JP7163281B2 - ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドによる血液系悪性腫瘍の治療 - Google Patents

２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドによる血液系悪性腫瘍の治療 Download PDF

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JP7163281B2
JP7163281B2 JP2019516086A JP2019516086A JP7163281B2 JP 7163281 B2 JP7163281 B2 JP 7163281B2 JP 2019516086 A JP2019516086 A JP 2019516086A JP 2019516086 A JP2019516086 A JP 2019516086A JP 7163281 B2 JP7163281 B2 JP 7163281B2
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JP2019517587A5 (cg-RX-API-DMAC7.html
JP2019517587A (ja
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カルランチオ ソラヤ
ホレンバッハ ポール
ロペス‐ジローナ アントニア
マクベス カイル
ポウルデフナド マイケル
ラップレイ イリット
ル ガン
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019516086A 2016-06-06 2017-06-05 ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドによる血液系悪性腫瘍の治療 Active JP7163281B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662346344P 2016-06-06 2016-06-06
US62/346,344 2016-06-06
PCT/US2017/035892 WO2017214014A1 (en) 2016-06-06 2017-06-05 Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Publications (3)

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JP2019517587A JP2019517587A (ja) 2019-06-24
JP2019517587A5 JP2019517587A5 (cg-RX-API-DMAC7.html) 2020-07-30
JP7163281B2 true JP7163281B2 (ja) 2022-10-31

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JP2019516086A Active JP7163281B2 (ja) 2016-06-06 2017-06-05 ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドによる血液系悪性腫瘍の治療

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US (4) US10245258B2 (cg-RX-API-DMAC7.html)
EP (1) EP3463358A4 (cg-RX-API-DMAC7.html)
JP (1) JP7163281B2 (cg-RX-API-DMAC7.html)
KR (1) KR20190015300A (cg-RX-API-DMAC7.html)
CN (2) CN109414436A (cg-RX-API-DMAC7.html)
AU (2) AU2017278114B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018075206A2 (cg-RX-API-DMAC7.html)
CA (1) CA3026396A1 (cg-RX-API-DMAC7.html)
CL (1) CL2018003499A1 (cg-RX-API-DMAC7.html)
EA (1) EA201892746A1 (cg-RX-API-DMAC7.html)
IL (1) IL262565B (cg-RX-API-DMAC7.html)
MX (1) MX388717B (cg-RX-API-DMAC7.html)
SG (1) SG11201809501PA (cg-RX-API-DMAC7.html)
WO (1) WO2017214014A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201807105B (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
US10648983B2 (en) * 2016-01-08 2020-05-12 Celgene Corporation Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies
US11535603B1 (en) 2016-09-30 2022-12-27 Deuterx, Llc Deuterium-enriched piperidinonyl-oxoisoindolinyl acetamides and methods of treating medical disorders using same
WO2018102725A1 (en) 2016-12-01 2018-06-07 Arvinas, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
EA202191833A1 (ru) * 2018-12-31 2021-10-11 Селджин Корпорейшн Композиции и способы применения 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида
AU2020336309A1 (en) 2019-08-26 2022-03-17 Arvinas Operations, Inc. Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
CN115607552B (zh) 2019-10-21 2024-06-18 新基公司 取代的4-氨基异二氢吲哚-1,3-二酮化合物和第二种活性剂的组合用途
JP2022554346A (ja) * 2019-11-05 2022-12-28 セルジーン コーポレーション ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドとの併用療法
CN114761004A (zh) 2019-12-06 2022-07-15 细胞基因公司 用于制备2-(4-氯苯基)-n-((2-(2，6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2，2-二氟乙酰胺的方法
IL296557A (en) * 2020-03-16 2022-11-01 Celgene Corp Combined treatment for acute myeloid leukemia
TW202214236A (zh) * 2020-09-14 2022-04-16 美商亞文納營運公司 用於靶向降解雌激素受體之化合物之結晶及非晶形形式
KR102499522B1 (ko) 2020-09-23 2023-02-13 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 세레브론 단백질의 조절제로서의 치환된 n-(2-(2,6-디옥소피페리딘-3-일)-1,3-디옥소이소인돌린-5-일)아릴설폰아미드 유사체
KR20240066906A (ko) * 2022-11-08 2024-05-16 주식회사 온코드바이오 퀴놀린 아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220144A1 (en) 2002-10-15 2004-11-04 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
US20090175869A1 (en) 2007-05-31 2009-07-09 Ascenta Therapeutics, Inc. Pulsatile Dosing of Gossypol for Treatment of Disease
US20150157603A1 (en) 2013-12-05 2015-06-11 Hoffmann-La Roche Inc. Novel combination treatment for acute myeloid leukemia (aml)
US20160009683A1 (en) 2014-07-11 2016-01-14 Celgene Corporation Antiproliferative compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100391464C (zh) * 2001-12-03 2008-06-04 诺瓦西股份有限公司 含活性维生素d化合物的药物组合物
US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
DK2263677T3 (da) 2009-05-20 2011-06-06 Hybrigenics Sa Nye terapeutiske anvendelser af inecalcitol
AU2012318239B2 (en) * 2011-11-01 2015-07-09 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
MX382150B (es) 2016-01-08 2025-03-13 Celgene Corp Formulaciones de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
MX385964B (es) 2016-01-08 2025-03-18 Celgene Corp Formas sólidas de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il) metil)-2,2-difluoroacetamida y sus composiciones farmacéuticas y usos.
TWI782395B (zh) 2016-01-08 2022-11-01 美商西建公司 抗增生化合物，及其醫藥組合物及用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220144A1 (en) 2002-10-15 2004-11-04 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
US20090175869A1 (en) 2007-05-31 2009-07-09 Ascenta Therapeutics, Inc. Pulsatile Dosing of Gossypol for Treatment of Disease
US20150157603A1 (en) 2013-12-05 2015-06-11 Hoffmann-La Roche Inc. Novel combination treatment for acute myeloid leukemia (aml)
US20160009683A1 (en) 2014-07-11 2016-01-14 Celgene Corporation Antiproliferative compounds and methods of use thereof

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AU2017278114B2 (en) 2023-01-12
BR112018075206A2 (pt) 2019-03-19
US11590117B2 (en) 2023-02-28
CL2018003499A1 (es) 2019-03-15
AU2017278114A1 (en) 2018-11-29
SG11201809501PA (en) 2018-12-28
ZA201807105B (en) 2020-01-29
US20210154182A1 (en) 2021-05-27
US20230158009A1 (en) 2023-05-25
US20190175573A1 (en) 2019-06-13
IL262565A (en) 2018-12-31
MX388717B (es) 2025-03-20
EP3463358A1 (en) 2019-04-10
WO2017214014A1 (en) 2017-12-14
CA3026396A1 (en) 2017-12-14
EA201892746A1 (ru) 2019-06-28
EP3463358A4 (en) 2020-07-22
MX2018015120A (es) 2019-04-15
US20170348298A1 (en) 2017-12-07
US10245258B2 (en) 2019-04-02
JP2019517587A (ja) 2019-06-24
KR20190015300A (ko) 2019-02-13
CN115282149A (zh) 2022-11-04
IL262565B (en) 2022-08-01
AU2023202159A1 (en) 2023-05-04
CN109414436A (zh) 2019-03-01

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