JP7357609B2 - 抗トランスサイレチン抗体 - Google Patents

抗トランスサイレチン抗体 Download PDF

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JP7357609B2
JP7357609B2 JP2020518649A JP2020518649A JP7357609B2 JP 7357609 B2 JP7357609 B2 JP 7357609B2 JP 2020518649 A JP2020518649 A JP 2020518649A JP 2020518649 A JP2020518649 A JP 2020518649A JP 7357609 B2 JP7357609 B2 JP 7357609B2
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antibody
ttr
seq
antibodies
amino acid
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JP2020536532A5 (https=
JP2020536532A (ja
Inventor
レジナルド サルマンズ，ジョシュア
アレクサンダー，スヴェトラナ
バーバー，ロビン
エヌ． ヒガキ，ジェフェリー
エス． ニハル，ターロチャン
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020518649A 2017-10-06 2018-10-05 抗トランスサイレチン抗体 Active JP7357609B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762569436P 2017-10-06 2017-10-06
US62/569,436 2017-10-06
US201762598965P 2017-12-14 2017-12-14
US62/598,965 2017-12-14
PCT/US2018/054720 WO2019071205A1 (en) 2017-10-06 2018-10-05 ANTI-TRANSTHYRETIN ANTIBODY

Publications (3)

Publication Number Publication Date
JP2020536532A JP2020536532A (ja) 2020-12-17
JP2020536532A5 JP2020536532A5 (https=) 2021-11-11
JP7357609B2 true JP7357609B2 (ja) 2023-10-06

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JP2020518649A Active JP7357609B2 (ja) 2017-10-06 2018-10-05 抗トランスサイレチン抗体

Country Status (15)

Country Link
US (1) US11267877B2 (https=)
EP (1) EP3691447A4 (https=)
JP (1) JP7357609B2 (https=)
KR (1) KR20200074956A (https=)
CN (1) CN111315213B (https=)
AU (1) AU2018345806A1 (https=)
BR (1) BR112020006434A2 (https=)
CA (1) CA3077361A1 (https=)
CU (1) CU24731B1 (https=)
MX (1) MX2020003041A (https=)
PE (1) PE20210552A1 (https=)
SA (1) SA520411703B1 (https=)
SG (1) SG11202002489YA (https=)
WO (1) WO2019071205A1 (https=)
ZA (1) ZA202002141B (https=)

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US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
CU24731B1 (es) 2017-10-06 2025-01-15 Prothena Biosciences Ltd Anticuerpos anti-transtiretina
AU2018345807B2 (en) 2017-10-06 2025-02-06 Novo Nordisk A/S Methods of detecting transthyretin
PE20211453A1 (es) 2017-11-29 2021-08-05 Prothena Biosciences Ltd Formulacion liofilizada de un anticuerpo monoclonal contra transtirretina
MX2022014223A (es) * 2020-05-12 2023-04-14 Neurimmune Ag Terapia de combinacion para amiloidosis de la ttr.
US20220267450A1 (en) 2020-10-14 2022-08-25 Viridian Therapeutics, Inc. Compositions and methods for treatment of thyroid eye disease
CN116635024A (zh) * 2020-10-14 2023-08-22 维里迪安治疗公司 用于治疗甲状腺眼病的组合物和方法
WO2022155608A2 (en) * 2021-01-15 2022-07-21 The General Hospital Corporation Cd64 chimeric receptor and uses thereof
EP4286406A4 (en) 2021-01-29 2025-07-23 Illimis Therapeutics Inc FUSION MOLECULE WITH NON-INFLAMMATORY PHAGOCYTOSIS-INDUCING ACTIVITY
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor
CA3247456A1 (en) * 2022-04-20 2023-10-26 Senti Biosciences, Inc. DOMAINS OF BINDING TO AN ANTIGEN AND THEIR METHODS OF USE
EP4630812A1 (en) 2022-12-05 2025-10-15 Neurimmune AG Cyclic compounds and their use in assays for detecting antibodies
EP4713354A1 (en) 2023-05-19 2026-03-25 Neurimmune AG Novel immunotherapy for musculoskeletal disorders and conditions
WO2024251997A1 (en) 2023-06-07 2024-12-12 Neurimmune Ag Vaccine for the treatment of amyloidosis
EP4727650A1 (en) * 2023-06-14 2026-04-22 Immutrin Ltd Anti-fibril antibodies
WO2025228442A1 (zh) * 2024-04-30 2025-11-06 厦门大学 氯苯唑酸在激活rxr活性中的用途

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JP2014510907A (ja) 2011-02-21 2014-05-01 ポリサッカリドフォルスクニング イー ウプサラ アーベー 診断方法及び治療方法
WO2015115331A1 (ja) 2014-01-29 2015-08-06 一般財団法人化学及血清療法研究所 抗トランスサイレチンヒト化抗体
JP2016514091A (ja) 2013-02-08 2016-05-19 ミスフォールディング ダイアグノスティクス， インコーポレイテッド トランスサイレチン抗体およびその使用

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CU24731B1 (es) 2025-01-15
SA520411703B1 (ar) 2024-04-28
EP3691447A1 (en) 2020-08-12
PE20210552A1 (es) 2021-03-17
CU20200021A7 (es) 2021-01-12
AU2018345806A1 (en) 2020-03-12
CN111315213A (zh) 2020-06-19
SG11202002489YA (en) 2020-04-29
ZA202002141B (en) 2023-01-25
US20200331992A1 (en) 2020-10-22
CN111315213B (zh) 2023-09-12
JP2020536532A (ja) 2020-12-17
EP3691447A4 (en) 2021-08-11
BR112020006434A2 (pt) 2020-11-03
US11267877B2 (en) 2022-03-08
MX2020003041A (es) 2020-10-05
KR20200074956A (ko) 2020-06-25
WO2019071205A1 (en) 2019-04-11
CA3077361A1 (en) 2019-04-11

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