JP7162901B2 - 生体模倣インプラント - Google Patents
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- JP7162901B2 JP7162901B2 JP2019551919A JP2019551919A JP7162901B2 JP 7162901 B2 JP7162901 B2 JP 7162901B2 JP 2019551919 A JP2019551919 A JP 2019551919A JP 2019551919 A JP2019551919 A JP 2019551919A JP 7162901 B2 JP7162901 B2 JP 7162901B2
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30838—Microstructures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
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Description
本出願は、2016年12月12日に出願された米国仮特許出願第62/433,142号明細書の利益を主張し、その開示はその全体が参照により本明細書に組み込まれる。
本発明は、国立衛生研究所によって授与された助成金番号EB014986の下で政府の支援を受けてなされた。政府は本発明において一定の権利を有する。
本明細書に開示されるのは、脊髄およびその神経損傷の治療のための幹細胞を含む3次元生体模倣インプラントである。
ラット脊髄を鋳型として用いて脊髄インプラントをデザインした。
(付記1)
第1端部および第2端部を含み、コアおよびシェルを含み、損傷部位の構造を模倣する3次元(3D)インプラントと、
前記第1端部から始まり前記第2端部で終わる前記シェル内の少なくとも1つのチャネルと、
前記少なくとも1つのチャネルに含まれる少なくとも1つの種類の幹細胞と、
を含む、脊髄または末梢神経損傷用の生体模倣インプラント。
インプラントは、3Dプリンティングによって製造される、付記1に記載のインプラント。
前記少なくとも1種類の幹細胞は、神経幹細胞である、付記1に記載のインプラント。
前記神経幹細胞は、胚性幹細胞、iPSC由来幹細胞、直接分化神経幹細胞、またはそれらの組み合わせである、付記3に記載のインプラント。
前記少なくとも1種類の幹細胞は、間葉系幹細胞である、付記1に記載のインプラント。
前記幹細胞は、BDNF、NT3、GDNF、またはそれらの組み合わせを発現するように操作される、付記1に記載のインプラント。
前記3次元プリントされたインプラントは、ポリエチレングリコールジアクリレートもしくはゼラチンメタクリロール、またはそれらの組み合わせを含む、付記1に記載のインプラント。
前記インプラントは、脊髄に対する生体模倣物である、付記1に記載のインプラント。
前記インプラントは、末梢神経に対する生体模倣物である、付記1に記載のインプラント。
前記チャネルは、線形である、付記1に記載のインプラント。
前記チャネルは、互いに平行である、付記1に記載のインプラント。
前記チャネルは、再生軸索を前記第1端部から前記第2端部へ案内する、付記1に記載のインプラント。
前記インプラントは、ハニカム構造としてクラスター化された六角形の断面を有する2つ以上のチャネルを含む、付記1に記載のインプラント。
神経損傷の治療を必要とする被移植体における前記神経損傷を治療する方法であって、
付記1に記載の生体模倣インプラントを治療を必要とする場所に移植することと、
前記損傷部位における細胞の再生を可能にすることと、
を含む、方法。
前記神経損傷は、脊髄損傷、運動完全脊髄損傷、運動不全脊髄損傷、または末梢神経損傷である、付記14に記載の方法。
前記神経損傷は、脊髄損傷である、付記15に記載の方法。
前記神経損傷は、末梢神経損傷である、付記15に記載の方法。
前記被移植体に理学療法を提供することをさらに含む、付記14に記載の方法。
前記損傷の領域を決定するために治療を必要とする被移植体の脊髄または末梢神経の位置をスキャンすることと、
前記損傷の領域を囲むように前記インプラントを3次元プリントすることと、
を含む、付記1に記載の生体模倣インプラントを製造する方法。
Claims (19)
- 第1端部および第2端部を含み、コアおよびシェルを含み、損傷部位の構造を模倣する3次元(3D)インプラントと、
前記第1端部から始まり前記第2端部で終わる前記シェル内の少なくとも1つのチャネルと、
前記少なくとも1つのチャネルに含まれる少なくとも1種類の幹細胞と、
を含み、
前記インプラントは200kPa~300kPaの弾性率を有する、
脊髄または末梢神経損傷用の生体模倣インプラント。 - インプラントは、3Dプリンティングによって製造される、請求項1に記載のインプラント。
- 前記少なくとも1種類の幹細胞は、神経幹細胞である、請求項1に記載のインプラント。
- 前記神経幹細胞は、胚性幹細胞、iPSC由来幹細胞、直接分化神経幹細胞、またはそれらの組み合わせである、請求項3に記載のインプラント。
- 前記少なくとも1種類の幹細胞は、間葉系幹細胞である、請求項1に記載のインプラント。
- 前記幹細胞は、BDNF、NT3、GDNF、またはそれらの組み合わせを発現するように操作される、請求項1に記載のインプラント。
- 前記3次元プリントされたインプラントは、ポリエチレングリコールジアクリレートもしくはゼラチンメタクリロール、またはそれらの組み合わせを含む、請求項1に記載のインプラント。
- 前記インプラントは、脊髄に対する生体模倣物である、請求項1に記載のインプラント。
- 前記インプラントは、末梢神経に対する生体模倣物である、請求項1に記載のインプラント。
- 前記チャネルは、線形である、請求項1に記載のインプラント。
- 前記チャネルは、互いに平行である、請求項1に記載のインプラント。
- 前記チャネルは、再生軸索を前記第1端部から前記第2端部へ案内する、請求項1に記載のインプラント。
- 前記インプラントは、ハニカム構造としてクラスター化された六角形の断面を有する2つ以上のチャネルを含む、請求項1に記載のインプラント。
- 神経損傷の治療を必要とする哺乳動物における前記神経損傷を治療するために構成されたインプラントであって、
前記 インプラントは、前記神経損傷の場所、またはその近傍に移植するように構成され、
前記インプラントは、その場所での細胞の再生を可能にするために構成される、
請求項1に記載のインプラント 。 - 前記神経損傷は、脊髄損傷、運動完全脊髄損傷、運動不全脊髄損傷、または末梢神経損傷である、請求項14に記載のインプラント。
- 前記神経損傷は、脊髄損傷である、請求項15に記載のインプラント。
- 前記神経損傷は、末梢神経損傷である、請求項15に記載のインプラント。
- 対象を身体的に訓練し、それによって対象の身体の損傷によって損なわれた部分に追加の神経信号を提供するように構成される 、
請求項1に記載のインプラント。 - 前記損傷の領域を決定するために治療を必要とする被移植体の脊髄または末梢神経の位置をスキャンすることと、
前記損傷の領域を囲むように前記インプラントを3次元プリントすることと、
を含む、請求項1に記載の生体模倣インプラントを製造する方法。
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US20220167988A1 (en) * | 2019-04-11 | 2022-06-02 | The Regents Of The University Of California | Biomimetic Scaffold for Peripheral Nerve Injuries |
CN111166939A (zh) * | 2019-10-29 | 2020-05-19 | 中山大学 | 一种基于3d打印的具有血管化潜能的脊髓补片及其制备方法 |
EP4051327A4 (en) * | 2019-11-01 | 2023-11-22 | Allegro 3D, Inc. | 3D BIOLOGICALLY PRINTED SCAFFOLDS FOR TISSUE REGENERATION |
CN111281608B (zh) * | 2020-02-28 | 2022-12-30 | 北京大学第一医院 | 软骨缺损处修复用模块及其形成方法 |
CN114366383B (zh) * | 2021-06-11 | 2023-01-17 | 冯世庆 | 促进脊髓损伤后轴突定向延伸的仿生脊髓支架 |
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- 2017-12-12 EP EP17882172.4A patent/EP3551139A4/en active Pending
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EP3551139A1 (en) | 2019-10-16 |
AU2017375956C1 (en) | 2023-12-14 |
CN110475528A (zh) | 2019-11-19 |
AU2017375956B2 (en) | 2023-05-25 |
KR102573503B1 (ko) | 2023-09-01 |
WO2018111900A1 (en) | 2018-06-21 |
AU2023219917A1 (en) | 2023-09-14 |
US20190350720A1 (en) | 2019-11-21 |
AU2017375956A1 (en) | 2019-07-04 |
EP3551139A4 (en) | 2020-08-05 |
CA3046959A1 (en) | 2018-06-21 |
KR20190095940A (ko) | 2019-08-16 |
JP2020504662A (ja) | 2020-02-13 |
JP2023009050A (ja) | 2023-01-19 |
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