JP7167171B2 - ４環性化合物の製造方法 - Google Patents

４環性化合物の製造方法 Download PDF

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Publication number
JP7167171B2
JP7167171B2 JP2020541220A JP2020541220A JP7167171B2 JP 7167171 B2 JP7167171 B2 JP 7167171B2 JP 2020541220 A JP2020541220 A JP 2020541220A JP 2020541220 A JP2020541220 A JP 2020541220A JP 7167171 B2 JP7167171 B2 JP 7167171B2
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formula
compound
group
reaction
ethyl
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Japanese (ja)
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JPWO2020050241A5 (https=
JPWO2020050241A1 (ja
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宏希 芹澤
朗 川瀬
弘志 福田
直人 濱
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020541220A 2018-09-04 2019-09-03 ４環性化合物の製造方法 Active JP7167171B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018165313 2018-09-04
JP2018165313 2018-09-04
PCT/JP2019/034543 WO2020050241A1 (ja) 2018-09-04 2019-09-03 ４環性化合物の製造方法

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JPWO2020050241A1 JPWO2020050241A1 (ja) 2021-08-30
JPWO2020050241A5 JPWO2020050241A5 (https=) 2022-08-01
JP7167171B2 true JP7167171B2 (ja) 2022-11-08

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US (1) US11939322B2 (https=)
EP (1) EP3848361B1 (https=)
JP (1) JP7167171B2 (https=)
KR (1) KR102635225B1 (https=)
CN (1) CN112585126B (https=)
AR (1) AR116113A1 (https=)
AU (1) AU2019337018B2 (https=)
BR (1) BR112021001145A2 (https=)
CA (1) CA3107270A1 (https=)
ES (1) ES3010145T3 (https=)
HR (1) HRP20250284T1 (https=)
HU (1) HUE070227T2 (https=)
IL (1) IL281079B2 (https=)
MX (1) MX2021002311A (https=)
PL (1) PL3848361T3 (https=)
SG (1) SG11202100983XA (https=)
TW (1) TWI825163B (https=)
WO (1) WO2020050241A1 (https=)

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EP4285907A4 (en) 2021-01-29 2024-11-13 Chugai Seiyaku Kabushiki Kaisha Drug composition for treating pediatric cancers
CN117024410A (zh) * 2023-08-15 2023-11-10 上海药坦药物研究开发有限公司 一种艾乐替尼中间体及其制备方法
WO2025067412A1 (zh) * 2023-09-28 2025-04-03 重庆博腾制药科技股份有限公司 一种抗肿瘤药物中间体的制备方法
CN120081779A (zh) * 2025-02-19 2025-06-03 江苏天士力帝益药业有限公司 一种阿来替尼杂质01a及其控制方法

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US20170247352A1 (en) 2014-11-12 2017-08-31 Suzhou Miracpharma Technolpgy Co., Ltd. Method for preparing alectinib
US20160257667A1 (en) 2015-03-02 2016-09-08 Yong Xu Synthesis of intermediates in the preparation of alk inhibitor
WO2017073706A1 (ja) 2015-10-30 2017-05-04 中外製薬株式会社 ジヒドロナフト［２，３－ｂ］ベンゾフラン誘導体
CN107033124A (zh) 2017-04-21 2017-08-11 湖南博奥德生物医药技术开发有限公司 一种艾乐替尼的制备方法

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CA3107270A1 (en) 2020-03-12
AU2019337018B2 (en) 2024-03-07
IL281079B1 (en) 2024-08-01
HUE070227T2 (hu) 2025-05-28
US20220372025A1 (en) 2022-11-24
WO2020050241A1 (ja) 2020-03-12
CN112585126B (zh) 2024-05-07
HRP20250284T1 (hr) 2025-04-25
AR116113A1 (es) 2021-03-31
EP3848361A1 (en) 2021-07-14
EP3848361C0 (en) 2025-01-22
EP3848361A4 (en) 2022-06-15
EP3848361B1 (en) 2025-01-22
TW202024050A (zh) 2020-07-01
KR20210053890A (ko) 2021-05-12
CN112585126A (zh) 2021-03-30
JPWO2020050241A1 (ja) 2021-08-30
IL281079B2 (en) 2024-12-01
PL3848361T3 (pl) 2025-07-07
AU2019337018A1 (en) 2021-03-18
SG11202100983XA (en) 2021-03-30
ES3010145T3 (en) 2025-04-01
MX2021002311A (es) 2021-04-28
BR112021001145A2 (pt) 2021-04-20
IL281079A (en) 2021-04-29
TWI825163B (zh) 2023-12-11
US11939322B2 (en) 2024-03-26
KR102635225B1 (ko) 2024-02-07

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