JP7193485B2 - ミクロトームおよびミクロトーム試料ヘッドの位置決め方法 - Google Patents
ミクロトームおよびミクロトーム試料ヘッドの位置決め方法 Download PDFInfo
- Publication number
- JP7193485B2 JP7193485B2 JP2019570072A JP2019570072A JP7193485B2 JP 7193485 B2 JP7193485 B2 JP 7193485B2 JP 2019570072 A JP2019570072 A JP 2019570072A JP 2019570072 A JP2019570072 A JP 2019570072A JP 7193485 B2 JP7193485 B2 JP 7193485B2
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- JP
- Japan
- Prior art keywords
- head
- microtome
- specimen
- sample
- sensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 claims description 23
- 230000007246 mechanism Effects 0.000 claims description 20
- 238000003384 imaging method Methods 0.000 claims description 11
- 230000004044 response Effects 0.000 claims description 8
- 239000000523 sample Substances 0.000 description 53
- 230000000875 corresponding effect Effects 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 241000078511 Microtome Species 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
- G01N2001/065—Drive details
- G01N2001/066—Drive details electric
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102017128491.5A DE102017128491B4 (de) | 2017-11-30 | 2017-11-30 | Mikrotom und Verfahren zum Positionieren eines Mikrotomobjektkopfes |
| DE102017128491.5 | 2017-11-30 | ||
| PCT/EP2018/082578 WO2019105894A1 (de) | 2017-11-30 | 2018-11-26 | Mikrotom und verfahren zum positionieren eines mikrotomobjektkopfes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021504671A JP2021504671A (ja) | 2021-02-15 |
| JP2021504671A5 JP2021504671A5 (enExample) | 2021-09-30 |
| JP7193485B2 true JP7193485B2 (ja) | 2022-12-20 |
Family
ID=64500398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570072A Active JP7193485B2 (ja) | 2017-11-30 | 2018-11-26 | ミクロトームおよびミクロトーム試料ヘッドの位置決め方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11467068B2 (enExample) |
| EP (1) | EP3625533B1 (enExample) |
| JP (1) | JP7193485B2 (enExample) |
| CN (1) | CN110832298B (enExample) |
| DE (1) | DE102017128491B4 (enExample) |
| WO (1) | WO2019105894A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4281047A1 (en) | 2021-01-21 | 2023-11-29 | XSpray Pharma AB (publ) | Fast dissolving pharmaceutical compositions of dasatinib |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000283899A (ja) | 1999-03-12 | 2000-10-13 | Leica Microsystems Nussloch Gmbh | ミクロトーム |
| JP2004515780A (ja) | 2000-12-13 | 2004-05-27 | メディカル リサーチ カウンシル | 組織標本を撮像するための装置および方法 |
| US20050036667A1 (en) | 2003-08-15 | 2005-02-17 | Massachusetts Institute Of Technology | Systems and methods for volumetric tissue scanning microscopy |
| JP2009244265A (ja) | 2008-03-28 | 2009-10-22 | Leica Biosystems Nussloch Gmbh | リニアモータをドライブシステムとして使用する、可変の切断行程を備えたミクロトーム |
| JP2014025934A (ja) | 2012-07-27 | 2014-02-06 | Leica Biosystems Nussloch Gmbh | オートロッキングモードを有するミクロトーム |
| JP2015503731A (ja) | 2011-12-21 | 2015-02-02 | サクラ ファインテック ユー.エス.エー., インコーポレイテッド | 往復運動ミクロトーム駆動システム |
| US20160245728A1 (en) | 2013-09-30 | 2016-08-25 | Leica Biosystems Nussloch Gmbh | Method and Microtome for Producing Thin Sections with a Section Profile Recording Mode |
| JP2017519200A (ja) | 2014-05-12 | 2017-07-13 | アメリカ合衆国 | ブロック面イメージング用の小型連続セクショニングミクロトーム |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3884563A (en) | 1971-04-07 | 1975-05-20 | Fox John C | Microtome with rotating knife |
| DE3830725A1 (de) | 1988-09-09 | 1990-03-22 | Leitz Wild Gmbh | Automatische arretierung der antriebseinrichtung eines mikrotoms |
| AT399226B (de) | 1990-04-11 | 1995-04-25 | Sitte Hellmuth | Automatische anschneidevorrichtung für mikrotome, insbesondere ultramikrotome |
| US5535654A (en) * | 1991-11-28 | 1996-07-16 | Microm Laborgerate Gmbh | Microtome |
| DE19528180C2 (de) | 1995-08-01 | 1997-06-19 | Microm Laborgeraete Gmbh | Kryostat-Mikrotom und Verfahren zum Betrieb eines Kryostat-Mikrotoms |
| US6253653B1 (en) | 1996-07-29 | 2001-07-03 | Leica Microsystems Nussloch Gmbh | Disc-microtome |
| GB9803425D0 (en) * | 1998-02-18 | 1998-04-15 | Shandon Scient Ltd | Microtome |
| DE19911005A1 (de) | 1999-03-12 | 2000-09-28 | Leica Microsystems | Verfahren zur Steuerung eines Scheibenmikrotoms |
| DE19911173C2 (de) * | 1999-03-12 | 2002-01-31 | Leica Microsystems | Mikrotom mit einem motorischen Zustellantrieb |
| CA2613218C (en) * | 2005-06-29 | 2010-11-23 | Premark Feg L.L.C. | Programmable slicer with powered food carriage |
| DE102005042367B4 (de) | 2005-09-07 | 2009-11-12 | Leica Microsystems Cms Gmbh | Vorrichtung zum Erzeugen von 3-D Bildern einer Probe |
| JP2008296348A (ja) * | 2007-06-01 | 2008-12-11 | Union Tool Co | 回転切削工具及び基準位置検出方法 |
| US8352212B2 (en) * | 2009-11-18 | 2013-01-08 | Hexagon Metrology, Inc. | Manipulable aid for dimensional metrology |
| JP2011221188A (ja) * | 2010-04-07 | 2011-11-04 | Sony Corp | ステージ制御装置、ステージ制御方法及び顕微鏡 |
| DE102010046498B3 (de) * | 2010-09-24 | 2011-12-15 | Hans Heid | Schneidehubverstellung eines Rotationsmikrotoms |
| US8869666B2 (en) | 2011-03-24 | 2014-10-28 | Sakura Finetek U.S.A., Inc. | Microtome with surface orientation sensor to sense orientation of surface of sample |
| CN103379619B (zh) * | 2012-04-16 | 2017-11-28 | 中兴通讯股份有限公司 | 一种定位方法和系统 |
| JP6249710B2 (ja) * | 2013-10-03 | 2017-12-20 | 株式会社島精機製作所 | 裁断機およびその裁断ヘッド昇降制御方法 |
| JP2015087329A (ja) * | 2013-10-31 | 2015-05-07 | シスメックス株式会社 | 吸引部の位置調整方法及び検体処理装置 |
-
2017
- 2017-11-30 DE DE102017128491.5A patent/DE102017128491B4/de active Active
-
2018
- 2018-11-26 US US16/623,796 patent/US11467068B2/en active Active
- 2018-11-26 EP EP18810995.3A patent/EP3625533B1/de active Active
- 2018-11-26 CN CN201880044186.7A patent/CN110832298B/zh active Active
- 2018-11-26 WO PCT/EP2018/082578 patent/WO2019105894A1/de not_active Ceased
- 2018-11-26 JP JP2019570072A patent/JP7193485B2/ja active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000283899A (ja) | 1999-03-12 | 2000-10-13 | Leica Microsystems Nussloch Gmbh | ミクロトーム |
| JP2004515780A (ja) | 2000-12-13 | 2004-05-27 | メディカル リサーチ カウンシル | 組織標本を撮像するための装置および方法 |
| US20050036667A1 (en) | 2003-08-15 | 2005-02-17 | Massachusetts Institute Of Technology | Systems and methods for volumetric tissue scanning microscopy |
| JP2009244265A (ja) | 2008-03-28 | 2009-10-22 | Leica Biosystems Nussloch Gmbh | リニアモータをドライブシステムとして使用する、可変の切断行程を備えたミクロトーム |
| JP2015503731A (ja) | 2011-12-21 | 2015-02-02 | サクラ ファインテック ユー.エス.エー., インコーポレイテッド | 往復運動ミクロトーム駆動システム |
| JP2014025934A (ja) | 2012-07-27 | 2014-02-06 | Leica Biosystems Nussloch Gmbh | オートロッキングモードを有するミクロトーム |
| US20160245728A1 (en) | 2013-09-30 | 2016-08-25 | Leica Biosystems Nussloch Gmbh | Method and Microtome for Producing Thin Sections with a Section Profile Recording Mode |
| JP2017519200A (ja) | 2014-05-12 | 2017-07-13 | アメリカ合衆国 | ブロック面イメージング用の小型連続セクショニングミクロトーム |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021504671A (ja) | 2021-02-15 |
| CN110832298B (zh) | 2024-02-13 |
| CN110832298A (zh) | 2020-02-21 |
| EP3625533B1 (de) | 2022-12-28 |
| DE102017128491A1 (de) | 2019-06-06 |
| WO2019105894A1 (de) | 2019-06-06 |
| EP3625533A1 (de) | 2020-03-25 |
| DE102017128491B4 (de) | 2022-12-22 |
| US11467068B2 (en) | 2022-10-11 |
| US20210140854A1 (en) | 2021-05-13 |
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