KR102730900B1 - Ｉｌ-1ｒａｐ를 표적화하는 ｃａｒ-ｔ 세포 및 그의 용도 - Google Patents

Ｉｌ-1ｒａｐ를 표적화하는 ｃａｒ-ｔ 세포 및 그의 용도 Download PDF

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KR102730900B1
KR102730900B1 KR1020207014799A KR20207014799A KR102730900B1 KR 102730900 B1 KR102730900 B1 KR 102730900B1 KR 1020207014799 A KR1020207014799 A KR 1020207014799A KR 20207014799 A KR20207014799 A KR 20207014799A KR 102730900 B1 KR102730900 B1 KR 102730900B1
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1rap
cells
domain
cell
amino acid
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KR20200121783A (ko
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크리스토프 페랑
마리나 데샹
파브리스 라로사
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에따블리스망 프랑세 뒤 상
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인쎄름)
쌍트르 오스삐딸리에 레지오날 위니베르시떼르 드 브쟝쏭
위니베르시테 드 프랑슈 콩테
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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KR1020207014799A 2017-11-23 2018-11-14 Ｉｌ-1ｒａｐ를 표적화하는 ｃａｒ-ｔ 세포 및 그의 용도 Active KR102730900B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17306630.9 2017-11-23
EP17306630.9A EP3489259A1 (en) 2017-11-23 2017-11-23 Anti-il-1rap-car-t cells and their use
PCT/EP2018/081273 WO2019101604A1 (en) 2017-11-23 2018-11-14 Car-t cells targeting il-1rap and their use

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Publication Number Publication Date
KR20200121783A KR20200121783A (ko) 2020-10-26
KR102730900B1 true KR102730900B1 (ko) 2024-11-18

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US (2) US11839630B2 (https=)
EP (2) EP3489259A1 (https=)
JP (2) JP7307083B2 (https=)
KR (1) KR102730900B1 (https=)
CN (1) CN111712517B (https=)
AU (1) AU2018371071B2 (https=)
CA (1) CA3080451A1 (https=)
WO (1) WO2019101604A1 (https=)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
EP3744400A1 (en) * 2019-05-28 2020-12-02 Etablissement Français du Sang Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)
WO2021207709A1 (en) * 2020-04-10 2021-10-14 Seattle Children's Hospital (dba Seattle Children's Research Institute) Binders and chimeric antigen receptors specific for interleukin-1 receptor accessory protein
WO2024150177A1 (en) 2023-01-11 2024-07-18 Advesya Treatment methods for solid tumors
WO2025104669A1 (en) 2023-11-15 2025-05-22 Advesya Anti-il-1rap car-t cells for the treatment of acute myeloid leukemia

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN106831998A (zh) * 2016-06-22 2017-06-13 徐州医科大学 一种人il1rap特异性car及其应用

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US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB201403875D0 (en) * 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
WO2015158671A1 (en) 2014-04-14 2015-10-22 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
GB201413913D0 (en) 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
AU2016350705A1 (en) * 2015-11-02 2018-05-17 Janssen Pharmaceutica Nv Anti-IL1RAP antibodies, bispecific antigen binding molecules that bind IL1RAP and CD3, and uses thereof
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
EP3744400A1 (en) * 2019-05-28 2020-12-02 Etablissement Français du Sang Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN106831998A (zh) * 2016-06-22 2017-06-13 徐州医科大学 一种人il1rap特异性car及其应用

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JP7628155B2 (ja) 2025-02-07
JP2021503952A (ja) 2021-02-15
CA3080451A1 (en) 2019-05-31
EP3489259A1 (en) 2019-05-29
AU2018371071A1 (en) 2020-05-14
US20240139249A1 (en) 2024-05-02
JP7307083B2 (ja) 2023-07-11
WO2019101604A1 (en) 2019-05-31
CN111712517B (zh) 2024-05-14
JP2023115299A (ja) 2023-08-18
EP3713960A1 (en) 2020-09-30
AU2018371071B2 (en) 2025-09-04
US11839630B2 (en) 2023-12-12
US20210008108A1 (en) 2021-01-14
CN111712517A (zh) 2020-09-25
KR20200121783A (ko) 2020-10-26

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