JP7258903B2 - スルホンピリジンアルキルアミド置換ヘテロアリール化合物 - Google Patents
スルホンピリジンアルキルアミド置換ヘテロアリール化合物 Download PDFInfo
- Publication number
- JP7258903B2 JP7258903B2 JP2020545054A JP2020545054A JP7258903B2 JP 7258903 B2 JP7258903 B2 JP 7258903B2 JP 2020545054 A JP2020545054 A JP 2020545054A JP 2020545054 A JP2020545054 A JP 2020545054A JP 7258903 B2 JP7258903 B2 JP 7258903B2
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- Prior art keywords
- amino
- substituted
- carboxamide
- alkyl
- methanesulfonylpyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023061359A JP7490107B2 (ja) | 2017-11-21 | 2023-04-05 | スルホンピリジンアルキルアミド置換ヘテロアリール化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589165P | 2017-11-21 | 2017-11-21 | |
| US62/589,165 | 2017-11-21 | ||
| PCT/US2018/061726 WO2019103952A1 (en) | 2017-11-21 | 2018-11-19 | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061359A Division JP7490107B2 (ja) | 2017-11-21 | 2023-04-05 | スルホンピリジンアルキルアミド置換ヘテロアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021504443A JP2021504443A (ja) | 2021-02-15 |
| JP2021504443A5 JP2021504443A5 (https=) | 2021-12-09 |
| JP7258903B2 true JP7258903B2 (ja) | 2023-04-17 |
Family
ID=65036887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545054A Active JP7258903B2 (ja) | 2017-11-21 | 2018-11-19 | スルホンピリジンアルキルアミド置換ヘテロアリール化合物 |
| JP2023061359A Active JP7490107B2 (ja) | 2017-11-21 | 2023-04-05 | スルホンピリジンアルキルアミド置換ヘテロアリール化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061359A Active JP7490107B2 (ja) | 2017-11-21 | 2023-04-05 | スルホンピリジンアルキルアミド置換ヘテロアリール化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11021462B2 (https=) |
| EP (1) | EP3713930A1 (https=) |
| JP (2) | JP7258903B2 (https=) |
| KR (1) | KR102702228B1 (https=) |
| CN (1) | CN111315737B (https=) |
| AR (1) | AR113895A1 (https=) |
| AU (3) | AU2018371010C1 (https=) |
| BR (1) | BR112020009606A2 (https=) |
| CA (1) | CA3083122A1 (https=) |
| CL (1) | CL2020001338A1 (https=) |
| CO (1) | CO2020006139A2 (https=) |
| EA (1) | EA202091269A1 (https=) |
| IL (1) | IL274816B2 (https=) |
| MX (1) | MX2020005210A (https=) |
| MY (1) | MY202167A (https=) |
| PE (1) | PE20211461A1 (https=) |
| SG (1) | SG11202004592TA (https=) |
| TW (1) | TWI776994B (https=) |
| WO (1) | WO2019103952A1 (https=) |
| ZA (1) | ZA202003717B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020005210A (es) * | 2017-11-21 | 2020-08-20 | Bristol Myers Squibb Co | Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona. |
| SG11202107614PA (en) | 2019-01-18 | 2021-08-30 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
| AU2020209216A1 (en) | 2019-01-18 | 2021-08-26 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| US12428395B2 (en) | 2019-08-01 | 2025-09-30 | Sperogenix Therapeutics Limited | Heterocyclic compounds as kinase inhibitor and uses thereof |
| WO2022135430A1 (en) * | 2020-12-22 | 2022-06-30 | InventisBio Co., Ltd. | Heteroaryl compounds, preparation methods and uses thereof |
| CN114805438A (zh) * | 2021-01-18 | 2022-07-29 | 正大天晴药业集团股份有限公司 | 含磷酰基的tyk2抑制剂化合物 |
| CA3207819A1 (en) | 2021-02-19 | 2022-08-25 | Anjali Pandey | Tyk2 inhibitors and uses thereof |
| IL305165A (en) | 2021-02-19 | 2023-10-01 | Sudo Biosciences Ltd | Tyk2 inhibitors and uses thereof |
| US12600721B2 (en) | 2021-02-19 | 2026-04-14 | Sudo Biosciences Limited | TYK2 inhibitors and uses thereof |
| EP4308556A4 (en) | 2021-03-16 | 2025-02-19 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| US20240226106A1 (en) * | 2021-03-17 | 2024-07-11 | Shire Human Genetic Therapies, Inc. | Inhibitors of plasma kallikrein |
| CN115141149A (zh) * | 2021-03-30 | 2022-10-04 | 浙江文达医药科技有限公司 | 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途 |
| KR20240008337A (ko) * | 2021-05-14 | 2024-01-18 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 헤테로시클릭 화합물 |
| CN115466289A (zh) * | 2021-06-11 | 2022-12-13 | 爱科诺生物医药(香港)有限公司 | 具有tyk2抑制活性的化合物，包含其的药物组合物，及其应用 |
| CN115724830A (zh) * | 2021-08-31 | 2023-03-03 | 浙江文达医药科技有限公司 | 作为tyk2/jak1假激酶结构域(jh2)抑制剂的化合物及合成和使用方法 |
| EP4448514A4 (en) | 2021-12-16 | 2025-10-29 | Lynk Pharmaceuticals Co Ltd | TYK2 INHIBITORS AND ASSOCIATED COMPOSITIONS AND PROCESSES |
| CN116693449A (zh) * | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
| CN117263913A (zh) * | 2022-06-20 | 2023-12-22 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物、固体形式、制备方法及其用途 |
| CN120661462A (zh) * | 2022-06-20 | 2025-09-19 | 益方生物科技(上海)股份有限公司 | 药物组合物及其用途 |
| WO2024125651A1 (zh) * | 2022-12-16 | 2024-06-20 | 津药生物科技（天津）有限公司 | 新型含杂环取代的丙烯酸衍生物及其用途 |
| WO2024217515A1 (zh) | 2023-04-19 | 2024-10-24 | 上海复宏汉霖生物技术股份有限公司 | 一种杂环取代的芳香化合物、其制备方法及用途 |
| WO2025036382A1 (zh) | 2023-08-14 | 2025-02-20 | 上海复宏汉霖生物医药有限公司 | 一种磺酰胺类化合物、其制备方法及用途 |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015503575A (ja) | 2012-01-10 | 2015-02-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピリダジンアミド化合物及びｓｙｋ阻害剤としてのそれらの使用 |
| JP2015534959A (ja) | 2012-10-19 | 2015-12-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｓｙｋの阻害剤 |
| JP2016506369A (ja) | 2012-11-08 | 2016-03-03 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＩＬ−１２、ＩＬ−２３および／またはＩＦＮα応答のモジュレーターとして有用なアミド置換ヘテロ環式化合物 |
| JP2016506368A (ja) | 2012-11-08 | 2016-03-03 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＩＬ−１２、ＩＬ−２３および／またはＩＦＮα応答のモジュレーターとして有用であるアルキルアミド置換ピリジル化合物 |
| JP2016539152A (ja) | 2013-12-05 | 2016-12-15 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼの阻害剤 |
| JP2017512749A (ja) | 2013-11-07 | 2017-05-25 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｉｌ−１２、ｉｌ−２３および／またはｉｆｎアルファ応答の調節因子として有用なアルキル−アミド−置換ピリジル化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110267964B (zh) | 2016-12-13 | 2022-05-03 | 百时美施贵宝公司 | 作为IL-12、IL-23及/或IFNα响应调节剂的经取代的杂芳基氧化膦化合物 |
| MX2020005210A (es) * | 2017-11-21 | 2020-08-20 | Bristol Myers Squibb Co | Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona. |
-
2018
- 2018-11-19 MX MX2020005210A patent/MX2020005210A/es unknown
- 2018-11-19 JP JP2020545054A patent/JP7258903B2/ja active Active
- 2018-11-19 AU AU2018371010A patent/AU2018371010C1/en active Active
- 2018-11-19 IL IL274816A patent/IL274816B2/en unknown
- 2018-11-19 MY MYPI2020002150A patent/MY202167A/en unknown
- 2018-11-19 EP EP18836556.3A patent/EP3713930A1/en active Pending
- 2018-11-19 PE PE2020000703A patent/PE20211461A1/es unknown
- 2018-11-19 KR KR1020207017459A patent/KR102702228B1/ko active Active
- 2018-11-19 BR BR112020009606-7A patent/BR112020009606A2/pt unknown
- 2018-11-19 SG SG11202004592TA patent/SG11202004592TA/en unknown
- 2018-11-19 CN CN201880072389.7A patent/CN111315737B/zh active Active
- 2018-11-19 CA CA3083122A patent/CA3083122A1/en active Pending
- 2018-11-19 WO PCT/US2018/061726 patent/WO2019103952A1/en not_active Ceased
- 2018-11-19 EA EA202091269A patent/EA202091269A1/ru unknown
- 2018-11-20 US US16/195,951 patent/US11021462B2/en active Active
- 2018-11-20 AR ARP180103395A patent/AR113895A1/es unknown
- 2018-11-20 TW TW107141159A patent/TWI776994B/zh active
-
2020
- 2020-05-19 CO CONC2020/0006139A patent/CO2020006139A2/es unknown
- 2020-05-20 CL CL2020001338A patent/CL2020001338A1/es unknown
- 2020-06-19 ZA ZA2020/03717A patent/ZA202003717B/en unknown
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2021
- 2021-04-28 US US17/242,428 patent/US11787779B2/en active Active
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2022
- 2022-09-06 AU AU2022228101A patent/AU2022228101B2/en active Active
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2023
- 2023-04-05 JP JP2023061359A patent/JP7490107B2/ja active Active
- 2023-09-05 US US18/461,093 patent/US12365667B2/en active Active
- 2023-10-27 AU AU2023255024A patent/AU2023255024B2/en active Active
-
2025
- 2025-06-11 US US19/234,470 patent/US20250304555A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015503575A (ja) | 2012-01-10 | 2015-02-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピリダジンアミド化合物及びｓｙｋ阻害剤としてのそれらの使用 |
| JP2015534959A (ja) | 2012-10-19 | 2015-12-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｓｙｋの阻害剤 |
| JP2016506369A (ja) | 2012-11-08 | 2016-03-03 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＩＬ−１２、ＩＬ−２３および／またはＩＦＮα応答のモジュレーターとして有用なアミド置換ヘテロ環式化合物 |
| JP2016506368A (ja) | 2012-11-08 | 2016-03-03 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＩＬ−１２、ＩＬ−２３および／またはＩＦＮα応答のモジュレーターとして有用であるアルキルアミド置換ピリジル化合物 |
| JP2017512749A (ja) | 2013-11-07 | 2017-05-25 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｉｌ−１２、ｉｌ−２３および／またはｉｆｎアルファ応答の調節因子として有用なアルキル−アミド−置換ピリジル化合物 |
| JP2016539152A (ja) | 2013-12-05 | 2016-12-15 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼの阻害剤 |
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