JP7150740B2 - ｓＧＣ刺激薬による中枢神経系疾患の治療 - Google Patents

ｓＧＣ刺激薬による中枢神経系疾患の治療 Download PDF

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JP7150740B2
JP7150740B2 JP2019545723A JP2019545723A JP7150740B2 JP 7150740 B2 JP7150740 B2 JP 7150740B2 JP 2019545723 A JP2019545723 A JP 2019545723A JP 2019545723 A JP2019545723 A JP 2019545723A JP 7150740 B2 JP7150740 B2 JP 7150740B2
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チュン，ジュン
リー，トーマス・ワイ－ホー
アイアンガー，ラジェシュ・アール
パール，ニコラス・ロバート
ジェルマーノ，ピーター
リバデネイラ，マリア・ディー
タン，キム
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サイクレリオン・セラピューティクス，インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019545723A 2016-11-08 2017-11-07 ｓＧＣ刺激薬による中枢神経系疾患の治療 Active JP7150740B2 (ja)

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JP2022126467A JP2022160605A (ja) 2016-11-08 2022-08-08 ｓＧＣ刺激薬による中枢神経系疾患の治療

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US201662419059P 2016-11-08 2016-11-08
US62/419,059 2016-11-08
PCT/US2017/060299 WO2018089328A1 (en) 2016-11-08 2017-11-07 Treatment of cns diseases with sgc stimulators

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JP2019534327A JP2019534327A (ja) 2019-11-28
JP2019534327A5 JP2019534327A5 (https=) 2020-12-17
JP7150740B2 true JP7150740B2 (ja) 2022-10-11

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JP2022126467A Pending JP2022160605A (ja) 2016-11-08 2022-08-08 ｓＧＣ刺激薬による中枢神経系疾患の治療

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US (4) US11690828B2 (https=)
EP (1) EP3538096B1 (https=)
JP (2) JP7150740B2 (https=)
KR (1) KR102475124B1 (https=)
CN (1) CN110267658B (https=)
AU (2) AU2017359018C1 (https=)
BR (1) BR112019009449A2 (https=)
CA (1) CA3042548A1 (https=)
CL (1) CL2019001256A1 (https=)
EA (1) EA201991147A1 (https=)
ES (1) ES2972711T3 (https=)
IL (1) IL266275B2 (https=)
MA (1) MA46752A (https=)
MX (2) MX2019005342A (https=)
PH (1) PH12019501016A1 (https=)
SG (1) SG10202104865UA (https=)
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WO (1) WO2018089328A1 (https=)

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US11180493B2 (en) * 2016-11-08 2021-11-23 Cyclerion Therapeutics, Inc. SGC stimulators
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KR20210031931A (ko) 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
US20220087970A1 (en) * 2019-01-18 2022-03-24 The Johns Hopkins University Prevention of anesthetic-induced neurocognitive dysfunction
CN114929207A (zh) * 2019-12-05 2022-08-19 载度思生命科学有限公司 利奥西呱的调节释放型药物组合物
WO2021158059A1 (ko) 2020-02-07 2021-08-12 건국대학교 글로컬산학협력단 릴메니딘 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
CN112924573B (zh) * 2021-01-21 2022-01-04 山东英盛生物技术有限公司 一种阿比多尔、利巴韦林、氯喹的hplc-ms/ms检测方法
TW202308634A (zh) * 2021-04-20 2023-03-01 美商賽克瑞恩醫療公司 使用sGC刺激劑之CNS疾病治療
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KR20250160137A (ko) * 2023-02-03 2025-11-11 알.피.쉐러 테크놀러지즈 엘엘씨 삼투압 약학적 캡슐

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AU2023270267A1 (en) 2023-12-07
EP3538096C0 (en) 2024-02-28
CL2019001256A1 (es) 2019-10-04
KR102475124B1 (ko) 2022-12-08
US11690828B2 (en) 2023-07-04
US20230381153A1 (en) 2023-11-30
IL266275B2 (en) 2023-12-01
NZ753434A (en) 2025-10-31
TW201822765A (zh) 2018-07-01
AU2017359018A1 (en) 2019-05-30
KR20190094167A (ko) 2019-08-12
MX2019005342A (es) 2019-10-02
BR112019009449A2 (pt) 2019-07-30
EA201991147A1 (ru) 2019-11-29
TWI812601B (zh) 2023-08-21
US20250108040A1 (en) 2025-04-03
EP3538096A1 (en) 2019-09-18
IL266275B1 (en) 2023-08-01
JP2022160605A (ja) 2022-10-19
AU2017359018B2 (en) 2023-08-31
AU2017359018C1 (en) 2023-12-21
IL266275A (en) 2019-06-30
MX2022010852A (es) 2022-09-27
PH12019501016A1 (en) 2019-09-09
MA46752A (fr) 2019-09-18
SG10202104865UA (en) 2021-06-29
JP2019534327A (ja) 2019-11-28
EP3538096B1 (en) 2024-02-28
US20190343813A1 (en) 2019-11-14
WO2018089328A1 (en) 2018-05-17
ES2972711T3 (es) 2024-06-14
CN110267658B (zh) 2024-02-02
CA3042548A1 (en) 2018-05-17
CN110267658A (zh) 2019-09-20
US20260000653A1 (en) 2026-01-01
WO2018089328A8 (en) 2019-03-28

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