CN111712517B - 靶向il-1rap的car-t细胞及它们的用途 - Google Patents

靶向il-1rap的car-t细胞及它们的用途 Download PDF

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Publication number
CN111712517B
CN111712517B CN201880075795.9A CN201880075795A CN111712517B CN 111712517 B CN111712517 B CN 111712517B CN 201880075795 A CN201880075795 A CN 201880075795A CN 111712517 B CN111712517 B CN 111712517B
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cells
1rap
cell
car
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CN111712517A (zh
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克里斯托夫·费朗
玛丽娜·德尚
法布里斯·拉洛萨
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French Blood Institution
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Franche-Comte
Centre Hospitalier Universitaire de Besancon
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French Blood Institution
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Franche-Comte
Centre Hospitalier Universitaire de Besancon
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
    • A61K2239/25—Suicide switch
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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CN201880075795.9A 2017-11-23 2018-11-14 靶向il-1rap的car-t细胞及它们的用途 Active CN111712517B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17306630.9 2017-11-23
EP17306630.9A EP3489259A1 (en) 2017-11-23 2017-11-23 Anti-il-1rap-car-t cells and their use
PCT/EP2018/081273 WO2019101604A1 (en) 2017-11-23 2018-11-14 Car-t cells targeting il-1rap and their use

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CN111712517A CN111712517A (zh) 2020-09-25
CN111712517B true CN111712517B (zh) 2024-05-14

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US (2) US11839630B2 (https=)
EP (2) EP3489259A1 (https=)
JP (2) JP7307083B2 (https=)
KR (1) KR102730900B1 (https=)
CN (1) CN111712517B (https=)
AU (1) AU2018371071B2 (https=)
CA (1) CA3080451A1 (https=)
WO (1) WO2019101604A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
EP3744400A1 (en) * 2019-05-28 2020-12-02 Etablissement Français du Sang Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)
WO2021207709A1 (en) * 2020-04-10 2021-10-14 Seattle Children's Hospital (dba Seattle Children's Research Institute) Binders and chimeric antigen receptors specific for interleukin-1 receptor accessory protein
WO2024150177A1 (en) 2023-01-11 2024-07-18 Advesya Treatment methods for solid tumors
WO2025104669A1 (en) 2023-11-15 2025-05-22 Advesya Anti-il-1rap car-t cells for the treatment of acute myeloid leukemia

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CN106459195A (zh) * 2014-03-05 2017-02-22 坎塔吉亚有限责任公司 抗人白介素‑1受体辅助蛋白(il1 rap)抗体及其用途
CN106831998A (zh) * 2016-06-22 2017-06-13 徐州医科大学 一种人il1rap特异性car及其应用

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WO2015158671A1 (en) 2014-04-14 2015-10-22 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
GB201413913D0 (en) 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
AU2016350705A1 (en) * 2015-11-02 2018-05-17 Janssen Pharmaceutica Nv Anti-IL1RAP antibodies, bispecific antigen binding molecules that bind IL1RAP and CD3, and uses thereof
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
EP3744400A1 (en) * 2019-05-28 2020-12-02 Etablissement Français du Sang Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)

Patent Citations (2)

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CN106459195A (zh) * 2014-03-05 2017-02-22 坎塔吉亚有限责任公司 抗人白介素‑1受体辅助蛋白(il1 rap)抗体及其用途
CN106831998A (zh) * 2016-06-22 2017-06-13 徐州医科大学 一种人il1rap特异性car及其应用

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抗人IL1RAP单克隆抗体重、轻链基因的克隆及重组嵌合受体的构建;尹玲玲;阮素红;田宇;赵恺;徐开林;;中国实验血液学杂志;第23卷(第05期);第1272-1276页 *

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JP7628155B2 (ja) 2025-02-07
JP2021503952A (ja) 2021-02-15
CA3080451A1 (en) 2019-05-31
EP3489259A1 (en) 2019-05-29
AU2018371071A1 (en) 2020-05-14
US20240139249A1 (en) 2024-05-02
JP7307083B2 (ja) 2023-07-11
WO2019101604A1 (en) 2019-05-31
JP2023115299A (ja) 2023-08-18
EP3713960A1 (en) 2020-09-30
KR102730900B1 (ko) 2024-11-18
AU2018371071B2 (en) 2025-09-04
US11839630B2 (en) 2023-12-12
US20210008108A1 (en) 2021-01-14
CN111712517A (zh) 2020-09-25
KR20200121783A (ko) 2020-10-26

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