JP7343910B2 - 肺線維症の治療方法 - Google Patents
肺線維症の治療方法 Download PDFInfo
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- JP7343910B2 JP7343910B2 JP2020536081A JP2020536081A JP7343910B2 JP 7343910 B2 JP7343910 B2 JP 7343910B2 JP 2020536081 A JP2020536081 A JP 2020536081A JP 2020536081 A JP2020536081 A JP 2020536081A JP 7343910 B2 JP7343910 B2 JP 7343910B2
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- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000004031 partial agonist Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- PMJHHCWVYXUKFD-UHFFFAOYSA-N penta-1,3-diene Chemical compound CC=CC=C PMJHHCWVYXUKFD-UHFFFAOYSA-N 0.000 description 1
- SLIUAWYAILUBJU-UHFFFAOYSA-N pentacene Chemical compound C1=CC=CC2=CC3=CC4=CC5=CC=CC=C5C=C4C=C3C=C21 SLIUAWYAILUBJU-UHFFFAOYSA-N 0.000 description 1
- GUVXZFRDPCKWEM-UHFFFAOYSA-N pentalene Chemical compound C1=CC2=CC=CC2=C1 GUVXZFRDPCKWEM-UHFFFAOYSA-N 0.000 description 1
- JQQSUOJIMKJQHS-UHFFFAOYSA-N pentaphene Chemical compound C1=CC=C2C=C3C4=CC5=CC=CC=C5C=C4C=CC3=CC2=C1 JQQSUOJIMKJQHS-UHFFFAOYSA-N 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- MPNNOLHYOHFJKL-UHFFFAOYSA-N peroxyphosphoric acid Chemical compound OOP(O)(O)=O MPNNOLHYOHFJKL-UHFFFAOYSA-N 0.000 description 1
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 description 1
- CSHWQDPOILHKBI-UHFFFAOYSA-N peryrene Natural products C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 CSHWQDPOILHKBI-UHFFFAOYSA-N 0.000 description 1
- 239000003186 pharmaceutical solution Substances 0.000 description 1
- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- NQFOGDIWKQWFMN-UHFFFAOYSA-N phenalene Chemical compound C1=CC([CH]C=C2)=C3C2=CC=CC3=C1 NQFOGDIWKQWFMN-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
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- 230000008092 positive effect Effects 0.000 description 1
- 238000010149 post-hoc-test Methods 0.000 description 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 125000006238 prop-1-en-1-yl group Chemical group [H]\C(*)=C(/[H])C([H])([H])[H] 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000004088 pulmonary circulation Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000003252 quinoxalines Chemical class 0.000 description 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- FMKFBRKHHLWKDB-UHFFFAOYSA-N rubicene Chemical compound C12=CC=CC=C2C2=CC=CC3=C2C1=C1C=CC=C2C4=CC=CC=C4C3=C21 FMKFBRKHHLWKDB-UHFFFAOYSA-N 0.000 description 1
- WEMQMWWWCBYPOV-UHFFFAOYSA-N s-indacene Chemical compound C=1C2=CC=CC2=CC2=CC=CC2=1 WEMQMWWWCBYPOV-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- WPWXYQIMXTUMJB-UHFFFAOYSA-N tert-butyl 3-(aminomethyl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(CN)C1 WPWXYQIMXTUMJB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000004867 thiadiazoles Chemical class 0.000 description 1
- 150000003557 thiazoles Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 150000003577 thiophenes Chemical class 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 125000005580 triphenylene group Chemical group 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000001196 vasorelaxation Effects 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000006815 ventricular dysfunction Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 125000001834 xanthenyl group Chemical class C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Description
「アルキル」又は「アルカニル」は、親アルカンの一つの炭素原子から一つの水素原子の除去により由来する、飽和した、枝分かれした又は直鎖又は環状の一価の炭化水素遊離基を意味する。典型的なアルキル基はメチル;エチル;プロピル例えばプロパン-1-イル、プロパン-2-イル、シクロプロパン-1-イル;ブチル例えばブタン-1-イル、ブタン-2-イル、2-メチル-プロパン-1-イル、2-メチル-プロパン-2-イル、シクロブタン-1-イル等を含むが限定されない。好ましくは、アルキル基は1-20の炭素原子を、より好ましくは、1から10又は1から6又は1-4の炭素原子を含む。
式(I)の化合物は本発明のために有用である。
-O-(CH2)n-、-(CH2)n-、-S-(CH2)n-、-S(O)(O)-(CH2)n-、-NH-(CH2)n-、-CH2-O-(CH2)n-、-(CH2)n-O-CH2-CH2-、-CH2-S-(CH2)n-、-(CH2)n-S-CH2-CH2-、-CH2-S(O)(O)-(CH2)n-、-(CH2)n-S(O)(O)-CH2-CH2-、-O-C(O)-(CH2)n-、-S-C(O)-(CH2)n-、-NH-C(O)-(CH2)n-、-CH2-C(O)-O-(CH2)n-、-CH2-C(O)-NH-(CH2)n-、-CH2―C(O)-S-(CH2)n-、-(CH2)n-C(O)-O-CH2-CH2-、-CH2-O-C(O)-(CH2)n-、-CH2-NH-C(O)-(CH2)n-、-CH2-S-C(O)-(CH2)n-、-(CH2)n-O-C(O)-CH2-CH2-、(CH2)n-NH-C(O)-CH2-CH2-、又は-(CH2)n-S-C(O)-CH2-CH2-であり、ここでnは1から7までの整数であり、好ましくはnは2から5であり、例えばnは4である。
BはO、S、S(O)(O)、又はNR5;及び
各R1、R2、R3、R4、R5、R6、R7及びR8は独立して水素、アルキル、置換したアルキル、アリール、置換したアリール、アリールアルキル、置換したアリールアルキル、シクロアルキル、置換したシクロアルキル、シクロヘテロアルキル、置換したシクロヘテロアルキル、ヘテロアリール、置換したヘテロアリール、ヘテロアリールアルキル、置換したヘテロアリールアルキル、アシルアルキルオキシカルボニル、アシルオキシアルキルオキシカルボニル、アシルアルキルオキシカルボニルアミノ、アシルオキシアルキルオキシカルボニルアミノ、アルコキシ、アルコキシカルボニル、アルコキシカルボニルアルコキシ、アルコキシカルボニルアルキルアミノ、アルキルスルフィニル、アルキルスルフォニル、アルキルチオ、アミノ、アルキルアミノ、アリールアルキルアミノ、ジアルキルアミノ、アリールアルコキシ、アリールアルコキシカルボニルアルコキシ、アリールオキシカルボニルアルキルアミノ、カルボキシ、カルバモイル、カルバミン酸、炭酸、シアノ、ハロ、ヘテロアリールオキシカルボニル、ヒドロキシ、リン酸、ホスホネート、硫酸、スルホン酸、又はスルホンアミドであって、ここでR1、R2、R3、R4、R5、R6、R7及びR8及びAは任意に2H(重水素)、3H(トリチウム)、13C、36Cl、18F、15N、17O、18O、31P、32P及び35S;好ましくは2H(重水素);又は医薬的に許容可能な塩、そのラセミ体又はジアステレオマーの混合物を含むが限定されないアイソトープと置換されてもよい。
本明細書は、肺線維症(PF)及び特発性肺線維症(IPF)の治療方法に関する。PFの原因が明確に同定できない場合に、その状態はIPFと呼ばれる。PF及びIPFの原因が異なりうるが、PF及びIPFの徴候及び症状は同じであって、そして本明細書は病気の原因に関わらず、PF及びIPFを治療するために効果的である。その方法は、肺線維症で苦しむ患者への式Iの化合物の有効量の投与のステップを含む。式I化合物は患者の肺動脈(心臓から肺へ導く血管)又は肺胞内の繊維症を減らし、肺線維症を治療しうる。治療はまた合併症、例えば、肺炎症、息切れ、疼痛発作、肺実質の炎症を減らしうり、生存期間を延長させうる。
本発明は肺線維症の治療のための製剤処方に関する。その製剤処方は式Iの1以上の治療有効量を好ましくは精製された形状で、医薬的に許容可能な溶媒の適当な量とともに含む。患者へ投与される場合に、製剤処方は好ましくは無菌である。本発明の化合物が静脈内に投与される場合水は好ましい溶媒である。生理食塩水溶液及び水溶性のブドウ糖及びグリセロール溶液は液体の媒体として、特に注射用の溶液としてまた利用されうる。適当な医薬的な媒体はまた賦形剤、例えばデンプン、グルコース、ラクトース、スクロース、ゼラチン、麦芽、米、小麦粉、チョーク、シリカゲル、ステアリン酸ナトリウム、グリセロールモノステアレート、タルク、塩化ナトリウム、脱脂粉乳、グリセロール、プロピレン、グリコール、水、エタノール等を含む。本薬剤又はpH緩衝剤。加えて、助剤、安定化剤、増粘剤、平滑材、及び着色剤は用いられうる。
投与した式I化合物の量は、他の因子、患者の治療歴、及び患者の体重、苦痛の重症度、投与方法及び処方する医師の判断に依存する。例えば、その投薬は単回投与により、多数回投与又は制御した放出により医薬的な化合物において送達されうる。一の態様において、本発明の化合物は、経口持続放出投与で送達される。一の態様において、本発明の化合物は、1日あたり2回、及び好ましくは1日あたり1回投与される。投薬は断続的に繰り返してよく、単体又は他の薬剤との組み合わせにおいて供給してよく、そして病気の状態又は障害の効果的な治療が求められる限り、続けてもよい。
本発明のある態様において、本発明の化合物は少なくとも一つの他の治療薬との併用療法で使用されうる。式I化合物及び治療薬は相加的及び相乗的に働きうる。一の態様において、式I化合物は、式I化合物の同じ組成物の一部になりうる、別の治療薬の投与と同時に投与される。別の態様において、本発明の化合物を含む組成物は別の治療薬の投与の前又は後に投与される。
材料及び方法:
受容体の供給源:ヒトリコンビナントD2S発現哺乳類細胞
放射性リガンド:[3H]スピペロン(20-60 Ci/mmol)又は[3H]-7-ヒドロキシDPAT,1.0nM
コントロール化合物:ハロペリドール又はクロルプロマジン
培養条件:反応を120mM NaCl、5mM KCl、5mM MgCl2、1mM EDTAを含む50mM Tris-HCl(pH7.4)において25℃で60分間行った。反応をガラス繊維フィルター上で急速真空濾過により終結した。フィルター上に捕捉した放射活性を決定し、そして試験化合物とクローン化したドーパミン-D2の短い結合部位のとの任意の相互作用を確認するためにコントロール値と比較した(文献参照:Jarvis,K.R.et al.Journal of Receptor Reserch 1993,13(1-4),573-590;Gundlach,A.L.et al.Life Sciences 1984,35,1981-1988)。
材料及び方法:
受容体の供給源:ヒトリコンビナント5-HT1A発現哺乳類細胞
放射性リガンド:[3H]-8-OH-DPAT(221 Ci/mmol)
コントロール化合物:8-OH-DPAT
培養条件:反応を10mM MgSO4,0.5mM EDTA及び0.1%アスコルビン酸を含む50mM Tris-HCl(pH7.4)において室温で1時間行った。反応をガラス繊維フィルター上で急速真空濾過により終結した。フィルター上に捕捉した放射活性を決定し、そして試験化合物とクローン化したセロトニン-5HT1A結合部位との任意の相互作用を確認するためにコントロール値と比較した(文献参照:Hoyer,D.et al.Eur.Journal Pharmacol.1985,118,13-23;Schoeffter,P.and Hoyer,D.Naunyn-Schmiedeberg’s Arch.Pharmac.1989,340,135-138)。
材料及び方法:
受容体の供給源:ヒト皮質又はヒトリコンビナント5-HT2A発現哺乳類細胞
放射性リガンド:[3H]-ケタンセリン(60-90 Ci/mmol)
コントロール化合物:ケタンセリン
培養条件:反応を50mM Tris-HCl(pH7.6)において室温で90分間行った。反応をガラス繊維フィルター上で急速真空濾過により終結した。フィルター上に捕捉した放射活性を決定し、そして試験化合物とセロトニン-5HT2A結合部位との任意の相互作用を確認するためにコントロール値と比較した(文献参照:Leysen,J.E.et al.Mol.Pharmacol.1982,21,301-314;Martin,G.R.and Humphrey,P.P.A.Neruopharmacol.1994,33(3/4),261-273)。
材料及び方法:
受容体の供給源:ヒトリコンビナント5-HT2B発現CHO-K1細胞
放射性リガンド:1.20nM [3H]リゼルグ酸ジエチルアミド(LSD)
コントロール化合物:ケタンセリン
培養条件:反応を50mM Tris-HCl(pH7.6)において室温で90分間行った。反応をガラス繊維フィルター上で急速真空濾過により終結した。フィルター上に捕捉した放射活性を決定し、そして試験化合物とセロトニン-5HT2B結合部位との任意の相互作用を確認するためにコントロール値と比較した。
材料及び方法:
受容体の供給源:ヒトリコンビナント5-HT6発現哺乳類細胞
放射性リガンド:[125I]SB258585、15nM又は[3H]LSD,2nM
コントロール化合物:メチオテピン又はセロトニン
培養条件:反応を10mM MgSO4、0.5mM EDTA及び0.1%アスコルビン酸を含む50mM Tris-HCl(pH7.4)において室温で1時間行った。反応をガラス繊維フィルター上で急速真空濾過により終結した。フィルター上に捕捉した放射活性を決定し、そして試験化合物とクローン化したセロトニン-5HT6結合部位との任意の相互作用を確認するためにコントロール値と比較した(文献参照:Gonzalo,R.,et al.,Br.J.Pharmacol.,2006(148),1133-1143)。
材料及び方法:
受容体の供給源:ヒトリコンビナント5-HT7発現CHO細胞
放射性リガンド:[3H]リゼルグ酸ジエチルアミド(LSD),4nM
コントロール化合物:セロトニン
培養条件:反応を50mM Tris-HCl(pH7.6)において室温で90分間行った。反応をガラス繊維フィルター上で急速真空濾過により終結した。フィルター上に捕捉した放射活性を決定し、そして試験化合物とクローン化したセロトニン-5HT7結合部位との任意の相互作用を確認するためにコントロール値と比較した。
Claims (8)
- 医薬的に許容可能な担体、賦形剤、又は希釈剤を含む、請求項1に記載の医薬組成物。
- 経口で投与される、請求項1又は2に記載の医薬組成物。
- 特発性肺線維症を治療する、請求項1又は2に記載の医薬組成物。
- 慢性閉塞性肺疾患(COPD)を有する対象の肺線維症を治療する、請求項1又は2に記載の医薬組成物。
- 鎌状赤血球症(SCD)を有する対象の肺線維症を治療する、請求項1又は2に記載の医薬組成物。
- 強皮症を有する対象の肺線維症を治療する、請求項1又は2に記載の医薬組成物。
- 肺癌を有する対象の肺線維症を治療する、請求項1又は2に記載の医薬組成物。
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US62/611,501 | 2017-12-28 | ||
PCT/US2018/067999 WO2019133901A1 (en) | 2017-12-28 | 2018-12-28 | Methods for treating pulmonary fibrosis |
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WO2014058000A1 (ja) | 2012-10-10 | 2014-04-17 | 大正製薬株式会社 | セロトニン2b受容体拮抗剤 |
WO2016115039A1 (en) | 2015-01-12 | 2016-07-21 | Reviva Pharmaceuticals Inc. | Methods for treating pulmonary hypertension |
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US20110171193A1 (en) * | 2008-06-12 | 2011-07-14 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating pulmonary hypertension |
KR101810975B1 (ko) * | 2010-07-08 | 2017-12-20 | 에스케이바이오팜 주식회사 | 카바모일옥시 아릴알칸노일 아릴피페라진계 화합물을 포함하는 약학적 조성물 |
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WO2014058000A1 (ja) | 2012-10-10 | 2014-04-17 | 大正製薬株式会社 | セロトニン2b受容体拮抗剤 |
WO2016115039A1 (en) | 2015-01-12 | 2016-07-21 | Reviva Pharmaceuticals Inc. | Methods for treating pulmonary hypertension |
Non-Patent Citations (2)
Title |
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European Journal of Pharmacology,2017年08月16日,Vol.814,p.114-123 |
Journal of the American College of Cardiology,Vol.62, No.25,2013年,p.D109-D116 |
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