JP7224289B2 - Ｃｄ１２３結合タンパク質並びに関連する組成物及び方法 - Google Patents

Ｃｄ１２３結合タンパク質並びに関連する組成物及び方法 Download PDF

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JP7224289B2
JP7224289B2 JP2019537049A JP2019537049A JP7224289B2 JP 7224289 B2 JP7224289 B2 JP 7224289B2 JP 2019537049 A JP2019537049 A JP 2019537049A JP 2019537049 A JP2019537049 A JP 2019537049A JP 7224289 B2 JP7224289 B2 JP 7224289B2
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acid sequence
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JP2019531764A (ja
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ヘルナンデス－ホヨス，ガブリエラ
シューエル，イレーヌ，ティー．
マクマハン，キャサリン，ジェイ．
ビアンヴニュ，デイビッド
ブランケンシップ，ジョン，ダブリュー．
ミッシェル，ダニエル
パブリック，ピーター
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アプティーボ リサーチ アンド デベロップメント エルエルシー
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/09—Recombinant DNA-technology
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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JP2019537049A 2016-09-21 2017-09-21 Ｃｄ１２３結合タンパク質並びに関連する組成物及び方法 Active JP7224289B2 (ja)

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PCT/US2017/052808 WO2018057802A1 (en) 2016-09-21 2017-09-21 Cd123 binding proteins and related compositions and methods

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JP2023058573A (ja) * 2016-09-21 2023-04-25 アプティーボ リサーチ アンド デベロップメント エルエルシー Ｃｄ１２３結合タンパク質並びに関連する組成物及び方法

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CN111171155B (zh) * 2020-02-05 2021-02-19 北京智仁美博生物科技有限公司 抗cd3和cd123双特异性抗体及其用途
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CN111732635B (zh) * 2020-06-22 2022-03-22 中国医学科学院基础医学研究所 与cd123蛋白特异性结合的多肽、多肽复合物、共递送系统及其制备方法与应用
US20230391856A1 (en) * 2020-10-23 2023-12-07 Icahn School Of Medicine At Mount Sinai Sars-cov-2 antibodies and uses thereof
US20240301086A1 (en) * 2020-12-01 2024-09-12 Aptevo Research And Development Llc Tumor-associated antigens and cd3-binding proteins, related compositions, and methods
US20240076392A1 (en) * 2021-02-17 2024-03-07 Igm Biosciences, Inc. Anti-cd123 binding molecules and uses thereof
JP2024519964A (ja) * 2021-05-21 2024-05-21 アプティーボ リサーチ アンド デベロップメント エルエルシー タンパク質治療薬のための投薬レジメン
CN116162148B (zh) * 2021-11-24 2025-09-09 中山光度生物医药有限公司 多特异性配体结合分子及其应用
CN116836282B (zh) * 2023-02-13 2024-03-29 北京艺妙神州医药科技有限公司 抗体、嵌合抗原受体及其用途
CN117660325B (zh) * 2024-01-31 2024-04-19 苏州科为康生物医药科技有限公司 一种制备脐带血msc的培养基及其方法

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