JP7339942B2 - サポニンを含むリポソーム製剤および使用方法 - Google Patents

Info

Publication number

JP7339942B2

JP7339942B2 JP2020514284A JP2020514284A JP7339942B2 JP 7339942 B2 JP7339942 B2 JP 7339942B2 JP 2020514284 A JP2020514284 A JP 2020514284A JP 2020514284 A JP2020514284 A JP 2020514284A JP 7339942 B2 JP7339942 B2 JP 7339942B2

Authority

JP

Japan

Prior art keywords

antigen

saponin

per dose

immune response

formulation

Prior art date

2017-09-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Active

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 title claims description 294
• 150000007949 saponins Chemical class 0.000 title claims description 180
• 229930182490 saponin Natural products 0.000 title claims description 174
• 238000009472 formulation Methods 0.000 title claims description 155
• 239000001397 quillaja saponaria molina bark Substances 0.000 title claims description 145
• 238000000034 method Methods 0.000 title claims description 58
• 108091007433 antigens Proteins 0.000 claims description 204
• 102000036639 antigens Human genes 0.000 claims description 204
• 239000000427 antigen Substances 0.000 claims description 202
• 239000002158 endotoxin Substances 0.000 claims description 122
• 229920006008 lipopolysaccharide Polymers 0.000 claims description 121
• OPGTXAUDXWCGFI-UHFFFAOYSA-N [1-[[6-[[3-(3-dodecanoyloxytetradecanoylamino)-6-(hydroxymethyl)-5-phosphonooxy-4-(3-tetradecanoyloxytetradecanoyloxy)oxan-2-yl]oxymethyl]-2,4,5-trihydroxyoxan-3-yl]amino]-1-oxotetradecan-3-yl] hexadecanoate Chemical group OC1C(O)C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(O)OC1COC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)C(OP(O)(O)=O)C(CO)O1 OPGTXAUDXWCGFI-UHFFFAOYSA-N 0.000 claims description 82
• 229960005486 vaccine Drugs 0.000 claims description 72
• 229930182558 Sterol Natural products 0.000 claims description 67
• 235000003702 sterols Nutrition 0.000 claims description 67
• 230000028993 immune response Effects 0.000 claims description 66
• 150000003432 sterols Chemical class 0.000 claims description 66
• 206010028980 Neoplasm Diseases 0.000 claims description 52
• 125000000217 alkyl group Chemical group 0.000 claims description 48
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 44
• 201000011510 cancer Diseases 0.000 claims description 40
• 239000002502 liposome Substances 0.000 claims description 37
• 150000003839 salts Chemical class 0.000 claims description 30
• 238000004519 manufacturing process Methods 0.000 claims description 27
• 239000008194 pharmaceutical composition Substances 0.000 claims description 25
• -1 DLPG Chemical compound 0.000 claims description 24
• 150000003904 phospholipids Chemical class 0.000 claims description 23
• 208000023275 Autoimmune disease Diseases 0.000 claims description 22
• 235000012000 cholesterol Nutrition 0.000 claims description 22
• 239000003795 chemical substances by application Substances 0.000 claims description 17
• 208000035473 Communicable disease Diseases 0.000 claims description 16
• UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims description 12
• 230000002708 enhancing effect Effects 0.000 claims description 12
• 208000015181 infectious disease Diseases 0.000 claims description 12
• 230000001939 inductive effect Effects 0.000 claims description 11
• 238000002156 mixing Methods 0.000 claims description 11
• SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims description 10
• 201000004792 malaria Diseases 0.000 claims description 10
• 238000011282 treatment Methods 0.000 claims description 9
• 241000710886 West Nile virus Species 0.000 claims description 8
• 238000000265 homogenisation Methods 0.000 claims description 8
• 239000012678 infectious agent Substances 0.000 claims description 8
• LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 claims description 5
• QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 claims description 5
• FVXDQWZBHIXIEJ-LNDKUQBDSA-N 1,2-di-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC FVXDQWZBHIXIEJ-LNDKUQBDSA-N 0.000 claims description 5
• KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 5
• DSNRWDQKZIEDDB-SQYFZQSCSA-N 1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-SQYFZQSCSA-N 0.000 claims description 5
• NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 5
• ZLGYVWRJIZPQMM-HHHXNRCGSA-N 2-azaniumylethyl [(2r)-2,3-di(dodecanoyloxy)propyl] phosphate Chemical compound CCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCC ZLGYVWRJIZPQMM-HHHXNRCGSA-N 0.000 claims description 5
• GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims description 5
• 101001000212 Rattus norvegicus Decorin Proteins 0.000 claims description 5
• BPHQZTVXXXJVHI-UHFFFAOYSA-N dimyristoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-UHFFFAOYSA-N 0.000 claims description 5
• BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 claims description 5
• FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 claims description 5
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 5
• 239000000872 buffer Substances 0.000 claims description 3
• 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
• 239000003623 enhancer Substances 0.000 claims 6
• 239000000411 inducer Substances 0.000 claims 6
• 235000017709 saponins Nutrition 0.000 description 162
• 239000002671 adjuvant Substances 0.000 description 37
• 108090000623 proteins and genes Proteins 0.000 description 32
• 102000004169 proteins and genes Human genes 0.000 description 31
• 210000004027 cell Anatomy 0.000 description 30
• 108090000765 processed proteins & peptides Proteins 0.000 description 30
• 235000018102 proteins Nutrition 0.000 description 30
• 102000004196 processed proteins & peptides Human genes 0.000 description 26
• 241000700605 Viruses Species 0.000 description 23
• 239000002245 particle Substances 0.000 description 23
• 229920001184 polypeptide Polymers 0.000 description 21
• 238000002360 preparation method Methods 0.000 description 21
• 108020001507 fusion proteins Proteins 0.000 description 20
• 102000037865 fusion proteins Human genes 0.000 description 20
• 108091034117 Oligonucleotide Proteins 0.000 description 18
• 102000008233 Toll-Like Receptor 4 Human genes 0.000 description 18
• 108010060804 Toll-Like Receptor 4 Proteins 0.000 description 18
• 125000003729 nucleotide group Chemical group 0.000 description 17
• 239000000556 agonist Substances 0.000 description 16
• 150000001875 compounds Chemical class 0.000 description 15
• 230000014509 gene expression Effects 0.000 description 15
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 14
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 14
• 239000000243 solution Substances 0.000 description 14
• 108020004414 DNA Proteins 0.000 description 13
• 241000701806 Human papillomavirus Species 0.000 description 13
• 150000002632 lipids Chemical class 0.000 description 13
• 150000007523 nucleic acids Chemical class 0.000 description 13
• 108700006640 OspA Proteins 0.000 description 12
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
• 230000003308 immunostimulating effect Effects 0.000 description 12
• 102000039446 nucleic acids Human genes 0.000 description 12
• 108020004707 nucleic acids Proteins 0.000 description 12
• 239000002773 nucleotide Substances 0.000 description 12
• 210000001519 tissue Anatomy 0.000 description 12
• 239000003053 toxin Substances 0.000 description 12
• 231100000765 toxin Toxicity 0.000 description 12
• 108700012359 toxins Proteins 0.000 description 12
• 241000894006 Bacteria Species 0.000 description 11
• 201000010099 disease Diseases 0.000 description 11
• 230000000694 effects Effects 0.000 description 11
• 102000004127 Cytokines Human genes 0.000 description 10
• 108090000695 Cytokines Proteins 0.000 description 10
• 210000001744 T-lymphocyte Anatomy 0.000 description 10
• 239000002253 acid Substances 0.000 description 10
• 210000000987 immune system Anatomy 0.000 description 10
• 230000036039 immunity Effects 0.000 description 10
• 230000004048 modification Effects 0.000 description 10
• 238000012986 modification Methods 0.000 description 10
• 102000040430 polynucleotide Human genes 0.000 description 10
• 108091033319 polynucleotide Proteins 0.000 description 10
• 239000002157 polynucleotide Substances 0.000 description 10
• 201000008827 tuberculosis Diseases 0.000 description 10
• 241000124008 Mammalia Species 0.000 description 9
• 229940024606 amino acid Drugs 0.000 description 9
• 235000001014 amino acid Nutrition 0.000 description 9
• 150000001413 amino acids Chemical class 0.000 description 9
• 238000003556 assay Methods 0.000 description 9
• 238000002296 dynamic light scattering Methods 0.000 description 9
• 239000000463 material Substances 0.000 description 9
• 230000004044 response Effects 0.000 description 9
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
• 241000588724 Escherichia coli Species 0.000 description 8
• 108700023315 OspC Proteins 0.000 description 8
• 241001454523 Quillaja saponaria Species 0.000 description 8
• 235000009001 Quillaja saponaria Nutrition 0.000 description 8
• 101100431670 Rattus norvegicus Ybx3 gene Proteins 0.000 description 8
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
• CTMZLDSMFCVUNX-VMIOUTBZSA-N cytidylyl-(3'->5')-guanosine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)[C@@H](CO)O1 CTMZLDSMFCVUNX-VMIOUTBZSA-N 0.000 description 8
• 239000012634 fragment Substances 0.000 description 8
• 230000001681 protective effect Effects 0.000 description 8
• UPAZUDUZKTYFBG-HNPUZVNISA-N azane [(2S,3R,4R,5S,6R)-2,5-dihydroxy-6-[[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-5-phosphonooxy-3-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]-4-[(3R)-3-tetradecanoyloxytetradecanoyl]oxyoxan-2-yl]oxymethyl]-3-[[(3R)-3-hydroxytetradecanoyl]amino]oxan-4-yl] (3R)-3-hydroxytetradecanoate Chemical compound [NH4+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@H]1[C@H](OC[C@H]2O[C@H](O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)O[C@H](CO)[C@@H](OP(O)([O-])=O)[C@@H]1OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC UPAZUDUZKTYFBG-HNPUZVNISA-N 0.000 description 7
• 230000001580 bacterial effect Effects 0.000 description 7
• 230000001404 mediated effect Effects 0.000 description 7
• 239000011780 sodium chloride Substances 0.000 description 7
• 108010012236 Chemokines Proteins 0.000 description 6
• 102000019034 Chemokines Human genes 0.000 description 6
• 241000606161 Chlamydia Species 0.000 description 6
• 229940046168 CpG oligodeoxynucleotide Drugs 0.000 description 6
• 241000701022 Cytomegalovirus Species 0.000 description 6
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
• 241000282412 Homo Species 0.000 description 6
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 6
• 241000725303 Human immunodeficiency virus Species 0.000 description 6
• 241001465754 Metazoa Species 0.000 description 6
• 241000224016 Plasmodium Species 0.000 description 6
• 241000242683 Schistosoma haematobium Species 0.000 description 6
• 241000242677 Schistosoma japonicum Species 0.000 description 6
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
• 238000007792 addition Methods 0.000 description 6
• 230000001363 autoimmune Effects 0.000 description 6
• 206010022000 influenza Diseases 0.000 description 6
• 239000007788 liquid Substances 0.000 description 6
• 244000045947 parasite Species 0.000 description 6
• 244000052769 pathogen Species 0.000 description 6
• 230000001717 pathogenic effect Effects 0.000 description 6
• 229920000642 polymer Polymers 0.000 description 6
• 229940002612 prodrug Drugs 0.000 description 6
• 239000000651 prodrug Substances 0.000 description 6
• 241000712461 unidentified influenza virus Species 0.000 description 6
• 241000589968 Borrelia Species 0.000 description 5
• 241000233866 Fungi Species 0.000 description 5
• 208000016604 Lyme disease Diseases 0.000 description 5
• 241001092142 Molina Species 0.000 description 5
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 5
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 5
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
• 241000607142 Salmonella Species 0.000 description 5
• 241000242678 Schistosoma Species 0.000 description 5
• 230000005867 T cell response Effects 0.000 description 5
• 239000004480 active ingredient Substances 0.000 description 5
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 5
• 230000004927 fusion Effects 0.000 description 5
• 230000002949 hemolytic effect Effects 0.000 description 5
• 208000006454 hepatitis Diseases 0.000 description 5
• 231100000283 hepatitis Toxicity 0.000 description 5
• 208000002672 hepatitis B Diseases 0.000 description 5
• 238000001727 in vivo Methods 0.000 description 5
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 5
• 201000001441 melanoma Diseases 0.000 description 5
• 230000003389 potentiating effect Effects 0.000 description 5
• 230000009885 systemic effect Effects 0.000 description 5
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 5
• 239000003981 vehicle Substances 0.000 description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• 101100162403 Arabidopsis thaliana ALEU gene Proteins 0.000 description 4
• 102100030009 Azurocidin Human genes 0.000 description 4
• 101710154607 Azurocidin Proteins 0.000 description 4
• 108030001720 Bontoxilysin Proteins 0.000 description 4
• 241000588807 Bordetella Species 0.000 description 4
• 241000222122 Candida albicans Species 0.000 description 4
• 102000016938 Catalase Human genes 0.000 description 4
• 108010053835 Catalase Proteins 0.000 description 4
• 241000700198 Cavia Species 0.000 description 4
• 241000193403 Clostridium Species 0.000 description 4
• 206010009944 Colon cancer Diseases 0.000 description 4
• 238000002965 ELISA Methods 0.000 description 4
• 241000224432 Entamoeba histolytica Species 0.000 description 4
• 241000588722 Escherichia Species 0.000 description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
• 101710154606 Hemagglutinin Proteins 0.000 description 4
• 241000701085 Human alphaherpesvirus 3 Species 0.000 description 4
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 4
• 108010074338 Lymphokines Proteins 0.000 description 4
• 102000008072 Lymphokines Human genes 0.000 description 4
• 101710105759 Major outer membrane porin Proteins 0.000 description 4
• 101710164702 Major outer membrane protein Proteins 0.000 description 4
• 101710085938 Matrix protein Proteins 0.000 description 4
• 101710127721 Membrane protein Proteins 0.000 description 4
• 241000186359 Mycobacterium Species 0.000 description 4
• 241000588653 Neisseria Species 0.000 description 4
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 4
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 4
• 241000233870 Pneumocystis Species 0.000 description 4
• 101710176177 Protein A56 Proteins 0.000 description 4
• 241000725643 Respiratory syncytial virus Species 0.000 description 4
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 4
• 108010046334 Urease Proteins 0.000 description 4
• 241000244005 Wuchereria bancrofti Species 0.000 description 4
• 241000907316 Zika virus Species 0.000 description 4
• 230000005875 antibody response Effects 0.000 description 4
• 230000002238 attenuated effect Effects 0.000 description 4
• 244000052616 bacterial pathogen Species 0.000 description 4
• 239000002585 base Substances 0.000 description 4
• 230000015572 biosynthetic process Effects 0.000 description 4
• 229940053031 botulinum toxin Drugs 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 239000000470 constituent Substances 0.000 description 4
• 239000006185 dispersion Substances 0.000 description 4
• 239000000839 emulsion Substances 0.000 description 4
• 229940007078 entamoeba histolytica Drugs 0.000 description 4
• 125000000524 functional group Chemical group 0.000 description 4
• 239000011521 glass Substances 0.000 description 4
• 150000004676 glycans Chemical class 0.000 description 4
• 239000000185 hemagglutinin Substances 0.000 description 4
• 238000004128 high performance liquid chromatography Methods 0.000 description 4
• 230000003053 immunization Effects 0.000 description 4
• 238000002649 immunization Methods 0.000 description 4
• 230000005847 immunogenicity Effects 0.000 description 4
• 238000000338 in vitro Methods 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 238000010255 intramuscular injection Methods 0.000 description 4
• 239000007927 intramuscular injection Substances 0.000 description 4
• 230000000670 limiting effect Effects 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 239000008363 phosphate buffer Substances 0.000 description 4
• 201000000317 pneumocystosis Diseases 0.000 description 4
• 229920001282 polysaccharide Polymers 0.000 description 4
• 239000005017 polysaccharide Substances 0.000 description 4
• 238000003259 recombinant expression Methods 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 230000004936 stimulating effect Effects 0.000 description 4
• 238000003786 synthesis reaction Methods 0.000 description 4
• 230000002477 vacuolizing effect Effects 0.000 description 4
• 239000013603 viral vector Substances 0.000 description 4
• 230000003612 virological effect Effects 0.000 description 4
• LUBKKVGXMXTXOZ-QGZVFWFLSA-N (+)-geodin Chemical compound COC(=O)C1=CC(=O)C=C(OC)[C@@]11C(=O)C(C(O)=C(Cl)C(C)=C2Cl)=C2O1 LUBKKVGXMXTXOZ-QGZVFWFLSA-N 0.000 description 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
• WTBFLCSPLLEDEM-JIDRGYQWSA-N 1,2-dioleoyl-sn-glycero-3-phospho-L-serine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC WTBFLCSPLLEDEM-JIDRGYQWSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 208000023328 Basedow disease Diseases 0.000 description 3
• 241000282472 Canis lupus familiaris Species 0.000 description 3
• 201000009030 Carcinoma Diseases 0.000 description 3
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 3
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
• 230000006820 DNA synthesis Effects 0.000 description 3
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 3
• 241000725619 Dengue virus Species 0.000 description 3
• QRLVDLBMBULFAL-UHFFFAOYSA-N Digitonin Natural products CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C8O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C QRLVDLBMBULFAL-UHFFFAOYSA-N 0.000 description 3
• 241000196324 Embryophyta Species 0.000 description 3
• 241000713800 Feline immunodeficiency virus Species 0.000 description 3
• 241000282326 Felis catus Species 0.000 description 3
• 241000710831 Flavivirus Species 0.000 description 3
• 241000224466 Giardia Species 0.000 description 3
• 208000015023 Graves' disease Diseases 0.000 description 3
• 241000700721 Hepatitis B virus Species 0.000 description 3
• 241000341655 Human papillomavirus type 16 Species 0.000 description 3
• 108010074328 Interferon-gamma Proteins 0.000 description 3
• 108010002350 Interleukin-2 Proteins 0.000 description 3
• 102000000588 Interleukin-2 Human genes 0.000 description 3
• 241000710842 Japanese encephalitis virus Species 0.000 description 3
• 102000004895 Lipoproteins Human genes 0.000 description 3
• 108090001030 Lipoproteins Proteins 0.000 description 3
• 241000712079 Measles morbillivirus Species 0.000 description 3
• 241000711386 Mumps virus Species 0.000 description 3
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
• 208000002606 Paramyxoviridae Infections Diseases 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 101710188053 Protein D Proteins 0.000 description 3
• 101710132893 Resolvase Proteins 0.000 description 3
• 241000702670 Rotavirus Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 241000710771 Tick-borne encephalitis virus Species 0.000 description 3
• 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 description 3
• 230000004075 alteration Effects 0.000 description 3
• 238000004458 analytical method Methods 0.000 description 3
• 239000007864 aqueous solution Substances 0.000 description 3
• 208000006673 asthma Diseases 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 150000001720 carbohydrates Chemical group 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000000576 coating method Methods 0.000 description 3
• 239000000356 contaminant Substances 0.000 description 3
• UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 description 3
• UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 3
• 239000002612 dispersion medium Substances 0.000 description 3
• 229940011399 escin Drugs 0.000 description 3
• 229930186222 escin Natural products 0.000 description 3
• 230000006870 function Effects 0.000 description 3
• 230000002538 fungal effect Effects 0.000 description 3
• 201000010175 gallbladder cancer Diseases 0.000 description 3
• 244000000013 helminth Species 0.000 description 3
• 239000005556 hormone Substances 0.000 description 3
• 229940088597 hormone Drugs 0.000 description 3
• 230000002163 immunogen Effects 0.000 description 3
• 230000016784 immunoglobulin production Effects 0.000 description 3
• 230000001965 increasing effect Effects 0.000 description 3
• 230000006698 induction Effects 0.000 description 3
• 239000004615 ingredient Substances 0.000 description 3
• 229960000367 inositol Drugs 0.000 description 3
• 238000007918 intramuscular administration Methods 0.000 description 3
• 238000001990 intravenous administration Methods 0.000 description 3
• 238000005259 measurement Methods 0.000 description 3
• 244000005700 microbiome Species 0.000 description 3
• 150000007522 mineralic acids Chemical class 0.000 description 3
• 238000012544 monitoring process Methods 0.000 description 3
• 230000007935 neutral effect Effects 0.000 description 3
• 231100000252 nontoxic Toxicity 0.000 description 3
• 230000003000 nontoxic effect Effects 0.000 description 3
• 150000007524 organic acids Chemical class 0.000 description 3
• 208000008443 pancreatic carcinoma Diseases 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 210000002307 prostate Anatomy 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 230000002829 reductive effect Effects 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• 230000000638 stimulation Effects 0.000 description 3
• 238000003860 storage Methods 0.000 description 3
• 238000007920 subcutaneous administration Methods 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 3
• 238000012360 testing method Methods 0.000 description 3
• 230000001988 toxicity Effects 0.000 description 3
• 231100000419 toxicity Toxicity 0.000 description 3
• 239000013598 vector Substances 0.000 description 3
• OIWCYIUQAVBPGV-DAQGAKHBSA-N {1-O-hexadecanoyl-2-O-[(Z)-octadec-9-enoyl]-sn-glycero-3-phospho}serine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC OIWCYIUQAVBPGV-DAQGAKHBSA-N 0.000 description 3
• OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 2
• KLFKZIQAIPDJCW-GPOMZPHUSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCC KLFKZIQAIPDJCW-GPOMZPHUSA-N 0.000 description 2
• OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 2
• 241000224422 Acanthamoeba Species 0.000 description 2
• 241000456624 Actinobacteria bacterium Species 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
• 241001147657 Ancylostoma Species 0.000 description 2
• 241000498253 Ancylostoma duodenale Species 0.000 description 2
• 241000243791 Angiostrongylus Species 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• 241000228212 Aspergillus Species 0.000 description 2
• 206010050245 Autoimmune thrombocytopenia Diseases 0.000 description 2
• 241000223836 Babesia Species 0.000 description 2
• 241000193830 Bacillus <bacterium> Species 0.000 description 2
• 206010005003 Bladder cancer Diseases 0.000 description 2
• 241000335423 Blastomyces Species 0.000 description 2
• 241001148604 Borreliella afzelii Species 0.000 description 2
• 241000142472 Borreliella andersonii Species 0.000 description 2
• 241000589969 Borreliella burgdorferi Species 0.000 description 2
• 241001148605 Borreliella garinii Species 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• 206010006187 Breast cancer Diseases 0.000 description 2
• 208000026310 Breast neoplasm Diseases 0.000 description 2
• 241000244038 Brugia malayi Species 0.000 description 2
• 244000197813 Camelina sativa Species 0.000 description 2
• 241000589876 Campylobacter Species 0.000 description 2
• 241000589875 Campylobacter jejuni Species 0.000 description 2
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
• 241000222178 Candida tropicalis Species 0.000 description 2
• 206010008342 Cervix carcinoma Diseases 0.000 description 2
• 208000026368 Cestode infections Diseases 0.000 description 2
• 241001647372 Chlamydia pneumoniae Species 0.000 description 2
• 206010008631 Cholera Diseases 0.000 description 2
• 108010049048 Cholera Toxin Proteins 0.000 description 2
• 102000009016 Cholera Toxin Human genes 0.000 description 2
• 241001508813 Clavispora lusitaniae Species 0.000 description 2
• 241000193163 Clostridioides difficile Species 0.000 description 2
• 241000193155 Clostridium botulinum Species 0.000 description 2
• 241000223203 Coccidioides Species 0.000 description 2
• 241000186216 Corynebacterium Species 0.000 description 2
• 241001337994 Cryptococcus <scale insect> Species 0.000 description 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• 102100029921 Dipeptidyl peptidase 1 Human genes 0.000 description 2
• 101710087078 Dipeptidyl peptidase 1 Proteins 0.000 description 2
• 108010053187 Diphtheria Toxin Proteins 0.000 description 2
• 102000016607 Diphtheria Toxin Human genes 0.000 description 2
• 208000025011 Distomatosis Diseases 0.000 description 2
• 241000605314 Ehrlichia Species 0.000 description 2
• 241000224431 Entamoeba Species 0.000 description 2
• 241000146407 Entamoeba coli Species 0.000 description 2
• 241000204733 Entamoeba dispar Species 0.000 description 2
• 241000146401 Entamoeba hartmanni Species 0.000 description 2
• 241000146402 Entamoeba polecki Species 0.000 description 2
• 241000498255 Enterobius vermicularis Species 0.000 description 2
• 241000194033 Enterococcus Species 0.000 description 2
• 241000283086 Equidae Species 0.000 description 2
• 241000204939 Fasciola gigantica Species 0.000 description 2
• 241000242711 Fasciola hepatica Species 0.000 description 2
• 101710154643 Filamentous hemagglutinin Proteins 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• 108091006027 G proteins Proteins 0.000 description 2
• 102000030782 GTP binding Human genes 0.000 description 2
• 108091000058 GTP-Binding Proteins 0.000 description 2
• 208000022072 Gallbladder Neoplasms Diseases 0.000 description 2
• 101000812705 Gallus gallus Endoplasmin Proteins 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
• 241001316290 Gypsophila Species 0.000 description 2
• 208000031886 HIV Infections Diseases 0.000 description 2
• 208000001204 Hashimoto Disease Diseases 0.000 description 2
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 2
• 241000589989 Helicobacter Species 0.000 description 2
• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 2
• 241000711549 Hepacivirus C Species 0.000 description 2
• 241000724675 Hepatitis E virus Species 0.000 description 2
• 241000709721 Hepatovirus A Species 0.000 description 2
• 241000700588 Human alphaherpesvirus 1 Species 0.000 description 2
• 241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
• 206010071038 Human anaplasmosis Diseases 0.000 description 2
• 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
• 108010007403 Immediate-Early Proteins Proteins 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• 102000008070 Interferon-gamma Human genes 0.000 description 2
• 102000015696 Interleukins Human genes 0.000 description 2
• 108010063738 Interleukins Proteins 0.000 description 2
• 241000220680 Lactobacillus psittaci Species 0.000 description 2
• 102000010445 Lactoferrin Human genes 0.000 description 2
• 241000589248 Legionella Species 0.000 description 2
• 208000007764 Legionnaires' Disease Diseases 0.000 description 2
• 241000222722 Leishmania <genus> Species 0.000 description 2
• 241000589902 Leptospira Species 0.000 description 2
• 241000186781 Listeria Species 0.000 description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• 241000588621 Moraxella Species 0.000 description 2
• 241000588655 Moraxella catarrhalis Species 0.000 description 2
• 241000186367 Mycobacterium avium Species 0.000 description 2
• 241000187482 Mycobacterium avium subsp. paratuberculosis Species 0.000 description 2
• 241000186362 Mycobacterium leprae Species 0.000 description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
• 241000498270 Necator americanus Species 0.000 description 2
• 208000000291 Nematode infections Diseases 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 206010030155 Oesophageal carcinoma Diseases 0.000 description 2
• 241000243985 Onchocerca volvulus Species 0.000 description 2
• 241000133504 Opisthorchis sinensis Species 0.000 description 2
• 101710116435 Outer membrane protein Proteins 0.000 description 2
• 206010033128 Ovarian cancer Diseases 0.000 description 2
• 206010061535 Ovarian neoplasm Diseases 0.000 description 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
• 241001480233 Paragonimus Species 0.000 description 2
• 241000721454 Pemphigus Species 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 208000031845 Pernicious anaemia Diseases 0.000 description 2
• 108010081690 Pertussis Toxin Proteins 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 240000009188 Phyllostachys vivax Species 0.000 description 2
• 241000235645 Pichia kudriavzevii Species 0.000 description 2
• 244000010922 Plantago major Species 0.000 description 2
• 241000223960 Plasmodium falciparum Species 0.000 description 2
• 241000223821 Plasmodium malariae Species 0.000 description 2
• 206010035501 Plasmodium malariae infection Diseases 0.000 description 2
• 102100035181 Plastin-1 Human genes 0.000 description 2
• 108010072866 Prostate-Specific Antigen Proteins 0.000 description 2
• 102100038358 Prostate-specific antigen Human genes 0.000 description 2
• 239000004365 Protease Substances 0.000 description 2
• 241000589516 Pseudomonas Species 0.000 description 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
• 208000006265 Renal cell carcinoma Diseases 0.000 description 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
• 241000606701 Rickettsia Species 0.000 description 2
• 241000283984 Rodentia Species 0.000 description 2
• 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 2
• 241000242680 Schistosoma mansoni Species 0.000 description 2
• 241001520868 Schistosoma mekongi Species 0.000 description 2
• 241000607768 Shigella Species 0.000 description 2
• 101710084578 Short neurotoxin 1 Proteins 0.000 description 2
• 241000700584 Simplexvirus Species 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• 241000256215 Spongomorpha aeruginosa Species 0.000 description 2
• 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 2
• 241000191940 Staphylococcus Species 0.000 description 2
• 208000005718 Stomach Neoplasms Diseases 0.000 description 2
• 241000193985 Streptococcus agalactiae Species 0.000 description 2
• 241000194019 Streptococcus mutans Species 0.000 description 2
• 241000244177 Strongyloides stercoralis Species 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 230000006052 T cell proliferation Effects 0.000 description 2
• 241000244159 Taenia saginata Species 0.000 description 2
• 241000244157 Taenia solium Species 0.000 description 2
• 101710157310 Tegument protein UL47 homolog Proteins 0.000 description 2
• 208000024313 Testicular Neoplasms Diseases 0.000 description 2
• 206010057644 Testis cancer Diseases 0.000 description 2
• 108010055044 Tetanus Toxin Proteins 0.000 description 2
• 208000003217 Tetany Diseases 0.000 description 2
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 2
• 206010043561 Thrombocytopenic purpura Diseases 0.000 description 2
• 208000007536 Thrombosis Diseases 0.000 description 2
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
• 101710182223 Toxin B Proteins 0.000 description 2
• 101710182532 Toxin a Proteins 0.000 description 2
• 241000223996 Toxoplasma Species 0.000 description 2
• 101710134694 Transcriptional regulator ICP22 homolog Proteins 0.000 description 2
• 102000010912 Transferrin-Binding Proteins Human genes 0.000 description 2
• 241000242541 Trematoda Species 0.000 description 2
• 241000589886 Treponema Species 0.000 description 2
• 241000589892 Treponema denticola Species 0.000 description 2
• 241000243777 Trichinella spiralis Species 0.000 description 2
• 241000224526 Trichomonas Species 0.000 description 2
• 241001489151 Trichuris Species 0.000 description 2
• 241000223104 Trypanosoma Species 0.000 description 2
• 241001310304 Trypanosoma microti Species 0.000 description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
• 241001467018 Typhis Species 0.000 description 2
• 206010046431 Urethral cancer Diseases 0.000 description 2
• 206010046458 Urethral neoplasms Diseases 0.000 description 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
• 241000607598 Vibrio Species 0.000 description 2
• 241000710772 Yellow fever virus Species 0.000 description 2
• 241000607734 Yersinia <bacteria> Species 0.000 description 2
• 241000607479 Yersinia pestis Species 0.000 description 2
• 208000025087 Yersinia pseudotuberculosis infectious disease Diseases 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 108060000200 adenylate cyclase Proteins 0.000 description 2
• 102000030621 adenylate cyclase Human genes 0.000 description 2
• 230000002411 adverse Effects 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 125000003277 amino group Chemical group 0.000 description 2
• 125000000129 anionic group Chemical group 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
• 229940121375 antifungal agent Drugs 0.000 description 2
• 239000003429 antifungal agent Substances 0.000 description 2
• 210000000612 antigen-presenting cell Anatomy 0.000 description 2
• 238000003782 apoptosis assay Methods 0.000 description 2
• 230000006907 apoptotic process Effects 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 2
• 230000005784 autoimmunity Effects 0.000 description 2
• 201000008680 babesiosis Diseases 0.000 description 2
• 230000006399 behavior Effects 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
• LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 2
• 229960000074 biopharmaceutical Drugs 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 125000004432 carbon atom Chemical group C* 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 125000002091 cationic group Chemical group 0.000 description 2
• 230000020411 cell activation Effects 0.000 description 2
• 230000024245 cell differentiation Effects 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 230000036755 cellular response Effects 0.000 description 2
• 201000010881 cervical cancer Diseases 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 231100001102 clostridial toxin Toxicity 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 201000003278 cryoglobulinemia Diseases 0.000 description 2
• 230000001461 cytolytic effect Effects 0.000 description 2
• 208000033921 delayed sleep phase type circadian rhythm sleep disease Diseases 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 208000008576 dracunculiasis Diseases 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 238000012377 drug delivery Methods 0.000 description 2
• 235000013601 eggs Nutrition 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 230000000369 enteropathogenic effect Effects 0.000 description 2
• 230000000688 enterotoxigenic effect Effects 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• 206010017758 gastric cancer Diseases 0.000 description 2
• 229960002442 glucosamine Drugs 0.000 description 2
• 230000012010 growth Effects 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
• 235000010181 horse chestnut Nutrition 0.000 description 2
• 201000009163 human granulocytic anaplasmosis Diseases 0.000 description 2
• 208000022340 human granulocytic ehrlichiosis Diseases 0.000 description 2
• 230000008348 humoral response Effects 0.000 description 2
• 235000011167 hydrochloric acid Nutrition 0.000 description 2
• 238000003119 immunoblot Methods 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 238000010324 immunological assay Methods 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 239000012535 impurity Substances 0.000 description 2
• 150000007529 inorganic bases Chemical class 0.000 description 2
• 229960003130 interferon gamma Drugs 0.000 description 2
• 229940047122 interleukins Drugs 0.000 description 2
• 230000003834 intracellular effect Effects 0.000 description 2
• 238000007912 intraperitoneal administration Methods 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 150000002605 large molecules Chemical class 0.000 description 2
• 238000011031 large-scale manufacturing process Methods 0.000 description 2
• 239000003446 ligand Substances 0.000 description 2
• 201000005202 lung cancer Diseases 0.000 description 2
• 208000020816 lung neoplasm Diseases 0.000 description 2
• 210000004698 lymphocyte Anatomy 0.000 description 2
• 101710130522 mRNA export factor Proteins 0.000 description 2
• 229920002521 macromolecule Polymers 0.000 description 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 2
• 230000009401 metastasis Effects 0.000 description 2
• 230000000813 microbial effect Effects 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 230000004899 motility Effects 0.000 description 2
• 201000006417 multiple sclerosis Diseases 0.000 description 2
• 206010028417 myasthenia gravis Diseases 0.000 description 2
• 201000005962 mycosis fungoides Diseases 0.000 description 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
• 150000007530 organic bases Chemical class 0.000 description 2
• 201000002528 pancreatic cancer Diseases 0.000 description 2
• 239000013610 patient sample Substances 0.000 description 2
• 108010021711 pertactin Proteins 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
• 150000004713 phosphodiesters Chemical class 0.000 description 2
• 235000011007 phosphoric acid Nutrition 0.000 description 2
• 239000004033 plastic Substances 0.000 description 2
• 229920003023 plastic Polymers 0.000 description 2
• 108010049148 plastin Proteins 0.000 description 2
• 229920001223 polyethylene glycol Polymers 0.000 description 2
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 230000005522 programmed cell death Effects 0.000 description 2
• 150000003212 purines Chemical class 0.000 description 2
• 150000003230 pyrimidines Chemical class 0.000 description 2
• 238000003127 radioimmunoassay Methods 0.000 description 2
• 230000009257 reactivity Effects 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 206010038038 rectal cancer Diseases 0.000 description 2
• 239000011347 resin Substances 0.000 description 2
• 229920005989 resin Polymers 0.000 description 2
• 206010039073 rheumatoid arthritis Diseases 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 239000000523 sample Substances 0.000 description 2
• 210000002966 serum Anatomy 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• QBSSGICBQYAHPS-OUPRKWGVSA-M sodium;(2s)-2-azaniumyl-3-[[(2r)-2,3-di(dodecanoyloxy)propoxy]-oxidophosphoryl]oxypropanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OC[C@H]([NH3+])C([O-])=O)OC(=O)CCCCCCCCCCC QBSSGICBQYAHPS-OUPRKWGVSA-M 0.000 description 2
• FGGPAWQCCGEWTJ-UHFFFAOYSA-M sodium;2,3-bis(sulfanyl)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(S)CS FGGPAWQCCGEWTJ-UHFFFAOYSA-M 0.000 description 2
• 239000007790 solid phase Substances 0.000 description 2
• 239000012453 solvate Substances 0.000 description 2
• 238000000527 sonication Methods 0.000 description 2
• 210000000952 spleen Anatomy 0.000 description 2
• 239000007921 spray Substances 0.000 description 2
• 238000011146 sterile filtration Methods 0.000 description 2
• 230000003637 steroidlike Effects 0.000 description 2
• 201000011549 stomach cancer Diseases 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 229940031626 subunit vaccine Drugs 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 201000003120 testicular cancer Diseases 0.000 description 2
• 229940118376 tetanus toxin Drugs 0.000 description 2
• 238000011285 therapeutic regimen Methods 0.000 description 2
• 125000003396 thiol group Chemical group [H]S* 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 229940096911 trichinella spiralis Drugs 0.000 description 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
• 241001529453 unidentified herpesvirus Species 0.000 description 2
• 201000005112 urinary bladder cancer Diseases 0.000 description 2
• 239000000277 virosome Substances 0.000 description 2
• 230000000007 visual effect Effects 0.000 description 2
• 244000298073 white hoary pea Species 0.000 description 2
• 229940051021 yellow-fever virus Drugs 0.000 description 2
• KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
• BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 1
• CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
• RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 description 1
• CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 1
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
• RHODCGQMKYNKED-SXOMAYOGSA-N 1,2-dilauroyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCC RHODCGQMKYNKED-SXOMAYOGSA-N 0.000 description 1
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
• IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 1
• MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
• KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
• FTZIQBGFCYJWKA-UHFFFAOYSA-N 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Chemical compound S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 FTZIQBGFCYJWKA-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
• 210000002925 A-like Anatomy 0.000 description 1
• 208000030507 AIDS Diseases 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 description 1
• 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 description 1
• 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 description 1
• 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 description 1
• 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 description 1
• 206010000830 Acute leukaemia Diseases 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 241000157282 Aesculus Species 0.000 description 1
• 241000157280 Aesculus hippocastanum Species 0.000 description 1
• 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 description 1
• 208000000884 Airway Obstruction Diseases 0.000 description 1
• 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 description 1
• 208000004881 Amebiasis Diseases 0.000 description 1
• 206010001980 Amoebiasis Diseases 0.000 description 1
• 206010061424 Anal cancer Diseases 0.000 description 1
• 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 description 1
• 206010059313 Anogenital warts Diseases 0.000 description 1
• 208000007860 Anus Neoplasms Diseases 0.000 description 1
• 241000272478 Aquila Species 0.000 description 1
• 241000712891 Arenavirus Species 0.000 description 1
• 241000244186 Ascaris Species 0.000 description 1
• 241000244185 Ascaris lumbricoides Species 0.000 description 1
• 206010003571 Astrocytoma Diseases 0.000 description 1
• 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 description 1
• 102100035526 B melanoma antigen 1 Human genes 0.000 description 1
• 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 description 1
• 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 description 1
• 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 description 1
• 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 description 1
• 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 description 1
• 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 description 1
• 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 description 1
• 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 description 1
• 108020000946 Bacterial DNA Proteins 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
• 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 description 1
• 206010005949 Bone cancer Diseases 0.000 description 1
• 208000018084 Bone neoplasm Diseases 0.000 description 1
• 241000588832 Bordetella pertussis Species 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• 206010006458 Bronchitis chronic Diseases 0.000 description 1
• 208000011691 Burkitt lymphomas Diseases 0.000 description 1
• 102100032367 C-C motif chemokine 5 Human genes 0.000 description 1
• 125000006538 C11 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• PIGTXFOGKFOFTO-PPEDVFHSSA-N CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O Chemical compound CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O PIGTXFOGKFOFTO-PPEDVFHSSA-N 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 108010055166 Chemokine CCL5 Proteins 0.000 description 1
• 102000001327 Chemokine CCL5 Human genes 0.000 description 1
• 240000006162 Chenopodium quinoa Species 0.000 description 1
• 235000015493 Chenopodium quinoa Nutrition 0.000 description 1
• 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
• LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
• 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 description 1
• 208000000907 Condylomata Acuminata Diseases 0.000 description 1
• 241000711573 Coronaviridae Species 0.000 description 1
• 241000709687 Coxsackievirus Species 0.000 description 1
• 208000009798 Craniopharyngioma Diseases 0.000 description 1
• 241000221204 Cryptococcus neoformans Species 0.000 description 1
• 241000223935 Cryptosporidium Species 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
• 102100031262 Deleted in malignant brain tumors 1 protein Human genes 0.000 description 1
• 102000007577 Desmoglein 3 Human genes 0.000 description 1
• 108010032035 Desmoglein 3 Proteins 0.000 description 1
• BDCFUHIWJODVNG-UHFFFAOYSA-N Desmosterol Natural products C1C=C2CC(O)C=CC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 BDCFUHIWJODVNG-UHFFFAOYSA-N 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 208000002699 Digestive System Neoplasms Diseases 0.000 description 1
• 240000001879 Digitalis lutea Species 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 241001115402 Ebolavirus Species 0.000 description 1
• 206010014561 Emphysema Diseases 0.000 description 1
• 206010014596 Encephalitis Japanese B Diseases 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 241000305071 Enterobacterales Species 0.000 description 1
• 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 description 1
• 241000709661 Enterovirus Species 0.000 description 1
• 241000991587 Enterovirus C Species 0.000 description 1
• 206010014967 Ependymoma Diseases 0.000 description 1
• 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 description 1
• 241000283073 Equus caballus Species 0.000 description 1
• DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
• 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 description 1
• 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 208000004413 Eyelid Neoplasms Diseases 0.000 description 1
• 206010050497 Eyelid tumour Diseases 0.000 description 1
• 241000711950 Filoviridae Species 0.000 description 1
• 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
• 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 description 1
• 201000003741 Gastrointestinal carcinoma Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 description 1
• 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 description 1
• 208000021309 Germ cell tumor Diseases 0.000 description 1
• 208000032612 Glial tumor Diseases 0.000 description 1
• 206010018338 Glioma Diseases 0.000 description 1
• BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 229930186217 Glycolipid Natural products 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 229920002683 Glycosaminoglycan Polymers 0.000 description 1
• NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 description 1
• 102000006771 Gonadotropins Human genes 0.000 description 1
• 108010086677 Gonadotropins Proteins 0.000 description 1
• 206010018612 Gonorrhoea Diseases 0.000 description 1
• 241000190708 Guanarito mammarenavirus Species 0.000 description 1
• 241000606790 Haemophilus Species 0.000 description 1
• 241000606768 Haemophilus influenzae Species 0.000 description 1
• 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 description 1
• 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 description 1
• 101100406392 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) omp26 gene Proteins 0.000 description 1
• 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 description 1
• BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 description 1
• 208000019645 Hemorrhagic fever-renal syndrome Diseases 0.000 description 1
• 241000893570 Hendra henipavirus Species 0.000 description 1
• 241000035314 Henipavirus Species 0.000 description 1
• 229940124872 Hepatitis B virus vaccine Drugs 0.000 description 1
• 241000175212 Herpesvirales Species 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 description 1
• 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
• 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
• 101000844721 Homo sapiens Deleted in malignant brain tumors 1 protein Proteins 0.000 description 1
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
• 101001005728 Homo sapiens Melanoma-associated antigen 1 Proteins 0.000 description 1
• 101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 description 1
• 101001057131 Homo sapiens Melanoma-associated antigen D4 Proteins 0.000 description 1
• 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 description 1
• 101000874141 Homo sapiens Probable ATP-dependent RNA helicase DDX43 Proteins 0.000 description 1
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 1
• 101001130441 Homo sapiens Ras-related protein Rap-2a Proteins 0.000 description 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• 206010020751 Hypersensitivity Diseases 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 208000029462 Immunodeficiency disease Diseases 0.000 description 1
• 102100037850 Interferon gamma Human genes 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 102000000589 Interleukin-1 Human genes 0.000 description 1
• 108090000174 Interleukin-10 Proteins 0.000 description 1
• 108010065805 Interleukin-12 Proteins 0.000 description 1
• 108090000176 Interleukin-13 Proteins 0.000 description 1
• 101800003050 Interleukin-16 Proteins 0.000 description 1
• 108090000171 Interleukin-18 Proteins 0.000 description 1
• 108010065637 Interleukin-23 Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 108090000978 Interleukin-4 Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 206010022998 Irritability Diseases 0.000 description 1
• 201000005807 Japanese encephalitis Diseases 0.000 description 1
• 241000712890 Junin mammarenavirus Species 0.000 description 1
• 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 description 1
• 102100034872 Kallikrein-4 Human genes 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• 231100000111 LD50 Toxicity 0.000 description 1
• 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 description 1
• LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 description 1
• 206010023825 Laryngeal cancer Diseases 0.000 description 1
• 241000712902 Lassa mammarenavirus Species 0.000 description 1
• 208000004554 Leishmaniasis Diseases 0.000 description 1
• 206010024229 Leprosy Diseases 0.000 description 1
• 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 241000711828 Lyssavirus Species 0.000 description 1
• 208000032271 Malignant tumor of penis Diseases 0.000 description 1
• 241001115401 Marburgvirus Species 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 102000000440 Melanoma-associated antigen Human genes 0.000 description 1
• 108050008953 Melanoma-associated antigen Proteins 0.000 description 1
• 102100025050 Melanoma-associated antigen 1 Human genes 0.000 description 1
• 102100025077 Melanoma-associated antigen 4 Human genes 0.000 description 1
• 102100026712 Metalloreductase STEAP1 Human genes 0.000 description 1
• 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 description 1
• 208000025370 Middle East respiratory syndrome Diseases 0.000 description 1
• 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 description 1
• 241000588622 Moraxella bovis Species 0.000 description 1
• 208000003445 Mouth Neoplasms Diseases 0.000 description 1
• 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 241000238367 Mya arenaria Species 0.000 description 1
• 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 description 1
• 108091061960 Naked DNA Proteins 0.000 description 1
• 241001644525 Nastus productus Species 0.000 description 1
• 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
• 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
• CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 description 1
• 102000005348 Neuraminidase Human genes 0.000 description 1
• 108010006232 Neuraminidase Proteins 0.000 description 1
• 241000526636 Nipah henipavirus Species 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 241001263478 Norovirus Species 0.000 description 1
• 208000010505 Nose Neoplasms Diseases 0.000 description 1
• HCUVEUVIUAJXRB-UHFFFAOYSA-N OC1=C(C=C(CNC(CCCC=2SC=CC=2)=O)C=C1)OC Chemical compound OC1=C(C=C(CNC(CCCC=2SC=CC=2)=O)C=C1)OC HCUVEUVIUAJXRB-UHFFFAOYSA-N 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 description 1
• 241000713112 Orthobunyavirus Species 0.000 description 1
• 241000150452 Orthohantavirus Species 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 102000036673 PRAME Human genes 0.000 description 1
• 108060006580 PRAME Proteins 0.000 description 1
• 235000021314 Palmitic acid Nutrition 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 208000002471 Penile Neoplasms Diseases 0.000 description 1
• 206010034299 Penile cancer Diseases 0.000 description 1
• 201000005702 Pertussis Diseases 0.000 description 1
• 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
• 206010034811 Pharyngeal cancer Diseases 0.000 description 1
• 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 description 1
• 101710099976 Photosystem I P700 chlorophyll a apoprotein A1 Proteins 0.000 description 1
• 235000014676 Phragmites communis Nutrition 0.000 description 1
• 241000709664 Picornaviridae Species 0.000 description 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
• 208000007452 Plasmacytoma Diseases 0.000 description 1
• 101000983333 Plasmodium falciparum (isolate NF54) 25 kDa ookinete surface antigen Proteins 0.000 description 1
• 101710183389 Pneumolysin Proteins 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 241000710884 Powassan virus Species 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 102100035724 Probable ATP-dependent RNA helicase DDX43 Human genes 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
• 206010060862 Prostate cancer Diseases 0.000 description 1
• 102100036735 Prostate stem cell antigen Human genes 0.000 description 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
• 108010067787 Proteoglycans Proteins 0.000 description 1
• 102000016611 Proteoglycans Human genes 0.000 description 1
• 108010010974 Proteolipids Proteins 0.000 description 1
• 102000016202 Proteolipids Human genes 0.000 description 1
• 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 description 1
• 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 description 1
• 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 description 1
• 101710201576 Putative membrane protein Proteins 0.000 description 1
• MQUFAARYGOUYEV-UWEXFCAOSA-N Quillaic acid Natural products CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@H]4[C@@]5(C)CC[C@H](O)[C@](C)(C=O)[C@H]5CC[C@@]34C)[C@H]2C1)C(=O)O MQUFAARYGOUYEV-UWEXFCAOSA-N 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 102100022851 Rab5 GDP/GTP exchange factor Human genes 0.000 description 1
• 241000711798 Rabies lyssavirus Species 0.000 description 1
• 102100031420 Ras-related protein Rap-2a Human genes 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 241001068263 Replication competent viruses Species 0.000 description 1
• 101710203837 Replication-associated protein Proteins 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 description 1
• 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 description 1
• 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 241000713124 Rift Valley fever virus Species 0.000 description 1
• 241000710799 Rubella virus Species 0.000 description 1
• 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 description 1
• 241000219287 Saponaria Species 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 description 1
• 108010011834 Streptolysins Proteins 0.000 description 1
• 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 description 1
• 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 description 1
• 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 101710137302 Surface antigen S Proteins 0.000 description 1
• 108010002687 Survivin Proteins 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 206010042971 T-cell lymphoma Diseases 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 230000029662 T-helper 1 type immune response Effects 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
• 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 description 1
• 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 208000024770 Thyroid neoplasm Diseases 0.000 description 1
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 1
• 102100033117 Toll-like receptor 9 Human genes 0.000 description 1
• 241000223997 Toxoplasma gondii Species 0.000 description 1
• YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
• 241000223109 Trypanosoma cruzi Species 0.000 description 1
• 102100040247 Tumor necrosis factor Human genes 0.000 description 1
• 102000003425 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 description 1
• 208000002495 Uterine Neoplasms Diseases 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 description 1
• 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 description 1
• 206010047741 Vulval cancer Diseases 0.000 description 1
• 208000004354 Vulvar Neoplasms Diseases 0.000 description 1
• 208000003152 Yellow Fever Diseases 0.000 description 1
• LALGUHSIWLNTNW-HBQZPISHSA-N [(2r)-3-[hydroxy-[(3r)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-2-[(z)-octadec-9-enoyl]oxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COP(O)(=O)OC1C(O)C(O)C(O)[C@@H](O)C1O LALGUHSIWLNTNW-HBQZPISHSA-N 0.000 description 1
• QNEPTKZEXBPDLF-JDTILAPWSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] carbonochloridate Chemical compound C1C=C2C[C@@H](OC(Cl)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 QNEPTKZEXBPDLF-JDTILAPWSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 235000011054 acetic acid Nutrition 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 208000004064 acoustic neuroma Diseases 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 125000002015 acyclic group Chemical group 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 230000007815 allergy Effects 0.000 description 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
• 229940063655 aluminum stearate Drugs 0.000 description 1
• 101150078331 ama-1 gene Proteins 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 201000007434 ampulla of Vater carcinoma Diseases 0.000 description 1
• 230000001195 anabolic effect Effects 0.000 description 1
• 238000000540 analysis of variance Methods 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 208000025009 anogenital human papillomavirus infection Diseases 0.000 description 1
• 201000004201 anogenital venereal wart Diseases 0.000 description 1
• 230000000798 anti-retroviral effect Effects 0.000 description 1
• 208000037908 antibody-mediated disorder Diseases 0.000 description 1
• 230000008350 antigen-specific antibody response Effects 0.000 description 1
• 201000011165 anus cancer Diseases 0.000 description 1
• 239000006286 aqueous extract Substances 0.000 description 1
• 239000013011 aqueous formulation Substances 0.000 description 1
• 239000012736 aqueous medium Substances 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 210000002769 b effector cell Anatomy 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 229960001212 bacterial vaccine Drugs 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
• 229940092714 benzenesulfonic acid Drugs 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
• MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 238000001815 biotherapy Methods 0.000 description 1
• 201000000053 blastoma Diseases 0.000 description 1
• 238000006664 bond formation reaction Methods 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 201000008275 breast carcinoma Diseases 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 244000309464 bull Species 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 235000000431 campesterol Nutrition 0.000 description 1
• SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 125000000837 carbohydrate group Chemical group 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 150000001735 carboxylic acids Chemical class 0.000 description 1
• 208000002458 carcinoid tumor Diseases 0.000 description 1
• 208000011825 carcinoma of the ampulla of vater Diseases 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 201000007455 central nervous system cancer Diseases 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 210000003837 chick embryo Anatomy 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 108091016312 choline binding proteins Proteins 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 208000007451 chronic bronchitis Diseases 0.000 description 1
• 208000037976 chronic inflammation Diseases 0.000 description 1
• 230000006020 chronic inflammation Effects 0.000 description 1
• 235000017803 cinnamon Nutrition 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 239000000084 colloidal system Substances 0.000 description 1
• 208000029742 colonic neoplasm Diseases 0.000 description 1
• 201000010989 colorectal carcinoma Diseases 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
• WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical class C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 229940097362 cyclodextrins Drugs 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• AVSXSVCZWQODGV-DPAQBDIFSA-N desmosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC=C(C)C)C)[C@@]1(C)CC2 AVSXSVCZWQODGV-DPAQBDIFSA-N 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 150000002016 disaccharides Chemical group 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 238000009509 drug development Methods 0.000 description 1
• 210000003162 effector t lymphocyte Anatomy 0.000 description 1
• 229920001971 elastomer Polymers 0.000 description 1
• 201000008184 embryoma Diseases 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 201000004101 esophageal cancer Diseases 0.000 description 1
• 201000005619 esophageal carcinoma Diseases 0.000 description 1
• ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 125000004494 ethyl ester group Chemical group 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000005713 exacerbation Effects 0.000 description 1
• 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 1
• 208000028149 female reproductive system neoplasm Diseases 0.000 description 1
• 239000010408 film Substances 0.000 description 1
• 238000005189 flocculation Methods 0.000 description 1
• 230000016615 flocculation Effects 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 230000004907 flux Effects 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000012458 free base Substances 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 235000011087 fumaric acid Nutrition 0.000 description 1
• 201000007487 gallbladder carcinoma Diseases 0.000 description 1
• 150000002270 gangliosides Chemical class 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 239000000174 gluconic acid Substances 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 239000002622 gonadotropin Substances 0.000 description 1
• 208000001786 gonorrhea Diseases 0.000 description 1
• 229940029575 guanosine Drugs 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 201000009277 hairy cell leukemia Diseases 0.000 description 1
• 208000014829 head and neck neoplasm Diseases 0.000 description 1
• 210000002443 helper t lymphocyte Anatomy 0.000 description 1
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 230000001744 histochemical effect Effects 0.000 description 1
• 230000036571 hydration Effects 0.000 description 1
• 238000006703 hydration reaction Methods 0.000 description 1
• 150000004679 hydroxides Chemical class 0.000 description 1
• 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 230000005965 immune activity Effects 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 230000008073 immune recognition Effects 0.000 description 1
• 230000007813 immunodeficiency Effects 0.000 description 1
• 229940072221 immunoglobulins Drugs 0.000 description 1
• 230000002055 immunohistochemical effect Effects 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 239000000568 immunological adjuvant Substances 0.000 description 1
• 230000001024 immunotherapeutic effect Effects 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 239000003701 inert diluent Substances 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000003978 infusion fluid Substances 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 238000007689 inspection Methods 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 201000002313 intestinal cancer Diseases 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 230000002427 irreversible effect Effects 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
• 108010024383 kallikrein 4 Proteins 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 229940058690 lanosterol Drugs 0.000 description 1
• CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
• 206010023841 laryngeal neoplasm Diseases 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
• 230000029226 lipidation Effects 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 201000003866 lung sarcoma Diseases 0.000 description 1
• 201000010453 lymph node cancer Diseases 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 229940124735 malaria vaccine Drugs 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 210000005015 mediastinal lymph node Anatomy 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 210000001806 memory b lymphocyte Anatomy 0.000 description 1
• 210000003071 memory t lymphocyte Anatomy 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 238000002493 microarray Methods 0.000 description 1
• 238000012737 microarray-based gene expression Methods 0.000 description 1
• 239000012569 microbial contaminant Substances 0.000 description 1
• 239000011859 microparticle Substances 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 210000005087 mononuclear cell Anatomy 0.000 description 1
• 210000000214 mouth Anatomy 0.000 description 1
• 230000016379 mucosal immune response Effects 0.000 description 1
• 210000003097 mucus Anatomy 0.000 description 1
• 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• 208000037830 nasal cancer Diseases 0.000 description 1
• 239000007922 nasal spray Substances 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 230000009826 neoplastic cell growth Effects 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 208000007538 neurilemmoma Diseases 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 230000003472 neutralizing effect Effects 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• 238000007899 nucleic acid hybridization Methods 0.000 description 1
• 239000007764 o/w emulsion Substances 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 229920001542 oligosaccharide Polymers 0.000 description 1
• 150000002482 oligosaccharides Chemical class 0.000 description 1
• 238000011275 oncology therapy Methods 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 229940099789 ospa protein Drugs 0.000 description 1
• 230000002188 osteogenic effect Effects 0.000 description 1
• 230000000010 osteolytic effect Effects 0.000 description 1
• 201000008968 osteosarcoma Diseases 0.000 description 1
• 235000006408 oxalic acid Nutrition 0.000 description 1
• 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 239000000813 peptide hormone Substances 0.000 description 1
• 210000005259 peripheral blood Anatomy 0.000 description 1
• 239000011886 peripheral blood Substances 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 150000003016 phosphoric acids Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 208000010916 pituitary tumor Diseases 0.000 description 1
• 235000002378 plant sterols Nutrition 0.000 description 1
• 210000002381 plasma Anatomy 0.000 description 1
• 210000004180 plasmocyte Anatomy 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229940068965 polysorbates Drugs 0.000 description 1
• 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
• 239000004810 polytetrafluoroethylene Substances 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 229910000027 potassium carbonate Inorganic materials 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 235000019260 propionic acid Nutrition 0.000 description 1
• 150000003180 prostaglandins Chemical class 0.000 description 1
• 229940023143 protein vaccine Drugs 0.000 description 1
• 244000000040 protozoan parasite Species 0.000 description 1
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
• 239000002510 pyrogen Substances 0.000 description 1
• 230000001698 pyrogenic effect Effects 0.000 description 1
• MQUFAARYGOUYEV-UAWZMHPWSA-N quillaic acid Chemical compound C1C[C@H](O)[C@@](C)(C=O)[C@@H]2CC[C@@]3(C)[C@]4(C)C[C@@H](O)[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MQUFAARYGOUYEV-UAWZMHPWSA-N 0.000 description 1
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 208000020615 rectal carcinoma Diseases 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 239000003488 releasing hormone Substances 0.000 description 1
• 201000010174 renal carcinoma Diseases 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 208000023504 respiratory system disease Diseases 0.000 description 1
• 230000001177 retroviral effect Effects 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 229920002477 rna polymer Polymers 0.000 description 1
• 235000002020 sage Nutrition 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 238000013341 scale-up Methods 0.000 description 1
• 206010039667 schwannoma Diseases 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 230000000405 serological effect Effects 0.000 description 1
• 235000015500 sitosterol Nutrition 0.000 description 1
• KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
• 229950005143 sitosterol Drugs 0.000 description 1
• NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
• 238000007390 skin biopsy Methods 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 208000014680 small intestine neoplasm Diseases 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 229940031439 squalene Drugs 0.000 description 1
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 229940032091 stigmasterol Drugs 0.000 description 1
• HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
• 235000016831 stigmasterol Nutrition 0.000 description 1
• BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 229940021747 therapeutic vaccine Drugs 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 239000010409 thin film Substances 0.000 description 1
• 229940104230 thymidine Drugs 0.000 description 1
• 208000008732 thymoma Diseases 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 201000002510 thyroid cancer Diseases 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 108040006218 thyroid-stimulating hormone receptor activity proteins Proteins 0.000 description 1
• 102000015486 thyroid-stimulating hormone receptor activity proteins Human genes 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 229910052722 tritium Inorganic materials 0.000 description 1
• 241000701161 unidentified adenovirus Species 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 210000003741 urothelium Anatomy 0.000 description 1
• 206010046766 uterine cancer Diseases 0.000 description 1
• 238000002255 vaccination Methods 0.000 description 1
• 229940125575 vaccine candidate Drugs 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 238000001291 vacuum drying Methods 0.000 description 1
• 206010046885 vaginal cancer Diseases 0.000 description 1
• 208000013139 vaginal neoplasm Diseases 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 230000001018 virulence Effects 0.000 description 1
• 238000011179 visual inspection Methods 0.000 description 1
• 201000005102 vulva cancer Diseases 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1