JP7319020B2 - がんの治療での使用のためのccr5阻害剤 - Google Patents

がんの治療での使用のためのccr5阻害剤 Download PDF

Info

Publication number
JP7319020B2
JP7319020B2 JP2020567109A JP2020567109A JP7319020B2 JP 7319020 B2 JP7319020 B2 JP 7319020B2 JP 2020567109 A JP2020567109 A JP 2020567109A JP 2020567109 A JP2020567109 A JP 2020567109A JP 7319020 B2 JP7319020 B2 JP 7319020B2
Authority
JP
Japan
Prior art keywords
cancer
ccr5
seq
administered
terminal portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020567109A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021525770A (ja
JP2021525770A5 (https=
Inventor
オリバー ハートレー,
ロビン エワート オフォード,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Biotechnology Switzerland SARL
Original Assignee
Orion Biotechnology Switzerland SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Biotechnology Switzerland SARL filed Critical Orion Biotechnology Switzerland SARL
Publication of JP2021525770A publication Critical patent/JP2021525770A/ja
Publication of JP2021525770A5 publication Critical patent/JP2021525770A5/ja
Priority to JP2023116746A priority Critical patent/JP2023134704A/ja
Application granted granted Critical
Publication of JP7319020B2 publication Critical patent/JP7319020B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/195Chemokines, e.g. RANTES
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2020567109A 2018-05-28 2019-05-24 がんの治療での使用のためのccr5阻害剤 Active JP7319020B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023116746A JP2023134704A (ja) 2018-05-28 2023-07-18 がんの治療での使用のためのccr5阻害剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862677114P 2018-05-28 2018-05-28
US62/677,114 2018-05-28
US201962792600P 2019-01-15 2019-01-15
US62/792,600 2019-01-15
PCT/IB2019/054350 WO2019229616A1 (en) 2018-05-28 2019-05-24 Ccr5 inhibitor for use in treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023116746A Division JP2023134704A (ja) 2018-05-28 2023-07-18 がんの治療での使用のためのccr5阻害剤

Publications (3)

Publication Number Publication Date
JP2021525770A JP2021525770A (ja) 2021-09-27
JP2021525770A5 JP2021525770A5 (https=) 2022-05-23
JP7319020B2 true JP7319020B2 (ja) 2023-08-01

Family

ID=67480241

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020567109A Active JP7319020B2 (ja) 2018-05-28 2019-05-24 がんの治療での使用のためのccr5阻害剤
JP2023116746A Pending JP2023134704A (ja) 2018-05-28 2023-07-18 がんの治療での使用のためのccr5阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023116746A Pending JP2023134704A (ja) 2018-05-28 2023-07-18 がんの治療での使用のためのccr5阻害剤

Country Status (11)

Country Link
US (1) US20210205411A1 (https=)
EP (1) EP3813870B1 (https=)
JP (2) JP7319020B2 (https=)
KR (1) KR20210016398A (https=)
CN (1) CN112469429B (https=)
AU (1) AU2019276939A1 (https=)
BR (1) BR112020024328A2 (https=)
CA (1) CA3101556A1 (https=)
MX (1) MX2020012782A (https=)
WO (1) WO2019229616A1 (https=)
ZA (1) ZA202007955B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021019405A2 (pt) * 2019-04-01 2021-11-30 Cytodyn Inc Agentes anti-ccr5 e métodos de tratamento que bloqueiam a metástase do câncer ou aumentam a morte celular induzida pela quimioterapia prejudicial ao dna
WO2021231648A2 (en) * 2020-05-12 2021-11-18 Gigagen, Inc. Cancer therapeutics comprising chemokine or its analog
WO2024146707A1 (en) * 2023-01-06 2024-07-11 Université De Genève Variant ligand conjugates for payload delivery
WO2025172252A1 (en) 2024-02-15 2025-08-21 Novo Nordisk A/S Protracted ccr5 antagonists and uses thereof
WO2025176787A1 (en) * 2024-02-22 2025-08-28 Orion Biotechnology Holding Sa Ccl5 variants for modulating gpr75

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544304A (ja) 2006-07-25 2009-12-17 ミンタカ ファンデーション フォア メディカル リサーチ サイトカイン誘導体
JP2017535534A (ja) 2014-10-27 2017-11-30 ルプレヒト−カールス−ウニヴェルジテート ハイデルベルクRuprecht−Karls−Universitaet Heidelberg がんを治療するための単独または併用療法におけるccr5拮抗剤の使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32808A (es) * 2009-07-29 2011-02-28 Abbott Lab Inmunoglobulinas como dominio variable dual y usos de las mismas
US8916696B2 (en) * 2011-06-12 2014-12-23 City Of Hope Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
ES2800316T3 (es) * 2011-06-13 2020-12-29 Tla Targeted Immunotherapies Ab Tratamiento del cáncer
JP6518585B2 (ja) * 2012-05-14 2019-05-22 リチャード ジー. ペステル がんの治療のためのccr5の修飾薬の使用
US20150250837A1 (en) * 2012-09-20 2015-09-10 Morningside Technology Ventures Ltd. Oncolytic virus encoding pd-1 binding agents and uses of the same
AR105654A1 (es) * 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544304A (ja) 2006-07-25 2009-12-17 ミンタカ ファンデーション フォア メディカル リサーチ サイトカイン誘導体
JP2017535534A (ja) 2014-10-27 2017-11-30 ルプレヒト−カールス−ウニヴェルジテート ハイデルベルクRuprecht−Karls−Universitaet Heidelberg がんを治療するための単独または併用療法におけるccr5拮抗剤の使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Oncotarget,2016年06月22日,Vol.7, No.30,p.48335-48345

Also Published As

Publication number Publication date
CN112469429A (zh) 2021-03-09
JP2021525770A (ja) 2021-09-27
CA3101556A1 (en) 2019-12-05
EP3813870A1 (en) 2021-05-05
EP3813870C0 (en) 2023-11-15
BR112020024328A2 (pt) 2021-02-23
WO2019229616A1 (en) 2019-12-05
MX2020012782A (es) 2021-04-28
KR20210016398A (ko) 2021-02-15
EP3813870B1 (en) 2023-11-15
ZA202007955B (en) 2022-06-29
CN112469429B (zh) 2025-02-14
JP2023134704A (ja) 2023-09-27
US20210205411A1 (en) 2021-07-08
AU2019276939A1 (en) 2021-01-21

Similar Documents

Publication Publication Date Title
JP7319020B2 (ja) がんの治療での使用のためのccr5阻害剤
JP4364510B2 (ja) 受容体型チロシンキナーゼ阻害剤および血管新生阻害剤を用いる併用療法
US20200138804A1 (en) Methods for treating cancer
KR20230006568A (ko) 낮은 면역원성을 갖는 암에서 암세포 사멸을 강화하기 위한 삼중 병용 요법
JP2020172502A (ja) 血液がん及び固形腫瘍の治療のための併用療法
CA2444821C (en) Combination therapy using anti-angiogenic agents and tnfa
JP2019511565A (ja) ツカレゾールまたはそのアナログを含む組成物
PT2100618E (pt) Um anticorpo anti-pdgfr-alfa para o tratamento de cancro ósseo metastático
US20180303935A1 (en) A nanomaterial complex comprising graphene oxide associated with a therapeutic agent and methods of use
TWI873485B (zh) 用於治療癌症之方法及包含cdk2抑制劑及cdk4抑制劑之給藥方案
BR112020009363A2 (pt) métodos e composições para tratar câncer por modificação de múltiplos braços do sistema imunológico
KR20220110494A (ko) 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일) 메틸)-2,2-디플루오로아세트아미드를 사용한 조합 요법
BR112021004935A2 (pt) combinação de antagonista de pd-1, inibidor de atr e agente de platinação para tratamento de câncer
CN111973747A (zh) 用于联合治疗卵巢癌的喹啉衍生物
CN112043831A (zh) 用于联合治疗乳腺癌的喹啉类化合物
CN119326902A (zh) 癌症联合治疗的组合物与方法
WO2022130206A1 (en) TGFβr1 INHIBITOR COMBINATION THERAPIES
RU2849370C1 (ru) Способы и схемы дозирования, содержащие ингибитор cdk2 и ингибитор cdk4, для лечения рака
HK40048943A (en) Ccr5 inhibitor for use in treating cancer
RU2842665C2 (ru) Фармацевтическая композиция для лечения опухоли
WO2023230554A1 (en) Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer
TW202315631A (zh) 增強低免疫原性癌症中癌細胞毒殺的三聯療法
BR112017016902B1 (pt) Composição farmacêutica, respectivo uso e uso de plinabulina

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220513

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220513

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230221

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230522

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230620

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230718

R150 Certificate of patent or registration of utility model

Ref document number: 7319020

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150