JP7244134B2 - アミド反応用反応剤及びそれを用いたアミド化合物の製造方法 - Google Patents

アミド反応用反応剤及びそれを用いたアミド化合物の製造方法 Download PDF

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JP7244134B2
JP7244134B2 JP2021553744A JP2021553744A JP7244134B2 JP 7244134 B2 JP7244134 B2 JP 7244134B2 JP 2021553744 A JP2021553744 A JP 2021553744A JP 2021553744 A JP2021553744 A JP 2021553744A JP 7244134 B2 JP7244134 B2 JP 7244134B2
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group
substituents
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JPWO2021085636A1 (https=
JPWO2021085636A5 (https=
Inventor
尚 山本
渉 村松
倫弘 服部
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Chubu University
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Chubu University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0272—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing elements other than those covered by B01J31/0201 - B01J31/0255
    • B01J31/0275—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing elements other than those covered by B01J31/0201 - B01J31/0255 also containing elements or functional groups covered by B01J31/0201 - B01J31/0269
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/025—Silicon compounds without C-silicon linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/04—Esters of silicic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
JP2021553744A 2019-10-30 2020-10-30 アミド反応用反応剤及びそれを用いたアミド化合物の製造方法 Active JP7244134B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2019197786 2019-10-30
JP2019197776 2019-10-30
JP2019197776 2019-10-30
JP2019197786 2019-10-30
JP2020059087 2020-03-27
JP2020059087 2020-03-27
PCT/JP2020/040960 WO2021085636A1 (ja) 2019-10-30 2020-10-30 アミド反応用反応剤及びそれを用いたアミド化合物の製造方法

Publications (3)

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JPWO2021085636A1 JPWO2021085636A1 (https=) 2021-05-06
JPWO2021085636A5 JPWO2021085636A5 (https=) 2022-07-28
JP7244134B2 true JP7244134B2 (ja) 2023-03-22

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JP2021553744A Active JP7244134B2 (ja) 2019-10-30 2020-10-30 アミド反応用反応剤及びそれを用いたアミド化合物の製造方法

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US (1) US20230002422A1 (https=)
EP (2) EP4053132A4 (https=)
JP (1) JP7244134B2 (https=)
WO (1) WO2021085636A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240368217A1 (en) 2021-05-31 2024-11-07 Chubu University Educational Foundation Peptide compound production method and amidation agent
EP4357353A4 (en) * 2021-06-17 2025-05-07 Chubu University Educational Foundation METHOD FOR PREPARING A PEPTIDE COMPOUND
WO2022265115A1 (ja) 2021-06-17 2022-12-22 学校法人中部大学 ペプチド化合物の製造方法
EP4446332A4 (en) 2022-01-17 2025-04-16 Chubu University Educational Foundation METHOD FOR PREPARING A PEPTIDE COMPOUND
JP7674770B2 (ja) 2022-04-27 2025-05-12 学校法人中部大学 ポリペプチド化合物の製造方法
US11878958B2 (en) 2022-05-25 2024-01-23 Ikena Oncology, Inc. MEK inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110662736A (zh) 2017-04-25 2020-01-07 学校法人中部大学 酰胺化合物的制造方法
CN112020492B (zh) * 2018-04-25 2023-05-05 学校法人中部大学 酰胺化合物的制造方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
MURAMATSU, Wataru et al.，Peptide bond-forming reaction via amino acid silyl esters: New catalytic reactivity of an aminosilan，ACS Catalysis，2020年，Vol. 10, No. 16，pp. 9594-9603
MURAMATSU, Wataru et al.，Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis，Journal of the American Chemical Society，2019年07月16日，Vol. 141, No. 31，pp. 12288-12295，ISSN 1520-5126
SCHMIDT, Michael A. et al.，Development of a Two-Step, Enantioselective Synthesis of an Amino Alcohol Drug Candidate，Organic Process Research & Development，2015年，Vol. 19, No. 9，pp. 1317-1322，ISSN 1083-6160
TOZAWA, Takashi et al.，A convenient method for preparations of 1-acylimidazoles and carboxamides by using novel imidazolyls，Chemistry Letters，2005年，Vol. 34, No. 5，pp. 734-735，ISSN 0366-7022
TOZAWA, Takashi et al.，An efficient method for the preparation of carboxamides by dehydration condensation using tetrakis(1，Chemistry Letters，2005年，Vol. 34, No. 12，pp. 1586-1587，ISSN 0366-7022
第５版 実験化学講座 １６，丸善株式会社，2005年，pp. 259-260, 268-269

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Publication number Publication date
EP4538279A2 (en) 2025-04-16
EP4053132A1 (en) 2022-09-07
JPWO2021085636A1 (https=) 2021-05-06
EP4053132A4 (en) 2024-02-21
WO2021085636A1 (ja) 2021-05-06
US20230002422A1 (en) 2023-01-05
EP4538279A3 (en) 2025-07-16

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