JP7223989B2 - 免疫調節組成物およびその使用方法 - Google Patents
免疫調節組成物およびその使用方法 Download PDFInfo
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- JP7223989B2 JP7223989B2 JP2018506211A JP2018506211A JP7223989B2 JP 7223989 B2 JP7223989 B2 JP 7223989B2 JP 2018506211 A JP2018506211 A JP 2018506211A JP 2018506211 A JP2018506211 A JP 2018506211A JP 7223989 B2 JP7223989 B2 JP 7223989B2
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| JP2022534783A (ja) * | 2019-06-03 | 2022-08-03 | イミュノルクス インターナショナル コーポレーション | 疾患を処置するための天然痘ワクチン及び幹細胞 |
| KR102149102B1 (ko) * | 2019-07-05 | 2020-08-27 | 에스케이바이오랜드 주식회사 | 피부보습 및 피부재생 기능이 있는 더모바이오틱스 블록 조성물의 제조방법 |
| EP3838269A1 (en) * | 2019-12-16 | 2021-06-23 | European Molecular Biology Laboratory | Compounds and pharmaceutical compositions for prevention and/or treatment of dysbiosis and antibacterial antidotes for microbiome-protection |
| CN113440609A (zh) * | 2020-03-27 | 2021-09-28 | 北京市农林科学院 | 一种双链rna复合物autp及其在疫苗制备中的应用 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
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Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US5736371A (en) | 1991-06-04 | 1998-04-07 | A Et S Biovecteurs | Biodegradable particulate vector for transporting molecules having biological activity |
| ES2141108T3 (es) | 1991-07-02 | 2000-03-16 | Inhale Inc | Metodo y dispositivo para proporcionar medicamentos en aerosol. |
| US5711968A (en) | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
| EP0671948B1 (en) | 1992-06-25 | 1997-08-13 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| DK0689454T4 (da) | 1993-03-23 | 2005-05-30 | Smithkline Beecham Biolog | Vaccinepræparater indeholdende 3-O-deacyleret monophosphoryl-lipid A |
| US5497763A (en) | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
| JP3220331B2 (ja) | 1993-07-20 | 2001-10-22 | エチコン・インコーポレーテツド | 非経口投与用の吸収性液体コポリマー類 |
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| JP3468773B2 (ja) | 1994-07-15 | 2003-11-17 | ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫調節オリゴヌクレオチド |
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| ES2241042T3 (es) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora. |
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| US6339068B1 (en) | 1997-05-20 | 2002-01-15 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
| ATE432348T1 (de) | 1997-06-06 | 2009-06-15 | Univ California | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GEP20022707B (en) | 1997-07-18 | 2002-06-25 | Infimed Inc Us | Biodegrading Macromers for the Controlled Release of Biologically Active Substances |
| EP1009382B1 (en) | 1997-09-05 | 2003-06-18 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
| EP1051157B1 (en) | 1998-01-30 | 2002-01-02 | Scios Inc. | Controlled release delivery of peptide or protein |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| EP1069910A1 (en) | 1998-04-09 | 2001-01-24 | GlaxoSmithKline Biologicals S.A. | Adjuvant compositions |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| PL201482B1 (pl) | 1998-10-16 | 2009-04-30 | Smithkline Beecham Biolog | Sposoby wytwarzania kompozycji szczepionki oraz kompozycja szczepionki |
| US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| WO2000050073A2 (en) * | 1999-02-22 | 2000-08-31 | University Of British Columbia | Caulobacter lps immunoadjuvant |
| DK1163000T3 (da) | 1999-03-19 | 2008-04-28 | Glaxosmithkline Biolog Sa | Vacciner imod antigener fra bakterier |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| BR0014285A (pt) | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Adjuvantes compreendendo um éster ou éter de alquila de polioxietileno e pelo menos um tensoativo não-iÈnico |
| PL355163A1 (en) | 1999-09-24 | 2004-04-05 | Smithkline Beecham Biologicals S.A. | Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
| US6458398B1 (en) | 1999-10-18 | 2002-10-01 | Eco Pure Food Safety Systems, Inc. | Cold water disinfection of foods |
| EP1255823A4 (en) | 2000-01-28 | 2007-10-31 | Azopax Therapeutics Llc | PROTEIN POLYMERS WITH SLOW RELEASE |
| US6296842B1 (en) | 2000-08-10 | 2001-10-02 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| EP1377275B1 (en) | 2001-03-27 | 2006-10-25 | Biomira, Inc. | Vaccine for modulating between t1 and t2 immune responses |
| US8501198B2 (en) | 2004-06-07 | 2013-08-06 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
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Non-Patent Citations (2)
| Title |
|---|
| Abraham, W. R. et al.,Phylogeny and polyphasic taxonomy of Caulobacter species. Proposal of Maricaulis gen. nov. with Mari,Int J Syst Bacteriol,Vol.49, Pt.3,1999年,p.1053-1073,(abstract),PubMed [online]; U.S. National Library of Medicine, [2022年6月28日検索], インターネット<URL: https://pubmed.ncbi.nlm.nih.gov/10425763/> |
| Bhatnagar, P. K. et al.,Anti-tumor effects of the bacterium Caulobacter crescentus in murine tumor models,Cancer Biology & Therapy,2006年,Vol.5, No.5,p.485-491,doi: 10.4161/cbt.5.5.2553 |
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| HK1248531A1 (zh) | 2018-10-19 |
| AU2016311387A1 (en) | 2018-03-29 |
| US20230084577A1 (en) | 2023-03-16 |
| AU2023203076A1 (en) | 2023-06-08 |
| US20210369792A1 (en) | 2021-12-02 |
| US11419904B2 (en) | 2022-08-23 |
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