JP7315564B2 - グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット - Google Patents

グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット Download PDF

Info

Publication number
JP7315564B2
JP7315564B2 JP2020541778A JP2020541778A JP7315564B2 JP 7315564 B2 JP7315564 B2 JP 7315564B2 JP 2020541778 A JP2020541778 A JP 2020541778A JP 2020541778 A JP2020541778 A JP 2020541778A JP 7315564 B2 JP7315564 B2 JP 7315564B2
Authority
JP
Japan
Prior art keywords
acid
boc
kit
glycans
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020541778A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019152724A5 (https=
JP2021513059A (ja
JP2021513059A5 (https=
Inventor
ブラセンコ，セルゲイ
アクソー，フランシス・ティー
ナヴァロ，アンドレス ゲレーロ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Publication of JP2021513059A publication Critical patent/JP2021513059A/ja
Publication of JPWO2019152724A5 publication Critical patent/JPWO2019152724A5/ja
Publication of JP2021513059A5 publication Critical patent/JP2021513059A5/ja
Application granted granted Critical
Publication of JP7315564B2 publication Critical patent/JP7315564B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2020541778A 2018-02-02 2019-01-31 グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット Active JP7315564B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862625846P 2018-02-02 2018-02-02
US62/625,846 2018-02-02
PCT/US2019/016169 WO2019152724A1 (en) 2018-02-02 2019-01-31 Methods and kits for using blocked 2-aa for glycan analysis

Publications (4)

Publication Number Publication Date
JP2021513059A JP2021513059A (ja) 2021-05-20
JPWO2019152724A5 JPWO2019152724A5 (https=) 2022-02-08
JP2021513059A5 JP2021513059A5 (https=) 2022-02-08
JP7315564B2 true JP7315564B2 (ja) 2023-07-26

Family

ID=67478869

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020541778A Active JP7315564B2 (ja) 2018-02-02 2019-01-31 グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット

Country Status (4)

Country Link
US (1) US11376200B2 (https=)
JP (1) JP7315564B2 (https=)
CN (1) CN111867549B (https=)
WO (1) WO2019152724A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040248890A1 (en) 2003-03-03 2004-12-09 Gonzalez Jesus E. Quinazolines useful as modulators of ion channels
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
US20090088454A1 (en) 1999-06-25 2009-04-02 The Regents Of The University Of Colorado Anti-cancer compounds
JP2012162516A (ja) 2010-11-19 2012-08-30 Mitsubishi Chemicals Corp ４−アルキニル−１，３−ジオキソラン−２−オン誘導体の製造法
JP2013506115A (ja) 2009-09-29 2013-02-21 レイデン ユニバーシティ メディカル センター 還元剤として２−ピコリンボランを使用する炭水化物の還元的アミノ化及び分析
JP2013525437A (ja) 2010-04-30 2013-06-20 プロステッタ アンチバイラル インコーポレイテッド 抗ウイルス化合物
JP2017524128A (ja) 2014-07-18 2017-08-24 ヘキサル・アクチェンゲゼルシャフト 血清試料中の糖タンパク質のグリカンをマッピングするための改善された方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE427493T1 (de) * 1992-05-29 2009-04-15 Univ Rockefeller Verfahren zur bestimmung der folge von peptiden unter verwendung eines massenspektrometers
GB9310467D0 (en) * 1993-05-20 1993-07-07 Oxford Glycosystems Ltd Glycoconjugates
JPH09505281A (ja) * 1993-10-01 1997-05-27 メレルファーマスーティカルズ インコーポレイテッド β−アミロイド蛋白質製造の阻害剤類
US5977074A (en) * 1993-10-01 1999-11-02 Merrell Pharmaceuticals, Inc. Inhibitors of β-amyloid protein production
US8524784B2 (en) * 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090088454A1 (en) 1999-06-25 2009-04-02 The Regents Of The University Of Colorado Anti-cancer compounds
US20040248890A1 (en) 2003-03-03 2004-12-09 Gonzalez Jesus E. Quinazolines useful as modulators of ion channels
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
JP2013506115A (ja) 2009-09-29 2013-02-21 レイデン ユニバーシティ メディカル センター 還元剤として２−ピコリンボランを使用する炭水化物の還元的アミノ化及び分析
JP2013525437A (ja) 2010-04-30 2013-06-20 プロステッタ アンチバイラル インコーポレイテッド 抗ウイルス化合物
JP2012162516A (ja) 2010-11-19 2012-08-30 Mitsubishi Chemicals Corp ４−アルキニル−１，３−ジオキソラン−２−オン誘導体の製造法
JP2017524128A (ja) 2014-07-18 2017-08-24 ヘキサル・アクチェンゲゼルシャフト 血清試料中の糖タンパク質のグリカンをマッピングするための改善された方法

Also Published As

Publication number Publication date
CN111867549B (zh) 2024-01-05
US20210045981A1 (en) 2021-02-18
WO2019152724A1 (en) 2019-08-08
US11376200B2 (en) 2022-07-05
JP2021513059A (ja) 2021-05-20
CN111867549A (zh) 2020-10-30

Similar Documents

Publication Publication Date Title
JP7315564B2 (ja) グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット
US5296599A (en) Activated carbamates compounds
Doran et al. Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits
US9188584B2 (en) Capture agents and related compositions, methods and systems
EP2969435B1 (en) Substrates for covalent tethering of proteins to functional groups or solid surfaces
CN102933554A (zh) 用于研究蛋白质-蛋白质相互作用的交联试剂、方法和组合物
JP5997543B2 (ja) 皮膚感作性測定試薬
EA032582B1 (ru) Библиотека случайных пептоидных лигандов для скрининга биологической жидкости
US11747310B2 (en) Methods for liquid chromatography calibration for rapid labeled N-glycans
JP4085443B2 (ja) アミノ酸の分析試薬及びアミノ酸の分析方法
US12416638B2 (en) Methods for labeling amine-containing compounds
Prokai et al. Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis
JP2002131232A (ja) ヒドロキシプロリンの検出方法および検出用キット
CN108884030B (zh) 使用双吡啶改善亲核物质的标记
JP4558297B2 (ja) 発現微量タンパク質／ペプチドの検出・分離・同定法
Park et al. Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group
JP6889432B2 (ja) 樹脂固定ペプチド
Ramanoudjame et al. Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs
Idso et al. Protein Catalyzed Capture (PCC) Agents for Antigen Targeting
Mata et al. Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability
Thomas et al. New insights from old data-Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter
CA2563026A1 (en) Method for analyzing n-terminal protein adducts
Stimmel A chemical method for the sequential degradation of peptides from the carboxy terminus
JP2006101767A (ja) キナーゼ活性検出法
JP2017198637A (ja) 被験物質の皮膚感作性の検定方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220127

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220127

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20221221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230417

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230630

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230713

R150 Certificate of patent or registration of utility model

Ref document number: 7315564

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150