JP7177047B2 - ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット - Google Patents

ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット Download PDF

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JP7177047B2
JP7177047B2 JP2019519648A JP2019519648A JP7177047B2 JP 7177047 B2 JP7177047 B2 JP 7177047B2 JP 2019519648 A JP2019519648 A JP 2019519648A JP 2019519648 A JP2019519648 A JP 2019519648A JP 7177047 B2 JP7177047 B2 JP 7177047B2
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cells
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gfp
cargo
shuttle
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JP2019531316A (ja
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トマス・デルジュディス
ジャン－パスカル・レペティット－ストファエス
ディヴィッド・グアイ
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フェルダン・バイオ・インコーポレーテッド
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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JP2019519648A 2016-10-12 2017-10-11 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット Active JP7177047B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022180534A JP2023010788A (ja) 2016-10-12 2022-11-10 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット
JP2024231097A JP2025062600A (ja) 2016-10-12 2024-12-26 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662407232P 2016-10-12 2016-10-12
US62/407,232 2016-10-12
US201762535015P 2017-07-20 2017-07-20
US62/535,015 2017-07-20
US15/666,139 US9982267B2 (en) 2016-10-12 2017-08-01 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
US15/666,139 2017-08-01
PCT/CA2017/051205 WO2018068135A1 (en) 2016-10-12 2017-10-11 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same

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JP2022180534A Division JP2023010788A (ja) 2016-10-12 2022-11-10 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット

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JP2019531316A JP2019531316A (ja) 2019-10-31
JP2019531316A5 JP2019531316A5 (enExample) 2020-11-26
JP7177047B2 true JP7177047B2 (ja) 2022-11-22

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JP2019519648A Active JP7177047B2 (ja) 2016-10-12 2017-10-11 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット
JP2022180534A Pending JP2023010788A (ja) 2016-10-12 2022-11-10 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット
JP2024231097A Pending JP2025062600A (ja) 2016-10-12 2024-12-26 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット

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JP2024231097A Pending JP2025062600A (ja) 2016-10-12 2024-12-26 ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット

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US (1) US12286632B2 (enExample)
EP (2) EP3526235A4 (enExample)
JP (3) JP7177047B2 (enExample)
KR (1) KR102626671B1 (enExample)
CN (2) CN110291100B (enExample)
AU (2) AU2017341736B2 (enExample)
CA (1) CA3038839A1 (enExample)
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JP6956705B2 (ja) 2015-04-10 2021-11-02 フェルダン・バイオ・インコーポレーテッド 標的真核細胞のサイトゾルへのポリペプチドカーゴの形質導入効率を改善するためのポリペプチドベースのシャトル剤、その使用、それと関連する方法及びキット
US11629170B2 (en) 2016-10-12 2023-04-18 Feldan Bio Inc. Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
AU2017341736B2 (en) * 2016-10-12 2022-09-08 Feldan Bio Inc. Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
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