JP7278210B2 - ジストニアを治療するためのプリドピジンの使用 - Google Patents

ジストニアを治療するためのプリドピジンの使用 Download PDF

Info

Publication number
JP7278210B2
JP7278210B2 JP2019531546A JP2019531546A JP7278210B2 JP 7278210 B2 JP7278210 B2 JP 7278210B2 JP 2019531546 A JP2019531546 A JP 2019531546A JP 2019531546 A JP2019531546 A JP 2019531546A JP 7278210 B2 JP7278210 B2 JP 7278210B2
Authority
JP
Japan
Prior art keywords
dystonia
pridopidine
patients
baseline
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019531546A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019524897A (ja
JP2019524897A5 (OSRAM
Inventor
ヘイデン、マイケル
パパペトロパウロス、スピリドン
サヴォラ、ユハマッティ
エヤル、エリ
ボロウスキー、ベス
グラチェフ、イゴール・ディー
ゴードン、マーク・フォレスト
Original Assignee
プリレニア ニューロセラピューティクス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by プリレニア ニューロセラピューティクス リミテッド filed Critical プリレニア ニューロセラピューティクス リミテッド
Publication of JP2019524897A publication Critical patent/JP2019524897A/ja
Publication of JP2019524897A5 publication Critical patent/JP2019524897A5/ja
Priority to JP2021078788A priority Critical patent/JP7278327B2/ja
Application granted granted Critical
Publication of JP7278210B2 publication Critical patent/JP7278210B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019531546A 2016-08-24 2017-08-24 ジストニアを治療するためのプリドピジンの使用 Active JP7278210B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021078788A JP7278327B2 (ja) 2016-08-24 2021-05-06 ジストニアを治療するためのプリドピジンの使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662379175P 2016-08-24 2016-08-24
US62/379,175 2016-08-24
US201662395319P 2016-09-15 2016-09-15
US62/395,319 2016-09-15
PCT/US2017/048458 WO2018039475A1 (en) 2016-08-24 2017-08-24 Use of pridopidine for treating dystonias

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021078788A Division JP7278327B2 (ja) 2016-08-24 2021-05-06 ジストニアを治療するためのプリドピジンの使用

Publications (3)

Publication Number Publication Date
JP2019524897A JP2019524897A (ja) 2019-09-05
JP2019524897A5 JP2019524897A5 (OSRAM) 2019-10-17
JP7278210B2 true JP7278210B2 (ja) 2023-05-19

Family

ID=61246309

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019531546A Active JP7278210B2 (ja) 2016-08-24 2017-08-24 ジストニアを治療するためのプリドピジンの使用
JP2021078788A Active JP7278327B2 (ja) 2016-08-24 2021-05-06 ジストニアを治療するためのプリドピジンの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021078788A Active JP7278327B2 (ja) 2016-08-24 2021-05-06 ジストニアを治療するためのプリドピジンの使用

Country Status (12)

Country Link
US (2) US11826361B2 (OSRAM)
EP (1) EP3503890B1 (OSRAM)
JP (2) JP7278210B2 (OSRAM)
CN (1) CN110012661A (OSRAM)
AU (1) AU2017315781B2 (OSRAM)
BR (1) BR112019003731A2 (OSRAM)
CA (1) CA3035099C (OSRAM)
DK (1) DK3503890T3 (OSRAM)
ES (1) ES3009437T3 (OSRAM)
MX (1) MX2019002190A (OSRAM)
PL (1) PL3503890T3 (OSRAM)
WO (1) WO2018039475A1 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2611759A1 (en) 2010-09-03 2013-07-10 Ivax International Gmbh Deuterated analogs of pridopidine useful as dopaminergic stabilizers
WO2014205229A1 (en) 2013-06-21 2014-12-24 IVAX International GmbH Use of high dose pridopidine for treating huntington's disease
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
WO2016138130A1 (en) 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Use of pridopidine to improve cognitive function and for treating alzheimer's disease
US11471449B2 (en) 2015-02-25 2022-10-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine to improve cognitive function and for treating Alzheimer's disease
CA3035092C (en) 2016-08-24 2022-05-31 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating functional decline
CA3035099C (en) 2016-08-24 2023-01-17 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating dystonias
US12102627B2 (en) 2016-09-16 2024-10-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating rett syndrome
US12036213B2 (en) 2017-09-08 2024-07-16 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
EP3678664A1 (en) 2017-09-08 2020-07-15 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
EP3920924A4 (en) 2019-02-04 2022-11-16 Prilenia Neurotherapeutics Ltd. LOW-DOSE PRIDOIDIN FOR THE TREATMENT OF PARKINSON'S DISEASE AND OTHER PARKINSONIC-RELATED DISEASES
JP7603713B2 (ja) * 2020-05-04 2024-12-20 プリレニア ニューロセラピューティクス リミテッド 選択的s1rアゴニストを使用するウイルス感染、疾患、又は障害の治療
CN120569199A (zh) * 2022-12-27 2025-08-29 普瑞尼亚神经治疗有限公司 普利多匹定用于治疗青少年亨廷顿病
WO2024258929A1 (en) * 2023-06-12 2024-12-19 Unravel Biosciences, Inc. Methods for treating diseases associated with taf1 loss of function
WO2025188979A1 (en) * 2024-03-06 2025-09-12 Ovid Therapeutics Inc. Fused amino pyrimidine compounds and pridopidine for treatment of huntington's disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016523862A (ja) 2013-06-21 2016-08-12 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーTeva Pharmaceuticals International GmbH ハンチントン病を治療するための高用量プリドピジンの使用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
ES2346452T3 (es) * 2004-06-08 2010-10-15 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Nuevas fenilpiperidinas/piperazinas disustituidas utilizadas como moduladores de la neurotransmision de la dopamina.
SE0401465D0 (sv) * 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
ES2659577T3 (es) 2004-10-13 2018-03-16 Teva Pharmaceuticals International Gmbh Proceso para la síntesis de 4-(3-metanosulfonilfenil)-1-N-propil-piperidina
SE529246C2 (sv) * 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
JP5393654B2 (ja) 2007-04-12 2014-01-22 イヴァックス インテルナツィオナール ゲゼルシャフト ミット ベシュレンクテル ハフツンク 改善された心血管副作用プロフィールを呈する、ドーパミン受容体安定剤/調節剤のn−オキシド誘導体及び/又はジ−n−オキシド誘導体
US8562488B2 (en) * 2009-10-05 2013-10-22 The Cleveland Clinic Foundation Systems and methods for improving motor function with assisted exercise
WO2011107583A1 (en) * 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
EP2611759A1 (en) 2010-09-03 2013-07-10 Ivax International Gmbh Deuterated analogs of pridopidine useful as dopaminergic stabilizers
CN103958469B (zh) 2011-09-07 2016-04-20 梯瓦制药国际有限责任公司 一种新的普利多匹定盐酸盐多晶型形态
UY34503A (es) 2011-12-08 2013-07-31 Ivax Int Gmbh ?sal de bromhidrato de pridopidina?
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
US20130267552A1 (en) 2012-04-04 2013-10-10 IVAX International GmbH Pharmaceutical compositions for combination therapy
US20140037850A1 (en) * 2012-08-06 2014-02-06 General Electric Company Corrosion and wear resistant organic coatings
MX377576B (es) * 2014-01-22 2025-03-04 Prilenia Neurotherapeutics Ltd Formulaciones de pridopidina de liberación modificada.
TW201613859A (en) 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
US9796673B2 (en) 2014-12-22 2017-10-24 Teva Pharmaceuticals International Gmbh L-tartrate salt of pridopidine
WO2016138135A1 (en) 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Sigma-1 receptor modulators for treating huntington's disease
WO2016138130A1 (en) 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Use of pridopidine to improve cognitive function and for treating alzheimer's disease
AR105434A1 (es) 2015-07-22 2017-10-04 Teva Pharmaceuticals Int Gmbh Proceso para preparar pridopidina
WO2017015615A1 (en) 2015-07-22 2017-01-26 Teva Pharmaceuticals International Gmbh Pridopidine base formulations and their use
CA3015512C (en) 2016-02-24 2024-01-16 Teva Pharmaceuticals International Gmbh Treatment of neurodegenerative eye disease using pridopidine
CA3035099C (en) 2016-08-24 2023-01-17 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating dystonias
CA3035092C (en) 2016-08-24 2022-05-31 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating functional decline
WO2018053287A1 (en) 2016-09-15 2018-03-22 Teva Pharmaceuticals International Gmbh Use of pridopidine for the treatment of anxiety and depression
DK4005570T3 (da) 2016-09-16 2024-08-19 Prilenia Neurotherapeutics Ltd Pridopidin til anvendelse behandling af retts syndroe
WO2018053275A1 (en) 2016-09-16 2018-03-22 Teva Pharmaceuticals International Gmbh Use of pridopidine for the treatment of familial dysautonomia
AU2018210145B2 (en) 2017-01-20 2023-06-29 Agency For Science, Technology And Research Use of pridopidine for the treatment of fragile X syndrome
BR112020003119A2 (pt) 2017-08-14 2020-10-13 Prilenia Neurotherapeutics Ltd. método de tratamento de esclerose lateral amiotrófica com pridopidina
EP3678664A1 (en) 2017-09-08 2020-07-15 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016523862A (ja) 2013-06-21 2016-08-12 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーTeva Pharmaceuticals International GmbH ハンチントン病を治療するための高用量プリドピジンの使用

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
European Journal of Neurology, 2017, Vol.24, pp.1140-1147
Lancet Neurology,2011年,Vol.10,pp.1049-1057
Movement Disorders, 1996, Vol.11, No.2, pp.136-142
Movement Disorders, 2013, Vol.28, No.7, pp.863-873
Movement Disorders, 2013, Vol.28, No.7, pp.874-883
Neurology, 1985, Vol.35, No.1, pp.73-77
日本臨床内科医会会誌,2015年,Vol.30, Nol.2,p.175
臨床神経学,2013年,Vol.53, No.6,pp.419-429

Also Published As

Publication number Publication date
PL3503890T3 (pl) 2025-03-24
CA3035099A1 (en) 2018-03-01
EP3503890B1 (en) 2024-12-18
JP2019524897A (ja) 2019-09-05
WO2018039475A1 (en) 2018-03-01
US11826361B2 (en) 2023-11-28
US20240075021A1 (en) 2024-03-07
ES3009437T3 (en) 2025-03-26
AU2017315781A1 (en) 2019-04-11
EP3503890A4 (en) 2020-05-06
CN110012661A (zh) 2019-07-12
CA3035099C (en) 2023-01-17
EP3503890A1 (en) 2019-07-03
JP7278327B2 (ja) 2023-05-19
MX2019002190A (es) 2019-09-11
AU2017315781B2 (en) 2021-01-28
DK3503890T3 (da) 2025-01-27
JP2021119189A (ja) 2021-08-12
US20190192496A1 (en) 2019-06-27
BR112019003731A2 (pt) 2019-07-16
WO2018039475A8 (en) 2018-10-04

Similar Documents

Publication Publication Date Title
JP7278327B2 (ja) ジストニアを治療するためのプリドピジンの使用
US11207310B2 (en) Use of pridopidine for treating functional decline
US12390456B2 (en) Pridopidine for treating Huntington's disease
US20250352533A1 (en) Pridopidine for treating huntington's disease
US20230181548A1 (en) Use of pridopidine for treating functional decline
US20250319076A1 (en) Use of pridopidine and analogs for treating symptoms of huntington disease
HK40115915A (en) Use of pridopidine for treating functional decline
EA041256B1 (ru) Применение придопидина для лечения ухудшения функциональной способности
HK40009736A (en) Use of pridopidine for treating functional decline
HK40009736B (en) Use of pridopidine for treating functional decline
NZ751156B2 (en) Use of pridopidine for treating functional decline
NZ791717A (en) Use of pridopidine for treating functional decline

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190826

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190826

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200630

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200930

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210506

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20210506

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20210518

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20210525

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20210618

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20210622

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20220412

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20221004

C28A Non-patent document cited

Free format text: JAPANESE INTERMEDIATE CODE: C2838

Effective date: 20221004

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221228

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20230201

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20230307

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20230411

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20230411

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230509

R150 Certificate of patent or registration of utility model

Ref document number: 7278210

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150