JP7346425B2 - 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 - Google Patents

疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 Download PDF

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JP7346425B2
JP7346425B2 JP2020538841A JP2020538841A JP7346425B2 JP 7346425 B2 JP7346425 B2 JP 7346425B2 JP 2020538841 A JP2020538841 A JP 2020538841A JP 2020538841 A JP2020538841 A JP 2020538841A JP 7346425 B2 JP7346425 B2 JP 7346425B2
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JP2021510818A5 (https=
JP2021510818A (ja
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ロメロ，ドナ，エル．
ブリッツァー，ジェレミー
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Centaurus Therapeutics Inc
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Veterinary Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Pyridine Compounds (AREA)
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JP2020538841A 2018-01-11 2019-01-11 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 Active JP7346425B2 (ja)

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JP2023143506A JP7692963B2 (ja) 2018-01-11 2023-09-05 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤

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US201862616253P 2018-01-11 2018-01-11
US62/616,253 2018-01-11
PCT/US2019/013193 WO2019140188A1 (en) 2018-01-11 2019-01-11 Inhibitors of dihydroceramide desaturase for treating disease

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JP2021510818A JP2021510818A (ja) 2021-04-30
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JP7346425B2 true JP7346425B2 (ja) 2023-09-19

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JP2023143506A Active JP7692963B2 (ja) 2018-01-11 2023-09-05 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤

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US (3) US11597715B2 (https=)
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KR (1) KR20250057925A (https=)
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AU (1) AU2019207887B2 (https=)
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Cited By (1)

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JP2023179445A (ja) * 2018-01-11 2023-12-19 セントラス セラピューティクス 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤

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JP2019533022A (ja) 2016-10-24 2019-11-14 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
US11135207B2 (en) 2016-12-13 2021-10-05 Centaurus Therapeutics Inhibitors of dihydroceramide desaturase for treating disease
EP3566055B1 (en) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Scd inhibitor for the treatment of neurological disorders
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
WO2019183587A1 (en) 2018-03-23 2019-09-26 Yumanity Therapeutics, Inc. Compounds and uses thereof
WO2020154571A1 (en) * 2019-01-24 2020-07-30 Yumanity Therapeutics, Inc. Compounds and uses thereof
WO2020168294A1 (en) 2019-02-15 2020-08-20 Lysosomal And Rare Disorders Research And Treatment Center, Llc Methods and compositions for treating lysosomal storage disorders: ambroxol as treatment agent for mucopolysaccharidoses iii (sanfilippo syndrome)
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
US20230404972A1 (en) * 2020-11-25 2023-12-21 Lysosomal and Rare Disorders Research and Treatment Center, Inc. Inhibition of caspase pathway as a treatment for lysosomal storage disorders
JP2024528021A (ja) * 2021-07-29 2024-07-26 上海齊魯制藥研究中心有限公司 新規なｐａｒｐ７阻害剤及びその使用
CN117897380A (zh) * 2021-08-17 2024-04-16 益方生物科技(上海)股份有限公司 哒嗪酮或吡啶酮化合物、其制备方法和用途
CN120136787A (zh) * 2023-12-13 2025-06-13 青岛清原化合物有限公司 一种吡唑取代的芳基硫化物类化合物及其应用

Citations (5)

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