KR101710518B1 - Method for preparing functional pills with nyoa fruticans and jaggery, and functional pills by the method - Google Patents
Method for preparing functional pills with nyoa fruticans and jaggery, and functional pills by the method Download PDFInfo
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- KR101710518B1 KR101710518B1 KR1020160082401A KR20160082401A KR101710518B1 KR 101710518 B1 KR101710518 B1 KR 101710518B1 KR 1020160082401 A KR1020160082401 A KR 1020160082401A KR 20160082401 A KR20160082401 A KR 20160082401A KR 101710518 B1 KR101710518 B1 KR 101710518B1
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- flower bud
- concentrate
- extract
- powder
- weight
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/38—Multiple-step
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/50—Concentrating, enriching or enhancing in functional factors
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
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- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
본 발명은 니파야자와 재거리를 이용한 기능성 환의 제조방법 및 그 기능성 환에 관한 것으로, 더욱 상세하게는 건강보조식품으로서 기능성 환을 제조하되, 니파야자의 꽃대 추출액과 분말, 그리고 재거리를 이용하는 기능성 환을 제조하는 방법 및 그 기능성 환에 관한 것이다.The present invention relates to a method for producing a functional ring using the distance between a nipahaya and a reedge, and more particularly, to a method for producing a functional ring as a health supplement, And a functional ring thereof.
일반적으로 인간이라면 누구나 질병 없이 건강한 삶을 영위하기를 원한다는 것은 재론의 여지가 없을 것이다.In general, it is not surprising that anyone who wants to live a healthy life without disease.
그러나 현대인들은 과중한 업무, 과음, 과로, 불규칙한 식사, 운동부족, 스트레스, 공해 및 기타 외부 환경요인 등으로 인하여 인체의 면역력이 날로 저하되고 있다. 이처럼 인체의 면역기능이 저하된다는 것은 건강과 직결된 문제라고 할 수 있다. However, modern people are suffering from the immaturity of the human body due to heavy work, excessive drinking, overwork, irregular eating, lack of exercise, stress, pollution and other external environmental factors. Such a decrease in the immune function of the human body is a problem directly related to health.
전술한 바와 같이 면역기능의 저하에 따라 현대를 살아가는 현대인들은 앞으로 발생할지 모르는 건강의 적신호와 건강의 이상에 대비하여 인체의 면역력을 증진시키기 위한 온갖 수단을 강구하고 있으며, 실제로도 건강을 지키기 위한 시간의 투자와 함께 경제적인 부분에서도 많은 지출이 따르고 있다. As described above, according to the decline of the immune function, modern people living in the modern world are taking all kinds of measures to improve the immunity of the human body in preparation for the right of health and the abnormality of health that may occur in the future. In addition to investment, there is also a lot of spending on the economic side.
인체의 면역력을 증진시키기 위해 현대인들이 가장 노력하고 있는 것이 운동과 건강보조식품의 복용이라 할 수 있다. 이러한 운동과 건강보조식품의 경우는 시간과 경제적인 부담이 다른 것에 비해 덜하기 때문에 건강을 지키기 위한 수단으로써 가장 애용되고 있다.The most active effort by modern people to improve the body 's immunity is to take exercise and health supplements. These exercises and health supplements are most often used as a means of maintaining health because they are less time and economic burdens than others.
특히, 건강보조식품의 경우는 수많은 종류의 것들이 우리의 생활 주변에 즐비하기 때문에 자신의 건강상태나 취향에 따라 골라서 복용할 수 있다. 이러한 건강보조식품은 신체의 육체적, 생리적 측면에서 유용성을 기대하여 섭취할 목적으로 식품 소재에 함유된 성분을 그대로 원료로 하거나 이들에 들어 있는 특정 성분을 분리 또는 추출, 농축, 정제, 혼합 등의 방법으로 제조 가공한 식품을 말하는 것이다. Especially, in the case of health supplements, many kinds of things are around our life, so they can be taken according to their health condition or taste. These health supplements are intended to be used for the purpose of consuming in the physical and physiological aspects of the body, in order to consume the ingredients contained in the food material as they are, or to separate or extract specific components contained therein, concentrate, refine, Which is manufactured and processed.
그러나 이러한 건강보조식품은 액상의 진공포장으로 시중에 유통되고 있는 것이 대부분이어서, 복용이나 휴대에 있어 많은 불편함이 따르고 있다. 특히, 액상을 싫어하는 사람은 복용에 어려움이 있고, 휴대하는 경우도 액상의 진공포장은 많은 제약을 받게 된다.However, most of these health supplements are distributed in the market as liquid vacuum packs, and many inconveniences are involved in taking and carrying them. In particular, people who do not like liquids have difficulties in taking them, and even when carrying them, liquid-phase vacuum packaging is subject to many restrictions.
따라서, 이러한 문제점을 해결하기 위해 환(丸) 형의 건강보조식품들이 출시됨에 따라 복용의 불편함이나 휴대의 불편함을 해소하였다.Therefore, in order to solve such a problem, circulation type health supplement foods have been released, thereby solving the inconvenience of taking or the inconvenience of carrying.
상기한 환 형의 건강보조식품으로는 다음과 같은 종래기술들이 있다.As the above-mentioned annular health supplement food, there are the following conventional techniques.
먼저, 대한민국 등록특허 제10-0705740호는 유산균 및 청국장을 제환기를 이용하여 환으로 성형하고, 건조하여 기능성의 환을 제조하는 방법을 제안하였다. 또한, 대한민국 등록특허 제10-1083458호에서는 흑마늘을 유효성분으로 하는 환의 제조방법이 제안되었는바, 흑마늘, 아가콩, 알파미를 일정한 비율로 혼합하여 반죽하고, 압출하여 환을 제조하는 방법을 제안하였다. 그리고 대한민국 등록특허 제10-1552389호에서는 초마늘과 죽염을 이용하여 환을 제조하는 방법을 제안하였다.First, Korean Patent No. 10-0705740 proposes a method of molding a lactic acid bacterium and a cheonggukjang into a ring using a ventilator and drying to produce a functional ring. Korean Patent No. 10-1083458 proposes a method for producing a ring containing black garlic as an active ingredient and suggests a method for producing a ring by mixing black gum, Respectively. Korean Patent No. 10-1552389 proposes a method of manufacturing a ring using ginger and bamboo salt.
상기한 제조방법들은 모두 복용 및 휴대의 불편함을 해소하였다.All of the above-mentioned manufacturing methods have solved the inconvenience of taking and carrying.
그러나 상기 선행기술들의 어디에서도 니파야자와 재거리를 이용하여 환을 제조한 예는 찾아볼 수 없었다.However, none of the above prior arts have ever found an example of manufacturing a ring using Nipahaya and ash.
따라서, 본 발명의 목적은 니파야자의 꽃대 추출액, 분말 및 재거리를 이용하여 환을 제조함으로써, 항산화 효능 및 항염증 효능이 우수하며, 영양성이 우수하도록 하는 것이다. Accordingly, an object of the present invention is to provide an antioxidative and anti-inflammatory effect and nutritional superiority by producing a ring using the extract of Liliaceae, powder and ash.
또한, 관능성 역시 우수하여 섭취가 용이하며, 스테로이드계 약물의 사용을 대체하고자 하는 데 그 목적이 있다.In addition, it is also excellent in the sensory properties and easy to ingest, and is intended to replace the use of steroid drugs.
상기한 목적을 달성하기 위한 본 발명의 니파야자와 재거리를 이용한 기능성 환의 제조방법은, 니파야자 꽃대 추출액을 준비하는 단계와, 니파야자의 꽃대를 분말로 제조하는 단계와, 상기 준비된 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 혼합하는 단계와, 상기 혼합된 혼합물을 환(丸)으로 성형하는 단계와, 상기 성형된 환의 표면에 재거리 농축액을 도포하는 단계와, 상기 재거리 농축액이 도포된 환을 건조하는 단계를 포함하는 것을 특징으로 한다. In order to accomplish the above object, the present invention provides a method for producing a functional ring using a distance between a nifa and a nifa, comprising the steps of preparing an extract of a nifa palm flower, preparing a nifaya flower as a powder, Comprising the steps of: mixing a pedicel powder and a re-distillation concentrate; molding the mixed mixture into a circle; applying a re-distillation concentrate to the surface of the formed ring; And drying the dried product.
상기 니파야자 꽃대 추출액을 준비하는 단계는, 니파야자의 꽃대를 절단하는 단계와, 상기 절단된 니파야자의 꽃대를 물을 용매로 하여 열수추출 또는 초음파추출하는 단계와, 상기 추출된 추출물을 농축하는 단계를 포함하는 것을 특징으로 한다.The step of preparing the extract of Nihon palm phlox may include the steps of cutting a flower bud of Nipaya, a step of extracting or ultrasonically extracting the flower bud of the cut Nipaya with water as a solvent, The method comprising the steps of:
니파야자의 꽃대를 분말로 제조하는 단계는, 니파야자의 꽃대를 절단하는 단계와, 상기 절단된 니파야자의 꽃대를 끓는 물에 데치는 단계와, 상기 데친 니파야자의 꽃대를 건조하는 단계와, 상기 건조된 니파야자의 꽃대를 분쇄하는 단계를 포함하는 것을 특징으로 한다.The step of producing the flower bud of nifayja as a powder includes the steps of cutting the flower bud of nifaya, the step of putting the flower bud of the cut nifaya into boiling water, drying the flower bud of the nepaya flower, And pulverizing the flower bud of the dried nippae.
상기 준비된 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 혼합하는 단계는, 상기 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 1:0.5~1.5: 0.2~0.5 중량비로 혼합하는 것을 특징으로 한다.The step of mixing the prepared pedicel extract, pedicel powder and retroreflective concentrate is characterized by mixing the pedicel extract, pedicel powder and retroreflective concentrate at a weight ratio of 1: 0.5 to 1.5: 0.2 to 0.5.
상기 재거리 농축액은, 재거리 100중량부에 대해 정제수 25~120중량부를 용기에 투입하는 단계와, 상기 재거리와 정제수가 투입된 용기의 내부 온도가 50~70℃가 되도록 하여 30분~120분간 재거리를 용해하고 농축하는 단계와, 상기 용해, 농축된 재거리 농축액을 필터로 걸러 내는 단계를 포함하여 제조된 것임을 특징으로 한다. The re-distillation concentrate is prepared by introducing 25 to 120 parts by weight of purified water into 100 parts by weight of the re-distillation into the vessel, and allowing the re-distillation and the purified water to stand at 50 to 70 ° C for 30 to 120 minutes Dissolving and concentrating the re-distillation, and filtering the dissolved and concentrated distillate concentrate through a filter.
그리고 본 발명에 의한 기능성 환은, 상기한 방법들로 제조되는 것을 특징으로 한다.The functional ring according to the present invention is characterized by being manufactured by the above-described methods.
본 발명에 의하면, 니파야자의 수액 농축액, 꽃대 등의 항산화 활성 및 항염증 효능으로 섭취자의 건강유지를 돕는 장점이 있다.According to the present invention, an antioxidative activity and an anti-inflammatory effect of a liquid concentrate, a flower bud, etc. of NiPhaya have an advantage of helping the health of the consumer.
또한, 관능성이 우수하여 섭취가 용이한 장점이 있다. In addition, it has an advantage of being excellent in the sensibility and easy to ingest.
도 1은 본 발명에 따른 니파야자와 재거리를 이용한 기능성 환의 제조공정도.
도 2 내지 5는 본 발명의 시험예 2에 따른 결과를 나타낸 그래프.BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process flow diagram for manufacturing a functional ring using a distance between a nipa and a nipa according to the present invention.
2 to 5 are graphs showing the results according to Test Example 2 of the present invention.
이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명의 기능성 환은 항산화 및 항염증 효능을 갖는 것으로, 환을 건강보조식품으로서 섭취하는 것만으로 인체에 우수한 항산화력 및 항염증력을 부여하는 효과가 있다.The functional ring of the present invention has antioxidant and anti-inflammatory effects, and has an effect of imparting excellent antioxidative and anti-inflammatory properties to the human body just by ingesting the ring as a health supplement.
이러한 본 발명의 기능성 환은 니파야자와 재거리를 이용하여 제조하는 것이다.Such a functional ring of the present invention is produced by using the distance between the nipahaya and the nipah.
여기서, 상기 니파야자(학명 : Nypa fruticans)는 인도, 말레이시아를 비롯한 동남아시아 및 오스트레일리아가 원산지이며, 맹그로브 지대 등의 습지에서 자란다. 뿌리는 땅속에서 여러 개로 갈라지며, 잎은 지면에서 뭉쳐나고 광택이 있는 녹색을 띤다. 그리고 꽃은 암수한그루이며, 지면의 잎겨드랑이에서 나오는데, 보통 10월에서 이듬해 6월 사이에 꽃대가 올라온다. Here, the Nypa fruticans originate in India, Malaysia, Southeast Asia and Australia, and grow in wetlands such as mangroves. The roots are divided into several pieces in the ground, and the leaves are gathered on the ground and have glossy green. And the flower is one male and one female, and it comes out from the axilla of the ground. Usually, the flower stands rise from October to June of the following year.
본 발명은 이러한 니파야자의 꽃대를 채취하고, 이를 가공하여 환으로서 제조하는 것인데, 특히 니파야자의 꽃대를 사용하는 이유는 니파야자의 다른 어떤 부위보다 꽃대에 폴리페놀 등의 항산화 성분이 풍부하고, 셀레늄 등의 각종 영양성분이 풍부할 뿐 아니라, 우수한 항염증 효능을 보이기 때문이다.The reason for using the flower buds of Nipaya is that it has abundant antioxidant components such as polyphenols in the flower bud than any other part of Nipaya, Selenium and other nutritional components, as well as show excellent anti-inflammatory effect.
상기 니파야자 꽃대의 성분분석 및 검사 결과를 하기 표 1 및 표 2에 나타내었는바, 상기 니파야자의 꽃대는 폴리페놀, 플라보노이드, 사포닌 등은 물론, 아스파르트산, 티로신, 히스티딘 등의 유효성분을 다량 함유한다. The results of the analysis and the results of the components of the above-mentioned Nihonpalaceae are shown in the following Tables 1 and 2. As shown in Table 1 and Table 2, the Niha-Paya's peduncle contains a large amount of effective components such as polyphenol, flavonoid, saponin, as well as aspartic acid, tyrosine and histidine .
따라서, 이러한 니파야자 꽃대를 이용하여 기능성의 환을 제조하면, 우수한 항산화력을 가지는 것은 물론, 셀레늄 등을 통해 항암 작용을 갖게 되는 등 인체에 유익한 효과를 부여하게 된다.Therefore, when a functional ring is manufactured using such a nifa palm phlox, it has an excellent antioxidant ability, and has an anticancer effect through selenium or the like, and gives a beneficial effect to the human body.
또한, 재거리(jaggery)는 인도에서 가장 널리 사용되는 감미료로서, 아시아, 아프리카, 라틴 아메리카 및 캐리비안에서 소비되는 전통적인 정제되지 않은 설탕이다. 재거리는 사탕수수나 야자수 즙으로부터 당밀이나 결정을 분리하지 않고 농축된 상태로 제조되며 황금색 진한 갈색을 띤다. 재거리는 약 50% 수크로스, 20%의 전화당 및 회분, 단백질, 섬유 등의 기타 불용성 성분을 함유하고 있다. 보통 설탕은 사탕수수를 화학적으로 처리하기 때문에 모든 영양소가 제거되나, 재거리는 사탕수수나 야자수 즙을 화학처리 없이 졸여서 제조되기 때문에 천연 미네랄이 설탕보다 50배 이상 많이 함유하고 있다. 또한, 정제 설탕에 들어있는 당은 가장 단순한 형태라서 몸에 들어오자마자 바로 혈관에서 흡수되어 에너지를 한꺼번에 방출해버리지만, 재거리는 당과 미네랄이 복합적으로 작용하는데다 당이 연결고리가 상대적으로 긴 체인의 형태를 띠고 있어 몸에 흡수되는 속도가 느리고 따라서 에너지를 천천히 발산해 설탕보다 몸에 좋다. 이에 재거리는 '약용 설탕'이라 불린다. 상기 재거리는 철이 풍부하여 빈혈이 있는 사람이나 임산부에게 유용하며, 나트륨 함량이 상대적으로 낮아 혈압을 조절하는데 유용하다. 또한, 재거리는 체내 수분 함량을 낮추는 효과가 있어서 다이어트에 좋으며, 항산화제가 풍부하여 자유라디칼을 제거하는데 유익하다. 더욱이 재거리는 몸을 세정하고, 소화제로서 작용하기도 한다. In addition, jaggery is the most widely used sweetener in India and is a traditional unpurified sugar consumed in Asia, Africa, Latin America and the Caribbean. The distillation is produced from sugarcane or palm juice in concentrated form without separating molasses or crystals and has a golden brown color. The re-distillation contains about 50% sucrose, 20% phosgene and other insoluble components such as ash, protein and fiber. Normally, sugar treats sugar cane chemically, so all nutrients are removed, but the re-distillation is made by sucking sugarcane or palm juice without chemical treatment, so natural minerals contain more than 50 times more sugar than sugar. In addition, the sugar contained in refined sugar is the simplest form. As soon as it enters the body, it is immediately absorbed from the blood vessels and releases energy at once. However, since the sugar and minerals are mixed, the sugar chain has a relatively long chain The body is absorbed at a slow rate of absorption and thus slowly emits energy to the body better than sugar. This distance is called 'medicinal sugar'. The re-distance is useful for people with anemia and pregnant women who are rich in iron, and the sodium content is relatively low, which is useful for controlling blood pressure. In addition, re-distance is effective in lowering the moisture content of the body, which is good for diet, and is rich in antioxidants and is useful for removing free radicals. Moreover, re-distillation also cleanses the body and acts as an extinguishing agent.
따라서, 이러한 재거리를 본 발명의 기능성 환에 사용할 경우, 높은 항산화 효능을 나타내도록 하는 것은 물론, 환의 관능성은 좋게할 수 있게 된다. Therefore, when such a re-distance is used in the functional ring of the present invention, it is possible not only to exhibit a high antioxidative effect, but also to improve the functionality of the ring.
본 발명에 따른 기능성 환을 제조하는 방법은, 구체적으로 니파야자 꽃대 추출액을 준비하는 단계와, 니파야자의 꽃대를 분말로 제조하는 단계와, 상기 준비된 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 혼합하는 단계와, 상기 혼합된 혼합물을 환(丸)으로 성형하는 단계와, 상기 성형된 환의 표면에 재거리 농축액을 도포하는 단계와, 상기 재거리 농축액이 도포된 환을 건조하는 단계를 포함한다.The method for producing a functional ring according to the present invention comprises the steps of preparing an extract of a nifa palm flower, preparing a flower bud of a nifaya flower, and mixing the prepared flower bud extract, Molding the mixed mixture into a circle, applying a remoteness concentrate to the surface of the formed annulus, and drying the ring coated with the remoteness concentrate.
이하, 도 1을 참조하여 본 발명을 단계별로 설명한다.Hereinafter, the present invention will be described step by step with reference to Fig.
니파야자Nipa 꽃대 추출액을 준비하는 단계. Preparing a pedicel extract.
먼저, 니파야자의 꽃대로부터 추출물을 추출한다.First, the extract is extracted from the flower bud of Nipaya.
그 방법은 구체적으로, 니파야자의 꽃대를 3~10cm의 크기로 절단하는 단계와, 상기 절단된 니파야자의 꽃대를 물을 용매로 하여 열수추출 또는 초음파추출하는 단계와, 상기 추출된 추출물을 농축하는 단계를 포함한다.Specifically, the method comprises the steps of: cutting a flower bud of nipaya into a size of 3 to 10 cm; subjecting the flower bud of the cut nipaya to hot water extraction or ultrasonic extraction using water as a solvent; .
여기서 열수추출이란, 상기 니파야자의 꽃대의 10~20중량배 정도의 물을 가한 후, 80~100℃의 온도에서 10~20시간 추출하는 것이고, 초음파 추출은 니파야자 꽃대의 8~12중량배의 물을 가한 후, 초음파 추출기를 이용하여 100~150kHz 정도의 조건으로 20~30분간 전처리하고, 이를 다시 50~60℃의 온도에서 열수추출을 10~12시간하는 것이다.Here, the hot water extraction is a method of extracting water at a temperature of 80 to 100 ° C for 10 to 20 hours after adding water of about 10 to 20 times the weight of the flower bud of the above-mentioned Nepalaya, and ultrasonic extraction is performed at 8 to 12 times And the mixture is pre-treated for 20 to 30 minutes under the condition of about 100 to 150 kHz by using an ultrasonic wave extractor, and further subjected to hot water extraction for 10 to 12 hours at a temperature of 50 to 60 ° C.
또한, 추출효율을 높이기 위하여 상기 절단된 니파야자를 자연건조, 냉풍건조 또는 열풍건조하여 함수율 10~20%가 되도록 한 후, 이를 100~200mesh 정도로 분쇄하고, 이러한 분말로부터 유효성분을 추출할 수 있다. 아울러, 상기 절단된 니파야자 꽃대를 100℃의 끓는 물에 10~20분간 데친 후, 상기 데친 꽃대를 탈수하고, 이로부터 유효성분을 추출할 수도 있다. In order to increase the extraction efficiency, the cut nipaya is subjected to natural drying, cold air drying or hot air drying to have a water content of 10 to 20%, followed by pulverization to a size of about 100 to 200 mesh, and extracting the active ingredient from the powder . In addition, it is also possible to dehydrate the cut nippa coconut palms in boiling water at 100 ° C for 10 to 20 minutes, dehydrate them, and extract the active ingredient therefrom.
그리고 상기 농축은 감압 농축하는 것을 의미하는 것으로, 50~60℃에서 용매를 제거하여 20~50Brix 정도로 농축하는 것이다. 또한, 필요에 따라 농축 전, 여과할 수 있음은 당연하며, 상기 농축액을 동결건조하여 분말화하여 사용할 수도 있는 것으로, 상기 동결건조는 이 기술이 속하는 분야에서 공지된 방법을 따르므로, 이에 대한 상세한 설명은 생략한다.The concentration means concentration under reduced pressure, and the solvent is removed at 50 to 60 ° C to concentrate the solution to about 20 to 50 Brix. The concentrate may be lyophilized and pulverized. The lyophilization is carried out according to a method known in the art to which the present invention belongs. The description is omitted.
니파야자의Nipaya 꽃대를 분말로 제조하는 단계. The step of preparing the flower bud as a powder.
한편, 상기 추출액의 제조와는 별도로, 니파야자의 꽃대를 분말로 제조한다. 그 방법은, 니파야자의 꽃대를 절단하는 단계와, 상기 절단된 니파야자의 꽃대를 끓는 물에 데치는 단계와, 상기 데친 니파야자의 꽃대를 건조하는 단계와, 상기 건조된 니파야자의 꽃대를 분쇄하는 단계를 포함한다. Separately from the preparation of the extract, the flower bud of nipaya is prepared as a powder. The method comprises the steps of cutting a flower bud of Nipaya, a step of putting the flower bud of the cut Nipaya flower into boiling water, drying the flower bud of the flavored Nipaya flower, pulverizing the dried flower bud of Nipaya flower, .
이를 상세히 설명하면, 먼저 니파야자의 꽃대를 채취하고, 이를 3~10cm의 길이 및 1cm 내외의 폭으로 절단한다. 그리고 절단된 꽃대를 끓는 물, 즉 100℃의 물에 2~10분간 데친다. 그리고 데친 꽃대를 수분함유율 10% 이내, 바람직하게는 5~10%가 되도록 건조한다. 이때, 상기 건조방법으로는 온풍건조, 냉풍건조 및 자연건조 등을 이용할 수 있는 것으로, 그 실시를 제한하지 않는다. 그리고 최종적으로 건조된 꽃대를 분쇄기로 200~300mesh 정도로 분쇄한다.To describe this in detail, first take a flower bud of Nipaya and cut it into a length of 3 to 10 cm and a width of about 1 cm. Then, cut the peduncle into boiling water, that is, water at 100 ° C for 2 to 10 minutes. Then, it is dried so as to have a moisture content of 10% or less, preferably 5 to 10%. At this time, as the drying method, hot air drying, cold air drying, natural drying, or the like can be used. Finally, the dried flower bud is pulverized to about 200 to 300 mesh by a pulverizer.
여기서, 본 발명은 니파야자의 꽃대를 이용하는 것이나, 니파야자의 꽃봉오리에도 인체 유익성분이 다량 함유되어 있으므로, 꽃대에 형성된 꽃봉오리를 제거하지 않고 그대로 사용할 수 있음은 당연하다.Here, it is natural that the present invention can be used as it is without removing the buds formed on the flower buds, since the flower buds of Nepalaya are used and the flower buds of Nepalaya contain a large amount of human beneficial ingredients.
상기 준비된 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 혼합하는 단계.Mixing the prepared pedicel extract, pedicel powder and ash-distillate concentrate.
다음으로, 상기 준비된 꽃대 추출액, 꽃대 분말을 재거리 농축액과 혼합한다. Next, the prepared pedicel extract and pedicel powder are mixed with the distillate concentrate.
상기 꽃대 추출액, 꽃대 분말 및 재거리 농축액의 혼합비는, 1:0.5~1.5: 0.2~0.5 중량비로 혼합하는 것이 바람직한바, 이러한 혼합비를 가질 경우 그 항산화 효능 및 항염증 효능이 가장 우수하면서도 관능성 역시 좋기 때문이다. It is preferable that the mixing ratio of the flower bud extract, flower bud powder and ash-distilled condensate is 1: 0.5 ~ 1.5: 0.2 ~ 0.5 weight ratio. When the mixing ratio of the flower bud extract and flower bud powder is as high as that of anti- Because it is good.
본 발명에서 상기 니파야자의 꽃대 추출액과 꽃대 분말을 함께 사용하는 이유는, 환의 항산화 및 항염 효과를 최대치로 높이면서도, 성형성을 좋게 하기 위함이다. 즉, 상기 꽃대 분말만을 사용할 경우 별도의 물이나 용매를 첨가하여 반죽하고, 환으로서 성형해야하는 바, 이러한 용매를 꽃대 추출액으로 이용함으로써 그 항산화 및 항염효능을 높이는 것이다. In the present invention, the flower bud extract of Nipaya is used together with the flower bud powder to maximize the antioxidative and anti-inflammatory effects of the ring, and to improve the moldability. That is, when only the above-described pedicel powder is used, it is necessary to add another water or a solvent to be kneaded and form it as a ring. The use of such a solvent as a flower base extract enhances its antioxidant and anti-inflammatory activity.
또한, 상기 재거리 농축액은 상기 혼합물에 점착성을 부여하여 성형을 용이하게 하는 것은 물론, 특유의 단맛과 풍미로 인해 환의 관능성을 좋게 한다. 또한, 상기 재거리는 철이 풍부하고, 나트륨 함량이 낮으며, 당이 몸에 흡수되는 속도가 느려 다이어트에 좋고, 항산화제가 풍부하여 자유라디칼을 제거하는 데 유익한 효과가 있다. In addition, the re-distillation concentrate imparts tackiness to the mixture to facilitate the molding, as well as to improve the sensuality of the ring due to its unique sweetness and flavor. In addition, the above-mentioned distance is rich in iron, low in sodium content, slow in absorbing sugar into the body, good for diet, and rich in antioxidants, which is beneficial for removing free radicals.
상기 혼합된 혼합물을 환(丸)으로 성형하는 단계.And molding the mixed mixture into a circle.
그리고 상기 혼합된 혼합물을 환으로 성형한다. 환으로의 성형 방법은 종래 공지된 방법, 즉 제환기 등을 이용하며, 환의 크기, 즉 환의 직경을 제한하지 않는다. And the mixed mixture is molded into a ring. The method of molding into a ring uses a conventionally known method, that is, a ventilator or the like, and does not limit the size of the ring, that is, the diameter of the ring.
상기 remind 성형된Molded 환의 표면에 On the surface of the ring 재거리Distance 농축액을 도포하는 단계. Applying the concentrate.
다음으로, 성형된 환의 표면에 재거리 농축액을 도포한다.Next, the distance distillate is applied to the surface of the formed ring.
상기 재거리 농축액은 앞서 설명한 바와 같이, 영양이 풍부하고, 항산화성이 우수한 특징을 갖는 것으로, 본 발명에서는 상기 재거리 농축액으로 환의 표면을 코팅함으로써, 환이 쉽게 붕괴되는 것을 방지한다. 또한, 표면에 코팅된 재거리 농축액으로 인해 환의 관능성이 현저히 개선됨으로써, 남녀노소 누구나 환을 손쉽게 섭취할 수 있도록 한다. 이때, 상기 재거리 농축액의 도포방법 및 두께는 제한하지 않으나, 예시적으로 0.5~1mm의 두께로 도포할 수 있다. As described above, the re-distilled concentrate is rich in nutrition and has excellent antioxidative properties. In the present invention, the surface of the ring is coated with the re-distilled concentrate to prevent the ring from easily collapsing. In addition, the surface distillate coated on the surface significantly improves the sensuality of the mouth, so that men and women of all ages can easily ingest the mouth. At this time, the method and thickness of the re-distilled concentrate are not limited, but may be applied in a thickness of 0.5-1 mm for example.
즉, 본 발명에서 상기 성형된 환의 표면에 재거리 농축액을 도포하는 이유는, 그 외관을 미려하게 하여 상품성을 높이고, 관능성을 좋게 하는 것은 물론, 환의 붕괴를 방지하기 위함이다. That is, in the present invention, the reason for applying the re-distillation concentrate on the surface of the formed ring is to prevent the collapse of the ring as well as to enhance the merchantability and the sensibility by making the appearance more beautiful.
상기 remind 재거리Distance 농축액이 도포된 환을 건조하는 단계. Drying the concentrate-applied ring.
최종적으로, 상기 재거리 농축액이 도포된 환을 건조한다. 이때, 상기 건조방법은 자연건조 및 냉풍건조를 이용한다.Finally, the re-distilled concentrate is dried with the applied ring. At this time, the drying method uses natural drying and cold air drying.
상기한 방법으로 제조된 본 발명의 기능성 환은 항산화 및 항염증 능력이 우수하여, 섭취자의 건강증진에 도움을 주는 것이다. The functional ring of the present invention produced by the above-mentioned method has excellent antioxidant and anti-inflammatory ability, and thus helps the health of the consumer.
본 발명의 기능성 환은 건강보조식품으로서, 그 섭취량을 제한하지 않으나, 직경이 0.7~1cm로 성형된 환을 1알/day 섭취하는 것이 바람직하다.The functional ring of the present invention is a health supplement, and its intake amount is not limited, but it is preferable to ingest 1 ring / day of a ring formed with a diameter of 0.7 to 1 cm.
한편, 앞서 사용된 재거리 농축액의 제조방법에 대해 설명한다. On the other hand, a method of manufacturing the previously used re-distilled concentrate will be described.
상기 재거리 농축액은 재거리 100중량부에 대해 정제수 25~120중량부를 용기에 투입하는 단계와, 상기 재거리와 정제수가 투입된 용기의 내부 온도가 50~70℃가 되도록 하여 30분~120분간 재거리를 용해하고 농축하는 단계와, 상기 용해, 농축된 재거리 농축액을 필터로 걸러 내는 단계를 통해 제조된다. Wherein the re-distillation concentrate comprises the steps of charging 25 to 120 parts by weight of purified water per 100 parts by weight of the re-distillation into the vessel, and mixing the re-distillate and purified water into the vessel for 30 to 120 minutes Dissolving and concentrating the distillate, and filtering out the dissolved, concentrated distillate concentrate.
이를 상세히 설명하면, 먼저 재거리와 정제수를 용기에 투입한다. 여기서, 상기 재거리와 정제수의 혼합비는 재거리 100중량부를 기준으로 정제수 25~120중량부를 투입하는데, 이는 정제수가 25중량부보다 적을 경우 물이 적어 재거리가 용해되어 농축되기 어렵고 정제수가 120중량부보다 많은 경우 과량이 되어 전체적으로 농축액이 묽어지기 때문이다. 다음으로, 상기 용기의 내부 온도가 50~70℃가 되도록 하여 30분~120분간 재거리를 용해하고 농축한다. 이때, 상기 재거리와 정제수가 투입된 용기의 내부 온도를 50~70℃로 하는 이유는 온도가 50℃보다 낮을 경우 농축액의 제조가 오래 걸려 생산성이 좋지 못하게 되고, 70℃보다 높을 경우 과도한 에너지를 소비하게 되어 비효율적일 뿐만 아니라 정제수가 필요 이상 증발되기 때문이다. 상기 재거리의 용해 및 농축은 30분~120분간 실시하는데, 이는 재거리의 양에 따라 달라질 수 있는 것으로, 그 시간을 제한하는 것은 아니다. 다음으로, 재거리의 농축액이 제조되면, 이를 필터로 걸러낸다. 상기 필터링을 하는 이유는 재거리의 경우 정제하지 않은 원당 덩어리이므로, 내부에 불순물이나 야자나무의 찌꺼기 등이 포함될 수 있어 이를 필터로 걸러내는 것이다. 여기서, 상기 필터의 종류는 제한하지 않으며 가장 쉽게는 가정에서 쉽게 사용하는 면포 등을 이용할 수 있다.To explain this in detail, first, re-distance and purified water are put into the container. In this case, 25 to 120 parts by weight of purified water is added based on 100 parts by weight of the distillation distance. When the purified water is less than 25 parts by weight, water is hardly dissolved due to low water content, More than one part is excessive and the concentrate becomes thin as a whole. Next, the re-distance is dissolved and concentrated for 30 to 120 minutes so that the inner temperature of the container becomes 50 to 70 ° C. When the temperature is lower than 50 ° C, the production of the concentrate takes a long time and the productivity becomes poor. When the temperature is higher than 70 ° C, excessive energy is consumed Not only is it inefficient, but also the purified water is evaporated more than necessary. The dissolution and concentration of the re-distance is carried out for 30 minutes to 120 minutes, which may vary depending on the amount of re-distance, and does not limit the time. Next, when the concentrate of the re-distillation is produced, it is filtered out. The reason for performing the filtering is that it is a raw lump of a raw material which is not refined in the case of re-distance, so that impurities or residues of palm trees may be contained therein, and the filter is filtered. Here, the type of the filter is not limited, and it is most easily possible to use a cotton cloth or the like that is easily used at home.
또한, 상기 재거리 농축액에 비타민 A, C, D, E, K, 티아민, 니아신, 비타민 B6, 엽산, 비타민 B12 및 판토텐산으로 이루어진 군으로부터 선택되는 적어도 하나 이상을 재거리 농축액 100중량부에 대해 각각 1~3중량부만큼 혼합할 수 있는바, 이러한 영양성분을 투입함으로써 전체적인 기능성 환의 영양성을 높일 수 있다. At least one selected from the group consisting of vitamins A, C, D, E, K, thiamine, niacin, vitamin B6, folic acid, vitamin B12 and pantothenic acid is added to the
이하, 본 발명을 구체적인 실시예를 통해 더욱 상세히 설명한다.Hereinafter, the present invention will be described in more detail with reference to specific examples.
(제조예 1)(Production Example 1)
먼저, 니파야자 꽃대를 채취하고, 깨끗이 세척한 후, 이를 10cm 길이 및 1cm 폭으로 절단하였다. 그리고 이를 100℃의 끓는 물에 3분간 데쳤다. 그리고 이를 그대로 자연건조하여 수분함유율이 7%가 되도록 한 후, 분쇄기로 분쇄하여 200mesh의 분말로 제조하였다. First, the nipponia palms were picked, cleaned and then cut into 10 cm lengths and 1 cm widths. Then, it was boiled in boiling water at 100 ° C for 3 minutes. Then, the mixture was naturally dried to have a moisture content of 7%, and then pulverized by a pulverizer to prepare a 200-mesh powder.
(시험예 1)(Test Example 1)
니파야자 꽃대의 항산화력 평가.Evaluation of Antioxidative Capacity of.
제조예 1과 같이 제조한 니파야자 꽃대의 항산화력을 측정하였다.The antioxidative capacity of the nifalcaya peduncle prepared in Preparation Example 1 was measured.
(1) 시료의 추출(1) Extraction of sample
시료의 에탄올 추출은 시료량의 9배량(w/v)의 95% 에탄올을 가하고, 상온에서 자동교반기를 이용하여 1주일 동안 교반하면서 1차 추출한 후, 여과지(Advantec No.2, Toyo Roshi Kainshm Ltd., Tokyo, Japan)를 사용하여 여과하여 rotary vacuum evaporator(EYELAA-1000S, Tokyo Rikakikai Co., Tokyo, Japan)로 40℃에서 감압농축하여 건조시킨 후 냉동보관하면서 실험에 사용하였다.The ethanol extract of the sample was prepared by adding 95% ethanol of 9 times the amount of the sample (w / v), firstly extracting it with stirring at room temperature for 1 week using an automatic stirrer, and filtering paper (Advantec No. 2, Toyo Roshi Kainshm. , Tokyo, Japan), and concentrated under reduced pressure at 40 ° C in a rotary vacuum evaporator (EYELAA-1000S, Tokyo Rikakikai Co., Tokyo, Japan).
(2) DPPH radical 소거능 측정(2) Measurement of DPPH radical scavenging ability
항산화 활성 측정은 DDPH(1,1-diphenyl-2-picryhydrazyl, Sigma-Aldrich Co.)를 이용하여 시료의 라디칼 소거효과를 보는 Biois법을 활용하였다. 각 추출물을 농도별 0.625~10mg/ml로 제조한 시료 용액 1ml에 0.2mM DPPH 1ml를 넣고, vortex mixer를 사용하여 혼합하고 암실에서 30분간 반응시킨 후 517nm에서 흡광도를 측정하였다. 그리고 아래의 식을 이용하여 free radical scavenging activity 곡선을 작성한 후, IC50을 산출하였으며, 양성대조군으로 ascorbic acid를 사용하였다. To determine the antioxidant activity, the Biois method was used to examine the radical scavenging effect of DDPH (1,1-diphenyl-2-picryhydrazyl, Sigma-Aldrich Co.). 1 ml of 0.2 mM DPPH was added to 1 ml of the sample solution prepared from 0.625 to 10 mg / ml of each extract, mixed using a vortex mixer, reacted for 30 minutes in a dark room, and absorbance was measured at 517 nm. Then, free radical scavenging activity curves were generated using the following equation, and IC 50 was calculated. As a positive control, ascorbic acid was used.
Radical scavenging activity(%)={(control Absorbance - Sample Absorbance)/control Absorbance}×100Radical scavenging activity (%) = {(control Absorbance - Sample Absorbance) / control Absorbance} × 100
(3) ABTS radical 소거능 측정(3) Measurement of ABTS radical scavenging ability
ABTS radical 소거능 측정은 Pellegrin 등의 방법으로 측정하였다. 7mM ABTS(2,2'-azinobis(3-ethylenbenzothiazoline-6-sulfonate), Sigma-Aldrich Co.) 5ml와 140mM K2S2O8(Sigma-Aldrich Co.) 88㎕를 잘 섞어 16시간 이상 암소에 방치시켰다. ABTS radical scavenging activity was measured by Pellegrin et al. 5 ml of 7 mM ABTS (2,2'-azinobis (3-ethylenbenzothiazoline-6-sulfonate), Sigma-Aldrich Co.) and 88 μl of 140 mM K 2 S 2 O 8 (Sigma-Aldrich Co.) .
이를 absolute ethanol과 1:88 비율로 섞어 734nm에서 대조구의 흡광도 값이 0.7±0.002가 되도록 조절한 ABTS solution을 만들었다. 시료 용액 50㎕에 ABTS solution 1ml를 넣어 혼합하고, 2.5분간 암실에서 방치한 후, 734nm에서 흡광도를 측정하였다.The mixture was mixed with absolute ethanol at a ratio of 1:88, and the ABTS solution was prepared so that the absorbance of the control was adjusted to 0.7 ± 0.002 at 734 nm. 1 ml of ABTS solution was added to 50 μl of the sample solution, and the mixture was allowed to stand in a dark room for 2.5 minutes, and the absorbance was measured at 734 nm.
그 결과는 하기 표 3 및 표 4에 나타내었다.The results are shown in Tables 3 and 4 below.
(mg/ml)Concentration
(mg / ml)
(mg.ml)IC 50
(mg.ml)
0.125
0.0625
0.03125
0.156250.025
0.125
0.0625
0.03125
0.15625
51.52±1.09
26.74±1.51
13.93±2.09
7.82±0.3785.83 + - 0.22
51.52 ± 1.09
26.74 1.51
13.93 ± 2.09
7.82 + - 0.37
0.5
0.25
0.125
0.0625One
0.5
0.25
0.125
0.0625
44.73±0.74
36.62±0.49
30.87±0.41
28.79±0.4160.70 + - 0.47
44.73 + - 0.74
36.62 ± 0.49
30.87 + - 0.41
28.79 + - 0.41
0.5
0.25
0.125
0.0625One
0.5
0.25
0.125
0.0625
37.41±0.41
32.67±0.43
30.27±0.14
28.98±0.4344.89 + - 0.41
37.41 + - 0.41
32.67 + - 0.43
30.27 + - 0.14
28.98 + - 0.43
IC50 값은 추출물을 첨가하지 않은 대조군의 값을 50% 감소시키는 추출물의 농도를 나타낸 것으로, IC50 값이 작을수록 항산화 활성이 높은 것을 뜻한다. 따라서 상기 표 3에서와 같이, DPPH radical scavenging activity 측정 결과에 따르면 니파야자 꽃대의 항산화능은 블루베리에 비하여 약 40배 높고, 홍삼에 비해 약 75배 높음을 알 수 있었다.The IC 50 value represents the concentration of the extract which reduces the value of the control without the extract by 50%. The smaller the IC 50 value, the higher the antioxidant activity. Therefore, as shown in Table 3, according to DPPH radical scavenging activity measurement results, the antioxidant activity of the Nypha palm phlox was about 40 times higher than that of blueberry and about 75 times higher than that of red ginseng.
(mg/ml)Concentration
(mg / ml)
(mg.ml)IC 50
(mg.ml)
0.125
0.0625
0.03125
0.156250.025
0.125
0.0625
0.03125
0.15625
23.28±0.99
11.54±0.94
5.87±0.27
2.50±0.5644.44 + - 0.42
23.28 ± 0.99
11.54 + - 0.94
5.87 ± 0.27
2.50 ± 0.56
0.5
0.25
0.125
0.0625One
0.5
0.25
0.125
0.0625
10.05±0.48
5.40±0.17
3.12±0.15
2.08±0.5917.68 ± 0.51
10.05 + 0.48
5.40 ± 0.17
3.12 ± 0.15
2.08 ± 0.59
0.5
0.25
0.125
0.0625One
0.5
0.25
0.125
0.0625
6.09±0.51
3.02±0.31
1.58±0.56
0.25±0.3111.89 + - 0.54
6.09 ± 0.51
3.02 ± 0.31
1.58 ± 0.56
0.25 0.31
상기 표 4에서와 같이, ABTS radical scavenging activity 측정 결과에 따르면, 니파야자 꽃대의 항산화능은 블루베리에 비하여 약 42배 높고, 홍삼에 비해 약 59배 높음을 알 수 있었다.As shown in Table 4, according to the result of ABTS radical scavenging activity measurement, the antioxidant activity of Nypha palm phlox was about 42 times higher than that of blueberry and about 59 times higher than that of red ginseng.
(시험예 2)(Test Example 2)
니파야자 꽃대의 항염증 효과.Anti - Inflammatory Effects of.
제조예 1과 같이 제조한 니파야자 꽃대의 항염증 효과를 측정하였다.The anti-inflammatory effect of the Nihonpalaceae prepared as in Preparation Example 1 was measured.
이때, 염증성 인자로는 Nitrite(혹은 일산화 산소), IL-1β(인터루킨-1베타, interleukin-1beta), IL-6(인터루킨-6, interleukin-6), TNF-α(종양괴사인자-알파, 혹은 tumor necrosis factor-alpha)를 사용하였다.IL-1β (interleukin-1beta), IL-6 (interleukin-6, interleukin-6) and TNF-α (tumor necrosis factor-alpha, Or tumor necrosis factor-alpha).
시험방법은, 대식세포(macrophage)에 LPS(lipopolysaccharide)를 이용하여 염증을 유발하고, 여기에 시료를 처리하였을 때의 일반적인 염증 지표들이 억제되었는지를 조사하였다. 양성 대조군으로서는 DEX(Dexamethasone)을 비교약물로 사용하였다. 상기 시료는 앞서 제조예 1과 같이 제조한 니파야자 꽃대 분말과 물을 1:5 부피비로 투입하고, 60∼80℃로 48시간 동안 가열하여 열수추출물을 제조하고, 이 추출물을 동결건조하여 분말을 제조한 후, 농도에 맞게 희석하여 사용하였다. The test method was to investigate whether inflammation was induced by macrophages using LPS (lipopolysaccharide) and the general inflammation index was suppressed when the sample was treated with LPS (lipopolysaccharide). As a positive control, DEX (Dexamethasone) was used as a comparative drug. The sample was prepared by adding a 1: 5 volume ratio of the nifedowana phalaenopsis powder prepared in Preparation Example 1 and water at a temperature of 60 to 80 DEG C for 48 hours to prepare a hot water extract. The extract was freeze- After the preparation, it was diluted to the concentration.
그리고 그 결과를 도 2 내지 도 5에 나타내었다. The results are shown in Figs. 2 to 5. Fig.
도 2에서 확인할 수 있는 바와 같이, LPS로 염증 유도시 Nitrite가 크게 증가하였으나, 니파야자 꽃대의 처리로 인하여 증가했던 Nitrite가 감소함을 확인할 수 있었다. As can be seen from FIG. 2, Nitrite was significantly increased upon induction of inflammation by LPS, but Nitrite increased due to treatment of NIPHACA.
그리고 도 3, 4, 5에서 확인할 수 있는 바와 같이, LPS로 인한 염증 유도시 cytokine이 크게 증가하였으나, 니파야자 꽃대의 처리로 그 염증이 완화되는 것을 확인하였다. As can be seen from FIGS. 3, 4 and 5, cytokine was significantly increased upon induction of inflammation induced by LPS, but it was confirmed that the inflammation was alleviated by the treatment of Nephala palmetto.
따라서, 상기 니파야자의 꽃대는 농도 의존적으로 염증성 인자들의 억제효과가 있으며, 항염증 성분으로 알려진 DEX와 유사한 수준의 억제 효과가 있을 것을 판단되었다. Therefore, it was judged that the stamen of the nipponeya had an inhibitory effect on inflammatory factors in a concentration-dependent manner and a suppressive effect similar to DEX known as an anti-inflammatory component.
(실시예 1)(Example 1)
상기 제조예 1과 동일한 방법으로 니파야자의 꽃대를 분말로서 준비하였다. In the same manner as in Preparation Example 1, a flower bud of NiPhaya was prepared as a powder.
그리고 니파야자 꽃대 추출액은 다음과 같이 추출하였다. 먼저, 니파야자 꽃대를 채취하고, 깨끗이 세척한 후, 이를 10cm 길이로 절단하였다. 50℃의 열풍으로 건조하여 함수율이 15%가 되도록 하고, 이를 100mesh 정도로 분쇄한 후, 이에 20중량배의 증류수를 가하고, 90~100℃에서 20시간 동안 추출하였다. 그리고 이를 여과한 후, 감압농축기를 이용하여 50℃에서 감압 농축하여 32Brix의 추출물을 얻었다.Then, the extracts of Nephila palm phlox were extracted as follows. First, the nipponia palms were picked, cleaned and then cut into 10 cm lengths. Dried by hot air at 50 캜 to have a water content of 15%, and pulverized to about 100 mesh. 20 wt. Parts of distilled water was added thereto, and the mixture was extracted at 90 to 100 캜 for 20 hours. After filtration, the filtrate was concentrated under reduced pressure at 50 ° C using a vacuum concentrator to obtain a 32Brix extract.
그리고 용기에 재거리 1kg과 50℃의 정제수 500g을 투입하고, 중탕을 통해 용기 내부 온도가 60℃가 되도록 하여 60분간 재거리를 용해, 농축하였다. 그리고 농축된 액을 면포를 이용하여 걸러냄으로써, 재거리 농축액을 제조하였다.Then, 1 kg of distillation water and 500 g of purified water of 50 ° C were fed into the container, and the distillate was dissolved and concentrated for 60 minutes so that the inside temperature of the container became 60 ° C through a bath. Then, the concentrated liquid was filtered using a cotton cloth to prepare a re-distilled concentrate.
상기 준비된 꽃대 추출액, 분말 및 재거리 농축액을 1:1:0.5중량비로 혼합하고, 지름이 0.7cm인 환으로 성형한 후, 이의 표면에 재거리 농축액을 도포하였다. 그리고 이를 1시간 동안 냉풍(5℃) 건조하였다.The prepared pedicel extracts, powders, and distillation concentrates were mixed at a weight ratio of 1: 1: 0.5, molded into a ring having a diameter of 0.7 cm, and then applied to the surface of the pedicles. And dried in cold air (5 ° C) for 1 hour.
(시험예 3)(Test Example 3)
상기 실시예 1을 통해 제조한 환에 대하여 훈련된 관능평가요원 20명을 대상으로 하여, 맛, 향기, 외관 및 전체적인 기호도를 9점 평점법(1; 매우 나쁘다, 9; 매우 좋다)으로 평가하여 그 평균값을 하기의 표 5에 나타냈다. 대조구는 시중에서 판매되고 있는 청국장환을 구입하여 비교하였다.The taste, aroma, appearance, and overall acceptability of the 20 sensory evaluation personnel trained in the rings prepared in Example 1 were evaluated by the 9-point scale method (1: very bad, 9: very good) The average value is shown in Table 5 below. The control was purchased and compared with the commercially available Cheonggukjang.
상기 표 5에서 확인할 수 있는 바와 같이, 본 발명의 실시예 1은 대조구에 비해 맛, 향기, 외관 및 전체적인 기호도가 높음을 확인할 수 있었다. 이는 섭취시 니파야자의 은은한 향과 풍미가 느껴져 기호도가 상승한 것으로 판단되었다.As can be seen from the above Table 5, it was confirmed that Example 1 of the present invention has higher taste, smell, appearance, and overall acceptability than the control. It was judged that the palatability and flavor of nipaya was felt during ingestion and the degree of preference increased.
이상, 본 발명을 바람직한 실시 예를 사용하여 상세히 설명하였으나, 본 발명의 범위는 특정 실시 예에 한정되는 것은 아니며, 첨부된 특허청구범위에 의하여 해석되어야 할 것이다. 또한, 이 기술분야에서 통상의 지식을 습득한 자라면, 본 발명의 범위에서 벗어나지 않으면서도 많은 수정과 변형이 가능함을 이해하여야 할 것이다.While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the scope of the present invention is not limited to the disclosed exemplary embodiments. It will also be appreciated that many modifications and variations will be apparent to those skilled in the art without departing from the scope of the invention.
Claims (6)
니파야자의 꽃대를 분말로 제조하는 단계;
상기 준비된 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 혼합하는 단계;
상기 혼합된 혼합물을 환(丸)으로 성형하는 단계;
상기 성형된 환의 표면에 재거리 농축액을 도포하는 단계; 및
상기 재거리 농축액이 도포된 환을 건조하는 단계;
를 포함하되,
상기 니파야자 꽃대 추출액을 제조하는 단계는,
니파야자의 꽃대를 채취하고 세척한 후, 3~10cm의 길이로 절단하는 단계;
상기 절단된 니파야자 꽃대를 물을 용매로 하여 추출하되, 니파야자의 꽃대의 10~20중량배 정도의 물을 가한 후 80~100℃의 온도에서 10~20시간 추출하거나, 니파야자 꽃대의 8~12중량배의 물을 가한 후 초음파 추출기를 이용하여 100~150kHz의 조건으로 20~30분간 전처리하고, 이를 다시 50~60℃의 온도에서 10~12시간 열수추출하거나, 상기 절단된 니파야자를 자연건조, 냉풍건조 또는 열풍건조 중 어느 하나를 통해 함수율 10~20%가 되도록 한 후 100~200mesh로 분쇄한 분말로부터 추출하거나, 상기 절단된 니파야자 꽃대를 100℃의 끓는 물에 10~20분간 데친 후 상기 데친 꽃대를 탈수하여 추출하는 단계; 및
상기 추출된 추출물을 감압 농축하되, 50~60℃에서 용매를 제거하여 20~50Brix로 농축하는 단계;
를 포함하며,
상기 니파야자의 꽃대를 분말로 제조하는 단계는,
니파야자의 꽃대를 채취하여, 3~10cm의 길이 및 1cm 내외의 폭으로 절단하는 단계;
상기 절단된 니파야자 꽃대를 100℃의 물에 2~10분간 데치는 단계; 및
상기 데친 니파야자 꽃대를 수분함유율이 5~10%가 되도록 온풍건조, 냉풍건조 또는 자연건조 중 어느 하나를 통해 건조하는 단계;
상기 건조된 니파야자의 꽃대를 분쇄기로 200~300mesh로 분쇄하는 단계;
를 포함하는 것을 특징으로 하는 니파야자와 재거리를 이용한 기능성 환의 제조방법.
A step of preparing an extract of the nifa palm flower;
Preparing a flower bud of nifayja as a powder;
Mixing the prepared flower bud extract, flower bud powder, and retorted concentrate;
Molding the mixed mixture into a circle;
Applying a remnant concentrate to the surface of the shaped ring; And
Drying the ring applied with the re-distillation concentrate;
, ≪ / RTI &
Wherein the step of preparing the extract of Nepharahia phalaenopsis comprises:
Collecting and washing the stalk of Nipaya, and then cutting to a length of 3 to 10 cm;
Extracting the cut nipponia palms with water as a solvent, adding water about 10 to 20 times by weight of the palm leaf of nippae, extracting it at a temperature of 80 to 100 ° C for 10 to 20 hours, To 12 times by weight of water is added and the mixture is pretreated at 100 to 150 kHz for 20 to 30 minutes by using an ultrasonic wave extractor and then subjected to hot water extraction at a temperature of 50 to 60 ° C for 10 to 12 hours, Dried or hot air dried to obtain a moisture content of 10 to 20% and then extracted from the powder pulverized at 100 to 200 mesh, or the cut nipponia can be added to boiling water at 100 DEG C for 10 to 20 minutes Dewatering and then extracting the dwarf buds; And
Concentrating the extracted extract to a concentration of 20 to 50 Brix by removing the solvent at 50 to 60 ° C under reduced pressure;
/ RTI >
The step of preparing the flower bud of the nipponja as a powder comprises:
Taking a flower bud of Nipaya, cutting it to a length of 3 to 10 cm and a width of about 1 cm;
Deg.] C for 2 to 10 minutes; And
Drying the wetted nipah palm fronds through any one of hot air drying, cold air drying or natural drying so that the moisture content is 5 to 10%;
Pulverizing the dried flower bud of Niepaya with a grinder at 200 to 300 mesh;
Wherein the method comprises the steps of:
상기 준비된 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 혼합하는 단계는,
상기 꽃대 추출액, 꽃대 분말 및 재거리 농축액을 1:0.5~1.5: 0.2~0.5 중량비로 혼합하는 것을 특징으로 하는 니파야자와 재거리를 이용한 기능성 환의 제조방법.
The method according to claim 1,
The step of mixing the prepared flower bud extract, flower bud powder,
Wherein the flower bud extract, flower bud powder, and distillation concentrate are mixed at a weight ratio of 1: 0.5 ~ 1.5: 0.2 ~ 0.5 by weight.
상기 재거리 농축액은,
재거리 100중량부를 기준으로 정제수 25~120중량부를 용기에 투입하는 단계;
상기 재거리와 정제수가 투입된 용기의 내부 온도가 50~70℃가 되도록 하여 30분~120분간 재거리를 용해하고 농축하는 단계; 및
상기 용해, 농축된 재거리 농축액을 필터로 걸러 내는 단계;
를 포함하여 제조되며,
재거리 농축액에 비타민 A, C, D, E, K, 티아민, 니아신, 비타민 B6, 엽산, 비타민 B12 및 판토텐산으로 이루어진 군으로부터 선택되는 적어도 하나 이상을 재거리 농축액 100중량부에 대해 각각 1~3중량부만큼 혼합하는 것을 특징으로 하는 니파야자와 재거리를 이용한 기능성 환의 제조방법.
The method according to claim 1,
The re-
Adding 25 to 120 parts by weight of purified water to a container based on 100 parts by weight of the re-distillation;
Dissolving and concentrating the re-distillation for 30 minutes to 120 minutes so that the re-distance and the internal temperature of the container into which the purified water is introduced become 50 to 70 ° C; And
Filtering the dissolved, concentrated retentate concentrate with a filter;
, ≪ / RTI >
At least one selected from the group consisting of vitamins A, C, D, E, K, thiamin, niacin, vitamin B6, folic acid, vitamin B12 and pantothenic acid is added to the remultiplex concentrate in an amount of 1 to 3 By weight, based on the total weight of the nipa.
6. A functional ring using a distance between a nipa and a nipa, which is manufactured by the manufacturing method of any one of claims 1, 4,
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