JP7307083B2 - Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用 - Google Patents

Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用 Download PDF

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JP7307083B2
JP7307083B2 JP2020545859A JP2020545859A JP7307083B2 JP 7307083 B2 JP7307083 B2 JP 7307083B2 JP 2020545859 A JP2020545859 A JP 2020545859A JP 2020545859 A JP2020545859 A JP 2020545859A JP 7307083 B2 JP7307083 B2 JP 7307083B2
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cells
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car
amino acid
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JP2021503952A (ja
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クリストフ フェラン，
マリーナ デシャン，
ファブリス ラロザ，
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Universite de Franche-Comte
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N15/09—Recombinant DNA-technology
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
    • A61K2239/25—Suicide switch
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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JP2020545859A 2017-11-23 2018-11-14 Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用 Active JP7307083B2 (ja)

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JP2023106930A JP7628155B2 (ja) 2017-11-23 2023-06-29 Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用

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EP17306630.9 2017-11-23
EP17306630.9A EP3489259A1 (en) 2017-11-23 2017-11-23 Anti-il-1rap-car-t cells and their use
PCT/EP2018/081273 WO2019101604A1 (en) 2017-11-23 2018-11-14 Car-t cells targeting il-1rap and their use

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JP2023106930A Active JP7628155B2 (ja) 2017-11-23 2023-06-29 Ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用

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US (2) US11839630B2 (https=)
EP (2) EP3489259A1 (https=)
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KR (1) KR102730900B1 (https=)
CN (1) CN111712517B (https=)
AU (1) AU2018371071B2 (https=)
CA (1) CA3080451A1 (https=)
WO (1) WO2019101604A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022534515A (ja) * 2019-05-28 2022-08-01 エタブリスマン フランセ デュ サン 急性骨髄性白血病（ａｍｌ）における、ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
WO2021207709A1 (en) * 2020-04-10 2021-10-14 Seattle Children's Hospital (dba Seattle Children's Research Institute) Binders and chimeric antigen receptors specific for interleukin-1 receptor accessory protein
WO2024150177A1 (en) 2023-01-11 2024-07-18 Advesya Treatment methods for solid tumors
WO2025104669A1 (en) 2023-11-15 2025-05-22 Advesya Anti-il-1rap car-t cells for the treatment of acute myeloid leukemia

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JP2017513478A (ja) 2014-04-14 2017-06-01 セレクティスＣｅｌｌｅｃｔｉｓ 癌免疫療法のためのｂｃｍａ（ｃｄ２６９）特異的キメラ抗原受容体
CN106831998A (zh) 2016-06-22 2017-06-13 徐州医科大学 一种人il1rap特异性car及其应用
JP2017515792A (ja) 2014-03-05 2017-06-15 カンタージア アクチエボラーグ 抗ヒトインターロイキン−１受容体アクセサリータンパク質（ｉｌ１ ｒａｐ）抗体およびその使用
JP2017530692A (ja) 2014-08-06 2017-10-19 カンタージア アクチエボラーグ 新規の抗体及びその使用

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US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
AU2016350705A1 (en) * 2015-11-02 2018-05-17 Janssen Pharmaceutica Nv Anti-IL1RAP antibodies, bispecific antigen binding molecules that bind IL1RAP and CD3, and uses thereof
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
EP3744400A1 (en) * 2019-05-28 2020-12-02 Etablissement Français du Sang Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)

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JP2017515792A (ja) 2014-03-05 2017-06-15 カンタージア アクチエボラーグ 抗ヒトインターロイキン−１受容体アクセサリータンパク質（ｉｌ１ ｒａｐ）抗体およびその使用
JP2017513478A (ja) 2014-04-14 2017-06-01 セレクティスＣｅｌｌｅｃｔｉｓ 癌免疫療法のためのｂｃｍａ（ｃｄ２６９）特異的キメラ抗原受容体
JP2017530692A (ja) 2014-08-06 2017-10-19 カンタージア アクチエボラーグ 新規の抗体及びその使用
CN106831998A (zh) 2016-06-22 2017-06-13 徐州医科大学 一种人il1rap特异性car及其应用

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Title
Journal of Experimental Hematology (2015) Vol.23, No.5, pp.1272-1276
PNAS (2015) Vol.112, No.34, pp.10786-10791

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022534515A (ja) * 2019-05-28 2022-08-01 エタブリスマン フランセ デュ サン 急性骨髄性白血病（ａｍｌ）における、ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用
JP7621278B2 (ja) 2019-05-28 2025-01-24 エタブリスマン フランセ デュ サン 急性骨髄性白血病（ａｍｌ）における、ｉｌ－１ｒａｐを標的とするｃａｒ－ｔ細胞及びその使用

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JP7628155B2 (ja) 2025-02-07
JP2021503952A (ja) 2021-02-15
CA3080451A1 (en) 2019-05-31
EP3489259A1 (en) 2019-05-29
AU2018371071A1 (en) 2020-05-14
US20240139249A1 (en) 2024-05-02
WO2019101604A1 (en) 2019-05-31
CN111712517B (zh) 2024-05-14
JP2023115299A (ja) 2023-08-18
EP3713960A1 (en) 2020-09-30
KR102730900B1 (ko) 2024-11-18
AU2018371071B2 (en) 2025-09-04
US11839630B2 (en) 2023-12-12
US20210008108A1 (en) 2021-01-14
CN111712517A (zh) 2020-09-25
KR20200121783A (ko) 2020-10-26

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