JP7353663B2 - Ｇａｂａａ受容体リガンド - Google Patents
Ｇａｂａａ受容体リガンド Download PDFInfo
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- JP7353663B2 JP7353663B2 JP2021514324A JP2021514324A JP7353663B2 JP 7353663 B2 JP7353663 B2 JP 7353663B2 JP 2021514324 A JP2021514324 A JP 2021514324A JP 2021514324 A JP2021514324 A JP 2021514324A JP 7353663 B2 JP7353663 B2 JP 7353663B2
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- pruritus
- treatment
- gaba
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P17/00—Drugs for dermatological disorders
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| WO2025056751A1 (en) * | 2023-09-15 | 2025-03-20 | Saniona A/S | A gaba receptor modulator for use in the treatment of absence seizures |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003508530A (ja) | 1999-09-07 | 2003-03-04 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体のリガンドとなるイミダゾ−ピリジン誘導体 |
| WO2003086406A1 (en) | 2002-04-11 | 2003-10-23 | Merck Sharp & Dohme Limited | Imidazo-pyridine derivatives as ligands for gaba receptors |
| WO2003087099A1 (en) | 2002-04-11 | 2003-10-23 | Merck Sharp & Dohme Limited | Imidazo-pyridine derivatives as ligands for gaba receptors |
| JP2005531582A (ja) | 2002-05-24 | 2005-10-20 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体のリガンドとしてのイミダゾ−ピリジン誘導体 |
| JP2009530353A (ja) | 2006-03-24 | 2009-08-27 | ノイロサーチ アクティーゼルスカブ | ベンズイミダゾール誘導体、及びｇａｂａａ受容体複合体をモジュレートするためのその使用 |
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| AU675484B2 (en) | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
| GB9702524D0 (en) | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
| ATE284403T1 (de) | 1999-01-27 | 2004-12-15 | Merck Sharp & Dohme | Triazolopyridazinderivate als liganden für gaba- rezeptoren |
| WO2004087690A2 (en) | 2003-04-03 | 2004-10-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex |
| TW201029986A (en) | 2008-11-14 | 2010-08-16 | Neurosearch As | Novel compounds |
| MX388862B (es) | 2016-01-27 | 2025-03-20 | Univ Zuerich | Uso de moduladores de receptores de gabaa para el tratamiento de picor. |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003508530A (ja) | 1999-09-07 | 2003-03-04 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体のリガンドとなるイミダゾ−ピリジン誘導体 |
| WO2003086406A1 (en) | 2002-04-11 | 2003-10-23 | Merck Sharp & Dohme Limited | Imidazo-pyridine derivatives as ligands for gaba receptors |
| WO2003087099A1 (en) | 2002-04-11 | 2003-10-23 | Merck Sharp & Dohme Limited | Imidazo-pyridine derivatives as ligands for gaba receptors |
| JP2005531582A (ja) | 2002-05-24 | 2005-10-20 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体のリガンドとしてのイミダゾ−ピリジン誘導体 |
| JP2009530353A (ja) | 2006-03-24 | 2009-08-27 | ノイロサーチ アクティーゼルスカブ | ベンズイミダゾール誘導体、及びｇａｂａａ受容体複合体をモジュレートするためのその使用 |
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| EP3849976B1 (en) | 2022-10-26 |
| KR102712565B1 (ko) | 2024-10-02 |
| JP2022500445A (ja) | 2022-01-04 |
| BR112021004661A2 (pt) | 2021-06-01 |
| EP3849976A1 (en) | 2021-07-21 |
| EA202190717A1 (ru) | 2021-09-22 |
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| PL3849976T3 (pl) | 2023-02-27 |
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| CA3110283A1 (en) | 2020-03-19 |
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