JP7274416B2 - 改善された免疫細胞療法のための標的指向遺伝子挿入 - Google Patents

改善された免疫細胞療法のための標的指向遺伝子挿入 Download PDF

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JP7274416B2
JP7274416B2 JP2019520742A JP2019520742A JP7274416B2 JP 7274416 B2 JP7274416 B2 JP 7274416B2 JP 2019520742 A JP2019520742 A JP 2019520742A JP 2019520742 A JP2019520742 A JP 2019520742A JP 7274416 B2 JP7274416 B2 JP 7274416B2
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JP2019531743A (ja
JP2019531743A5 (enExample
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ブライアン ビュッセル
フィリップ ドゥシャトー
アレクサンドル ジュイレラット
ローラント ポアロ
ジュリアン ヴァルトン
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Cellectis SA
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JP2019520742A 2016-10-19 2017-10-19 改善された免疫細胞療法のための標的指向遺伝子挿入 Active JP7274416B2 (ja)

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Application Number Priority Date Filing Date Title
US201662410187P 2016-10-19 2016-10-19
US62/410,187 2016-10-19
DKPA201670840 2016-10-27
DKPA201670840 2016-10-27
PCT/EP2017/076798 WO2018073391A1 (en) 2016-10-19 2017-10-19 Targeted gene insertion for improved immune cells therapy

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JP2019531743A JP2019531743A (ja) 2019-11-07
JP2019531743A5 JP2019531743A5 (enExample) 2020-11-12
JP7274416B2 true JP7274416B2 (ja) 2023-05-16

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EP (1) EP3529351A1 (enExample)
JP (1) JP7274416B2 (enExample)
KR (1) KR102709329B1 (enExample)
CN (1) CN110023490B (enExample)
AU (1) AU2017347637B2 (enExample)
BR (1) BR112019007715A2 (enExample)
CA (1) CA3040048A1 (enExample)
IL (1) IL265953A (enExample)
MX (1) MX2019004215A (enExample)

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BR112018001232A2 (pt) 2015-07-21 2018-09-25 The Children's Medical Center Corporation pd-l1 que expressa células-tronco hematopoéticas e usos
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
CN110841058B (zh) * 2019-11-21 2022-09-02 北京启辰生生物科技有限公司 用于协同改善免疫应答的组合物及应用
CN110790842B (zh) * 2019-11-25 2021-03-30 贵州康钦承平生物科技有限公司 一种FasL-CAR融合蛋白和表达融合蛋白的T细胞及其制备方法和应用
EP4171616A1 (en) * 2020-06-26 2023-05-03 Juno Therapeutics GmbH Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
KR102491095B1 (ko) * 2021-01-22 2023-01-20 한국생명공학연구원 Cas 단백질 및 HIF의 TAD 도메인을 포함하는 단백질 융합체 및 이의 용도
KR102500873B1 (ko) * 2021-02-03 2023-02-17 한국과학기술연구원 자연살해세포 특이적 CRISPR/Cas 시스템을 위한 융합 단백질 및 이의 용도
US20230016422A1 (en) * 2021-06-23 2023-01-19 Crispr Therapeutics Ag Engineered cells with improved protection from natural killer cell killing
CN113604437A (zh) * 2021-08-13 2021-11-05 青岛华赛伯曼医学细胞生物有限公司 过表达ccr2的免疫细胞及其应用
CN118234851A (zh) * 2021-11-19 2024-06-21 南开大学 重组武装溶瘤病毒组合物及其在til过继治疗中的用途
WO2024022509A1 (en) * 2022-07-29 2024-02-01 Nanjing Legend Biotech Co., Ltd. Methods for promoting persistence of cell therapy
CN115820697B (zh) * 2022-09-23 2024-07-30 中国海洋大学 一种免疫细胞及其制备方法和应用
CN115286697B (zh) * 2022-09-29 2022-12-13 烟台蓝纳成生物技术有限公司 一种双重靶向化合物及其制备方法和应用
CN115851909B (zh) * 2022-11-21 2023-09-08 郑州大学第一附属医院 检测fosb基因的试剂在制备诊断腹主动脉瘤产品的应用

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CN110023490B (zh) 2024-08-09
KR20190065397A (ko) 2019-06-11
JP2019531743A (ja) 2019-11-07
IL265953A (en) 2019-05-30
RU2019113911A3 (enExample) 2021-06-28
US12391933B2 (en) 2025-08-19
US20240141293A1 (en) 2024-05-02
AU2017347637A1 (en) 2019-05-02
KR102709329B1 (ko) 2024-09-23
US20200224163A1 (en) 2020-07-16
CA3040048A1 (en) 2018-04-26
AU2017347637B2 (en) 2024-02-15
RU2019113911A (ru) 2020-11-20
BR112019007715A2 (pt) 2019-07-09
EP3529351A1 (en) 2019-08-28
US11873511B2 (en) 2024-01-16
CN110023490A (zh) 2019-07-16
MX2019004215A (es) 2019-08-21

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