JP7271532B2 - 生物学的結合分子 - Google Patents

生物学的結合分子 Download PDF

Info

Publication number
JP7271532B2
JP7271532B2 JP2020522786A JP2020522786A JP7271532B2 JP 7271532 B2 JP7271532 B2 JP 7271532B2 JP 2020522786 A JP2020522786 A JP 2020522786A JP 2020522786 A JP2020522786 A JP 2020522786A JP 7271532 B2 JP7271532 B2 JP 7271532B2
Authority
JP
Japan
Prior art keywords
cell
cells
seq
binding molecule
autonomously
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020522786A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020526590A (ja
JP2020526590A5 (enExample
Inventor
ビアスナー ウルリヒ
ユマー ハッサン
クラップロート ホルガー
アー. ケセマイアー マーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AVA Lifescience GmbH
Original Assignee
AVA Lifescience GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AVA Lifescience GmbH filed Critical AVA Lifescience GmbH
Publication of JP2020526590A publication Critical patent/JP2020526590A/ja
Publication of JP2020526590A5 publication Critical patent/JP2020526590A5/ja
Application granted granted Critical
Publication of JP7271532B2 publication Critical patent/JP7271532B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020522786A 2017-07-07 2018-07-05 生物学的結合分子 Active JP7271532B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17001166.2 2017-07-07
EP17001167.0 2017-07-07
EP17001167 2017-07-07
EP17001166 2017-07-07
EP18162672.2A EP3424528A1 (de) 2017-07-07 2018-03-19 Biologische bindemoleküle
EP18162672.2 2018-03-19
PCT/EP2018/068317 WO2019008129A1 (de) 2017-07-07 2018-07-05 Biologische bindemoleküle

Publications (3)

Publication Number Publication Date
JP2020526590A JP2020526590A (ja) 2020-08-31
JP2020526590A5 JP2020526590A5 (enExample) 2021-08-12
JP7271532B2 true JP7271532B2 (ja) 2023-05-11

Family

ID=64500047

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020522786A Active JP7271532B2 (ja) 2017-07-07 2018-07-05 生物学的結合分子
JP2020522785A Active JP7239575B2 (ja) 2017-07-07 2018-07-05 サンプル中の自律的に活性なb細胞受容体または自律的に活性化されたb細胞受容体を認識する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020522785A Active JP7239575B2 (ja) 2017-07-07 2018-07-05 サンプル中の自律的に活性なb細胞受容体または自律的に活性化されたb細胞受容体を認識する方法

Country Status (5)

Country Link
US (2) US11634487B2 (enExample)
EP (4) EP3424527A1 (enExample)
JP (2) JP7271532B2 (enExample)
CA (2) CA3070847A1 (enExample)
WO (2) WO2019008129A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3424527A1 (de) * 2017-07-07 2019-01-09 AVA Lifescience GmbH Diagnostisches verfahren
US20220227864A1 (en) * 2019-05-02 2022-07-21 Ava Lifescience Gmbh Biological binding molecules
EP3733709A1 (de) * 2019-05-02 2020-11-04 AVA Lifescience Biologische bindemoleküle
WO2020221463A1 (de) * 2019-05-02 2020-11-05 Ava Lifescience Gmbh Verfahren zur selektion biologischer bindemoleküle
CN118613499A (zh) * 2021-08-18 2024-09-06 宾夕法尼亚大学董事会 对b细胞受体特异的嵌合抗原受体的组合物和方法
EP4476264A1 (en) 2022-02-10 2024-12-18 SinABioSolution GmbH Antibodies targeting the b-cell receptor of chronic lymphocytic leukemia and uses thereof
EP4227321A1 (en) 2022-02-10 2023-08-16 AVA Lifescience GmbH Antibodies targeting the b-cell receptor of chronic lymphocytic leukemia (cll) for use in treatment of cll
KR20250075563A (ko) * 2022-07-25 2025-05-28 시나바이오솔루션 게엠베하 만성 림프구성 백혈병의 b-세포 수용체를 표적으로 하는 인간화 키메라 항원 수용체 및 이의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393531B2 (en) * 2003-01-21 2008-07-01 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of MCSP
ES2741936T3 (es) * 2012-02-24 2020-02-12 Abbvie Stemcentrx Llc Anticuerpos anti-SEZ6 y procedimientos de uso
US9770504B2 (en) * 2013-05-03 2017-09-26 The Board Of Regents Of The University Of Texas System Generating peptoid vaccines
PE20160674A1 (es) * 2013-08-28 2016-07-21 Stemcentrx Inc Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
EP3424527A1 (de) 2017-07-07 2019-01-09 AVA Lifescience GmbH Diagnostisches verfahren

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Biochim. Biophys. Acta, 2016, 1863(3), pp.401-413
Blood Cells Mol. Dis., 2015, 55(3), pp.255-265
Nat. Commun., 2017, 8:15746
Nature, 2012, 489(7415), pp.309-312

Also Published As

Publication number Publication date
JP2020526590A (ja) 2020-08-31
EP3424527A1 (de) 2019-01-09
US20200209246A1 (en) 2020-07-02
CA3070847A1 (en) 2019-01-10
CA3070848A1 (en) 2019-01-10
JP7239575B2 (ja) 2023-03-14
EP3615072A1 (de) 2020-03-04
EP3424528A1 (de) 2019-01-09
EP3615073A1 (de) 2020-03-04
US11591391B2 (en) 2023-02-28
WO2019008128A1 (de) 2019-01-10
US20200199225A1 (en) 2020-06-25
WO2019008129A1 (de) 2019-01-10
US11634487B2 (en) 2023-04-25
JP2020527727A (ja) 2020-09-10

Similar Documents

Publication Publication Date Title
JP7271532B2 (ja) 生物学的結合分子
JP6799101B2 (ja) クローディンを発現するガン疾患を処置するための剤
CN109963591B (zh) B7h3抗体-药物偶联物及其医药用途
JP7070932B2 (ja) Baff-r標的化キメラ抗原受容体修飾t細胞及びその使用
US12241068B2 (en) CD79-specific chimeric antigen receptor
TW201643195A (zh) 對細胞內致癌基因產物的單株抗原結合蛋白
KR20150002621A (ko) 항 sez6 항체들 및 사용 방법
CN102918062A (zh) 使用抗cd200抗体的治疗方法
JP2016039824A (ja) 生物学的材料およびそれらの使用法
JP2024096892A (ja) 生物学的結合分子
US20240141038A1 (en) Antibody against nkp46 and application thereof
TW201920657A (zh) 藉由細胞表現之調控生物活性的抗體
JP2021130676A (ja) 抗体
CN108138172A (zh) 抗体
JP7711208B2 (ja) Dll3に対する結合分子及びその使用
JP2017511152A (ja) 二重特異性抗原結合ポリペプチド
JP2024028850A (ja) 抗pd-l1抗体及びその製薬用途
AU2017207082A1 (en) Anti-Myl9 antibody
CN107810191B (zh) Aml抗原及其用途
WO2024199454A1 (en) Antibodies and variants thereof against human cluster of differentiation 3 protein
NZ744187B2 (en) Therapeutic anti-cd9 antibody
BR112018013801B1 (pt) Anticorpo isolado, sintético ou recombinante, ou parte funcional ou equivalente funcional do mesmo, peptídeo de cd9 isolado, recombinante ou purificado, e uso dos mesmos, bem como um anticorpo cd9-específico ou parte funcional ou equivalente funcional do mesmo, peptídeo de cd9 isolado, recombinante ou purificado, molécula de ácido nucleico isolada sintética ou recombinante, vetor, micro-organismo isolado ou recombinante ou célula bacteriana, composição, kit de partes, método para determinar se células que expressam cd9 estão presentes em uma amostra, método para produzir um anticorpo ou parte funcional ou equivalente funcional, método ex vivo para determinar se um indivíduo está sofrendo de um câncer positivo para cd9, método para produzir uma célula imune esp(...)
HK1228954A1 (en) T cell-redirected antigen-binding molecule for cells having immunosuppression function

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210705

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210705

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220428

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220516

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220815

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221014

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230303

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230404

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230426

R150 Certificate of patent or registration of utility model

Ref document number: 7271532

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150