JP2010508126A - 椎間円板の修復と再生、および、関節修復と再生のための基盤の作成 - Google Patents
椎間円板の修復と再生、および、関節修復と再生のための基盤の作成 Download PDFInfo
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- JP2010508126A JP2010508126A JP2009535421A JP2009535421A JP2010508126A JP 2010508126 A JP2010508126 A JP 2010508126A JP 2009535421 A JP2009535421 A JP 2009535421A JP 2009535421 A JP2009535421 A JP 2009535421A JP 2010508126 A JP2010508126 A JP 2010508126A
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Abstract
Description
Claims (75)
- 生体内における基盤を構成する複数の多孔質微細構造体を画像ベースフォーマットで表す第1のデータベースの組を作り、
前記生体内における生まれつきの組織を交換する必要のある前記基盤の外形形状を画像ベースフォーマットで表す第2のデータベースを作り、
前記基盤の固定構造を表す第3のデータベースを作り、そして
前記第2のデータベースと前記第3のデータベースとを、所望の微細構造体を表す前記第1のデータベースの組に組み合わせて、画像ベースによる前記基盤の設計形状を得る
ことを特徴とする生体内における組織の基盤を設計する方法。 - 前記設計形状を加工形状に変換する工程を、さらに有することを特徴とする請求項1記載の方法。
- 前記製造形状が、少なくとも1つの表面表現とワイヤーフレーム表現を備えていることを特徴とする請求項2記載の方法。
- 前記基盤の固定構造が、多孔質で形成されていることを特徴とする請求項1記載の方法。
- 前記基盤の固定構造には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられていることを特徴とする請求項1記載の方法。
- 前記突起が、ペグ、スパイクあるいは板で構成されていることを特徴とする請求項5記載の方法。
- 前記突起には、ネジ及び又は貫通穴の中から選択された固定手段が備えられていることを特徴とする請求項5記載の方法。
- 前記基盤が、椎間円板の補修のために構成されていることを特徴とする請求項1記載の方法。
- 前記基盤が、関節の補修のために構成されていることを特徴とする請求項1記載の方法。
- 前記基盤が、全関節交換部のために構成されていることを特徴とする請求項1記載の方法。
- 前記基盤の固定構造には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられ、医療用画像装置を介し改善された画像を提供するトレーサーを有する少なくとも1つのマーキングが、前記少なくとも1つの突起に配置されることを特徴とする請求項1記載の方法。
- 前記基盤の固定構造には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられ、X線透視装置を介し改善された画像を提供する少なくとも1つのX線不透過性のマーキングが、前記少なくとも1つの突起に配置されることを特徴とする請求項1記載の方法。
- 前記基盤には、空間を有する領域、あるいは、X線透過性の材料の領域が備えられ、前記領域が、医療用画像装置を介し改善された画像が通るための画像ウインドウを構成することを特徴とする請求項1記載の方法。
- 前記基盤の固定構造には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられ、移殖中の位置調整のために、少なくとも1つのマーキングが、前記少なくとも1つの突起に配置されることを特徴とする請求項1記載の方法。
- 前記基盤の複数の多孔質微細構造体を画像ベースフォーマットで表す第1のデータベースの組を作り、
生体内で生まれつきの円板を交換するために設計された基盤の形状を画像ベースフォーマットで表す第2のデータベースを作り、そして
前記第2のデータベースを、所望の前記微細構造体を表す前記第1のデータベースに組み合わせて、画像ベースによる前記基盤の設計形状を得る
ことを特徴とする椎間円板の基盤を設計する方法。 - 前記設計形状を加工形状に変換する工程をさらに備えることを特徴とする請求項15記載の方法。
- 前記第2のデータベースが、前記基盤により占有された脊椎間の空間を表すことを特徴とする請求項15記載の方法。
- 前記基盤の前記設計形状には、第1の多孔質微細構造体を有する外側環帯と、第2の微細構造体を有する中央領域が備えられていることを特徴とする請求項15記載の方法。
- 前記基盤の前記設計形状には、第1の多孔質の微細構造体を有する外側環帯と、生体適応性の材料を含む中央領域が備えられていることを特徴とする請求項15記載の方法。
- 前記微細構造体の少なくとも1つが、波状線維設計形状であることを特徴とする請求項15記載の方法。
- 前記基盤には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられ、医療用画像装置を介し改善された画像を提供するトレーサーを備える少なくとも1つのマーキングが、少なくとも1つの前記突起に配置されていることを特徴とする請求項15記載の方法。
- 前記突起が、板、ペグ、あるいは、スパイクで構成されていることを特徴とする請求項21記載の方法。
- 前記基盤には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられ、X線透視装置を介し改善された画像を提供する少なくとも1つのX線不透過性のマーキングが、少なくとも1つの前記突起に配置されていることを特徴とする請求項15記載の方法。
- 前記基盤には、空間を有する領域又はX線透過性の材料の領域が備えられ、前記領域が、医療用画像装置の画像ウインドウを通る改善された画像のための画像ウインドウを構成することを特徴とする請求項15記載の方法。
- 前記基盤には、前記基盤から離れる方向に延在する少なくとも1つの突起が備えられ、移殖中に調整をするための少なくとも1つのマーキングが、少なくとも1つの前記突起に配置されることを特徴とする請求項15記載の方法。
- 前記基盤の前記設計形状には、球形又は楕円形の孔が備えられていることを特徴とする請求項15記載の方法。
- 生体内における生まれつきの組織を交換するための骨軟骨基盤を設計する方法において、
前記基盤の複数の多孔質微細構造体を画像ベースフォーマットで表す第1のデータベースの組を作り、
前記生体内における前記生まれつきの組織を交換することを所望される基盤の外形形状を画像ベースフォーマットで表す第2のデータベースを作り、
前記第2のデータベースを、所望の微細構造体を表す前記第1のデータベースに組み合わせて、画像ベースによる前記基盤の設計形状を得て、そして
前記設計形状には、第1の物理的又は生物化学的特性を有する骨領域と、第2の物理的又は生物化学的特性を有する軟骨領域と、が備えられている
ことを特徴とする骨軟骨基盤を設計する方法。 - 前記第1の物理的又は生物化学的特性が、機械的特性であり、前記第2の物理的又は生物化学的特性が、機械的特性であることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、質量移送特性であり、前記第2の物理的又は生物化学的特性が、質量移送特性であることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、生物化学的特性であり、前記第2の物理的又は生物化学的特性が、生物化学的特性であることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、カルシウム化合物から成る骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、ヒドロキシアパタイト、カルシウム欠乏の炭酸含有ヒドロキシアパタイト、リン酸三カルシウム、リン酸オクタカルシウム、リン酸二カルシウム、リン酸カルシウム及びそれらの混合から選択された材料を有する骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、複数の分割されたミネラル小区分を有する骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、均質なミネラル皮膜となるように骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項27記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、骨伝導ミネラルを用いてコーティングし、前記ミネラル皮膜に生物活性物質を協働させることにより、得られることを特徴とする請求項27記載の方法。
- 前記生物活性物質が、骨形態発生プロテインの中から選択されることを特徴とする請求項36記載の方法。
- 前記微細構造体の少なくとも1つが、波状線維の設計形状であることを特徴とする請求項27記載の方法。
- 前記骨領域が、前記軟骨領域の多孔質構造体と異なる多孔質構造体を有していることを特徴とする請求項27記載の方法。
- 前記軟骨領域が、球形又は楕円形の孔を有していることを特徴とする請求項27記載の方法。
- 前記骨領域が、前記軟骨領域よりも、大きな質量移送性を有することを特徴とする請求項27記載の方法。
- 生体内における関節交換部のための複数の多孔質微細構造体を画像ベースフォーマットで表す第1のデータベースの組を作り、
前記関節交換部の外側形状を画像ベースフォーマットで表す第2のデータベースを作り、
前記第2のデータベースを、所望の微細構造体の設計を表す前記第1のデータベースの組に組み合わせて、画像ベースによる前記関節交換部の設計形状を得て、そして
前記設計形状には、第1の物理的又は生物化学的特性を有する骨領域と、第2の物理的又は生物化学的特性を有する表面領域とが設けられている
ことを特徴とする生体内における関節交換部を設計する方法。 - 前記第1の物理的又は生物化学的特性が、機械的特性であり、前記第2の物理的又は生物化学的特性が、機械的特性であることを特徴とする請求項42記載の方法。
- 前記第1の物理的又は生物化学的特性が、質量の移送特性であり、前記第2の物理的又は生物化学的特性が、質量の移送特性であることを特徴とする請求項42記載の方法。
- 前記第1の物理的又は生物化学的特性が、生物化学的特性であり、前記第2の物理的又は生物化学的特性が、生物化学的特性であることを特徴とする請求項42記載の方法
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項42記載の方法
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、カルシウム化合物を有する骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項42記載の方法
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、ヒドロキシアパタイト、カルシウム欠乏の炭酸含有ヒドロキシアパタイト、リン酸三カルシウム、リン酸オクタカルシウム、リン酸二カルシウム、リン酸カルシウム及びそれらの混合から選択された材料を有する骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項42記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、複数の分割されたミネラル小区分を有する骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項42記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、均質なミネラル皮膜となるように骨伝導ミネラルを用いてコーティングすることにより、得られることを特徴とする請求項42記載の方法。
- 前記第1の物理的又は生物化学的特性が、前記骨の領域の少なくとも一部を、骨伝導ミネラルを用いてコーティングし、前記ミネラル皮膜に、生物活性物質を協働させることにより、得られることを特徴とする請求項42記載の方法。
- 前記生物活性物質が、骨形態発生プロテインの中から選択されることを特徴とする請求項51記載の方法。
- 前記微細構造体の少なくとも1つが、波状線維の設計形状であることを特徴とする請求項42記載の方法。
- 前記骨領域が、前記表面領域の多孔質構造体と異なる多孔質構造体を有することを特徴とする請求項42記載の方法。
- 前記表面領域が、球形又は楕円形の孔を有していることを特徴とする請求項42記載の方法。
- 前記骨領域が、前記表面領域よりも、大きな質量移送性を有することを特徴とする請求項42記載の方法。
- 生まれつきの椎間円板の髄核に似せて形成された、第1の多孔質構造体を有する中央コアと、
前記生まれつきの椎間円板の環状の線維輪に似せて形成された、前記中央コアの周囲を取り囲んで結合した、第2の多孔質構造体を有する外側環帯と、が設けられ、かつ、
前記中央コアと前記外側環帯とが、異なる弾性率を有するものとされている
ことを特徴とする椎間円板の補修及び又は再生用の基盤。 - 生まれつきの椎間円板の髄核に似せて形成された、第1の多孔質構造体を有する中央コアと、
前記生まれつきの椎間円板の環状の線維輪に似せて形成された、前記中央コアの周囲を取り囲んで結合した、第2の多孔質構造体を有する外側環帯と、が設けられ、かつ、
前記中央コアと前記外側環帯とが、異なる浸透性を有するものとされている
ことを特徴とする椎間円板の補修及び又は再生用の基盤。 - 前記中央コアが、生体適合性の材料を有することを特徴とする請求項57又は58記載の基盤。
- 前記中央コアが、ヒドロゲルを有することを特徴とする請求項57又は58記載の基盤。
- 前記中央コアが、生物活性物質を有することを特徴とする請求項57又は58記載の基盤。
- 前記生物活性物質が、骨膜からの未分化軟骨細胞の前駆体細胞、骨髄からの軟骨幹細胞、軟骨細胞、硬化剤、脈管形成活性化剤、脈管形成阻害剤、およびそれらの混合とから選択されることを特徴とする請求項61記載の基盤。
- 前記中央コアには、波状線維が備えられていることを特徴とする請求項57または58記載の基盤。
- 前記基盤が、生分解性ポリマー、生分解性セラミックス、非生分解性金属、非生分解性金属合金あるいはそれらの混合から選択された材料で構成されていることを特徴とする請求項57または58記載の基盤。
- 医療用画像装置を介し改善された画像を提供するトレーサーを有する少なくとも1つのマーキングが、さらに備えられていることを特徴とする請求項57または58記載の基盤。
- X線透視装置を介し改善された画像を提供する、少なくとも1つのX線不透過性のマーキングが、さらに備えられていることを特徴とする請求項57または58記載の基盤。
- 空間を有する領域、あるいは、X線透過性の材料の領域が備えられ、前記領域が、医療用画像装置を介し改善された画像が通るための画像ウインドウを構成することを特徴とする請求項57または58記載の基盤。
- 移殖中に位置調整を行うための少なくとも1つのマーキングが備えられていることを特徴とする請求項57または58記載の基盤。
- 前記基盤の少なくとも一部には、骨伝導ミネラル皮膜が、さらに備えられていることを特徴とする請求項57又は58記載の基盤。
- 前記骨伝導ミネラル皮膜には、複数の分割されたミネラル小区分が備えられていることを特徴とする請求項69記載の基盤。
- 前記骨伝導ミネラル皮膜が、事実上均質なミネラル皮膜で構成されていることを特徴とする請求項69記載の基盤。
- 前記骨伝導ミネラル皮膜が、カルシウム化合物で構成されていることを特徴とする請求項69記載の基盤。
- 前記骨伝導ミネラル皮膜が、ヒドロキシアパタイト、カルシウム欠乏の炭酸含有ヒドロキシアパタイト、リン酸三カルシウム、リン酸オクタカルシウム、リン酸二カルシウム、リン酸カルシウム及びそれらの混合で構成されていることを特徴とする請求項69記載の基盤。
- 生物活性物質が、ミネラル皮膜と協働することを特徴とする請求項69記載の基盤。
- 前記生物活性物質が、骨形態発生プロテインから選択されることを特徴とする請求項69記載の基盤。
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2007
- 2007-10-29 US US11/927,281 patent/US8275594B2/en active Active
- 2007-10-30 CA CA2671159A patent/CA2671159C/en active Active
- 2007-10-30 JP JP2009535421A patent/JP2010508126A/ja active Pending
- 2007-10-30 WO PCT/US2007/082958 patent/WO2008082766A2/en active Application Filing
- 2007-10-30 EP EP07871283.3A patent/EP2092455B1/en not_active Not-in-force
- 2007-10-30 AU AU2007340301A patent/AU2007340301B2/en not_active Ceased
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2012
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013526385A (ja) * | 2010-05-24 | 2013-06-24 | エピサーフ メディカル エービー | インプラント及び器具のセットを含む、軟骨治療用外科手術キット |
JP2013526386A (ja) * | 2010-05-24 | 2013-06-24 | エピサーフ メディカル エービー | 関節の軟骨修復のための外科手術キットの製造システム |
JP2016525415A (ja) * | 2013-07-24 | 2016-08-25 | レノビス サージカル テクノロジーズ,インコーポレイテッド | 多孔質表面を組み込んでいる外科用インプラント装置 |
JP2020504662A (ja) * | 2016-12-12 | 2020-02-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生体模倣インプラント |
JP7162901B2 (ja) | 2016-12-12 | 2022-10-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生体模倣インプラント |
Also Published As
Publication number | Publication date |
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US8275594B2 (en) | 2012-09-25 |
WO2008082766A2 (en) | 2008-07-10 |
US20120330423A1 (en) | 2012-12-27 |
CA2671159C (en) | 2016-06-28 |
AU2007340301B2 (en) | 2012-07-26 |
AU2007340301A1 (en) | 2008-07-10 |
EP2092455A4 (en) | 2012-09-05 |
WO2008082766A3 (en) | 2008-12-04 |
CA2671159A1 (en) | 2008-07-10 |
AU2007340301A2 (en) | 2009-12-24 |
EP2092455A2 (en) | 2009-08-26 |
EP2092455B1 (en) | 2015-05-13 |
US20080195211A1 (en) | 2008-08-14 |
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