JP7349786B2 - Cns浮腫に関連する損傷または状態を処置する方法 - Google Patents

Cns浮腫に関連する損傷または状態を処置する方法 Download PDF

Info

Publication number
JP7349786B2
JP7349786B2 JP2018517841A JP2018517841A JP7349786B2 JP 7349786 B2 JP7349786 B2 JP 7349786B2 JP 2018517841 A JP2018517841 A JP 2018517841A JP 2018517841 A JP2018517841 A JP 2018517841A JP 7349786 B2 JP7349786 B2 JP 7349786B2
Authority
JP
Japan
Prior art keywords
subject
hours
composition
sur1
edema
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018517841A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018530564A (ja
JP2018530564A5 (enExample
Inventor
スヴェン マーティン ジェイコブソン,
Original Assignee
バイオジェン チェサピーク エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオジェン チェサピーク エルエルシー filed Critical バイオジェン チェサピーク エルエルシー
Publication of JP2018530564A publication Critical patent/JP2018530564A/ja
Publication of JP2018530564A5 publication Critical patent/JP2018530564A5/ja
Application granted granted Critical
Publication of JP7349786B2 publication Critical patent/JP7349786B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/64Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018517841A 2015-10-07 2016-10-07 Cns浮腫に関連する損傷または状態を処置する方法 Active JP7349786B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562238461P 2015-10-07 2015-10-07
US62/238,461 2015-10-07
PCT/US2016/055988 WO2017062765A1 (en) 2015-10-07 2016-10-07 Methods of treating injuries or conditions related to cns edema

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021022562A Division JP2021073317A (ja) 2015-10-07 2021-02-16 Cns浮腫に関連する損傷または状態を処置する方法

Publications (3)

Publication Number Publication Date
JP2018530564A JP2018530564A (ja) 2018-10-18
JP2018530564A5 JP2018530564A5 (enExample) 2019-11-14
JP7349786B2 true JP7349786B2 (ja) 2023-09-25

Family

ID=58488580

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018517841A Active JP7349786B2 (ja) 2015-10-07 2016-10-07 Cns浮腫に関連する損傷または状態を処置する方法
JP2021022562A Withdrawn JP2021073317A (ja) 2015-10-07 2021-02-16 Cns浮腫に関連する損傷または状態を処置する方法
JP2023020327A Active JP7592768B2 (ja) 2015-10-07 2023-02-13 Cns浮腫に関連する損傷または状態を処置する方法
JP2024142687A Pending JP2024164167A (ja) 2015-10-07 2024-08-23 Cns浮腫に関連する損傷または状態を処置する方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021022562A Withdrawn JP2021073317A (ja) 2015-10-07 2021-02-16 Cns浮腫に関連する損傷または状態を処置する方法
JP2023020327A Active JP7592768B2 (ja) 2015-10-07 2023-02-13 Cns浮腫に関連する損傷または状態を処置する方法
JP2024142687A Pending JP2024164167A (ja) 2015-10-07 2024-08-23 Cns浮腫に関連する損傷または状態を処置する方法

Country Status (15)

Country Link
US (4) US20180280325A1 (enExample)
EP (1) EP3359162B1 (enExample)
JP (4) JP7349786B2 (enExample)
KR (2) KR20240105519A (enExample)
CN (2) CN108348534A (enExample)
AU (3) AU2016335767B2 (enExample)
BR (1) BR112018006925A2 (enExample)
CA (1) CA3001321A1 (enExample)
EA (1) EA201890893A1 (enExample)
ES (1) ES2940669T3 (enExample)
HK (1) HK1257542A1 (enExample)
IL (1) IL258509B2 (enExample)
MA (1) MA45574A (enExample)
MX (1) MX392466B (enExample)
WO (1) WO2017062765A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014027983B1 (pt) 2012-05-08 2022-05-24 Aeromics, Inc Uso de inibidores de aquaporina seletivos
WO2015069961A1 (en) 2013-11-06 2015-05-14 Aeromics, Llc Novel prodrug salts
KR20240105519A (ko) * 2015-10-07 2024-07-05 레메디 파마슈티칼즈, 인크. Cns 부종과 관련한 손상 또는 병태의 치료 방법
WO2020041905A1 (en) * 2018-08-31 2020-03-05 The University Of British Columbia Methods for identifying compounds suitable for treatment of central nervous system trauma and uses of those compounds
CN113874002A (zh) * 2019-05-02 2021-12-31 生物切萨皮克有限责任公司 治疗患有中枢神经系统挫伤的受试者的方法
TW202214561A (zh) * 2020-07-17 2022-04-16 大陸商上海森輝醫藥有限公司 磺醯脲類衍生物及其醫藥用途
US12251388B1 (en) 2024-05-09 2025-03-18 Remedy Pharmaceuticals, Inc. Methods of treating ischemic stroke at risk for cerebral or cerebellar edema
WO2025212189A1 (en) * 2024-04-05 2025-10-09 Remedy Pharmaceuticals, Inc. Methods of treating ischemic stroke at risk for cerebral or cerebellar edema using a sur1-trpm4 channel inhibitor
WO2025212155A1 (en) * 2024-04-05 2025-10-09 Remedy Pharmaceuticals, Inc. Methods of treating ischemic stroke with large vessel occlusion using a sur1-trpm4 channel inhibitor
US12251389B1 (en) 2024-04-22 2025-03-18 Remedy Pharmaceuticals, Inc. Methods of treating ischemic stroke at risk for cerebral or cerebellar edema
WO2025212154A1 (en) * 2024-04-05 2025-10-09 Remedy Pharmaceuticals, Inc. Methods of treating ischemic stroke at risk for cerebral or cerebellar edema

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534285A (ja) 2002-03-20 2005-11-17 ユニバーシティ・オブ・メリーランド, ボルティモア 神経細胞の非選択的陽イオンチャネルおよび脳腫脹を治療する方法
JP2013532658A (ja) 2010-07-19 2013-08-19 レメディー ファーマシューティカルズ, インコーポレイテッド グリブリドおよび他の薬剤の静脈内投与方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856360A (en) 1996-05-03 1999-01-05 Children's Hospital Medical Center Pharmaceutical method for the treatment of severe blood loss and for the inhibition or treatment of hemorrhagic shock
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
US20050246000A1 (en) * 2004-05-03 2005-11-03 Seacoast Technologies, Inc. Cooled craniectomy
EP2167107B1 (en) 2007-06-22 2016-12-14 University of Maryland, Baltimore Inhibitors of ncca-atp channels for therapy
WO2009073711A1 (en) * 2007-12-04 2009-06-11 Remedy Pharmaceuticals, Inc. Improved formulations and methods for lyophilization and lyophilates provided thereby
KR20240105519A (ko) * 2015-10-07 2024-07-05 레메디 파마슈티칼즈, 인크. Cns 부종과 관련한 손상 또는 병태의 치료 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534285A (ja) 2002-03-20 2005-11-17 ユニバーシティ・オブ・メリーランド, ボルティモア 神経細胞の非選択的陽イオンチャネルおよび脳腫脹を治療する方法
JP2013532658A (ja) 2010-07-19 2013-08-19 レメディー ファーマシューティカルズ, インコーポレイテッド グリブリドおよび他の薬剤の静脈内投与方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Nature Medicine, 2006, Vol.12 No.4 p.433-440
Neurocrit Care,2014 Aug., Vol.21,p.43-51
Trans.Stroke.Res.,2012,Vol.3,p.286-295

Also Published As

Publication number Publication date
AU2016335767A8 (en) 2018-06-28
IL258509B (en) 2022-12-01
IL258509B2 (en) 2023-04-01
JP2023053274A (ja) 2023-04-12
KR20180063296A (ko) 2018-06-11
JP2021073317A (ja) 2021-05-13
WO2017062765A1 (en) 2017-04-13
BR112018006925A2 (pt) 2018-10-16
US20250017880A1 (en) 2025-01-16
CA3001321A1 (en) 2017-04-13
AU2016335767B2 (en) 2022-10-06
EP3359162A1 (en) 2018-08-15
MX392466B (es) 2025-03-24
EP3359162A4 (en) 2019-08-28
IL258509A (en) 2018-05-31
JP2024164167A (ja) 2024-11-26
US20240216309A1 (en) 2024-07-04
CN108348534A (zh) 2018-07-31
US11951085B2 (en) 2024-04-09
EP3359162B1 (en) 2022-12-21
AU2022279369B2 (en) 2025-02-13
AU2022279369A1 (en) 2023-01-19
JP7592768B2 (ja) 2024-12-02
KR102681027B1 (ko) 2024-07-02
ES2940669T3 (es) 2023-05-10
KR20240105519A (ko) 2024-07-05
HK1257542A1 (zh) 2019-10-25
JP2018530564A (ja) 2018-10-18
US20180280325A1 (en) 2018-10-04
AU2025202620A1 (en) 2025-05-01
AU2016335767A1 (en) 2018-05-24
MX2018004286A (es) 2018-08-09
US20220125750A1 (en) 2022-04-28
EA201890893A1 (ru) 2018-09-28
CN115737816A (zh) 2023-03-07
MA45574A (fr) 2019-05-15

Similar Documents

Publication Publication Date Title
JP7592768B2 (ja) Cns浮腫に関連する損傷または状態を処置する方法
JP2020203892A (ja) S1p受容体モジュレーターの投与計画
Liotta Management of cerebral edema, brain compression, and intracranial pressure
CN109689037B (zh) 利用sur1-trpm4通道抑制剂的医学治疗方法
JP2018530564A5 (enExample)
Nivatpumin et al. Ephedrine versus ondansetron in the prevention of hypotension during cesarean delivery: a randomized, double-blind, placebo-controlled trial
Matsota et al. The effect of 0.5 L 6% hydroxyethyl starch 130/0.42 versus 1 L Ringer’s lactate preload on the hemodynamic status of parturients undergoing spinal anesthesia for elective cesarean delivery using arterial pulse contour analysis
Chatterjee et al. Effectiveness of granisetron in prevention of hypotension following spinal anaesthesia in patients undergoing elective caesarean section
AL-Morsy et al. Effect of adding nalbuphine hydrochloride versus fentanyl on the characteristic of hyperbaric bupivacaine spinal block for lower limb orthopedic surgery
JP5509085B2 (ja) 血栓溶解についての新規な患者亜群
Shannon et al. An intravenous fluid bolus is not necessary before administration of intrathecal fentanyl for labor analgesia
US20220226353A1 (en) Method for treating subjects suffering from central nervous system contusions
AbdelRady et al. Role of Granisetron in preventing hypotension after spinal anaesthesia with Levobupivacaine in rheumatic patients undergoing elective cesarean section: A randomized controlled trial
JP2011500617A5 (enExample)
Hasanein et al. Extending labor epidural analgesia using lidocaine plus either dexmedetomidine or epinephrine for emergency cesarean section
Murthy et al. Attenuating emergence response: Fentanyl or dexmedetomidine, which is better?

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191004

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191004

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201005

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210104

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210216

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210715

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211112

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20211112

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20211112

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20211206

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20211207

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20211224

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20211228

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20221114

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20221219

C28A Non-patent document cited

Free format text: JAPANESE INTERMEDIATE CODE: C2838

Effective date: 20221219

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230301

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230619

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230912

R150 Certificate of patent or registration of utility model

Ref document number: 7349786

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350