JP7227967B2 - ウイルス感染および細菌感染の処置のための新規mek阻害剤 - Google Patents

ウイルス感染および細菌感染の処置のための新規mek阻害剤 Download PDF

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JP7227967B2
JP7227967B2 JP2020521541A JP2020521541A JP7227967B2 JP 7227967 B2 JP7227967 B2 JP 7227967B2 JP 2020521541 A JP2020521541 A JP 2020521541A JP 2020521541 A JP2020521541 A JP 2020521541A JP 7227967 B2 JP7227967 B2 JP 7227967B2
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シュテファン ルートヴィヒ
オリバー プランツ
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アトリバ セラピューティクス ゲーエムベーハー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2020521541A 2017-10-17 2018-10-17 ウイルス感染および細菌感染の処置のための新規mek阻害剤 Active JP7227967B2 (ja)

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JP2023018912A JP7618276B2 (ja) 2017-10-17 2023-02-10 ウイルス感染および細菌感染の処置のための新規mek阻害剤
JP2024228526A JP2025031917A (ja) 2017-10-17 2024-12-25 ウイルス感染および細菌感染の処置のための新規mek阻害剤

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Application Number Priority Date Filing Date Title
LU100487 2017-10-17
LULU100487 2017-10-17
PCT/EP2018/078335 WO2019076947A1 (en) 2017-10-17 2018-10-17 NEW MEK INHIBITOR FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS

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JP2023018912A Division JP7618276B2 (ja) 2017-10-17 2023-02-10 ウイルス感染および細菌感染の処置のための新規mek阻害剤

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JP2020537659A JP2020537659A (ja) 2020-12-24
JP2020537659A5 JP2020537659A5 (enExample) 2021-09-16
JP7227967B2 true JP7227967B2 (ja) 2023-02-22

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JP2023018912A Active JP7618276B2 (ja) 2017-10-17 2023-02-10 ウイルス感染および細菌感染の処置のための新規mek阻害剤
JP2024228526A Pending JP2025031917A (ja) 2017-10-17 2024-12-25 ウイルス感染および細菌感染の処置のための新規mek阻害剤

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JP2024228526A Pending JP2025031917A (ja) 2017-10-17 2024-12-25 ウイルス感染および細菌感染の処置のための新規mek阻害剤

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EP (2) EP3973960B1 (enExample)
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KR (1) KR102848960B1 (enExample)
CN (2) CN118141795A (enExample)
AU (2) AU2018351475A1 (enExample)
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CY (1) CY1124507T1 (enExample)
DK (1) DK3697405T3 (enExample)
EA (1) EA202090693A1 (enExample)
ES (2) ES2883639T3 (enExample)
HR (1) HRP20211252T1 (enExample)
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MX (2) MX2020003473A (enExample)
PL (1) PL3697405T3 (enExample)
PT (1) PT3697405T (enExample)
SI (1) SI3697405T1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023058631A (ja) * 2017-10-17 2023-04-25 アトリバ セラピューティクス ゲーエムベーハー ウイルス感染および細菌感染の処置のための新規mek阻害剤

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU101183B1 (en) * 2019-04-16 2020-10-16 Atriva Therapeutics Gmbh Novel mek-inhibitor for the treatment of viral and bacterial infections
KR20220074869A (ko) 2019-08-27 2022-06-03 아트리바 테라퓨틱스 게엠베하 Mek 억제제와 캡-의존성 엔도뉴클레아제 억제제의 조합
KR20220079573A (ko) * 2019-10-08 2022-06-13 아트리바 테라퓨틱스 게엠베하 한타바이러스 감염의 치료를 위한 mek 억제제
ES2995196T3 (en) * 2020-05-20 2025-02-07 Atriva Therapeutics Gmbh Pd-0184264 for the treatment of coronavirus infections and/or covid-19 cytokine storm
CN112957361B (zh) * 2021-03-24 2022-07-29 中国科学院武汉病毒研究所 曲美替尼在制备抗沙粒病毒的抗病毒制剂中的应用
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

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JP2002534381A (ja) 1999-01-07 2002-10-15 ワーナー−ランバート・カンパニー Mek阻害剤を用いた抗ウィルス法
JP2003504400A (ja) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Mek阻害剤を用いた慢性痛の治療方法
JP2004505891A (ja) 2000-04-07 2004-02-26 メドルノバ ゲゼルシャフト フュア メディシンシェ イノバション アウス アカデミッシャー フォルシュング エムベーハー DNAウイルス及びRNAウイルスに対する薬品の生産における、Raf/MEK/ERKシグナル伝達連鎖に対して連鎖阻害剤として作用する物質の応用
JP2006517204A (ja) 2003-01-03 2006-07-20 イネイムド ゲーエムベーハー インスティチュート フル アエロソルメディジン ウイルス性疾患の予防及び/又は治療用活性成分の使用
JP2007055983A (ja) 2005-08-26 2007-03-08 Tokyo Univ Of Science 細胞内に侵入した病原性細菌に起因する疾患の予防・改善剤
JP2015534562A (ja) 2012-10-08 2015-12-03 シュテファン プレシュカ ウイルス疾患の処置におけるmek阻害物質
JP2017515910A (ja) 2014-05-16 2017-06-15 アトリバ セラピューティクス ゲーエムベーハー インフルエンザウイルスおよび黄色ブドウ球菌の重感染に対する新規の抗感染戦略

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US6310060B1 (en) * 1998-06-24 2001-10-30 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
EP1467968A1 (en) 2002-01-23 2004-10-20 Warner-Lambert Company LLC N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
US20150141380A1 (en) * 2010-08-05 2015-05-21 Case Western Reserve University Inhibitors of erk for developmental disorders of neuronal connectivity
ES2883639T3 (es) 2017-10-17 2021-12-09 Atriva Therapeutics Gmbh Nuevo inhibidor de MEK para el tratamiento de infecciones víricas y bacterianas
KR20220079573A (ko) 2019-10-08 2022-06-13 아트리바 테라퓨틱스 게엠베하 한타바이러스 감염의 치료를 위한 mek 억제제
ES2995196T3 (en) 2020-05-20 2025-02-07 Atriva Therapeutics Gmbh Pd-0184264 for the treatment of coronavirus infections and/or covid-19 cytokine storm

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JP2002534381A (ja) 1999-01-07 2002-10-15 ワーナー−ランバート・カンパニー Mek阻害剤を用いた抗ウィルス法
JP2003504400A (ja) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Mek阻害剤を用いた慢性痛の治療方法
JP2004505891A (ja) 2000-04-07 2004-02-26 メドルノバ ゲゼルシャフト フュア メディシンシェ イノバション アウス アカデミッシャー フォルシュング エムベーハー DNAウイルス及びRNAウイルスに対する薬品の生産における、Raf/MEK/ERKシグナル伝達連鎖に対して連鎖阻害剤として作用する物質の応用
JP2006517204A (ja) 2003-01-03 2006-07-20 イネイムド ゲーエムベーハー インスティチュート フル アエロソルメディジン ウイルス性疾患の予防及び/又は治療用活性成分の使用
JP2007055983A (ja) 2005-08-26 2007-03-08 Tokyo Univ Of Science 細胞内に侵入した病原性細菌に起因する疾患の予防・改善剤
JP2015534562A (ja) 2012-10-08 2015-12-03 シュテファン プレシュカ ウイルス疾患の処置におけるmek阻害物質
JP2017515910A (ja) 2014-05-16 2017-06-15 アトリバ セラピューティクス ゲーエムベーハー インフルエンザウイルスおよび黄色ブドウ球菌の重感染に対する新規の抗感染戦略

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Antiviral Research,2017年,142,pp.178-184
Journal of Clinical Oncology,2005年,23(23),pp.5281-5293

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023058631A (ja) * 2017-10-17 2023-04-25 アトリバ セラピューティクス ゲーエムベーハー ウイルス感染および細菌感染の処置のための新規mek阻害剤
JP7618276B2 (ja) 2017-10-17 2025-01-21 アトリバ セラピューティクス ゲーエムベーハー ウイルス感染および細菌感染の処置のための新規mek阻害剤

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US20200289445A1 (en) 2020-09-17
CY1124507T1 (el) 2022-07-22
SI3697405T1 (sl) 2021-11-30
US20240245637A1 (en) 2024-07-25
MX2020003473A (es) 2020-10-01
HUE055738T2 (hu) 2021-12-28
HRP20211252T1 (hr) 2021-11-12
JP7618276B2 (ja) 2025-01-21
PL3697405T3 (pl) 2021-12-13
CN111479566B (zh) 2024-05-07
PT3697405T (pt) 2021-08-27
JP2023058631A (ja) 2023-04-25
EP3973960C0 (en) 2025-09-03
ES2883639T3 (es) 2021-12-09
EP3697405A1 (en) 2020-08-26
EP3973960B1 (en) 2025-09-03
JP2020537659A (ja) 2020-12-24
CN118141795A (zh) 2024-06-07
CA3078424A1 (en) 2019-04-25
AU2018351475A1 (en) 2020-04-30
DK3697405T3 (da) 2021-08-23
EP3697405B1 (en) 2021-07-14
KR102848960B1 (ko) 2025-08-21
ES3041322T3 (en) 2025-11-11
BR112020007442A2 (pt) 2020-10-27
US11903917B2 (en) 2024-02-20
ZA202002069B (en) 2021-10-27
LT3697405T (lt) 2021-10-25
KR20200072499A (ko) 2020-06-22
EP3973960A1 (en) 2022-03-30
JP2025031917A (ja) 2025-03-07
WO2019076947A1 (en) 2019-04-25
EA202090693A1 (ru) 2020-10-19
AU2024205853A1 (en) 2024-09-05
MX2022016066A (es) 2023-02-02
CN111479566A (zh) 2020-07-31

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