JPH02152926A - Brain edema depressant - Google Patents

Abstract

PURPOSE:To obtain a brain edema depressant useful for treating various brain diseases caused by brain edema, having excellent suppressing effects on brain edema, containing a solution of SHOSHIKOYUGOKEISHIKASHAKUYAKU comprising formula of Chinese herbal remedies as an active ingredient. CONSTITUTION:A brain edema depressant containing a solution of SHOSHIKOYUGOKEISHIKASHAKUYAKU comprising formula of Chinese herbal remedies useful for various diseases such as epilepsy, bed-wetting or colitis ulcerosa as an active ingredient. The active ingredient is obtained by boiling 7g Bupleuri Radix, 6g Paeoniae Radix, 5g Pinelliae Tuber, 4g Cinnamomi Cortex, 4g iryphi Fructus, 3g Scutellariae Radix, 3g Ginseng Radix, 2g Glycyrrhizae Radix and 1g Zingiberis Rhizoma in 600ml water to give 350ml solution, removing dregs, is administered as a brain edema depressant dividedly three times and used as an essence agent of Chinese herbal remedies by taking readiness of administration and convenience of carrying. The active ingredient is blended with a carrier and an auxiliary, pharmaceutically manufactured into powder, granule, tablet, capsule, etc., administered. A dose is 3-15g/day calculated as dried weight of the active ingredient and administered dividedly several times.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a cerebral edema inhibitor useful for treating various diseases caused by cerebral edema.

[Prior Art and Issues] Cerebral edema is a state in which abnormal fluid accumulates inside and outside brain cells due to metabolic disorders in brain tissue, and is associated with many diseases that occur within the skull, such as infection, tumor, hemorrhagic or blockage. Causes include sexual vascular disorders. Moreover, the mechanism of occurrence is still unclear today. Cerebral edema is a state of swelling of the brain parenchyma, and if left untreated, it can lead to increased cerebral pressure, resulting in incarceration and death.

To treat the edema itself, drugs such as steroid therapy and dehydration therapy using hypertonic solutions are used.

However, none of these drugs were desirable in terms of efficacy or side effects. Therefore, the present invention
The purpose is to provide a brain edema inhibitor.

[Means for Solving the Problems] As a result of conducting research on the brain edema suppressing effects of various Chinese herbal prescriptions, the present inventors found that Bupleuri
Radix), Paeoniae Radix
, Half Summer (Pinelliae Tuber), Cinnamon (C
innamomi Cortex), Dai 11 (Ziz
yphi Fructus), Scutella
riae Radix), Ginseng (Ra
dix), licorice (Glycyrrhizae Radi)
x), Fresh '3 (Zingiberis Rhizom
We have found that a Chinese herbal medicine prescription consisting of a), namely Shosaikoto Gokeishikashakuyakuto, has a cerebral edema suppressing effect. The present invention is based on this knowledge, and is a cerebral edema suppressant comprising Shosaikoto Gokeishikashakuyakuto.

The medicinal effects of Shosaikoto Gikaedekakokuyakuto are listed in the Chinese medicine text (National Medical Dictionary), and it is used for various diseases such as epilepsy, nocturnal enuresis, and ulcerative colitis. This was completely unknown until now.

[Actions and Effects of the Invention] The cerebral edema inhibitor according to the present invention (hereinafter referred to as the drug of the present invention) exhibits an excellent cerebral edema inhibiting effect.

Therefore, the present invention has the significant effect of providing an innovative therapeutic drug for brain diseases caused by cerebral edema, for which no useful therapeutic drug has hitherto existed.

In other words, the present invention is considered to be a more excellent cerebral edema inhibitor due to its effects.

In the case of Xiao Chai Hu, Jiajikashu medicinal tea is made by boiling Chai Hu 79.5 medicine 6 g, Hanxia 5 g, cinnamon 4 g, large bunch 49, Oriental 3 g, ginseng 3 g, licorice 2 g, main 19 with 6007 water to make 350 d and the residue. It can be removed and taken in three doses as a brain edema suppressant, but for ease of administration and portability, a Chinese herbal medicine extract can also be used as a brain edema suppressant. can. For example, 5 to 8 parts by weight of Saiko,
4 to 7 parts by weight of Xun medicine, 4 to 6 parts by weight of Banxia, 3 to 5 parts by weight of cinnamon, 2 to 5 parts by weight of Dayan, 2 to 4 parts by weight of Huanglong, 2 to 4 parts by weight of ginseng.
1 part by weight, 1 to 3 parts by weight of licorice, 0.5 to 3 parts by weight of fresh wilt to 1 part by weight
The extract obtained by hot extraction with 0 times m water is filtered and dried to obtain a powder of Xiao Chai Hu Dang He Guizhi Kashu medicine dry extract, which is supplemented with suitable excipients used in ordinary preparations. It can be made into powders, granules, tablets, capsules, and other preparations by adding adjuvants and the like according to conventional methods for preparing preparations.

A specific example of the production of the drug of the present invention is as follows.

Specific examples: Saiko 79.5 medicine 6g, Hanka 59, cinnamon bark 4g, large bunch 49,
Add 10 times the amount of water, i.e. 3507, to 39 mg of Orientalium japonica, 3 g of ginseng, 29 g of licorice, and 3,507 g of water, heat and extract at 100°C for 1 hour, reduce the amount of the obtained extract, and spray dry.4. 59 dry extract powders were obtained.

[Effects of the Invention] The cerebral edema suppressing effect of the drug of the present invention will be explained by giving experimental examples.

Experimental Example Extract powder 1 obtained from Wistar male rats
9/kliI was dissolved in distilled water and administered orally once every summer day using an oral sonde, the head was closed under Nembutal anesthesia for 300 days, and the skull in the front half of the left hemisphere was removed using a dental drill to expose the dura mater. I let it happen.

Cobalt powder 50s9 was applied on the dura mater, the bone fragments were returned, the skull surface was fixed with dental cement, and the scalp was sutured.After 20 days of cobalt application, administration was continued.
On day 0, the cortical tissue was removed by rot extraction and the wet weight of the cortical tissue was measured. For the control group, the wet weight of the cortical tissue was measured in the same manner as above except that only distilled water was administered. The result is the first
Shown in the table.

(Table 1) As a result, a marked increase in brain weight was observed 20 days after cobalt application.

On the other hand, in the group administered with the dried extract powder obtained in the specific example, this increase in brain weight was significantly suppressed, confirming the effect of suppressing brain edema.

Next, an acute toxicity test for oral administration of the drug of the present invention was conducted using IC.
When conducted using R strain male and female mice and SD strain male and female rats, the dry extract powder obtained in the specific example was 15g/&
There were no deaths even after oral administration of 9 (dose limit). Thus, the drug of the present invention has extremely low toxicity and high safety.

Next, the dosage and formulation of the active ingredient of the drug of the present invention will be explained.

The active ingredient of the drug of the present invention can be administered to animals and humans as is or together with a conventional pharmaceutical carrier.

The dosage form is not particularly limited and may be selected and used as required, and includes oral preparations such as tablets, capsules, granules, fine granules, and powders.

In order to exert the desired effect as an oral agent, the dry weight of the active ingredient of the drug of the present invention is usually 3 to 15 g for an adult, although it varies depending on the child's age, weight, and degree of disease.
■It seems appropriate to take the drug in divided doses several times a day.

In the present invention, oral preparations such as tablets, capsules, and granules are manufactured according to conventional methods using, for example, starch, lactose, self-help, mannitol, carboxymethylcellulose, cornstarch, inorganic salts, and the like.

In addition to the excipients mentioned above, binders, disintegrants, surfactants, lubricants, fluidity promoters, flavoring agents, coloring agents, fragrances, and the like can be used in this type of preparation as appropriate. Specific examples of each are shown below.

[Binder] Starch, dextrin, gum arabic powder, gelatin,
Hydroxypropyl starch, methylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose, crystalline cellulose, ethylcellulose, polyvinylpyrrolidone, macrogol.

[Disintegrant co-starch, hydroxypropyl starch, sodium carboxymethylcellulose, calcium carboxylmethylcellulose, carboxymethylcellulose, low substituted hydroxypropylcellulose.

[Surfactant] Sodium lauryl sulfate, soy lecithin, sidi sugar fatty acid ester, polysorbate 80° [Lubricant kotalc, waxes, hydrogenated vegetable oil, Sil M fatty acid ester, magnesium stearate, calcium stearate, aluminum stearate, Polyethylene glycol.

[Fluidity promoter] Light anhydrous silicic acid, dry aluminum hydroxide gel, synthetic aluminum silicate, magnenoum silicate.

Furthermore, the active ingredient of the drug of the present invention can be administered as a suspension, emulsion, syrup, or elixir, and each of these volatile forms may contain a flavoring agent and a coloring agent. good.

The present invention will be described in detail below with reference to Examples, but the present invention is not limited to the same.

Example 1 ■Corn starch 2I9 ■Crystalline cellulose 109 ■Carboxymethyl cellulose calcium 79 ■Light anhydrous silicic acid 19 ■Magnesium stearate 10 0 Dried extract powder obtained in specific example 2009 Mix ■ to ■ uniformly according to the above recipe, Compression molding was performed using a key press to obtain tablets weighing 200 Q each.

This tablet contains 160% of the dry extract powder obtained in the specific example.
It contains 29 tablets, and adults should take 20 to 80 tablets a day in several doses.

Example 2 ■Corn starch 299 ■Magnesium stearate 29 ■Calcium carboxymethyl cellulose 89 ■Light anhydrous silicic acid zr ■Dried extract powder obtained in the specific example 2007 Mix ■~■ uniformly according to the above recipe and put it into a compression molding machine. After compression molding, the mixture was crushed using a crusher and sieved to obtain granules.

This granule 19 contains 80% of the dry extract powder obtained in the specific example.
0 m9 is 11, and adults should take 1 to 18 g per day in several doses.

Example 3 ■Corn starch 199■Light silicic anhydride 19 ■Dry extract powder obtained in the specific example! 80 total 200g Mix ■~■ uniformly according to the above recipe, 20019
was filled into a No. 2 capsule.

This capsule contains 180 my of the dried extract powder obtained in the specific example, and contains 180 my of the dried extract powder obtained in the specific example, and is
Take 80 capsules in several doses.

Claims (1)

[Claims] A cerebral edema inhibitor consisting of Shosaikoto Gokeishikashakuyakuto.