WO2023090075A1 - Oral composition containing processed mulberry leaf - Google Patents

Oral composition containing processed mulberry leaf Download PDF

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Publication number
WO2023090075A1
WO2023090075A1 PCT/JP2022/039709 JP2022039709W WO2023090075A1 WO 2023090075 A1 WO2023090075 A1 WO 2023090075A1 JP 2022039709 W JP2022039709 W JP 2022039709W WO 2023090075 A1 WO2023090075 A1 WO 2023090075A1
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Prior art keywords
component
oral composition
weight
extract
present
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PCT/JP2022/039709
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French (fr)
Japanese (ja)
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公一 大河内
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小林製薬株式会社
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Publication of WO2023090075A1 publication Critical patent/WO2023090075A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives

Definitions

  • the present invention relates to an oral composition containing a processed mulberry leaf and having a reduced odor peculiar to the component.
  • Aojiru which is mainly composed of crushed powder and squeezed juice of green leafy plants such as kale, barley grass, Angelica keiskei, and mulberry leaves, is rich in vegetable fiber and vitamins, and can easily be used as a vegetable ingredient. It is used as a health food that can be acquired.
  • Aojiru is used for the purpose of supplementing the lack of vegetables, constipation relief, elimination of lifestyle-related diseases, beautiful skin and beauty, diet, cancer prevention, prevention and elimination of skin diseases, anti-aging, blood smoothing, allergy prevention. ⁇ It is also being used in hopes of improving immunity and other effects, and demand is growing along with the recent rise in health consciousness.
  • Patent Document 1 describes adding a processed soybean product to kale green juice as a compositional device
  • Patent Document 2 describes adding a predetermined amount of cocoa powder to kale powder.
  • Patent Document 3 describes contacting acetic acid bacteria with a kale component-containing liquid in a method for producing a beverage containing a kale component
  • Patent Document 4 describes a packaged green juice beverage. In the method for producing, it is described that metal ions are added to the green juice, the pH of the green juice is adjusted, and the green juice is directly sterilized.
  • an object of the present invention is to provide a new oral composition in which the odor peculiar to mulberry leaves is improved.
  • the present inventors have made intensive studies to solve the above problems, and found that the extract of a plant of the genus Salacia has an excellent effect of reducing the odor peculiar to mulberry leaves in oral compositions containing processed mulberry leaves. I found The present invention has been completed through further studies based on such findings.
  • Section 1 An oral composition comprising (A) a powder, press and/or extract of mulberry leaves and (B) an extract of a plant of the genus Salacia. Section 2. Item 2. The oral composition according to Item 1, which contains 0.03 parts by weight or more of the component (B) per 1 part by weight of the component (A). Item 3. Item 3. The oral composition according to Item 1 or 2, further comprising (C) matcha powder and/or extract. Section 4. Item 4. The oral composition according to any one of Items 1 to 3, which is a granule, fine granule, or powder.
  • an oral composition with improved odor characteristic of mulberry leaves is provided.
  • the oral composition of the present invention includes (A) mulberry leaf powder, pressed product and / or extract, (hereinafter referred to as "(A) component” or these powders, pressed products and extracts are collectively referred to as "mulberry leaf processing It is characterized by containing an extract of a plant belonging to the genus Salacia (hereinafter also referred to as “ingredient (B)").
  • (A) component or these powders, pressed products and extracts are collectively referred to as "mulberry leaf processing It is characterized by containing an extract of a plant belonging to the genus Salacia (hereinafter also referred to as “ingredient (B)").
  • the oral composition of the present invention is described in detail below.
  • the oral composition of the present invention contains mulberry leaf powder, pressed product and/or extract as component (A). Although these processed mulberry leaves have a peculiar odor, the oral composition of the present invention preferably suppresses the peculiar odor.
  • Mulberry is the general term for the genus Mulberry (scientific name Morus) of the family Moraceae.
  • the type of mulberry is not particularly limited, and examples thereof include Karayamawa, Yamaguwa, Logwa, Shimaguwa, Chosenqua, and hybrids and hybrids thereof. These can be used singly or in combination of two or more.
  • Mulberry leaf powder is a processed product prepared by drying and pulverizing mulberry leaves.
  • the pressed mulberry leaf is a processed product obtained by squeezing stems and leaves or shreds thereof, and specifically, squeezed juice or dried product thereof.
  • the mulberry leaf extract is an extract obtained by extracting mulberry leaf components from mulberry leaves with water and/or an organic solvent, or a concentrate thereof (concentrated extract or dry extract).
  • Solvents used for extraction include water; monohydric lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; , preferably water, monohydric lower alcohols, and mixed solvents thereof, more preferably water, ethanol, and mixed solvents thereof, particularly preferably water.
  • powder of mulberry leaves is preferably used as the component (A).
  • the average particle size of the mulberry leaf powder is not particularly limited, but is, for example, 8 to 28 ⁇ m, preferably 13 to 22 ⁇ m, more preferably 15 to 20 ⁇ m.
  • the average particle diameter is the 50% diameter (D50) in the volume-based integrated fraction measured by a laser diffraction/scattering particle size distribution analyzer.
  • the content of component (A) when the dry weight of the oral composition is 100% by weight may be appropriately set according to the form and application of the oral composition. , for example, 10% by weight or more in terms of dry weight of the component (A). Since the oral composition of the present invention is excellent in suppressing the odor peculiar to mulberry leaves, the odor suppressing effect can be effectively obtained even when the processed mulberry leaf product is contained in a relatively large amount. From such a point of view, the content of component (A) (dry weight conversion amount) when the dry weight of the oral composition of the present invention is 100% by weight is preferably 15% by weight or more, more preferably 20% by weight. % by weight or more, more preferably 30% by weight or more.
  • the upper limit of the content of component (A) (in terms of dry weight) is not particularly limited, but for example, it is 50% by weight or less. More preferably 40% by weight or less, still more preferably 35% by weight or less.
  • the oral composition of the present invention contains an extract of a plant of the genus Salacia as the component (B).
  • the extract of Salacia plant has neither masking effect nor taste-masking effect, the odor peculiar to mulberry leaves can be preferably suppressed by adding the extract to the oral composition containing the component (A).
  • a Salacia plant extract is a component obtained by performing an extraction process using a Salacia plant as an extraction raw material.
  • the type of Salacia genus plant used as an extraction raw material is not particularly limited, but for example, Salacia chinensis, Salacia reticulata, Salacia oblonga, Salacia purinoides prinoides), Salacia latifolia, Salacia brunoniana, Salacia grandiflora, Salacia macrosperma and the like.
  • Salacia chinensis is preferred.
  • the part of the Salacia plant used as the raw material for extraction is not particularly limited, but examples include rhizomes, leaves, fruits, and bark. Among these, stems, roots and bark are preferred, and stems are more preferred.
  • the part of the Salacia genus plant to be extracted may be subjected to drying, cutting, pulverization, or the like, if necessary, in order to increase the extraction efficiency.
  • any general extraction method used in the production of plant extracts may be used, for example, solvent extraction process, supercritical extraction process, steam distillation process, etc. Among these, solvent extraction treatment is preferred.
  • Extraction solvents used in solvent extraction include, for example, water; monohydric lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; A mixed solvent and the like are included.
  • water, monohydric lower alcohols and mixed solvents thereof are preferred, water, ethanol and mixed solvents thereof are more preferred, and water is particularly preferred.
  • the solvent extraction treatment may be performed by immersing the part of the Salacia plant to be extracted in the extraction solvent and stirring if necessary. For example, 1 to 50 L of the extraction solvent per 100 g of the part to be extracted of the Salacia plant. It may be soaked for about 0.5 to 24 hours, for example.
  • the solvent extraction treatment may be performed by heating, for example, it is preferably performed under conditions of 60 to 110°C, preferably 80 to 98°C.
  • extract of the Salacia plant.
  • the extract obtained by the extraction treatment is optionally subjected to filtration treatment; polystyrene gel (polystyrene-divinylbenzene copolymer, etc.), ion exchange resin, various chromatography using a column filled with a carrier such as activated carbon, etc. may be subjected to adsorption treatment and subjected to purification treatment.
  • the obtained extract may be used as it is as a non-concentrated extract, but if necessary, it may be subjected to a concentration process and used as a soft extract, or further subjected to a drying process and used as an extract powder.
  • the content of component (B) can be appropriately set according to the odor suppressing effect to be obtained.
  • the content of component (B) (dry weight equivalent) is, for example, 0.03 parts by weight or more.
  • the content of component (B) (in terms of dry weight) per 1 part by weight of component (A) (in terms of dry weight) is preferably 0.05 parts by weight or more, More preferably, it is 0.1 part by weight or more.
  • the upper limit of the content of component (B) (in terms of dry weight) per 1 part by weight (in terms of dry weight) of component (A) is not particularly limited. 2 parts by weight or less, more preferably 0.16 parts by weight or less, and even more preferably 0.13 parts by weight or less.
  • the specific content of component (B) depends on the content of component (A) and the content of component (B) per part by weight of component (A).
  • the amount of component (B) in terms of dry weight is, for example, 0.5% by weight or more. is 1% by weight or more, more preferably 2% by weight or more, still more preferably 3% by weight or more, and still more preferably 3.5% by weight or more.
  • the content of component (B) when the dry weight of the oral composition of the present invention is 100% by weight it is, for example, 10% by weight or less.
  • the component (B) Since the component (B) is excellent in suppressing the odor peculiar to mulberry leaves, the odor suppressing effect can be effectively obtained even if the component (B) is used in a relatively small amount. From this point of view, the upper limit of the content (in terms of dry weight) of component (B) is preferably 7% by weight or less, preferably 5% by weight or less, and more preferably 4% by weight or less.
  • the oral composition of the present invention can further contain matcha powder or extract as component (C).
  • Component (C) can be blended for the purpose of further enhancing the odor suppressing effect.
  • the matcha powder is made from tencha (tea leaves grown in Ohishita that are dried without being kneaded in a tencha furnace) into a fine powder using a tea mill.
  • the tea leaves are the leaves of the camellia plant, tea tree (scientific name: Thea sinensis).
  • a matcha extract is an extract or its concentrate (concentrated extract or dried extract) obtained from tencha as an extraction raw material.
  • Solvents used for extraction include water; lower monohydric alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; , preferably water, monohydric lower alcohols, and mixed solvents thereof, more preferably water, ethanol, and mixed solvents thereof, particularly preferably water.
  • component (C) powdered green tea is preferably used as component (C).
  • the particle size of matcha powder is not particularly limited, but for example, the size fraction of a 60-mesh pass is 90% or more, preferably 95% or more.
  • the content of component (C) is, for example, component (C) per part by weight of component (A) (in terms of dry weight) (in terms of dry weight amount) is, for example, 0.1 parts by weight or more.
  • the content of component (C) (in terms of dry weight) per 1 part by weight of component (A) (in terms of dry weight) is preferably 0.15 parts by weight or more, More preferably, it is 0.2 parts by weight or more.
  • the upper limit of the content of component (C) (in terms of dry weight) per 1 part by weight (in terms of dry weight) of component (A) is not particularly limited. 25 parts by weight or less.
  • the specific content of component (C) is determined by the content of component (A) and component (C) per 1 part by weight of component (A).
  • the dry weight conversion amount of the component (C) when the dry weight of the oral composition is 100% by weight for example, 3% by weight or more, and the odor suppressing effect is further enhanced. From the viewpoint of increasing the content, it is preferably 5% by weight or more, more preferably 6% by weight or more.
  • the upper limit of the content of component (C) is not particularly limited when the dry weight of the oral composition of the present invention is 100% by weight, it is, for example, 12% by weight or less, preferably 9% by weight or less.
  • the oral composition of the present invention may contain other nutritional ingredients and pharmacological ingredients in addition to the above-described components (A) and (B) and optional component (C).
  • Such nutritional ingredients and pharmacological ingredients are not particularly limited as long as they can be used in foods and internal medicines. (Other than extracts of component (A), component (B), and component (C)), antioxidants, hypoglycemic agents, anticholesterol agents, immunostimulants, and the like. These components may be used singly or in combination of two or more. In addition, the content of these components is appropriately set according to the type of additive used, the application of the oral composition, and the like.
  • Agents, additives, and the like may be contained.
  • bases and additives are not particularly limited as long as they can be used in foods and pharmaceuticals. Examples include lower alcohols, solid oils, higher alcohols, water-soluble polymers, starch hydrolysates, surfactants. , polyhydric alcohols, pH adjusters, buffers, antioxidants, preservatives, thickeners, chelating agents and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type.
  • starch decomposition products include dextrin, maltodextrin, and powdered candy, preferably maltodextrin.
  • the maltodextrin is not particularly limited as long as it has a DE of 10 or more and less than 20, preferably 15 or more and less than 20, more preferably 16 to 19.
  • the contents of these bases and additives are appropriately set according to the type of ingredients used, the application of the oral composition, and the like.
  • the starch hydrolyzate content can be an appropriate amount as a powder base.
  • the content when the dry weight is 100% by weight is, for example, 20 to 80% by weight, preferably 25 to 55% by weight.
  • the dosage form of the oral composition of the present invention is not particularly limited as long as it can be taken orally. It may be solid (specifically, paste, gel, etc.) or liquid, and may be appropriately set according to the type and use of the oral composition. Since the oral composition of the present invention has an excellent odor suppressing effect, it is possible to effectively obtain an odor suppressing effect even in a dosage form that is inherently susceptible to odor. From this point of view, preferred dosage forms of the oral composition of the present invention include granules, fine granules, and powders.
  • the formulation form of the oral composition of the present invention is not particularly limited as long as it can be taken orally, but typically includes foods.
  • the oral composition of the present invention is made into a food preparation form
  • the above-described components (A) and (B) and optionally the component (C) are used as they are or in combination with other food materials and additives as desired.
  • should be prepared in the form of Examples of such food and drink include general food and drink, foods for specified health uses, dietary supplements, foods with function claims, and foods for sick people.
  • the form of these foods and drinks is not particularly limited, but specific examples include supplements such as tablets (particularly uncoated tablets) and jellies;
  • the oral composition of the present invention may or may not be prepared in such a manner that it can be ingested as it is.
  • the composition of the present invention may be prepared, for example, in a form suitable for ingestion at the time of ingestion.
  • the oral composition of the present invention when the oral composition of the present invention is a beverage, the oral composition of the present invention may be provided as a liquid that can be drunk as it is (liquid beverage), or dispersed or dissolved in a liquid such as water before drinking. It may be prepared as a concentrate, or a concentrate such as granules, fine granules, powder (powder beverage).
  • the oral composition of the present invention is preferably prepared as a powdered drink.
  • the oral composition of the present invention has an intake or administration amount of component (A), for example, 0.5 to 1.5 g, preferably 0.8 to 1.2 g. It may be prepared as
  • Mulberry leaf powder Dry mulberry leaf powder (average particle size 15 to 20 ⁇ m) obtained by drying and pulverizing mulberry leaves
  • Salacia extract "Salacia extract powder K” (manufactured by Nippon Shinyaku Co., Ltd.) (dry powder of hot water extract of stem of Salacia chinensis)
  • Matcha powder Matcha dry powder (60 mesh pass 95% or more) obtained by drying Tencha tea leaves and pulverizing with a tea mill Maltodextrin: “TK16” (Matsutani Chemical Industry Co., Ltd., DE18)
  • An oral composition having the composition shown in Test Example Table 1 was prepared. Specifically, each component was mixed and granulated to prepare granule powder (powdered beverage). The obtained granular powder was stored in a glass bottle at 50° C. for 2 days, and then 3 g of the granular powder (corresponding to 1 g of component (A)) was dispersed in 100 mL at room temperature to prepare a sample solution. The odor of the sample solution was sensory evaluated by 6 trained panelists. Specifically, the degree of unpleasant grassy odor peculiar to (A) component was evaluated by 10-step VAS evaluation (10 points: strong unpleasant smell, 1 point: no unpleasant smell), and 6 people The panelists' ratings were averaged to give an average score.
  • the unpleasant odor peculiar to component (A) could be suppressed by combining component (A) with component (B) (Examples 1 to 7).
  • the unpleasant odor peculiar to component (A) could be further suppressed (Examples 6 and 7).
  • component (B) was derived from Salacia chinensis. When replaced with an extract of Salacia reticulata or Salacia purinoides, the unpleasant odor peculiar to component (A) could be similarly suppressed.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

[Problem] The purpose of the present invention is to provide an oral composition in which the odor peculiar to mulberry leaf has been improved. [Solution] Provided is an oral composition obtained by combining (A) a powder, pressed product and/or extract of mulberry leaf and (B) an extract of a plant belonging to the genus Salacia. For this oral composition, the odor peculiar to the mulberry leaf is improved.

Description

桑葉加工物を含有する経口組成物Oral composition containing processed mulberry leaf
　本発明は、桑葉加工物を含み、当該成分特有の臭気が低減された経口組成物に関する。 The present invention relates to an oral composition containing a processed mulberry leaf and having a reduced odor peculiar to the component.
　ケール、大麦若葉、明日葉、桑葉等の緑葉植物の破砕粉末や搾汁等を主成分として調製された青汁は、植物繊維及びビタミン類が豊富に含まれており、簡易に野菜成分を取得できる健康飲食品として利用されている。 Aojiru, which is mainly composed of crushed powder and squeezed juice of green leafy plants such as kale, barley grass, Angelica keiskei, and mulberry leaves, is rich in vegetable fiber and vitamins, and can easily be used as a vegetable ingredient. It is used as a health food that can be acquired.
　青汁は、野菜不足を補う目的で利用されるほか、便秘解消、生活習慣病の解消、美肌・美容、ダイエット、がん予防、皮膚疾患の予防や解消、アンチエイジング、血液さらさら化、アレルギー予防・免疫力の向上などの作用効果を期待した利用も広がっており、昨今の健康志向の高まりとともに需要が伸びている。 Aojiru is used for the purpose of supplementing the lack of vegetables, constipation relief, elimination of lifestyle-related diseases, beautiful skin and beauty, diet, cancer prevention, prevention and elimination of skin diseases, anti-aging, blood smoothing, allergy prevention.・It is also being used in hopes of improving immunity and other effects, and demand is growing along with the recent rise in health consciousness.
　一方で、青汁の原料には特有の臭みがあるため、継続的に摂取することをしばしば困難にする。このため、青汁の臭みを抑制するために、組成上の工夫や製法上の工夫がなされている。例えば、組成上の工夫として、特許文献１に、ケール青汁に大豆加工品を添加することが記載されており、特許文献２に、ケール粉末にココアパウダーを所定量配合することが記載されている。また、製法上の工夫として、特許文献３に、ケール成分を含有する飲料の製造方法においてケール成分含有液に酢酸菌を接触させることが記載されており、特許文献４に、容器詰青汁飲料を製造する方法において、青汁に金属イオンを添加し、青汁のｐＨを調整し、青汁を直接殺菌することが記載されている。 On the other hand, the ingredients of green juice have a unique smell, which often makes it difficult to consume continuously. For this reason, in order to suppress the odor of green juice, efforts have been made to improve its composition and manufacturing method. For example, Patent Document 1 describes adding a processed soybean product to kale green juice as a compositional device, and Patent Document 2 describes adding a predetermined amount of cocoa powder to kale powder. there is In addition, as a device for the production method, Patent Document 3 describes contacting acetic acid bacteria with a kale component-containing liquid in a method for producing a beverage containing a kale component, and Patent Document 4 describes a packaged green juice beverage. In the method for producing, it is described that metal ions are added to the green juice, the pH of the green juice is adjusted, and the green juice is directly sterilized.
特開２００４－２１５６０７号公報Japanese Patent Application Laid-Open No. 2004-215607 特開２０１５－１０４３４７号公報JP 2015-104347 A 特開２００６－３２０２２４号公報JP 2006-320224 A 特開２００９－１６５４３９号公報JP 2009-165439 A
　青汁原料の１つである桑葉には特有の青臭さがあり、桑葉を原料とする青汁の経口時の臭気に対しては未だ改善の余地がある。そこで、本発明は、桑葉特有の臭気が改善された新たな経口組成物を提供することを目的とする。

Mulberry leaves, which are one of the raw materials for green juice, have a unique grassy odor, and there is still room for improvement in terms of the odor of oral green juice made from mulberry leaves. Accordingly, an object of the present invention is to provide a new oral composition in which the odor peculiar to mulberry leaves is improved.
　本発明者は、前記課題を解決すべく鋭意検討を行ったところ、サラシア属植物の抽出物に、桑葉加工物を含む経口組成物における桑葉特有の臭気を低減できる優れた効果があることを見出した。本発明は、かかる知見に基づいて、更に検討を重ねることにより完成したものである。 The present inventors have made intensive studies to solve the above problems, and found that the extract of a plant of the genus Salacia has an excellent effect of reducing the odor peculiar to mulberry leaves in oral compositions containing processed mulberry leaves. I found The present invention has been completed through further studies based on such findings.
　即ち、本発明は、下記に掲げる態様の発明を提供する。
項１．　(A)桑葉の粉末、圧搾物及び／又は抽出物、並びに(B)サラシア属植物の抽出物を含有する、経口組成物。
項２．　前記(A)成分１重量部に対して、前記(B)成分を０．０３重量部以上含有する、項１に記載の経口組成物。
項３．　さらに(C)抹茶の粉末及び／又は抽出物を含む、項１又は２に記載の経口組成物。
項４．　顆粒剤、細粒剤、又は散剤である、項１～３のいずれかに記載の経口組成物。 That is, the present invention provides inventions in the following aspects.
Section 1. An oral composition comprising (A) a powder, press and/or extract of mulberry leaves and (B) an extract of a plant of the genus Salacia.
Section 2. Item 2. The oral composition according to Item 1, which contains 0.03 parts by weight or more of the component (B) per 1 part by weight of the component (A).
Item 3. Item 3. The oral composition according to Item 1 or 2, further comprising (C) matcha powder and/or extract.
Section 4. Item 4. The oral composition according to any one of Items 1 to 3, which is a granule, fine granule, or powder.
　本発明によれば、桑葉特有の臭気が改善された経口組成物が提供される。 According to the present invention, an oral composition with improved odor characteristic of mulberry leaves is provided.
　本発明の経口組成物は、(A)桑葉の粉末、圧搾物及び／又は抽出物、（以下において「(A)成分」又はこれら粉末、圧搾物及び抽出物を包括して「桑葉加工物」とも記載する）、並びにサラシア属植物の抽出物（以下において「(B)成分」とも記載する）を含有することを特徴とする。以下、本発明の経口組成物について詳述する。 The oral composition of the present invention includes (A) mulberry leaf powder, pressed product and / or extract, (hereinafter referred to as "(A) component" or these powders, pressed products and extracts are collectively referred to as "mulberry leaf processing It is characterized by containing an extract of a plant belonging to the genus Salacia (hereinafter also referred to as "ingredient (B)"). The oral composition of the present invention is described in detail below.
［(A)桑葉加工物］
　本発明の経口組成物は、(A)成分として、桑葉の粉末、圧搾物及び／又は抽出物を含む。これら桑葉加工物には特有の臭気があるが、本発明の経口組成物は、当該特有の臭気が好ましく抑制されている。 [(A) Processed mulberry leaf]
The oral composition of the present invention contains mulberry leaf powder, pressed product and/or extract as component (A). Although these processed mulberry leaves have a peculiar odor, the oral composition of the present invention preferably suppresses the peculiar odor.
　桑は、クワ科クワ属（学名Morus）の総称である。桑の種類については特に限定されず、カラヤマグワ、ヤマグワ、ログワ、シマグワ、チョウセンクワ、これらの交配種及び交雑種等が挙げられる。これらは１種又は２種以上を組み合わせて用いることができる。 Mulberry is the general term for the genus Mulberry (scientific name Morus) of the family Moraceae. The type of mulberry is not particularly limited, and examples thereof include Karayamawa, Yamaguwa, Logwa, Shimaguwa, Chosenqua, and hybrids and hybrids thereof. These can be used singly or in combination of two or more.
　桑葉の粉末は、桑葉に対して乾燥処理及び粉砕処理を行うことで調製される加工物である。桑葉の圧搾物は、茎葉又はその細片化物を圧搾して得られる加工物であり、具体的には、搾汁又はその乾燥物である。桑葉の抽出物は、桑葉から桑葉成分を水及び／又は有機溶媒で抽出して得られる抽出液又はその濃縮物（濃縮エキス又は乾燥エキス）である。抽出に用いられる溶媒としては、水；メタノール、エタノール等の１価低級アルコール；プロピレングリコール、１，３－ブチレングリコール等の多価アルコール；アセトン等の親水性溶媒；これらの混合溶媒等が挙げられ、好ましくは水、１価低級アルコール、及びこれらの混合溶媒が挙げられ、さらに好ましくは水、エタノール、及びこれらの混合溶媒、特に好ましくは水が挙げられる。 Mulberry leaf powder is a processed product prepared by drying and pulverizing mulberry leaves. The pressed mulberry leaf is a processed product obtained by squeezing stems and leaves or shreds thereof, and specifically, squeezed juice or dried product thereof. The mulberry leaf extract is an extract obtained by extracting mulberry leaf components from mulberry leaves with water and/or an organic solvent, or a concentrate thereof (concentrated extract or dry extract). Solvents used for extraction include water; monohydric lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; , preferably water, monohydric lower alcohols, and mixed solvents thereof, more preferably water, ethanol, and mixed solvents thereof, particularly preferably water.
　本発明においては、(A)成分として、上記の桑葉加工物の中でも、好ましくは桑葉の粉末が用いられる。 In the present invention, among the above-mentioned processed mulberry leaves, powder of mulberry leaves is preferably used as the component (A).
　桑葉の粉末の平均粒子径としては特に限定されないが、例えば８～２８μｍ、好ましくは１３～２２μｍ、より好ましくは１５～２０μｍが挙げられる。本発明において、平均粒子径は、レーザー回析散乱光式粒度分布測定装置により測定される体積基準の積算分率における５０％径（Ｄ５０）である。 The average particle size of the mulberry leaf powder is not particularly limited, but is, for example, 8 to 28 μm, preferably 13 to 22 μm, more preferably 15 to 20 μm. In the present invention, the average particle diameter is the 50% diameter (D50) in the volume-based integrated fraction measured by a laser diffraction/scattering particle size distribution analyzer.
　本発明の経口組成物において、経口組成物の乾燥重量を１００重量％とした場合の(A)成分の含有量については、当該経口組成物の形態や用途等に応じて適宜設定すればよいが、例えば、(A)成分の乾燥重量換算量で、例えば１０重量％以上が挙げられる。本発明の経口組成物は桑葉特有の臭気抑制効果に優れるため、桑葉加工物が比較的多く含まれていても、効果的に臭気抑制効果を得ることができる。このような観点から、本発明の経口組成物の乾燥重量を１００重量％とした場合の(A)成分の含有量（乾燥重量換算量）としては、好ましくは１５重量％以上、より好ましくは２０重量％以上、さらに好ましくは３０重量％以上が挙げられる。当該(A)成分の含有量（乾燥重量換算量）の上限については特に制限はないが、例えば５０重量％以下が挙げられ、臭気抑制効果をより一層高める観点から、好ましくは４５重量％以下、より好ましくは４０重量％以下、さらに好ましくは３５重量％以下が挙げられる。 In the oral composition of the present invention, the content of component (A) when the dry weight of the oral composition is 100% by weight may be appropriately set according to the form and application of the oral composition. , for example, 10% by weight or more in terms of dry weight of the component (A). Since the oral composition of the present invention is excellent in suppressing the odor peculiar to mulberry leaves, the odor suppressing effect can be effectively obtained even when the processed mulberry leaf product is contained in a relatively large amount. From such a point of view, the content of component (A) (dry weight conversion amount) when the dry weight of the oral composition of the present invention is 100% by weight is preferably 15% by weight or more, more preferably 20% by weight. % by weight or more, more preferably 30% by weight or more. The upper limit of the content of component (A) (in terms of dry weight) is not particularly limited, but for example, it is 50% by weight or less. More preferably 40% by weight or less, still more preferably 35% by weight or less.
［(B)サラシア属植物の抽出物］
　本発明の経口組成物は、(B)成分としてサラシア属植物の抽出物を含有する。サラシア属植物の抽出物については、マスキング効果も矯味効果も知られていないが、(A)成分を含む経口組成物に配合することによって、桑葉特有の臭気を好ましく抑制することができる。 [(B) Salacia plant extract]
The oral composition of the present invention contains an extract of a plant of the genus Salacia as the component (B). Although the extract of Salacia plant has neither masking effect nor taste-masking effect, the odor peculiar to mulberry leaves can be preferably suppressed by adding the extract to the oral composition containing the component (A).
　サラシア属植物の抽出物とは、サラシア属植物を抽出原料として抽出処理を行うことにより得られる成分である。 A Salacia plant extract is a component obtained by performing an extraction process using a Salacia plant as an extraction raw material.
　抽出原料として使用されるサラシア属植物の種類については、特に制限されないが、例えば、サラシア・キネンシス（Salacia chinensis)、サラシア・レティキュラータ（Salacia reticulata)、サラシア・オブロンガ（Salacia oblonga)、サラシア・プリノイデス（Salacia prinoides)、サラシア・ラフォティリア（Salacia latifolia）、サラシア・ブルノニアーナ（Salacia burunoniana)、サラシア・グランディフローラ(Salacia grandiflora)、サラシア・マクロスペルマ（Salacia macrosperma）等が挙げられる。これらのサラシア属植物の中でも、好ましくはサラシア・キネンシスが挙げられる。 The type of Salacia genus plant used as an extraction raw material is not particularly limited, but for example, Salacia chinensis, Salacia reticulata, Salacia oblonga, Salacia purinoides prinoides), Salacia latifolia, Salacia brunoniana, Salacia grandiflora, Salacia macrosperma and the like. Among these plants belonging to the genus Salacia, Salacia chinensis is preferred.
　抽出原料として使用されるサラシア属植物の抽出対象部位については、特に制限されないが、例えば、根茎、葉、果実、樹皮等が挙げられる。これらの中でも、好ましくは茎、根、樹皮、より好ましくは茎が挙げられる。また、抽出処理に供されるサラシア属植物の抽出対象部位は、抽出効率を高めるために、必要に応じて、乾燥、裁断、粉砕等の処理が施されていてもよい。 The part of the Salacia plant used as the raw material for extraction is not particularly limited, but examples include rhizomes, leaves, fruits, and bark. Among these, stems, roots and bark are preferred, and stems are more preferred. In addition, the part of the Salacia genus plant to be extracted may be subjected to drying, cutting, pulverization, or the like, if necessary, in order to increase the extraction efficiency.
　抽出処理については、植物抽出物の製造に使用される一般的な抽出手法であればよく、例えば、溶媒抽出処理、超臨界抽出処理、水蒸気蒸留処理等が挙げられる。これらの中でも、好ましくは溶媒抽出処理が挙げられる。 Regarding the extraction process, any general extraction method used in the production of plant extracts may be used, for example, solvent extraction process, supercritical extraction process, steam distillation process, etc. Among these, solvent extraction treatment is preferred.
　溶媒抽出処理で使用される抽出溶媒としては、例えば、水；メタノール、エタノール等の１価低級アルコール；プロピレングリコール、１，３－ブチレングリコール等の多価アルコール；アセトン等の親水性溶媒；これらの混合溶媒等が挙げられる。これらの抽出溶媒の中でも、好ましくは水、１価低級アルコール、及びこれらの混合溶媒、より好ましくは水、エタノール、及びこれらの混合溶媒、特に好ましくは水が挙げられる。 Extraction solvents used in solvent extraction include, for example, water; monohydric lower alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; A mixed solvent and the like are included. Among these extraction solvents, water, monohydric lower alcohols and mixed solvents thereof are preferred, water, ethanol and mixed solvents thereof are more preferred, and water is particularly preferred.
　溶媒抽出処理は、抽出溶媒中に、サラシア属植物の抽出対象部位を浸漬させて、必要に応じて撹拌することによって行えばよく、例えば、サラシア属植物の抽出対象部位１００ｇ当たり抽出溶媒１～５０Ｌ程度に浸漬させて、例えば０．５～２４時間程度行えばよい。 The solvent extraction treatment may be performed by immersing the part of the Salacia plant to be extracted in the extraction solvent and stirring if necessary. For example, 1 to 50 L of the extraction solvent per 100 g of the part to be extracted of the Salacia plant. It may be soaked for about 0.5 to 24 hours, for example.
　また、溶媒抽出処理は、加熱することによって行えばよく、例えば、６０～１１０℃、好ましくは８０～９８℃条件下で行うことが好ましい。 In addition, the solvent extraction treatment may be performed by heating, for example, it is preferably performed under conditions of 60 to 110°C, preferably 80 to 98°C.
　抽出処理後に固液分離により固形物を除去することにより、サラシア属植物の抽出物（抽出液）が得られる。抽出処理により得られた抽出液は、必要に応じて、濾過処理；ポリスチレンゲル（ポリスチレン・ジビニルベンゼン共重合体等）、イオン交換樹脂、活性炭等の担体を充填したカラムを用いた各種クロマトグラフィー等の吸着処理に供して精製処理に供してもよい。また、得られた抽出液は、非濃縮エキスとしてそのまま使用してもよいが、必要に応じて濃縮工程に供して軟エキスとして使用したり、更に乾燥工程に供してエキス末として使用したりしてもよい。 After the extraction process, solids are removed by solid-liquid separation to obtain an extract (extract) of the Salacia plant. The extract obtained by the extraction treatment is optionally subjected to filtration treatment; polystyrene gel (polystyrene-divinylbenzene copolymer, etc.), ion exchange resin, various chromatography using a column filled with a carrier such as activated carbon, etc. may be subjected to adsorption treatment and subjected to purification treatment. In addition, the obtained extract may be used as it is as a non-concentrated extract, but if necessary, it may be subjected to a concentration process and used as a soft extract, or further subjected to a drying process and used as an extract powder. may
　本発明の経口組成物において、(B)成分の含有量については、得るべき臭気抑制効果に応じて適宜設定することができるが、例えば、(A)成分１重量部（乾燥重量換算量）当たりの(B)成分（乾燥重量換算量）の含有量が、例えば０．０３重量部以上となる量が挙げられる。臭気抑制効果をより一層高める観点から、(A)成分１重量部（乾燥重量換算量）当たりの(B)成分の含有量（乾燥重量換算量）としては、好ましくは０．０５重量部以上、より好ましくは０．１重量部以上が挙げられる。(A)成分１重量部（乾燥重量換算量）当たりの(B)成分の含有量（乾燥重量換算量）の上限としては特に制限はないが、例えば
０．３重量部以下、好ましくは０．２重量部以下、より好ましくは０．１６重量部以下、さらに好ましくは０．１３重量部以下が挙げられる。 In the oral composition of the present invention, the content of component (B) can be appropriately set according to the odor suppressing effect to be obtained. The content of component (B) (dry weight equivalent) is, for example, 0.03 parts by weight or more. From the viewpoint of further enhancing the odor suppressing effect, the content of component (B) (in terms of dry weight) per 1 part by weight of component (A) (in terms of dry weight) is preferably 0.05 parts by weight or more, More preferably, it is 0.1 part by weight or more. The upper limit of the content of component (B) (in terms of dry weight) per 1 part by weight (in terms of dry weight) of component (A) is not particularly limited. 2 parts by weight or less, more preferably 0.16 parts by weight or less, and even more preferably 0.13 parts by weight or less.
　本発明の経口組成物において、(B)成分の具体的な含有量については、上記(A)成分の含有量と(A)成分１重量部当たりの(B)成分の含有量とに応じて定まるが、経口組成物の乾燥重量を１００重量％とした場合の(B)成分の乾燥重量換算量で、例えば０．５重量％以上が挙げられ、臭気抑制効果をより一層高める観点から、好ましくは１重量％以上、より好ましくは２重量％以上、さらに好ましくは３重量％以上、一層好ましくは３．５重量％以上が挙げられる。本発明の経口組成物の乾燥重量を１００重量％とした場合の(B)成分の含有量の上限としては特に制限はないが、例えば１０重量％以下が挙げられる。(B)成分は桑葉特有の臭気抑制効果に優れるため、(B)成分が比較的少量であっても、効果的に臭気抑制効果を得ることができる。このような観点から、当該(B)成分の含有量（乾燥重量換算量）の上限としては、好ましくは７重量％以下、好ましくは５重量％以下、より好ましくは４重量％以下が挙げられる。 In the oral composition of the present invention, the specific content of component (B) depends on the content of component (A) and the content of component (B) per part by weight of component (A). However, when the dry weight of the oral composition is 100% by weight, the amount of component (B) in terms of dry weight is, for example, 0.5% by weight or more. is 1% by weight or more, more preferably 2% by weight or more, still more preferably 3% by weight or more, and still more preferably 3.5% by weight or more. Although there is no particular upper limit for the content of component (B) when the dry weight of the oral composition of the present invention is 100% by weight, it is, for example, 10% by weight or less. Since the component (B) is excellent in suppressing the odor peculiar to mulberry leaves, the odor suppressing effect can be effectively obtained even if the component (B) is used in a relatively small amount. From this point of view, the upper limit of the content (in terms of dry weight) of component (B) is preferably 7% by weight or less, preferably 5% by weight or less, and more preferably 4% by weight or less.
［(C)抹茶の粉末又は抽出物］
　本発明の経口組成物は、さらに(C)成分として抹茶の粉末又は抽出物を含むことができる。(C)成分は、臭気抑制効果をより一層高めることを目的として配合することができる。 [(C) Matcha powder or extract]
The oral composition of the present invention can further contain matcha powder or extract as component (C). Component (C) can be blended for the purpose of further enhancing the odor suppressing effect.
　抹茶の粉末は、碾茶（覆下栽培した茶葉を碾茶炉等で揉まずに乾燥したもの）を茶臼等で微粉末状に製造したものである。茶葉は、ツバキ科植物・チャノキ（学名：Thea sinensis）の葉である。 The matcha powder is made from tencha (tea leaves grown in Ohishita that are dried without being kneaded in a tencha furnace) into a fine powder using a tea mill. The tea leaves are the leaves of the camellia plant, tea tree (scientific name: Thea sinensis).
　抹茶の抽出物は、碾茶を抽出原料として得られる抽出液又はその濃縮物（濃縮エキス又は乾燥エキス）である。抽出に用いられる溶媒としては、水；メタノール、エタノール等の低級１価アルコール；プロピレングリコール、１，３－ブチレングリコール等の多価アルコール；アセトン等の親水性溶媒；これらの混合溶媒等が挙げられ、好ましくは水、１価低級アルコール、及びこれらの混合溶媒が挙げられ、さらに好ましくは水、エタノール、及びこれらの混合溶媒、特に好ましくは水が挙げられる。 A matcha extract is an extract or its concentrate (concentrated extract or dried extract) obtained from tencha as an extraction raw material. Solvents used for extraction include water; lower monohydric alcohols such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; , preferably water, monohydric lower alcohols, and mixed solvents thereof, more preferably water, ethanol, and mixed solvents thereof, particularly preferably water.
　本発明の経口組成物が(C)成分を含む場合、(C)成分として、好ましくは抹茶の粉末が用いられる。 When the oral composition of the present invention contains component (C), powdered green tea is preferably used as component (C).
　抹茶の粉末の粒度としては特に限定されないが、６０メッシュパスのサイズ画分として例えば９０％以上、好ましくは９５％以上が挙げられる。 The particle size of matcha powder is not particularly limited, but for example, the size fraction of a 60-mesh pass is 90% or more, preferably 95% or more.
　本発明の経口組成物が(C)成分を含む場合、(C)成分の含有量については、例えば、(A)成分１重量部（乾燥重量換算量）当たりの(C)成分（乾燥重量換算量）の含有量が、例えば０．１重量部以上となる量が挙げられる。臭気抑制効果をより一層高める観点から、(A)成分１重量部（乾燥重量換算量）当たりの(C)成分の含有量（乾燥重量換算量）としては、好ましくは０．１５重量部以上、より好ましくは０．２重量部以上が挙げられる。(A)成分１重量部（乾燥重量換算量）当たりの(C)成分の含有量（乾燥重量換算量）の上限としては特に制限はないが、例えば０．３重量部以下、好ましくは０．２５重量部以下が挙げられる。 When the oral composition of the present invention contains component (C), the content of component (C) is, for example, component (C) per part by weight of component (A) (in terms of dry weight) (in terms of dry weight amount) is, for example, 0.1 parts by weight or more. From the viewpoint of further enhancing the odor suppressing effect, the content of component (C) (in terms of dry weight) per 1 part by weight of component (A) (in terms of dry weight) is preferably 0.15 parts by weight or more, More preferably, it is 0.2 parts by weight or more. The upper limit of the content of component (C) (in terms of dry weight) per 1 part by weight (in terms of dry weight) of component (A) is not particularly limited. 25 parts by weight or less.
　本発明の経口組成物が(C)成分を含む場合、(C)成分の具体的な含有量については、上記(A)成分の含有量と(A)成分１重量部当たりの(C)成分の含有量とに応じて定まるが、経口組成物の乾燥重量を１００重量％とした場合の(C)成分の乾燥重量換算量で、例えば３重量％以上が挙げられ、臭気抑制効果をより一層高める観点から、好ましくは５重量％以上、より好ましくは６重量％以上が挙げられる。本発明の経口組成物の乾燥重量を１００重量％とした場合の(C)成分の含有量の上限としては特に制限はないが、例えば１２重量％以下、好ましくは９重量％以下が挙げられる。 When the oral composition of the present invention contains component (C), the specific content of component (C) is determined by the content of component (A) and component (C) per 1 part by weight of component (A). Although it is determined according to the content of the oral composition, the dry weight conversion amount of the component (C) when the dry weight of the oral composition is 100% by weight, for example, 3% by weight or more, and the odor suppressing effect is further enhanced. From the viewpoint of increasing the content, it is preferably 5% by weight or more, more preferably 6% by weight or more. Although the upper limit of the content of component (C) is not particularly limited when the dry weight of the oral composition of the present invention is 100% by weight, it is, for example, 12% by weight or less, preferably 9% by weight or less.
［その他の成分］
　本発明の経口組成物は、前述する(A)、(B)成分及び場合により配合される(C)成分に加えて、他の栄養成分や薬理成分を含有していてもよい。このような栄養成分や薬理成分としては、食品や内服用医薬品に使用可能なものであれば特に制限されないが、例えば、ビタミン、アミノ酸、ミネラル、糖質、脂肪酸、香料、調味剤、植物エキス（上記(A)成分の抽出物、上記(B)成分、及び上記(C)成分の抽出物以外）、抗酸化剤、血糖降下剤、抗コレステロール剤、免疫賦活剤等が挙げられる。これらの成分は、１種単独で使用してもよく、また２種以上を組み合わせて使用してもよい。また、これらの成分の含有量については、使用する添分の種類や経口組成物の用途等に応じて適宜設定される。 [Other ingredients]
The oral composition of the present invention may contain other nutritional ingredients and pharmacological ingredients in addition to the above-described components (A) and (B) and optional component (C). Such nutritional ingredients and pharmacological ingredients are not particularly limited as long as they can be used in foods and internal medicines. (Other than extracts of component (A), component (B), and component (C)), antioxidants, hypoglycemic agents, anticholesterol agents, immunostimulants, and the like. These components may be used singly or in combination of two or more. In addition, the content of these components is appropriately set according to the type of additive used, the application of the oral composition, and the like.
　更に、本発明の経口組成物は、所望の製剤形態に調製するために、必要に応じて、前述する(A)、(B)成分及び場合により配合される(C)成分の他に、基剤や添加剤等が含まれていてもよい。このような基剤及び添加剤としては、食品や医薬品に使用可能なものであれば特に制限されないが、例えば、低級アルコール、固形油、高級アルコール、水溶性高分子、澱粉分解物、界面活性剤、多価アルコール、ｐＨ調整剤、緩衝剤、酸化防止剤、防腐剤、増粘剤、キレート剤等が挙げられる。これらは、１種単独で使用してもよく、また２種以上を組み合わせて使用してもよい。なお、澱粉分解物としては、例えば、デキストリン、マルトデキストリン、粉あめが挙げられ、好ましくはマルトデキストリンが挙げられる。また、マルトデキストリンは、ＤＥが１０以上２０未満の物であれば特に限定されないが、好ましくはＤＥ１５以上２０未満のもの、より好ましくは１６～１９のものが挙げられる。これらの基剤や添加剤の含有量については、使用する成分の種類や経口組成物の用途等に応じて適宜設定される。例えば澱粉分解物の含有量としては、本発明の経口組成物が顆粒剤、細粒剤、又は散剤として調製される場合に、粉末基剤として適切な量を用いることができ、経口組成物の乾燥重量を１００重量％とした場合の含有量として、例えば２０～８０重量％、好ましくは２５～５５重量％が挙げられる。 Furthermore, in order to prepare the oral composition of the present invention into a desired pharmaceutical form, if necessary, in addition to the above-described components (A) and (B) and the optionally blended component (C), Agents, additives, and the like may be contained. Such bases and additives are not particularly limited as long as they can be used in foods and pharmaceuticals. Examples include lower alcohols, solid oils, higher alcohols, water-soluble polymers, starch hydrolysates, surfactants. , polyhydric alcohols, pH adjusters, buffers, antioxidants, preservatives, thickeners, chelating agents and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type. Examples of starch decomposition products include dextrin, maltodextrin, and powdered candy, preferably maltodextrin. The maltodextrin is not particularly limited as long as it has a DE of 10 or more and less than 20, preferably 15 or more and less than 20, more preferably 16 to 19. The contents of these bases and additives are appropriately set according to the type of ingredients used, the application of the oral composition, and the like. For example, when the oral composition of the present invention is prepared as granules, fine granules, or powders, the starch hydrolyzate content can be an appropriate amount as a powder base. The content when the dry weight is 100% by weight is, for example, 20 to 80% by weight, preferably 25 to 55% by weight.
［剤型・製剤形態］
　本発明の経口組成物の剤型については、経口摂取が可能であることを限度として特に制限されず、固体状（具体的には、顆粒剤、細粒剤、散剤、タブレット剤等）、半固体状（具体的には、ペースト剤、ゲル剤等）、又は液体状のいずれであってもよく、該経口組成物の種類や用途に応じて適宜設定すればよい。本発明の経口組成物は臭気抑制効果に優れているため、本来的に臭気を感じやすい剤型であっても効果的に臭気抑制効果を得ることができる。このような観点から本発明の経口組成物の好ましい剤型として、顆粒剤、細粒剤、散剤が挙げられる。 [Dosage form/Formulation]
The dosage form of the oral composition of the present invention is not particularly limited as long as it can be taken orally. It may be solid (specifically, paste, gel, etc.) or liquid, and may be appropriately set according to the type and use of the oral composition. Since the oral composition of the present invention has an excellent odor suppressing effect, it is possible to effectively obtain an odor suppressing effect even in a dosage form that is inherently susceptible to odor. From this point of view, preferred dosage forms of the oral composition of the present invention include granules, fine granules, and powders.
　本発明の経口組成物の製剤形態については、経口摂取が可能であることを限度として特に制限されないが、典型的には、食品が挙げられる。 The formulation form of the oral composition of the present invention is not particularly limited as long as it can be taken orally, but typically includes foods.
　本発明の経口組成物を食品の製剤形態にする場合、前述する(A)、(B)成分及び場合により配合される(C)成分を、そのまま又は他の食品素材や添加成分と組み合わせて所望の形態に調製すればよい。このような飲食品としては、一般の飲食品の他、特定保健用食品、栄養補助食品、機能性表示食品、病者用食品等が挙げられる。これらの飲食品の形態として、特に制限されないが、具体的には、錠剤（特に素錠）、ゼリー剤等のサプリメント；栄養ドリンク、清涼飲料、炭酸飲料、乳酸飲料等の飲料等が挙げられる。 When the oral composition of the present invention is made into a food preparation form, the above-described components (A) and (B) and optionally the component (C) are used as they are or in combination with other food materials and additives as desired. should be prepared in the form of Examples of such food and drink include general food and drink, foods for specified health uses, dietary supplements, foods with function claims, and foods for sick people. The form of these foods and drinks is not particularly limited, but specific examples include supplements such as tablets (particularly uncoated tablets) and jellies;
　本発明の経口組成物は、そのまま摂取できる態様で調製されていてもよく、そうでなくてもよい。本発明の組成物は、例えば、摂取時に、摂取に適した態様に調製されてもよい。例えば、本発明の経口組成物が飲料である場合、本発明の経口組成物は、そのまま飲用できる液体（液体飲料）として提供されてもよく、水等の液体に分散又は溶解させて飲用する、濃縮液、若しくは顆粒剤、細粒剤、散剤（粉末飲料）等の濃縮物として調製されていてもよい。特に、本発明の経口組成物は、粉末飲料として調製されていることが好ましい。 The oral composition of the present invention may or may not be prepared in such a manner that it can be ingested as it is. The composition of the present invention may be prepared, for example, in a form suitable for ingestion at the time of ingestion. For example, when the oral composition of the present invention is a beverage, the oral composition of the present invention may be provided as a liquid that can be drunk as it is (liquid beverage), or dispersed or dissolved in a liquid such as water before drinking. It may be prepared as a concentrate, or a concentrate such as granules, fine granules, powder (powder beverage). In particular, the oral composition of the present invention is preferably prepared as a powdered drink.
　本発明の経口組成物は、１回当たりの摂取量又は投与量が、(A)成分の摂取量又は投与量として例えば０．５～１．５ｇ、好ましくは０．８～１．２ｇとなるように調製されていてよい。 The oral composition of the present invention has an intake or administration amount of component (A), for example, 0.5 to 1.5 g, preferably 0.8 to 1.2 g. It may be prepared as
　以下、本発明を実施例により具体的に説明するが、本発明はこれらの実施例に限定されるものではない。 The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.
　なお、以下に示す実施例及び比較例において使用した成分の詳細は、以下の通りである。
(A)桑葉粉末：桑の葉を乾燥し粉砕処理した桑葉乾燥粉末（平均粒径１５～２０μｍ）
(B)サラシアエキス：「サラシアエキスパウダーＫ」（日本新薬株式会社製）（サラシア
　キネンシス（Salacia chinensis）の茎の熱水抽出物の乾燥粉末）
(C)抹茶粉末：碾茶の茶葉を乾燥して茶臼で粉末化した抹茶乾燥粉末（６０メッシュパス９５％以上）マルトデキストリン：「ＴＫ１６」（松谷化学工業株式会社製、ＤＥ１８） The details of the components used in the examples and comparative examples below are as follows.
(A) Mulberry leaf powder: Dry mulberry leaf powder (average particle size 15 to 20 μm) obtained by drying and pulverizing mulberry leaves
(B) Salacia extract: "Salacia extract powder K" (manufactured by Nippon Shinyaku Co., Ltd.) (dry powder of hot water extract of stem of Salacia chinensis)
(C) Matcha powder: Matcha dry powder (60 mesh pass 95% or more) obtained by drying Tencha tea leaves and pulverizing with a tea mill Maltodextrin: “TK16” (Matsutani Chemical Industry Co., Ltd., DE18)
試験例
　表１に示す組成の経口組成物を調製した。具体的には、各成分を混合し、造粒して顆粒粉末（粉末飲料）を調製した。得られた顆粒粉末をガラス瓶に５０℃２日間保管し、その後３ｇの顆粒粉末（(A)成分１ｇ相当）を常温１００ｍＬに分散させ、試料液とした。試料液について、６名の訓練されたパネラーにより臭気を官能評価した。具体的には、(A)成分特有の不快な青臭い臭気の程度について、１０段階ＶＡＳ評価（１０点：不快な香りが強い　１点：不快な臭いを感じない）にて評点し、６名のパネラーの評点を平均し、平均スコアを得た。比較例１の粉末飲料から調製した試料液の平均スコアを１００とした場合の、各比較例及び各実施例の粉末飲料から調製した試料液の平均スコアの相対値について小数点第一を四捨五入し「臭気」の評価値として算出した。算出された「臭気」の評価値が小さいほど、臭気抑制効果が高いと評価できる。得られた結果を表１に示す。
　 An oral composition having the composition shown in Test Example Table 1 was prepared. Specifically, each component was mixed and granulated to prepare granule powder (powdered beverage). The obtained granular powder was stored in a glass bottle at 50° C. for 2 days, and then 3 g of the granular powder (corresponding to 1 g of component (A)) was dispersed in 100 mL at room temperature to prepare a sample solution. The odor of the sample solution was sensory evaluated by 6 trained panelists. Specifically, the degree of unpleasant grassy odor peculiar to (A) component was evaluated by 10-step VAS evaluation (10 points: strong unpleasant smell, 1 point: no unpleasant smell), and 6 people The panelists' ratings were averaged to give an average score. When the average score of the sample solution prepared from the powdered beverage of Comparative Example 1 is set to 100, the relative value of the average score of the sample solution prepared from the powdered beverage of each Comparative Example and each Example is rounded off to the first decimal place. It was calculated as an evaluation value of "odor". It can be evaluated that the smaller the calculated "odor" evaluation value, the higher the odor suppressing effect. Table 1 shows the results obtained.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
　表１から明らかな通り、(A)成分に(B)成分を組み合わせることによって、(A)成分特有の不快な臭気を抑制できていた（実施例１～７）。特に、(A)成分に(B)成分とともに(C)成分を組み合わせて配合することで、(A)成分特有の不快な臭気をより一層抑制できていた（実施例６、７）。 As is clear from Table 1, the unpleasant odor peculiar to component (A) could be suppressed by combining component (A) with component (B) (Examples 1 to 7). In particular, by combining component (A) with component (B) and component (C), the unpleasant odor peculiar to component (A) could be further suppressed (Examples 6 and 7).
　なお、実施例１～７では、(B)成分として、由来となるサラシア属植物がサラシア・キネンシスであるものを用いたが、実施例１～７での(B)成分を、サラシア・オブロンガ、サラシア・レティキュラータ、又はサラシア・プリノイデスの抽出物に置き換えた場合も、同様に(A)成分特有の不快な臭気を抑制できた。 In Examples 1 to 7, the component (B) was derived from Salacia chinensis. When replaced with an extract of Salacia reticulata or Salacia purinoides, the unpleasant odor peculiar to component (A) could be similarly suppressed.

Claims (4)

  1. 　(A)桑葉の粉末、圧搾物及び／又は抽出物、並びに(B)サラシア属植物の抽出物を含有する、経口組成物。 An oral composition containing (A) a powder, press and/or extract of mulberry leaves, and (B) an extract of a plant of the genus Salacia.
  2. 　前記(A)成分１重量部に対して、前記(B)成分を０．０３重量部以上含有する、請求項１に記載の経口組成物。 The oral composition according to claim 1, which contains 0.03 parts by weight or more of the component (B) with respect to 1 part by weight of the component (A).
  3. 　さらに(C)抹茶の粉末及び／又は抽出物を含む、請求項１又は２に記載の経口組成物。 The oral composition according to claim 1 or 2, further comprising (C) matcha powder and/or extract.
  4. 　顆粒剤、細粒剤、又は散剤である、請求項１～３のいずれかに記載の経口組成物。 The oral composition according to any one of claims 1 to 3, which is a granule, fine granule, or powder.
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