JP7220439B1 - キメラ分子の製造方法 - Google Patents

キメラ分子の製造方法 Download PDF

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Publication number
JP7220439B1
JP7220439B1 JP2022039293A JP2022039293A JP7220439B1 JP 7220439 B1 JP7220439 B1 JP 7220439B1 JP 2022039293 A JP2022039293 A JP 2022039293A JP 2022039293 A JP2022039293 A JP 2022039293A JP 7220439 B1 JP7220439 B1 JP 7220439B1
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Japan
Prior art keywords
nucleic acid
group
chimeric molecule
derivative
formula
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JP2022039293A
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English (en)
Japanese (ja)
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JP2023133992A (ja
Inventor
健彦 和田
雅仁 稲垣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tohoku University NUC
Tokai National Higher Education and Research System NUC
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Tohoku University NUC
Tokai National Higher Education and Research System NUC
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Priority to JP2022039293A priority Critical patent/JP7220439B1/ja
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Publication of JP7220439B1 publication Critical patent/JP7220439B1/ja
Priority to JP2024508154A priority patent/JP7730126B2/ja
Priority to PCT/JP2023/009612 priority patent/WO2023176773A1/ja
Priority to EP23770728.6A priority patent/EP4495129A1/en
Publication of JP2023133992A publication Critical patent/JP2023133992A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2022039293A 2022-03-14 2022-03-14 キメラ分子の製造方法 Active JP7220439B1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2022039293A JP7220439B1 (ja) 2022-03-14 2022-03-14 キメラ分子の製造方法
JP2024508154A JP7730126B2 (ja) 2022-03-14 2023-03-13 キメラ分子の製造方法
PCT/JP2023/009612 WO2023176773A1 (ja) 2022-03-14 2023-03-13 キメラ分子の製造方法
EP23770728.6A EP4495129A1 (en) 2022-03-14 2023-03-13 Method for producing chimeric molecule

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2022039293A JP7220439B1 (ja) 2022-03-14 2022-03-14 キメラ分子の製造方法

Publications (2)

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JP7220439B1 true JP7220439B1 (ja) 2023-02-10
JP2023133992A JP2023133992A (ja) 2023-09-27

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JP2022039293A Active JP7220439B1 (ja) 2022-03-14 2022-03-14 キメラ分子の製造方法
JP2024508154A Active JP7730126B2 (ja) 2022-03-14 2023-03-13 キメラ分子の製造方法

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EP (1) EP4495129A1 (https=)
JP (2) JP7220439B1 (https=)
WO (1) WO2023176773A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026030418A2 (en) * 2024-07-31 2026-02-05 Eli Lilly And Company Oligonucleotide synthesis using cyclic-phosphorous nucleosides

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012157723A1 (ja) 2011-05-17 2012-11-22 味の素株式会社 オリゴヌクレオチドの製造方法
WO2017086397A1 (ja) 2015-11-17 2017-05-26 日産化学工業株式会社 オリゴヌクレオチドの製造方法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
WO2017111137A1 (ja) 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7661794A (en) * 1993-09-21 1995-04-10 Amersham International Plc Reagents comprising chimeric molecules of nucleic acids and nucleic acid analogs
US8569453B2 (en) 2009-03-12 2013-10-29 Ajinomoto Co., Inc. Fluorene compound
WO2010113939A1 (ja) 2009-03-30 2010-10-07 味の素株式会社 ジフェニルメタン化合物
EP2518041A4 (en) 2009-12-25 2013-12-11 Ajinomoto Kk benzyl
DK3015467T3 (da) 2013-05-24 2025-02-10 Ajinomoto Kk Morpholino-oligonukleotidfremstillingsfremgangsmåde
CN113717239B (zh) 2015-01-21 2024-12-24 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
US12378280B2 (en) 2019-06-21 2025-08-05 Northwestern University Deoxynucleic guanidines (DNG)-modified oligonucleotides and methods of synthesizing deoxynucleic guanidine strands
CN114144525B (zh) 2019-07-24 2024-11-12 国立大学法人东北大学 嵌合分子、药物组合物、靶核酸的切割方法以及靶核酸切割用或诊断用试剂盒
JP2022039293A (ja) 2020-08-28 2022-03-10 セイコーエプソン株式会社 固体電解質、固体電解質の製造方法および複合体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012157723A1 (ja) 2011-05-17 2012-11-22 味の素株式会社 オリゴヌクレオチドの製造方法
WO2017086397A1 (ja) 2015-11-17 2017-05-26 日産化学工業株式会社 オリゴヌクレオチドの製造方法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
WO2017111137A1 (ja) 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Recl. Trav. Chim. Pays-Bas，1995年，114，295-297
Tetrahedron，2001年，57，9481-9486

Also Published As

Publication number Publication date
JP7730126B2 (ja) 2025-08-27
JPWO2023176773A1 (https=) 2023-09-21
EP4495129A1 (en) 2025-01-22
WO2023176773A1 (ja) 2023-09-21
JP2023133992A (ja) 2023-09-27

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