JP7149183B2 - 癌治療のためのシタラビンコンジュゲート - Google Patents

癌治療のためのシタラビンコンジュゲート Download PDF

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JP7149183B2
JP7149183B2 JP2018527797A JP2018527797A JP7149183B2 JP 7149183 B2 JP7149183 B2 JP 7149183B2 JP 2018527797 A JP2018527797 A JP 2018527797A JP 2018527797 A JP2018527797 A JP 2018527797A JP 7149183 B2 JP7149183 B2 JP 7149183B2
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leukemia
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JP2018535989A (ja
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ジェングリノビッチ，ステラ
ヤカール，ルース ベン
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バイオサイト リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Virology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2018527797A 2015-12-03 2016-01-25 癌治療のためのシタラビンコンジュゲート Active JP7149183B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562262428P 2015-12-03 2015-12-03
US62/262,428 2015-12-03
PCT/IL2016/050077 WO2017093993A1 (en) 2015-12-03 2016-01-25 Cytarabine conjugates for cancer therapy

Related Child Applications (1)

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JP2020122708A Division JP2020183419A (ja) 2015-12-03 2020-07-17 癌治療のためのシタラビンコンジュゲート

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JP2018535989A JP2018535989A (ja) 2018-12-06
JP2018535989A5 JP2018535989A5 (https=) 2019-03-07
JP7149183B2 true JP7149183B2 (ja) 2022-10-06

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JP2018527797A Active JP7149183B2 (ja) 2015-12-03 2016-01-25 癌治療のためのシタラビンコンジュゲート
JP2020122708A Pending JP2020183419A (ja) 2015-12-03 2020-07-17 癌治療のためのシタラビンコンジュゲート
JP2022077787A Active JP7417658B2 (ja) 2015-12-03 2022-05-10 癌治療のためのシタラビンコンジュゲート

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JP2020122708A Pending JP2020183419A (ja) 2015-12-03 2020-07-17 癌治療のためのシタラビンコンジュゲート
JP2022077787A Active JP7417658B2 (ja) 2015-12-03 2022-05-10 癌治療のためのシタラビンコンジュゲート

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US (1) US11058701B2 (https=)
EP (1) EP3383407B1 (https=)
JP (3) JP7149183B2 (https=)
CN (1) CN108289905A (https=)
AU (2) AU2016362830B2 (https=)
BR (1) BR112018011177A2 (https=)
CA (1) CA3007058C (https=)
IL (2) IL259631B (https=)
RU (1) RU2708672C1 (https=)
WO (1) WO2017093993A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12071450B2 (en) 2015-12-03 2024-08-27 Biosight Ltd. Salts of conjugates for cancer therapy
US12064445B2 (en) 2015-12-03 2024-08-20 Biosight Ltd. Cytarabine conjugates for cancer therapy
US11104698B2 (en) 2015-12-03 2021-08-31 Biosight Ltd. Salts of conjugates for cancer therapy
WO2019012328A1 (en) * 2017-07-09 2019-01-17 Biosight Pharma ANTICANCER POLY THERAPY
CN110590862A (zh) * 2019-11-01 2019-12-20 南京师范大学 阿糖胞苷4-n位氨基酸衍生物及其制备方法与应用
KR20220137028A (ko) * 2020-02-04 2022-10-11 바이오사이트 리미티드 아스파시타라빈 약제학적 조성물 및 이의 용도
JP2023522420A (ja) * 2020-04-23 2023-05-30 バイオサイト リミテッド 血液がんの治療のための方法及びレジメン
KR20230074156A (ko) * 2020-09-21 2023-05-26 바이오사이트 리미티드 아스파시타라빈의 결정질 형태
CN112409431B (zh) * 2020-12-07 2023-04-21 武汉伯瑞恒医药科技有限公司 阿糖胞苷结构类似物及其制备方法和用途
JP2024540613A (ja) * 2021-11-21 2024-10-31 バイオサイト リミテッド がんの治療のためのシタラビン－アミノ酸系プロドラッグ
WO2023175622A1 (en) * 2022-03-17 2023-09-21 Biosight Ltd. Crystalline forms of aspacytarabine
WO2023228177A1 (en) * 2022-05-22 2023-11-30 Biosight Ltd. Compositions comprising aspacytarabine and additional compounds, and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110275590A1 (en) 2004-02-02 2011-11-10 BioSight Ltd., Conjugates for cancer therapy and diagnosis

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949451A (en) 1959-04-21 1960-08-16 Hoffmann La Roche Preparation of thymidine and deoxyfluorouridine, and intermediates therefor
US3041335A (en) 1959-04-21 1962-06-26 Hoffmann La Roche Mercury salts of nitrogen heterocyclics and preparation thereof
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4296105A (en) 1978-08-03 1981-10-20 Institut International De Pathologie Cellulaire Et Moleculaire Derivatives of doxorubicine, their preparation and use
US4348522A (en) 1980-01-23 1982-09-07 Starks Associates, Inc. N-(phosphonacetyl)-L-aspartic acid salts with piperazine, cyclohexylamine and calcium
EP0329184A3 (en) 1988-02-19 1990-05-23 Neorx Corporation Antimers and antimeric conjugation
RU2085557C1 (ru) 1991-09-30 1997-07-27 Санкио Компани Лимитед Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP0737077A1 (en) * 1994-01-11 1996-10-16 Targetech, Inc. Hepatocyte-targeted drug conjugates
JP4157600B2 (ja) 1994-08-19 2008-10-01 ラ レフィオン バロンネ 化合物、製剤用組成物及びこれらを含む診断装置とこれらの利用
JPH0859688A (ja) 1994-08-25 1996-03-05 Mitsui Toatsu Chem Inc ５’−チオノエステル置換トリフルオロチミジン誘導体およびそれを有効成分とする制癌剤
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
US6258774B1 (en) 1998-03-19 2001-07-10 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
PT1144011E (pt) 1998-12-11 2010-06-16 Coulter Pharm Inc Compostos pró-fármacos e processo para a sua preparação
JP5046219B2 (ja) 2002-10-31 2012-10-10 リガンド・ファーマシューティカルズ・インコーポレイテッド １，３−プロパン−１−アリールジオールの新規環状リン酸ジエステルおよびそのプロドラッグへの使用
KR101442288B1 (ko) 2006-12-13 2014-09-19 지보당 네덜란드 서비시즈 비.브이. 카복실산과 퓨린, 피리미딘, 뉴클레오사이드 또는 뉴클레오타이드의 향미 조절 유도체
CN101812105A (zh) 2009-02-25 2010-08-25 沈阳药科大学 阿糖胞苷5’-o-氨基酸酯和其盐类及其制备方法
JP5873656B2 (ja) * 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
KR20140079831A (ko) 2011-10-18 2014-06-27 아지노모토 가부시키가이샤 췌장암 및／또는 담도암 치료약
JP2016503005A (ja) * 2012-12-18 2016-02-01 ゴーダーヴァリ バイオリファイナリーズ リミテッド 腫瘍始原細胞を除去するための薬剤
WO2015178265A1 (ja) 2014-05-23 2015-11-26 日本化薬株式会社 新規なグルタミン酸誘導体およびその用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110275590A1 (en) 2004-02-02 2011-11-10 BioSight Ltd., Conjugates for cancer therapy and diagnosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Ａｎｔｉｍｉｃｒｏｂｉａｌ Ａｇｅｎｔｓ ａｎｄ Ｃｈｅｍｏｔｈｅｒａｐｙ，１９７３年，Ｖｏｌ．４，Ｎｏ．４，ｐ．４３９－４４４
Ｂｌｏｏｄ，１９９６，Ｖｏｌ．８７，Ｎｏ．５，ｐ．１７１０－１７１７
Ｃｌｉｎｉｃａｌｔｒｉａｌｓ．ｇｏｖ，ＮＣＴ０２５４４４３８，プロトコル，２０１５／９／６時点
Ｃｕｒｒ Ｈｅｍａｔｏｌ Ｍａｌｉｇ Ｒｅｐ，２０１３，Ｖｏｌ．８，ｐ．１４１－１４８
ＥｘｐｅｒｔＯｐｉｎ．ＤｒｕｇＤｅｌｉｖ．，２０１０，Ｖｏｌ．７，Ｎｏ．１２，ｐ．１３９９－１４１４
Ｌａｎｃｅｔ，２００９，Ｖｏｌ．３７４，ｐ．１５１２－１５２０
Ｎｅｗｓ ｐｒｏｖｉｄｅｄ ｂｙ ＢｉｏＳｉｇｈｔ Ｌｔｄ， ＫＡＲＭＩＥＬ， Ｉｓｒａｅｌ，"ＢｉｏＳｉｇｈｔ Ｗｉｌｌ Ｐｒｅｓｅｎｔ Ｉｎｔｅｒｉｍ Ｒｅｓｕｌｔｓ Ｆｒｏｍ ａ Ｐｈａｓｅ １／２ Ｃｌｉｎｉｃａｌ Ｔｒｉａｌ ｏｆ Ａｓｔａｒａｂｉｎｅ ｆｏｒ Ｔｒｅａｔｉｎｇ Ａｃｕｔｅ Ｌｅｕｋｅｍｉａ ａｔ ｔｈｅ ＡＳＨ Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ ２０１５"， ２０１５．１０．２６， ［ｒｅｔｒｉｅｖｅｄ ｏｎ ２０２１．０８．０３］，Ｒｅｔｒｉｅｖｅｄ ｆｒｏｍ ｔｈｅ Ｉｎｔｅｒｎｅｔ：＜ＵＲＬ：ｈｔｔｐｓ：／／ｗｗｗ．ｐｒｎｅｗｓｗｉｒｅ．ｃｏｍ／ｎｅｗｓ－ｒｅｌｅａｓｅｓ／ｂｉｏｓｉｇｈｔ－ｗｉｌｌ－ｐｒｅｓｅｎｔ－ｉｎｔｅｒｉｍ－ｒｅｓｕｌｔｓ－ｆｒｏｍ－ａ－ｐｈａｓｅ－１２－ｃｌｉｎｉｃａｌ－ｔｒｉａｌ－ｏｆ－ａｓｔａｒａｂｉｎｅ－ｆｏｒ－ｔｒｅａｔｉｎｇ－ａｃｕｔｅ－ｌｅｕｋｅｍｉａ－ａｔ－ｔｈｅ－ａｓｈ－ａｎｎｕａｌ－ｍｅｅｔｉｎｇ－２０１５－５３７０５８６９１．ｈｔｍｌ＞及び＜ＵＲＬ：ｈｔｔｐｓ：／／ｗｗｗ．ｂｉｏｓｉｇｈｔ－ｐｈａｒｍａ．ｃｏｍ／ｎｅｗｓ＞
Ｒｕｔｈ Ｂｅｎ Ｙａｋｅｒ，"ＢｉｏＳｉｇｈｔ Ｃｏｍｐｌｅｔｅｄ Ｓｕｃｃｅｓｓｆｕｌ Ｐｒｅ－ＩＮＤ Ｍｅｅｔｉｎｇ ｆｏｒ ＡＭＬ Ｐｈａｓｅ ２ｂ ｓｔｕｄｙ"，２０１５．０７．０１，［ｒｅｔｒｉｅｖｅｄ ｏｎ ２０２１．０８．０３］， Ｒｅｔｒｉｅｖｅｄ ｆｒｏｍ ｔｈｅ Ｉｎｔｅｒｎｅｔ：＜ＵＲＬ：ｈｔｔｐｓ：／／ｗｗｗ．ｌｉｎｋｅｄｉｎ．ｃｏｍ／ｐｕｌｓｅ／ｂｉｏｓｉｇｈｔ－ｃｏｍｐｌｅｔｅｄ－ｓｕｃｃｅｓｓｆｕｌ－ｐｒｅ－ｉｎｄ－ｍｅｅｔｉｎｇ－ａｍｌ－ｐｈａｓｅ－ｂｅｎ－ｙａｋａｒ＞
金沢大学十全医学会雑誌，２００６年，第１１５巻 第１号，ｐ．５１－５５

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IL287644A (en) 2021-12-01
US20180369265A1 (en) 2018-12-27
JP7417658B2 (ja) 2024-01-18
AU2016362830A1 (en) 2018-07-12
CN108289905A (zh) 2018-07-17
AU2022204373B2 (en) 2024-01-25
WO2017093993A1 (en) 2017-06-08
IL259631A (en) 2018-07-31
JP2018535989A (ja) 2018-12-06
EP3383407A4 (en) 2019-07-17
JP2022097619A (ja) 2022-06-30
RU2708672C1 (ru) 2019-12-11
US11058701B2 (en) 2021-07-13
CA3007058C (en) 2023-10-17
CA3007058A1 (en) 2017-06-08
IL259631B (en) 2021-10-31
EP3383407B1 (en) 2023-12-06
AU2022204373A1 (en) 2022-07-28
EP3383407A1 (en) 2018-10-10
JP2020183419A (ja) 2020-11-12
AU2016362830B2 (en) 2022-07-14
BR112018011177A2 (pt) 2018-11-21

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