepare francolin leaf extract powder；Above-mentioned francolin leaf extract powder and moisturizer are mixed in the ratio, and are sufficiently mixed stirring into the water, mixed aqueous solution is made；It then is proportionally added into thickener, rubbing agent and foaming agent, is sufficiently mixed stirring；It carries out vacuumizing process；It waits after vacuumizing, high-speed stirred is milled 25~35 minutes, then vacuum outgas；Sweetener, essence and food coloring are added, is stirred for milling 10~20 minutes, obtains lotion of toothpaste.The toothpaste can be with health role.
Description
The application be September in 2016 submit within 30th application No. is 201610871213.0, it is entitled that " one kind containing francolin
The divisional application of medicated toothpaste of leaf extract and preparation method thereof ".
Technical field
The invention belongs to technical field of daily necessities, more particularly to a kind of with health role to tooth and mouth disease and
More effects, the medicated toothpaste and preparation method thereof containing francolin leaf extract.
Background technology
Toothpaste is the essential cleaning supplies of common oral care, and it is cleaning to have long history, main purpose
Tooth.But as people are gradually increased for what health care was realized, the toothpaste with single cleaning action has been unable to meet
Daily nursing requirement, then various kinds, toothpaste vdiverse in function come into being, wherein the health care based on health care and treatment
Toothpaste is in the majority.Toothpaste at present on the market is dazzling, also has in the prior art using the various active ingredient of Chinese herbs conducts of addition
Toothpaste ancillary drug, such as mica filled polypropylene, shiny pricklyash toothpaste, tianqi toothpaste, effect have nothing in common with each other.With with anti-inflammatory,
For the medicated toothpaste of analgesic activity, existing such toothpaste is such as：Mica filled polypropylene, tianqi toothpaste, it is used main
Functional component is pseudo-ginseng, this medicinal material distributional region is few, and growth cycle is long and price is very high.In the prior art in order to make drug
Toothpaste reaches more effects, often needs to add a variety of or even upper ten kinds of different efficacies medicinal materials, so that such Chinese medicinal toothpaste
Production process is very long, complex process, high expensive.
Francolin leaf [Mallotus oblongifolius (Miq.) Muell.-Arg] is Euphorbiaceae (Euphorbiaceae)
Mallotus plant, property is out-of-the-way drought-resistant, likes being grown in barren hill stone seam.Francolin leaf has the edible of more than one thousand years to go through in Hainan
History is distributed mainly on the mountain area, hills and coastal area in Hainan, is especially to contain with Wanning Dongshan Ridge, is that the one kind in Hainan is great
The tannin plant on behalf of the tea and medicinal plant of national characters and region feature.Francolin leaf also known as francolin tea, mountain herb mixtures tea, gross tea, standing grain tea,
Its leaf circle is sweet in flavor, is a kind of peculiar wild plant, and tree is generally 1 to 3 meter or more high, and highest is even up to 10 meters.Francolin
Leaf blade alternate, the top of branch is to life, and blade is oval in round shape, and blade grows 5 to 15 centimetres, and top is pointed, and side is complete green in wavy
Tooth, it is in pinniform that, which there are a small number of transparent arteries and veins points, vein in the back side, and petiole grows 1 to 3 centimetre.Francolin leaf is fragrant with peculiar medicine, there is heat-clearing solution
Poison, heat-clearing quench one's thirst, the cholagogic that helps digestion, decompression, weight-reducing, invigorating the spleen, nourishing the stomach the benefits of, can also prevent curing cold.In recent years, people are to francolin
Leaf has carried out new exploratory development again.
Francolin leaf is containing 18 kinds of amino acid needed by human, such as tryptophan, threonine, lysine, alanine, glutamic acid, dried meat
Propylhomoserin etc..Main function is played to brain development, removing toxic substances, protein metabolism etc., and is had to enamel reparation and tooth whitening
Good effect.Francolin leaf has crease-resistant, immune, metabolism etc. rich in multivitamins such as vitamin A, vitamin C, vitamin Es
Function promotes dental growth, safeguards gums healthy, prevents bleeding gums, and generate positive effect to tooth whitening；Francolin leaf is same
Shi Fuhan various trace elements, such as calcium, potassium, zinc, iron, fluorine, selenium, phosphorus, magnesium, sodium, barium various trace elements not only have preferable
Health-care effect and there is good medical value, while to growth in humans's development, improve bone hardness, cartilage-derived growth etc. and have actively
Effect, thus there is higher value of exploiting and utilizing.
Civil francolin leaf tea of drinking is with a long history, and francolin leaf tea is sweet ice-cold tasty and refreshing, and has the medicine of smelling good fragrant, there is heat-clearing solution
Poison, heat-clearing quench one's thirst, the cholagogic that helps digestion, decompression, weight-reducing, invigorating the spleen, nourishing the stomach the benefits of, can also prevent curing cold.Francolin leaf tea fragrance is strong, punching
Soup look is limpid after bubble, drinks deutostoma sweet tea sweet in flavor, lingering fragrance is long, is preferably to solve greasy, digestant health drink.
Since the distribution of francolin leaf is relatively narrow, distributional region has limitation, therefore although francolin leaf has significantly
Medicinal efficacy and health-care effect are recorded the pharmacological property and effect of francolin leaf in China's successive dynasties pharmaceutical texts and other ancient books less.
Written by such as the Qing Dynasty, what gram is remonstrated with《Crude drug pharmacological property is standby will to go up volume》Francolin tea is described in this way：" francolin tea, it is sweet in flavor, it is fragrant, it is warm-natured, it dissipates
Heat toxin, cough-relieving are coughed, and convulsive seizure due to phlegm-fire is managed.Cough expansion, five infantile malnutrition due to digestive disturbances or intestinalparasites of children are controlled in the wind-dispelling of leaflet.Its root is only had a toothache ", written by its light of Qing Dynasty Zhao
《Book on Chinese herbal medicine seeks one of reel》Cloud：" francolin tea, Gan Xin, fragrant temperature, main cough, convulsive seizure due to phlegm-fire internal injury dissipate pathopyretic scrofula；Root controls toothache,
Infantile malnutrition due to digestive disturbances or intestinalparasites ".Description in above-mentioned pharmacy ancient books about the property, taste of francolin leaf, it is all to drink experiencing per capita for francolin leaf tea.
Also there are many scholars to study the pharmacological action of francolin leaf and its extract in recent years.Lin Lianbo, Liu Mingsheng, woods are strong etc.
The chemical composition of the volatile oil in the francolin leaf of Hainan is analyzed and identified using gas chromatography-mass spectromet,
One isolates and identifies 50 kinds of ingredients.Fu little Wen, Zhang Junqing, Liu Mingsheng etc., in francolin leaf " Ca, Mg, Zn, Cu,
Mn, Fe, Al, S and nine kinds of Mineral element contents of P " are determined.Wide, Tang little Shan of vast stretch of wooded country, wheat etc., with the water of francolin leaf
Distillate carries out antibacterial tests to 6 kinds of bacteriums such as gold-coloured staphylococci (Staphylococcus aureus), it was demonstrated that major part
Test organisms all has certain inhibition, and proves that the fungistatic effect of francolin leaf fresh goods is generally higher than dry product.Hua Yunqun, Europe
Tree peace uses small white mouse as experimental animal, it was confirmed that francolin leaf has apparent analgesic activity, can be used to treat toothache.Li Yan
It is army, Wang Yong, high gorgeous beautiful etc., the bacteriostatic activity and its material base of francolin leaf are studied, using filter paper enzyme, with antibacterial
Circle size is evaluation index, is tested the bacteriostasis property of francolin leaf extract.Li Xiaotong, Wei Jing, paddy completely collect, and use
DPPH systems, ABTS systems and Oyaizu methods are determined the antioxidant activity of francolin tea, and utilize HPLC-MS/MS pairs
Its antioxidant characteristics ingredient analyzed, the results showed that francolin tea has certain oxidation resistance.
The application aspect of francolin leaf at present, existing is that tea-drinking is made based on leaf, such as：Patent No.
CN200910135176.7, patent name are the Chinese patent of " a kind of Mallotus furetianus tea bag ", which uses based on francolin tealeaves
Raw material is wanted, raw material is matched as auxiliary using chrysanthemum, lemon, while holding francolin tea original flavour, improves product
Quality improves product mouthfeel, is effectively improved the added value of product of francolin tea.For another example Patent No.
CN201210052585.2, patent name are the Chinese patent of " partridge tea liquid beverage ", which is main former with francolin tea
Material, is prepared using chrysanthemum, matrimony vine, lemon etc., solves existing francolin tea product unicity, original extensive property, product matter
The problems such as amount is not easy to control, the shelf-life is short, quality more comprehensive with good mouthfeel, nutrition, improving francolin tea converted products,
The effects that extending the shelf life.For another example Patent No. CN201310567879.3, patent name be " a kind of francolin buccal tablet and its
The Chinese patent of preparation method ", the patent, for main raw material, coordinate the clearing heat and detoxicating ingredients such as licorice with francolin tea extraction
Prepare buccal tablet, have characteristic that is natural, not adding pigment, corrigent and unique flavor, have anti-inflammatory, antibacterial, clearing away heat and removing summer,
It is antifatigue, improve the healthcare functions such as body Scavenging ability.For another example Patent No. CN200810210670.0, patent name
For the Chinese patent of " intelligent benefiting francolin tea ", the patent with intelligent promoting fruit, francolin tea etc. for primary raw material, have fall fire, it is clearing heat and detoxicating,
Slake thirst and help produce saliva, the stomach Qi that helps digestion, hypertension and hyperlipemia, the weight-reducing health-care efficacies such as anti-ageing.
Therefore, the application of francolin leaf at present substantially makes tea-drinking, and application in other respects is less.At present both at home and abroad
It there are no the open report using medicated toothpaste correlative study made of francolin leaf extract.
Invention content
The present invention is to provide a kind of drug containing francolin leaf extract to overcome the shortcomings of existing medicated toothpaste technology
Toothpaste and preparation method thereof.The medicated toothpaste has anti-inflammatory, antibacterial, whitening, antioxidation, can be used for treating toothache, oral cavity
Inflammation, periodontitis, canker sore, can repairing dental enamel, prevent bleeding gums, reduce mouth disease, and without any side effects.
One of main object of the present invention is to provide a kind of medicated toothpaste containing francolin leaf extract, the medicated toothpaste
Dispensing includes francolin leaf extract, rubbing agent, moisturizer, thickener, foaming agent, sweetener, essence, water and food coloring.
The medicated toothpaste containing francolin leaf extract, by weight percentage, in toothpaste francolin leaf extract be 1~
20%, rubbing agent is 10~50%, and moisturizer is 5~45%, and foaming agent is 0.2~8%, and thickener is 0.2~5%, sweet taste
Agent is 0.1~1%, and essence is 0.1~2%, and water is 5~40%, and food coloring is 0.1~1.2%.
The medicated toothpaste containing francolin leaf extract is preferably that francolin leaf extracts in toothpaste by weight percentage
Object be 3~15%, rubbing agent be 15~35%, moisturizer be 15~35%, foaming agent be 0.5~3%, thickener be 0.5~
2.5%, sweetener is 0.1~0.5%, and essence is 0.5~1%, and water is 15~30%, and food coloring is 0.1~1.2%.
Francolin leaf is Hainan specialty also known as francolin tea, mountain herb mixtures tea, gross tea, standing grain tea, belongs to wild plant.What the present invention selected
In fine jade of the francolin leaf place of production selected from Hainan, Le Dong, Bao Ting, lead to assorted mountain area, Wanning Dongshan Ridge and Wenchang Bronze Drum Ridge, wherein it is preferred that ten thousand
The rather francolin leaf of Dongshan Ridge, Wenchang Bronze Drum Ridge.
Francolin leaf extract of the present invention, is prepared in accordance with the following methods：
(1) francolin leaf is taken to be sorted, cleaned, dry, pulverize sieving after francolin leaf coarse powder is made, it is spare；
(2) the francolin leaf coarse powder in step (1) is obtained into aqueous extract with water heating and refluxing extraction；
(3) aqueous extract described in step (2) is filtered, and concentrated, obtain concentrate；
(4) concentrate in step (3) is added into ethyl alcohol, is filtered after placing a period of time, obtains precipitation solution；
(5) precipitation solution is recycled into ethyl alcohol and concentrated, obtain concentrate；
(6) by the concentrate in step (5) by macroporous absorbent resin, water elution, after discarding eluent, then with ethanol elution,
Eluent is collected, and recycles ethyl alcohol, after reduced pressure, obtains medicinal extract；
(7) extract dry in step (6), crushing are to get francolin leaf extract.
Preferably, francolin leaf extract of the present invention, is prepared as follows：
(1) it takes francolin leaf to be sorted, cleaned, dried, crushed, then crosses 20-40 mesh screens, it is thick to obtain francolin leaf for extracting screen underflow
Powder, it is spare；
(2) the francolin leaf coarse powder in step (1) is obtained into aqueous extract with water heating and refluxing extraction；
(3) aqueous extract described in step (2) is filtered, and it is 1.0~1.2 to be concentrated into relative density, obtains concentrate；
(4) it is 50~80% the concentrate in step (3) to be added in 90~95% ethyl alcohol to determining alcohol, after placing 4~6h
Filtering, obtains precipitation solution；
(5) it is 1.0~1.1 precipitation solution to be recycled ethyl alcohol and be concentrated into relative density, obtains concentrate；
(6) by the concentrate in step (5) by macroporous absorbent resin, the water elution measured using 1~5 times, after discarding eluent,
Again with the ethanol elution of 1~5 times of amount a concentration of 5~10%, eluent is collected, and recycle ethyl alcohol, be concentrated under reduced pressure into relative density
It is 1.0~1.2, obtains medicinal extract；
(7) the medicinal extract microwave drying in step (6), crushing are to get francolin leaf extract.
In above-mentioned steps (6), the macroporous absorbent resin uses in D101, DM130, GHP-8, XAD-16, PRP-2A
One kind, preferably D101.
Medicated toothpaste of the present invention containing francolin leaf extract, in addition to above-mentioned francolin leaf extract is added, also
Some medicinal materials with pharmacological effect, including but not limited to ganoderma lucidum, honeysuckle, dandelion, rhodiola root, Cordyceps militaris, worm can be added
One or more of careless essence, Amomum cardamomum and emblic.
The second object of the present invention is to provide a kind of preparation method of the medicated toothpaste containing francolin leaf extract, including
Following steps：
(1) francolin leaf extract powder is prepared；
(2) above-mentioned francolin leaf extract powder and moisturizer are mixed in the ratio, and is sufficiently mixed stirring into the water, made
At mixed aqueous solution；
(3) it is then proportionally added into rubbing agent, thickener and foaming agent, is sufficiently mixed stirring；
(4) it is sent into three-in-one vacuum Manufacturing medicine extract machine, then carries out vacuumizing process；
(5) it waits after vacuumizing, high-speed stirred is milled 25~35 minutes, then vacuum outgas；
(6) sweetener, essence and food coloring are added, is stirred for milling 10~20 minutes, obtains lotion of toothpaste；
(7) by sterilizing, filling, packaging to get toothpaste finished product.
In the preparation method of the above-mentioned medicated toothpaste containing francolin leaf extract, the francolin leaf in the step (1) carries
It is 1~20%, preferably 3~15% to take object powder to account for the weight ratio of the medicated toothpaste lotion.Moisturizing in the step (2)
Agent includes but not limited to one or more of glycerine, glycerine, sorbierite, propylene glycol, polyethylene glycol, is formulated usage amount range
It is 5~45%, preferably 15~35%.Water in the step (2) is one kind of pure water or deionized water, is formulated usage amount
Ranging from 5~40%, preferably 15~30%.Rubbing agent in the step (3) includes but not limited to calcium monohydrogen phosphate, titanium dioxide
One or more of silicon, aluminium hydroxide, powdered whiting, precipitated calcium carbonate, calcite in powder, leuchtenbergite, formula use
Amount ranging from 10~50%, preferably 15~35%.Thickener in the step (3) includes but not limited to hydroxylmethyl cellulose
One or more of element, hydroxypropyl cellulose, sodium alginate, carragheen, xanthans, formula usage amount ranging from 0.2~
5%, preferably 0.5~2.5%.Foaming agent in the step (3) includes but not limited to lauryl sodium sulfate, N- lauroyl
The one or more of sodium sarcosinate, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate, formula usage amount ranging from 0.2~
8%, preferably 0.5~3%.Sweetener in the step (6) include but not limited to saccharin, sucrose, xylitol, honey element,
One or more of dipeptide sodium is formulated usage amount ranging from 0.1~1%, preferably 0.1~0.5%.The step
(6) essence in include but not limited to peppermint oil, spearmint oil, perilla herb oil, lemon sesame oil, mandarin oil, caryophyllus oil, cinnamon oil,
One or more of orange oil, menthol, borneol, vanillic aldehyde, citral, lauryl aldehyde, pentyl acetate, formula usage amount is ranging from
0.1~2%, preferably 0.5~1%.Food coloring in the step (6) is green, formula usage amount ranging from 0.1~
1.2%.
Sterilization method is microwave sterilization, intense pulse laser irradiation, the irradiation of high-voltage pulse xenon lamp, high temperature in the step (7)
One kind in hot air sterilization, preferably microwave sterilization.
In the preparation method of the above-mentioned medicated toothpaste containing francolin leaf extract, filling use in the step (7)
Dentifrice tube is hose, one kind of specially overall plastic composite soft tube or aluminium-plastic composite hose.
As seen from the above technical solution provided by the invention, medicated toothpaste of the invention and the side of the toothpaste is prepared
Method can give full play to its effect, which has anti-inflammatory analgetic, sterilization, tooth-whitening etc. by adding francolin leaf extract
Effect, also can the symptoms such as effectively preventing bleeding gums, gingivitis, periodontitis, canker sore, can also pre- anti-caries hair
It is raw.
Specific implementation mode
Disclosed by the invention is a kind of medicated toothpaste and preparation method thereof containing francolin leaf extract.The present invention is with Zhe
Gu leaf extracts are toothpaste the effect of property ingredient, make full use of the pharmacological property of francolin leaf, realize the anti-inflammatory analgetic to tooth, kill
Bacterium, whitening, nutrition and other effects.
In a preferred specific embodiment of the invention, the francolin leaf is selected from Forests in Wanning, Hainan Islands Dongshan Ridge or Wenchang, hainan copper
The francolin leaf that drum ridge produces.
Technology disclosed by the invention is related to a kind of medicated toothpaste containing francolin leaf extract, by weight percentage, tooth
Francolin leaf extract is 1~20% in cream, and rubbing agent is 10~50%, and moisturizer is 5~45%, and foaming agent is 0.2~8%,
Thickener be 0.2~5%, sweetener be 0.1~1%, essence be 0.1~2%, water be 5~40%, food coloring be 0.1~
1.2%.
The preparation method of medicated toothpaste of the present invention containing francolin leaf extract, includes the following steps：
(1) it takes francolin leaf to be sorted, cleaned, dried, crushed, then crosses 20-40 mesh screens, it is thick to obtain francolin leaf for extracting screen underflow
Powder；
(2) by the coarse powder water heating and refluxing extraction in step (1), aqueous extract is obtained；After filtering, being concentrated into relative density is
1.0~1.2, obtain concentrate；It is 50~80% that the concentrate, which is added in 90~95% ethyl alcohol to determining alcohol, places 4~6h
After filter, obtain precipitation solution；It is 1.0~1.1 that precipitation solution, which is recycled ethyl alcohol, and is concentrated into relative density, obtains concentrate；Upper step is obtained
The concentrate arrived is by macroporous absorbent resin, the water elution measured using 1~5 times, after discarding eluent, then with 1~5 times of amount concentration
For 5~10% ethanol elution, eluent is collected, and recycle ethyl alcohol, it is 1.0~1.2 to be concentrated under reduced pressure into relative density, must be soaked
Cream；By medicinal extract microwave drying, crush to get francolin leaf extract powder.
(3) in this step, if not specifically defined, percentages are each dispensing and the weight ratio of lotion of toothpaste.It takes
It is obtained in step (2), by weight percentage, 1~20% francolin leaf extract powder, the moisturizer with 5~45% is mixed
It closes uniformly, and is put into 5~40% water and is sufficiently mixed stirring, mixed aqueous solution is made；Then 10~50% are sequentially added to rub
Liniment, 0.2~5% thickener and 0.2~8% foaming agent are sufficiently mixed uniformly and stir；Then mixed liquor is sent into three
Unify vacuum Manufacturing medicine extract machine, carries out vacuumizing process；It waits after vacuumizing, high-speed stirred is milled 25~35 minutes, then vacuum
Degassing；Sequentially added after degassing 0.1~1% sweetener, 0.1~2% essence and 0.1~1.2% edible color
Element is stirred for milling 10~20 minutes, obtains lotion of toothpaste；Lotion is sterilized, is filling, packaging is to get tooth of the invention
Cream finished product.
It should be noted that those skilled in the art also can be of the present invention except being added according to the desired use of toothpaste
Outside francolin leaf extract, some medicinal materials with pharmacological effect can also be added, the medicinal material of these pharmacological effects includes but not limited to
One or more of ganoderma lucidum, honeysuckle, dandelion, rhodiola root, Cordyceps militaris, Chinese caterpillar fungus extract, Amomum cardamomum and emblic.
The present invention will be further illustrated by specific embodiment below, althoughs note that the present invention is not limited thereto.
Embodiment 1
A kind of medicated toothpaste containing francolin leaf extract, by weight percentage, francolin leaf extract is 5% in toothpaste, is rubbed
Liniment is 25%, moisturizer 35%, foaming agent 2%, thickener 1.8%, sweetener 0.5%, essence 0.5%,
Water is 30%, food coloring 0.2%.
The francolin leaf is selected from the francolin leaf that Forests in Wanning, Hainan Islands Dongshan Ridge produces.
The preparation method of medicated toothpaste of the present invention containing francolin leaf extract, includes the following steps：
(1) it takes francolin leaf to be sorted, cleaned, dried, crushed, then crosses 40 mesh screens, extracting screen underflow obtains francolin leaf coarse powder；
(2) by the coarse powder water heating and refluxing extraction in step (1), aqueous extract is obtained；After filtering, being concentrated into relative density is
1.2, obtain concentrate；It is 80% that the concentrate, which is added in 95% ethyl alcohol to determining alcohol, is filtered after placing 6h, obtains precipitation solution；
It is 1.1 that precipitation solution, which is recycled ethyl alcohol, and is concentrated into relative density, obtains concentrate；The concentrate that upper step obtains is passed through into macroporous absorption
Resin D101, the water elution measured using 5 times, after discarding eluent, then with the ethanol elution of 5 times of amounts a concentration of 10%, collection is washed
De- liquid, and ethyl alcohol is recycled, it is 1.2 to be concentrated under reduced pressure into relative density, obtains medicinal extract；By medicinal extract microwave drying, crush to get francolin leaf
Extract powder.
(3) the francolin leaf extract obtained in step (2) is taken, by weight percentage, by 5% francolin leaf extract powder
End is uniformly mixed with 35% moisturizer, and is put into 30% pure water and is sufficiently mixed stirring, and mixed aqueous solution is made；With
Sequentially add afterwards 25% rubbing agent, 1.8% thickener and 2% foaming agent, be sufficiently mixed uniformly and stir；
(4) mixed liquor in step (3) is sent into three-in-one vacuum Manufacturing medicine extract machine, carries out vacuumizing process；It waits after vacuumizing,
High-speed stirred is milled 35 minutes, then vacuum outgas；0.5% sweetener, 0.5% essence are sequentially added after degassing
Food coloring with 0.2%, is stirred for milling 20 minutes, obtains lotion of toothpaste；Lotion is sterilized, is filling, pack to get
The toothpaste finished product of the present invention.
Embodiment 2
A kind of medicated toothpaste containing francolin leaf extract, by weight percentage, francolin leaf extract is 15% in toothpaste, is rubbed
Liniment is 20%, moisturizer 30%, foaming agent 3%, thickener 2.5%, sweetener 0.2%, essence 0.2%,
Water is 29%, food coloring 0.1%.
The francolin leaf is selected from the francolin leaf that Forests in Wanning, Hainan Islands Dongshan Ridge produces.
The preparation method of medicated toothpaste of the present invention containing francolin leaf extract, includes the following steps：
(1) according to the step (1) and step (2) in embodiment (1), francolin leaf extract powder is prepared；
(2) the francolin leaf extract obtained in step (1) is taken, by weight percentage, by 15% francolin leaf extract powder,
It is uniformly mixed with 30% moisturizer, and is put into 29% deionized water and is sufficiently mixed stirring, mixed aqueous solution is made；Then
Sequentially add 20% rubbing agent, 2.5% thickener and 3% foaming agent, be sufficiently mixed uniformly and stir；
(4) mixed liquor in step (3) is sent into three-in-one vacuum Manufacturing medicine extract machine, carries out vacuumizing process；It waits after vacuumizing,
High-speed stirred is milled 25 minutes, then vacuum outgas；0.2% sweetener, 0.2% essence are sequentially added after degassing
Food coloring with 0.1%, is stirred for milling 20 minutes, obtains lotion of toothpaste；Lotion is sterilized, is filling, pack to get
The toothpaste finished product of the present invention.
Embodiment 3
A kind of medicated toothpaste containing francolin leaf extract, by weight percentage, francolin leaf extract is 10% in toothpaste, is rubbed
Liniment is 30%, moisturizer 35%, foaming agent 1%, thickener 1.5%, sweetener 0.1%, essence 0.1%,
Water is 22%, food coloring 0.3%.
The francolin leaf is selected from the francolin leaf that Wenchang, hainan Bronze Drum Ridge produces.
The preparation method of medicated toothpaste of the present invention containing francolin leaf extract, includes the following steps：
(1) it takes francolin leaf to be sorted, cleaned, dried, crushed, then crosses 30 mesh screens, extracting screen underflow obtains francolin leaf coarse powder；
(2) by the coarse powder water heating and refluxing extraction in step (1), aqueous extract is obtained；After filtering, being concentrated into relative density is
1.0, obtain concentrate；It is 60% that the concentrate, which is added in 90% ethyl alcohol to determining alcohol, is filtered after placing 6h, obtains precipitation solution；
It is 1.0 that precipitation solution, which is recycled ethyl alcohol, and is concentrated into relative density, obtains concentrate；The concentrate that upper step obtains is passed through into macroporous absorption
Resin DM130, the water elution measured using 5 times, after discarding eluent, then with the ethanol elution of 5 times of amounts a concentration of 10%, collection is washed
De- liquid, and ethyl alcohol is recycled, it is 1.0 to be concentrated under reduced pressure into relative density, obtains medicinal extract；By medicinal extract microwave drying, crush to get francolin leaf
Extract powder.
(3) the francolin leaf extract obtained in step (2) is taken, by weight percentage, by 10% francolin leaf extract
Powder is uniformly mixed with 35% moisturizer, and is put into 22% pure water and is sufficiently mixed stirring, and mixed aqueous solution is made；
Then sequentially add 30% rubbing agent, 1.5% thickener and 1% foaming agent, be sufficiently mixed uniformly and stir；
(4) mixed liquor in step (3) is sent into three-in-one vacuum Manufacturing medicine extract machine, carries out vacuumizing process；It waits after vacuumizing,
High-speed stirred is milled 35 minutes, then vacuum outgas；0.1% sweetener, 0.1% essence are sequentially added after degassing
Food coloring with 0.3%, is stirred for milling 20 minutes, obtains lotion of toothpaste；Lotion is sterilized, is filling, pack to get
The toothpaste finished product of the present invention.
Embodiment 4
A kind of medicated toothpaste containing francolin leaf extract, by weight percentage, francolin leaf extract is 3% in toothpaste, is rubbed
Liniment is 35%, moisturizer 26%, foaming agent 2.5%, thickener 2.5%, sweetener 0.3%, and essence is
0.3%, water 30%, food coloring 0.4%.
The francolin leaf is selected from the francolin leaf that Wenchang, hainan Bronze Drum Ridge produces.
The preparation method of medicated toothpaste of the present invention containing francolin leaf extract, includes the following steps：
(1) according to the step (1) and step (2) in embodiment (1), francolin leaf extract powder is prepared；
(2) the francolin leaf extract obtained in step (1) is taken, by weight percentage, by 3% francolin leaf extract powder,
It is uniformly mixed with 26% moisturizer, and is put into 30% deionized water and is sufficiently mixed stirring, mixed aqueous solution is made；Then
Sequentially add 35% rubbing agent, 2.5% thickener and 2.5% foaming agent, be sufficiently mixed uniformly and stir；
(4) mixed liquor in step (3) is sent into three-in-one vacuum Manufacturing medicine extract machine, carries out vacuumizing process；It waits after vacuumizing,
High-speed stirred is milled 25 minutes, then vacuum outgas；0.3% sweetener, 0.3% essence are sequentially added after degassing
Food coloring with 0.4%, is stirred for milling 20 minutes, obtains lotion of toothpaste；Lotion is sterilized, is filling, pack to get
The toothpaste finished product of the present invention.
Embodiment 5
A kind of medicated toothpaste containing francolin leaf extract, by weight percentage, francolin leaf extract is 20% in toothpaste, is rubbed
Liniment is 20%, moisturizer 20%, foaming agent 4%, thickener 0.5%, sweetener 0.2%, essence 0.2%,
Water is 35%, food coloring 0.1%.
The francolin leaf is selected from the francolin leaf that Forests in Wanning, Hainan Islands Dongshan Ridge and Wenchang, hainan Bronze Drum Ridge produce, two kinds of different sources
Francolin leaf respectively account for 50%.
The preparation method of medicated toothpaste of the present invention containing francolin leaf extract, includes the following steps：
(1) it takes francolin leaf to be sorted, cleaned, dried, crushed, then crosses 20 mesh screens, extracting screen underflow obtains francolin leaf coarse powder；
(2) by the coarse powder water heating and refluxing extraction in step (1), aqueous extract is obtained；After filtering, being concentrated into relative density is
1.2, obtain concentrate；It is 80% that the concentrate, which is added in 95% ethyl alcohol to determining alcohol, is filtered after placing 6h, obtains precipitation solution；
It is 1.1 that precipitation solution, which is recycled ethyl alcohol, and is concentrated into relative density, obtains concentrate；The concentrate that upper step obtains is passed through into macroporous absorption
Resin D101, the water elution measured using 5 times, after discarding eluent, then with the ethanol elution of 5 times of amounts a concentration of 10%, collection is washed
De- liquid, and ethyl alcohol is recycled, it is 1.2 to be concentrated under reduced pressure into relative density, obtains medicinal extract；By medicinal extract microwave drying, crush to get francolin leaf
Extract powder.
(3) the francolin leaf extract obtained in step (2) is taken, by weight percentage, by 20% francolin leaf extract
Powder is uniformly mixed with 20% moisturizer, and is put into 35% pure water and is sufficiently mixed stirring, and mixed aqueous solution is made；
Then sequentially add 20% rubbing agent, 0.5% thickener and 4% foaming agent, be sufficiently mixed uniformly and stir；
(4) mixed liquor in step (3) is sent into three-in-one vacuum Manufacturing medicine extract machine, carries out vacuumizing process；It waits after vacuumizing,
High-speed stirred is milled 35 minutes, then vacuum outgas；0.2% sweetener, 0.2% essence are sequentially added after degassing
Food coloring with 0.1%, is stirred for milling 20 minutes, obtains lotion of toothpaste；Lotion is sterilized, is filling, pack to get
The toothpaste finished product of the present invention.
The basic principles and main features and good characteristics of the present invention have been shown and described above.The technical staff of the industry
It should be appreciated that the present invention is not limited to the above embodiments, the above embodiments and description only describe the present invention
Principle, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these variation and
Improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
Object defines.
Claims (8)
1. a kind of medicated toothpaste containing francolin leaf extract, which is characterized in that contain francolin leaf extract in the medicated toothpaste.
2. the medicated toothpaste containing francolin leaf extract, the medicated toothpaste further includes other dispensings, other described dispensings
Including rubbing agent, moisturizer, thickener, foaming agent, sweetener, essence, water and food coloring, by weight percentage, toothpaste
Middle francolin leaf extract is 1~20%, preferably 3~15%；Rubbing agent is 10~50%, preferably 15~35%；Moisturizer
It is 5~45%, preferably 15~35%；Foaming agent is 0.2~8%, preferably 0.5~3%；Thickener is 0.2~5%, excellent
It is selected as 0.5~2.5%；Sweetener is 0.1~1%, preferably 0.1~0.5%；Essence be 0.1~2%, preferably 0.5~
1%；Water is 5~40%, preferably 15~30%；Food coloring is 0.1~1.2%.
3. a kind of medicated toothpaste containing francolin leaf extract according to claim 1, which is characterized in that the francolin leaf carries
Take object that can be prepared in accordance with the following methods：
It takes francolin leaf to be sorted, cleaned, dried, crushed, then crosses 20-40 mesh screens, extracting screen underflow obtains francolin leaf coarse powder；
Francolin leaf coarse powder in step (1) is obtained into aqueous extract with water heating and refluxing extraction；
By the aqueous extract filtering described in step (2), and it is 1.0~1.2 to be concentrated into relative density, obtains concentrate；
It is 50~80% that concentrate in step (3), which is added in 90~95% ethyl alcohol to determining alcohol, filters, obtains after placing 2h
Precipitation solution；
It is 1.0~1.1 that precipitation solution, which is recycled ethyl alcohol, and is concentrated into relative density, obtains concentrate；
By the concentrate in step (5) by macroporous absorbent resin, the water elution measured using 1~5 times, after discarding eluent, then
With the ethanol elution of 1~5 times of amount a concentration of 5~10%, eluent is collected, and recycle ethyl alcohol, being concentrated under reduced pressure into relative density is
1.0~1.2, obtain medicinal extract；
Medicinal extract microwave drying in step (6) crushes to get francolin leaf extract.
4. a kind of preparation method of the medicated toothpaste containing francolin leaf extract, includes the following steps described in a kind of claim 1：
Prepare francolin leaf extract powder；
Above-mentioned francolin leaf extract powder and moisturizer are mixed in the ratio, and are sufficiently mixed stirring into the water, is made
Mixed aqueous solution；
It then is proportionally added into thickener, rubbing agent and foaming agent, is sufficiently mixed stirring；
It carries out vacuumizing process；
It waits after vacuumizing, high-speed stirred is milled 25~35 minutes, then vacuum outgas；
Sweetener, essence and food coloring are added, is stirred for milling 10~20 minutes, obtains lotion of toothpaste.
5. a kind of preparation method of medicated toothpaste containing francolin leaf extract according to claim 3, which is characterized in that
The weight ratio that francolin leaf extract powder in the step (1) accounts for the medicated toothpaste lotion is 0.1~25%, preferably 1
~15%.
6. a kind of preparation method of medicated toothpaste containing francolin leaf extract according to claim 3, which is characterized in that
Moisturizer in the step (2) include but not limited to one kind in glycerine, glycerine, sorbierite, propylene glycol, polyethylene glycol or
It is several；Water in the step (2) is one kind of pure water or deionized water.
7. a kind of preparation method of medicated toothpaste containing francolin leaf extract according to claim 3, which is characterized in that
Rubbing agent in the step (3) includes but not limited to calcium monohydrogen phosphate, silica, aluminium hydroxide, powdered whiting, lightweight carbon
One or more of sour calcium, calcite in powder, leuchtenbergite；Thickener in the step (3) includes but not limited to hydroxyl first
One or more of base cellulose, hydroxypropyl cellulose, sodium alginate, carragheen, xanthans；Hair in the step (3)
Infusion includes but not limited to lauryl sodium sulfate, N- sodium lauroyl sarcosines, methyl cocoa ester group sodium taurocholate, phenolic group paddy ammonia
The one or more of sour sodium.
8. a kind of preparation method of medicated toothpaste containing francolin leaf extract according to claim 3, which is characterized in that
Sweetener in the step (6) include but not limited to saccharin, sucrose, xylitol, honey element, one kind in dipeptide sodium or
It is several；Essence in the step (6) includes but not limited to peppermint oil, spearmint oil, perilla herb oil, lemon sesame oil, mandarin oil, fourth
One or more of sesame oil, cinnamon oil, orange oil, menthol, borneol, vanillic aldehyde, citral, lauryl aldehyde, pentyl acetate；It is described
Food coloring in step (6) is green.
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| CN201610871213.0A CN106265368A (en) | 2016-09-30 | 2016-09-30 | A kind of medicated toothpaste containing Francolini pintadeani leaf extract and preparation method thereof |
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| CN107028813A (en) * | 2017-04-18 | 2017-08-11 | 新疆中草堂医药科技有限公司 | Application of the Fructus Perillae quintessence oil in oral care product is prepared |
| CN107184473B (en) * | 2017-06-05 | 2020-02-21 | 洛阳师范学院 | Toothpaste containing spina gleditsiae extract and preparation method thereof |
| CN110538104A (en) * | 2018-05-29 | 2019-12-06 | 张文利 | Shampoo containing Mallotus oblongifolius muell-Arg extract and preparation method thereof |
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| CN110179724A (en) * | 2019-07-16 | 2019-08-30 | 大理大学 | A kind of medicated toothpaste of the extract containing RADIX SANGUISORBA and preparation method thereof |
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Application publication date: 20180914 |