JP7246595B2 - 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法 - Google Patents

毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法 Download PDF

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JP7246595B2
JP7246595B2 JP2018210524A JP2018210524A JP7246595B2 JP 7246595 B2 JP7246595 B2 JP 7246595B2 JP 2018210524 A JP2018210524 A JP 2018210524A JP 2018210524 A JP2018210524 A JP 2018210524A JP 7246595 B2 JP7246595 B2 JP 7246595B2
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cells
hair follicle
mesenchymal
follicle primordium
stem cells
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JP2020074718A5 (enExample
JP2020074718A (ja
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淳二 福田
達斗 景山
芳樹 楯
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Yokohama National University
Kanagawa Institute of Industrial Science and Technology
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Yokohama National University
Kanagawa Institute of Industrial Science and Technology
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Priority to JP2018210524A priority Critical patent/JP7246595B2/ja
Priority to PCT/JP2019/040444 priority patent/WO2020095631A1/ja
Priority to CN201980059873.0A priority patent/CN112703247A/zh
Priority to EP19881986.4A priority patent/EP3878946A4/en
Priority to US17/276,628 priority patent/US20220041983A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C12N5/0628—Hair stem cells; Hair progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1382—Adipose-derived stem cells [ADSC], adipose stromal stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2018210524A 2018-11-08 2018-11-08 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法 Active JP7246595B2 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2018210524A JP7246595B2 (ja) 2018-11-08 2018-11-08 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法
PCT/JP2019/040444 WO2020095631A1 (ja) 2018-11-08 2019-10-15 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法
CN201980059873.0A CN112703247A (zh) 2018-11-08 2019-10-15 毛囊原基、毛囊原基的制造方法、以及毛囊原基中所含的细胞的活化方法
EP19881986.4A EP3878946A4 (en) 2018-11-08 2019-10-15 HAIR FOLLICLE BOILS, METHOD OF PREPARING HAIR FOLLICLE BOILS AND METHOD OF ACTIVATING CELLS CONTAINED IN HAIR FOLLICLE BOILS
US17/276,628 US20220041983A1 (en) 2018-11-08 2019-10-15 Hair Follicle Germs, Method for Producing Hair Follicle Germs, and Method for Activating Cells Included in Hair Follicle Germs

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JP2018210524A JP7246595B2 (ja) 2018-11-08 2018-11-08 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法

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JP2020074718A JP2020074718A (ja) 2020-05-21
JP2020074718A5 JP2020074718A5 (enExample) 2021-11-11
JP7246595B2 true JP7246595B2 (ja) 2023-03-28

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US (1) US20220041983A1 (enExample)
EP (1) EP3878946A4 (enExample)
JP (1) JP7246595B2 (enExample)
CN (1) CN112703247A (enExample)
WO (1) WO2020095631A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7835162B2 (ja) * 2020-11-26 2026-03-25 東ソー株式会社 細胞塊の製造方法
WO2023171395A1 (ja) * 2022-03-09 2023-09-14 株式会社 資生堂 間葉系細胞を含む細胞集団の毛髪再生能を評価する方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008001938A1 (en) 2006-06-27 2008-01-03 Shiseido Company, Ltd. Cell cluster comprising plural kinds of cells derived from soma with ability to form primitive organ-like structure
JP2010534072A (ja) 2007-07-20 2010-11-04 ドングク・ユニヴァーシティー・インダストリー−アカデミック・コーオペレーション・ファンデーション 間葉系幹細胞を利用して毛乳頭組職を製造する方法
WO2017073625A1 (ja) 2015-10-30 2017-05-04 国立大学法人横浜国立大学 再生毛包原基の集合体の製造方法、毛包組織含有シート、及び毛包組織含有シートの製造方法
US20180271913A1 (en) 2017-03-21 2018-09-27 National Cheng Kung University Pharmaceutical compositions for promoting hair follicle regeneration and methods for preparing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016006788A1 (ko) * 2014-07-07 2016-01-14 메디포스트(주) 작은 크기 줄기세포의 발모 촉진능 및 이의 용도
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008001938A1 (en) 2006-06-27 2008-01-03 Shiseido Company, Ltd. Cell cluster comprising plural kinds of cells derived from soma with ability to form primitive organ-like structure
JP2010534072A (ja) 2007-07-20 2010-11-04 ドングク・ユニヴァーシティー・インダストリー−アカデミック・コーオペレーション・ファンデーション 間葉系幹細胞を利用して毛乳頭組職を製造する方法
WO2017073625A1 (ja) 2015-10-30 2017-05-04 国立大学法人横浜国立大学 再生毛包原基の集合体の製造方法、毛包組織含有シート、及び毛包組織含有シートの製造方法
US20180271913A1 (en) 2017-03-21 2018-09-27 National Cheng Kung University Pharmaceutical compositions for promoting hair follicle regeneration and methods for preparing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chong Hyun Won et al.，Hair growth promoting effects of adipose tissue-derived stem cells.，J. Dermatol. Sci.，2010年02月，Vol.57, No.2，p.134-137，doi: 10.1016/j.jdermsci.2009.10.013
Koh-ei Toyoshima. et al.，Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches，Nat. Commun.，2012年04月17日，3:784，doi: 10.1038/ncomms1784

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Publication number Publication date
EP3878946A4 (en) 2022-07-27
EP3878946A1 (en) 2021-09-15
CN112703247A (zh) 2021-04-23
JP2020074718A (ja) 2020-05-21
US20220041983A1 (en) 2022-02-10
WO2020095631A1 (ja) 2020-05-14

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