JP7220746B2 - 鉄-カゼイン錯体及び酸化感受性化合物を含む粉末形態の組成物 - Google Patents
鉄-カゼイン錯体及び酸化感受性化合物を含む粉末形態の組成物 Download PDFInfo
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- JP7220746B2 JP7220746B2 JP2021104952A JP2021104952A JP7220746B2 JP 7220746 B2 JP7220746 B2 JP 7220746B2 JP 2021104952 A JP2021104952 A JP 2021104952A JP 2021104952 A JP2021104952 A JP 2021104952A JP 7220746 B2 JP7220746 B2 JP 7220746B2
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Description
本発明者らは、驚くべきことに、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体が、LC-PUFA、ビタミン、ポリフェノール及びこれらの混合物から選択される少なくとも1つの酸化感受性化合物を含有する組成物中の鉄源として使用される場合、当該感受性化合物の著しい酸化を引き起こさないことを見出した。
本明細書で使用する場合、用語「鉄-カゼイン錯体」は、カゼインでキレートされた鉄カチオンから形成される錯体を意味する。
本発明の組成物は、LC-PUFA、ビタミン、ポリフェノール及びこれらの混合物から選択される少なくとも1つの酸化感受性化合物及び鉄源を含み、当該鉄源は、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体である。
更なる実施形態によれば、本発明の根底にある目的は、結果として、好ましくは、本明細書に定義される組成物を調製するためのプロセスによってもまた解決される。この点に関して、前述のプロセスは、本発明の組成物に関して定義される任意の量及び成分を含有、又は含んでもよい。
a)成分を混合又は乾燥ブレンド後に得られる混合物に少なくとも1つの加熱処理工程を実施する工程と、
b)加熱処理工程の前又は後に混合物を任意に均質化する工程と、
を更に含む。
本発明の組成物は、上記のように、非常に生物学的利用能が高い、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体によって強化される。本発明はまた、個体における鉄欠乏症を予防、軽減及び/又は治療する方法において使用するための組成物にも関する。
個体に本発明の食用組成物を供給することを含む、個体に栄養を提供する方法もまた企図される。本方法において使用される組成物は、食品組成物又は飲料組成物である。好ましくは、上記に定義される栄養組成物である。このような食用組成物は、生物学的に利用可能な鉄源を含む、かつ、栄養価を低下し得る酸化LC-PUFA、ビタミン及び/又はポリフェノールを低レベルしか含まないため、栄養を提供するのに特に有利である。
a)本発明の任意の実施形態に従って粉末形態の食用組成物を再構成する工程と、
b)当該再構成組成物を個体に供給する工程と、
を含む。
本発明は、添加鉄源を含む組成物中の、LC-PUFA、ビタミン、ポリフェノール及びこれらの混合物から選択される少なくとも1つの酸化感受性化合物の酸化を軽減及び/又は予防するための方法に関し、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体が当該添加鉄源として使用されることを特徴とする。
好ましくはLC-PUFAを含む本発明の組成物は、本明細書に定義される疾患又は障害の予防、改善又は治療のために使用され得る。本明細書で使用するとき、用語「障害」又は「疾患」は、機能の撹乱又は異常;身体的又は精神的に病的な状態のいずれかを指す。Dorland’s Illustrated Medical Dictionary,(W.B.Saunders Co.27th ed.1988)を参照されたい。このような疾患又は障害は、栄養不良、代謝性疾患、神経変性疾患、アルツハイマー病/認知障害、パーキンソン病、神経疾患、筋萎縮性側索硬化症、外傷性脳損傷、低酸素性/虚血性脳損傷、自閉症、ADHD(注意欠陥多動性障害)、抑うつ、頭痛、片頭痛、ナルコレプシー、GLUT-1欠損症、ピルビン酸デヒドロゲナーゼ(PDH)欠損症、ホスホフルクトキナーゼ(PFK)欠損症、糖原病V型(マッカードル病)、心虚血、レット症候群、結節性硬化症、糖尿病及び癌(星状細胞腫、前立腺癌、胃癌、腎臓癌、頭頸部癌)から選択することができ、好ましくは栄養不良、代謝性疾患、神経変性疾患の予防、改善又は治療において、好ましくは栄養補助食品として使用される。組成物は、好ましくは栄養組成物又は栄養補助食品として使用される。
2つの粉末組成物(試料A及びB)を調製した。各々が以下の表1に要約される量のDHA及び鉄源を含む。
2つの粉末組成物(試料C及びD)を調製し、各々が以下の表2に要約される量のDHA及び鉄源を含む。
3つの試料(試料E~G)を調製し、各々が以下の表3に要約される量の魚油及び鉄源を含む。
Claims (13)
- LC-PUFA、ビタミン、ポリフェノール及びこれらの混合物から選択される少なくとも1つの酸化感受性化合物と鉄源とを含む組成物であって、
前記鉄源が、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体であり、
前記鉄-カゼイン錯体中の鉄がFe3+の形態であり、
前記組成物が、
a.前記組成物の総乾燥重量に基づいて、100g当たり10~500mgのLC-PUFA、
b.100Kcal当たり200~1000IUのビタミンA、
c.100Kcal当たり10~100mgのビタミンC、又は
d.前記組成物の総乾燥重量に基づいて、100g当たり500~5000mgのフラボノール、
を含むことを特徴とする、組成物。 - 前記錯体中の前記カゼイン対オルトリンw/w比が64:1~6.25:1であることを特徴とする、請求項1に記載の組成物。
- 前記錯体が、生理的pHで、好ましくは6.6~6.9で可溶であることを特徴とする、請求項1又は2に記載の組成物。
- 前記錯体が、1% w/w超の結合鉄を含むことを特徴とする、請求項1~3のいずれか一項に記載の組成物。
- カゼイン対鉄のw/w比が92:1~19.5:1であることを特徴とする、請求項1~4のいずれか一項に記載の組成物。
- 前記組成物が栄養組成物であることを特徴とする、請求項1~5のいずれか一項に記載の組成物。
- 前記鉄源が、組成物100g当たり6~50mgの鉄を提供するような量で存在することを特徴とする、請求項1~6のいずれか一項に記載の組成物。
- 前記組成物が、
a.前記組成物の総乾燥重量に基づいて、100g当たり10~500mgのLC-PUFA、
b.100Kcal当たり200~1000IUのビタミンA、
c.100Kcal当たり10~100mgのビタミンC、及び
d.前記組成物の総乾燥重量に基づいて、100g当たり500~5000mgのフラボノール、
を含むことを特徴とする、請求項1~7のいずれか一項に記載の組成物。 - 個体における鉄欠乏症の予防、軽減及び/又は治療方法において使用するための、LC-PUFA、ビタミン、ポリフェノール及びこれらの混合物から選択される少なくとも1つの酸化感受性化合物と、添加鉄源とを含む食用組成物であって、
前記添加鉄源が、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体であり、
前記鉄-カゼイン錯体中の鉄がFe3+の形態であり、
前記組成物が、
a.前記組成物の総乾燥重量に基づいて、100g当たり10~500mgのLC-PUFA、
b.100Kcal当たり200~1000IUのビタミンA、
c.100Kcal当たり10~100mgのビタミンC、又は
d.前記組成物の総乾燥重量に基づいて、100g当たり500~5000mgのフラボノール、
を含むことを特徴とする、食用組成物。 - 個体に食用組成物である組成物を供給することを含む、前記個体に栄養を提供する方法において使用するための、請求項1~8のいずれか一項に記載の組成物。
- 添加鉄源を含む組成物中の、LC-PUFA、ビタミン、ポリフェノール及びこれらの混合物から選択される少なくとも1つの酸化感受性化合物の酸化を軽減及び/又は予防するための方法であって、
前記添加鉄源として、外因性鉄、カゼイン及び外因性オルトリンを含む非ミセルの鉄-カゼイン錯体が使用され、
前記鉄-カゼイン錯体中の鉄がFe3+の形態であり、
前記組成物が、
a.前記組成物の総乾燥重量に基づいて、100g当たり10~500mgのLC-PUFA、
b.100Kcal当たり200~1000IUのビタミンA、
c.100Kcal当たり10~100mgのビタミンC、又は
d.前記組成物の総乾燥重量に基づいて、100g当たり500~5000mgのフラボノール、
を含むことを特徴とする、方法。 - 栄養不良、代謝性疾患、神経変性疾患の予防、改善又は治療に使用するための、請求項1~8のいずれか一項に記載の組成物。
- 乳児又は児童の、神経システム及び/又は網膜の発達促進、メンタルパフォーマンス、行動機能及び視機能の増進及び/又は改善における使用、腸内細菌叢の発達を含む免疫増強、並びに/又は、過体重、肥満及びインスリン抵抗性の発症リスク低減のための、請求項1~8のいずれか一項に記載の組成物。
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2017
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CN109982586A (zh) | 2019-07-05 |
BR112019008785A2 (pt) | 2019-07-16 |
MX2019005486A (es) | 2019-09-09 |
US20190364949A1 (en) | 2019-12-05 |
AU2021215159A1 (en) | 2021-09-02 |
CL2019001350A1 (es) | 2019-10-11 |
EP3554286A1 (en) | 2019-10-23 |
WO2018109079A1 (en) | 2018-06-21 |
JP6974460B2 (ja) | 2021-12-01 |
PH12019550051A1 (en) | 2019-12-02 |
JP2021168660A (ja) | 2021-10-28 |
AU2021215159B2 (en) | 2023-08-24 |
AU2017376591A1 (en) | 2019-04-18 |
JP2020501526A (ja) | 2020-01-23 |
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