JP7246133B2 - アンブロクスを単離および精製するためのプロセス - Google Patents

アンブロクスを単離および精製するためのプロセス Download PDF

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JP7246133B2
JP7246133B2 JP2017555602A JP2017555602A JP7246133B2 JP 7246133 B2 JP7246133 B2 JP 7246133B2 JP 2017555602 A JP2017555602 A JP 2017555602A JP 2017555602 A JP2017555602 A JP 2017555602A JP 7246133 B2 JP7246133 B2 JP 7246133B2
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Prior art keywords
ambrox
homofarnesol
mixture
iii
reaction
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JP2018513198A5 (https=
JP2018513198A (ja
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アイクホルン，エリック
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ジボダン エス エー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/0069—Heterocyclic compounds
    • C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
    • C11B9/0076—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing less than six atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Furan Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treating Waste Gases (AREA)
JP2017555602A 2015-04-24 2016-04-22 アンブロクスを単離および精製するためのプロセス Active JP7246133B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1507170.7A GB201507170D0 (en) 2015-04-24 2015-04-24 Process
GB1507170.7 2015-04-24
PCT/EP2016/058997 WO2016170106A1 (en) 2015-04-24 2016-04-22 Process for isolating and purifying ambrox

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021011646A Division JP2021090423A (ja) 2015-04-24 2021-01-28 アンブロクスを単離および精製するためのプロセス

Publications (3)

Publication Number Publication Date
JP2018513198A JP2018513198A (ja) 2018-05-24
JP2018513198A5 JP2018513198A5 (https=) 2023-01-06
JP7246133B2 true JP7246133B2 (ja) 2023-03-27

Family

ID=53488739

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017555602A Active JP7246133B2 (ja) 2015-04-24 2016-04-22 アンブロクスを単離および精製するためのプロセス
JP2021011646A Pending JP2021090423A (ja) 2015-04-24 2021-01-28 アンブロクスを単離および精製するためのプロセス
JP2023057205A Active JP7690510B2 (ja) 2015-04-24 2023-03-31 アンブロクスを単離および精製するためのプロセス

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021011646A Pending JP2021090423A (ja) 2015-04-24 2021-01-28 アンブロクスを単離および精製するためのプロセス
JP2023057205A Active JP7690510B2 (ja) 2015-04-24 2023-03-31 アンブロクスを単離および精製するためのプロセス

Country Status (13)

Country Link
US (1) US10294211B2 (https=)
EP (1) EP3286309B1 (https=)
JP (3) JP7246133B2 (https=)
CN (1) CN107548418B (https=)
BR (1) BR112017021789B1 (https=)
CO (1) CO2017010720A2 (https=)
ES (1) ES2856887T3 (https=)
GB (1) GB201507170D0 (https=)
IL (1) IL254836B2 (https=)
MX (1) MX381562B (https=)
RU (1) RU2720094C2 (https=)
SG (1) SG11201708085TA (https=)
WO (1) WO2016170106A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201507207D0 (en) 2015-04-24 2015-06-10 Givaudan Sa Enzymes and applications thereof
GB201618090D0 (en) 2016-10-26 2016-12-07 Givaudan Sa Product
JP2020508651A (ja) * 2017-02-24 2020-03-26 インターナショナル フレーバーズ アンド フラグランシズ インコーポレイテッド スクアレンホペンシクラーゼ、およびアンブロキサンを生成するためのその使用
EP3677683B1 (en) * 2017-09-01 2024-07-17 Niigata University Efficient method for producing ambrein
EP3476822A1 (en) 2017-10-31 2019-05-01 Givaudan SA Process of making organic compounds
GB201917688D0 (en) 2019-12-04 2020-01-15 Givaudan Sa SHC enzymes and enzyme variants
GB202011823D0 (en) 2020-07-30 2020-09-16 Givaudan Sa Method
GB202115120D0 (en) * 2021-10-21 2021-12-08 Givaudan Sa Organic compounds
WO2024181354A1 (ja) 2023-03-01 2024-09-06 オムロン株式会社 制御装置、制御方法、及び制御プログラム
CN119876059A (zh) * 2025-01-25 2025-04-25 天津大学浙江研究院(绍兴) 一种降龙涎醚的生物催化合成方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2000198778A (ja) 1999-01-07 2000-07-18 Japan Science & Technology Corp 光学活性環状化合物類の製造方法
JP2009060799A (ja) 2007-09-04 2009-03-26 Kao Corp （−）−アンブロキサンの製造方法
JP2012528578A (ja) 2009-06-05 2012-11-15 ビーエーエスエフ ソシエタス・ヨーロピア アンブロキサンの生物触媒的生産
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
WO2013156398A1 (de) 2012-04-16 2013-10-24 Basf Se Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol

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SU910561A1 (ru) * 1980-08-19 1982-03-07 Всесоюзный научно-исследовательский институт синтетических и натуральных душистых веществ Способ получени смеси душистых веществ дитерпеноидного р да
SU1498767A1 (ru) * 1987-06-04 1989-08-07 Институт Химии Ан Мсср Способ получени ( @ ) 3 @ ,6,6,9 @ -тетраметилпергидронафто [2,1-в]фурана
US5463089A (en) * 1994-07-22 1995-10-31 Quest International B.V. Preparation of ambrox
DE19524584A1 (de) * 1995-07-06 1997-01-09 Basf Ag Verfahren zur stereoselektiven Herstellung von (-)3a,6,6,9a-Tetramethyl-perhydronaphtho[2,1-b]furan
DE19649655A1 (de) 1996-11-29 1998-06-04 Haarmann & Reimer Gmbh Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung
DE19960106A1 (de) 1999-12-14 2001-06-21 Haarmann & Reimer Gmbh Enzyme und Gene für die Herstellung von Vanillin
WO2004063699A2 (en) 2002-12-02 2004-07-29 The Ohio State University Research Foundation Rapid detection of microorganisms
US20040265850A1 (en) 2002-12-02 2004-12-30 Hua Wang Rapid detection of microorganisms
CN100488940C (zh) * 2004-06-11 2009-05-20 湖南中烟工业有限责任公司 用于制备降龙涎醚或向卷烟烟气释放降龙涎醚的草酸酯及应用
US8507564B2 (en) * 2005-08-04 2013-08-13 Shiseido Co., Ltd. Method for selecting perfume ingredient, method for formulating fragrance, and preference-enhancing agent
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EP4112727A3 (de) 2010-11-17 2023-03-15 Basf Se Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten
US8932839B2 (en) 2010-11-17 2015-01-13 Basf Se Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein
JP2013132226A (ja) 2011-12-26 2013-07-08 Kao Corp （−）−３ａ，６，６，９ａ−テトラメチルドデカヒドロナフト［２，１−ｂ］フランの製造方法
WO2015033746A1 (ja) 2013-09-05 2015-03-12 国立大学法人新潟大学 アンブレインの製造方法
GB201318894D0 (en) 2013-10-25 2013-12-11 Givaudan Sa Improvements in or relating to organic compounds
GB201318886D0 (en) 2013-10-25 2013-12-11 Givaudan Sa Improvements i or relating to organic compounds
GB201507207D0 (en) * 2015-04-24 2015-06-10 Givaudan Sa Enzymes and applications thereof
CN105037308B (zh) 2015-07-06 2017-06-06 四川中烟工业有限责任公司 一种制备降龙涎香醚的方法

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JP2000198778A (ja) 1999-01-07 2000-07-18 Japan Science & Technology Corp 光学活性環状化合物類の製造方法
JP2009060799A (ja) 2007-09-04 2009-03-26 Kao Corp （−）−アンブロキサンの製造方法
JP2012528578A (ja) 2009-06-05 2012-11-15 ビーエーエスエフ ソシエタス・ヨーロピア アンブロキサンの生物触媒的生産
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
WO2013156398A1 (de) 2012-04-16 2013-10-24 Basf Se Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol

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Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ，２００２年，１２４（１４），３６４７－３６５５
Ｔｅｔｒａｈｅｄｒｏｎ，１９８７年，４３（８），１８７１－９

Also Published As

Publication number Publication date
SG11201708085TA (en) 2017-11-29
BR112017021789A2 (pt) 2018-07-31
CO2017010720A2 (es) 2018-01-31
IL254836B2 (en) 2023-08-01
IL254836A0 (en) 2017-12-31
MX2017013100A (es) 2018-01-26
RU2720094C2 (ru) 2020-04-24
RU2017134436A (ru) 2019-05-24
CN107548418B (zh) 2022-05-03
EP3286309A1 (en) 2018-02-28
GB201507170D0 (en) 2015-06-10
JP2023093498A (ja) 2023-07-04
CN107548418A (zh) 2018-01-05
RU2017134436A3 (https=) 2019-10-09
US10294211B2 (en) 2019-05-21
US20180346434A9 (en) 2018-12-06
JP2018513198A (ja) 2018-05-24
US20180134678A1 (en) 2018-05-17
EP3286309B1 (en) 2020-11-25
JP2021090423A (ja) 2021-06-17
WO2016170106A1 (en) 2016-10-27
IL254836B1 (en) 2023-04-01
JP7690510B2 (ja) 2025-06-10
MX381562B (es) 2025-03-12
BR112017021789B1 (pt) 2022-11-29
ES2856887T3 (es) 2021-09-28

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