JP7128816B2 - 疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤 - Google Patents

疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤 Download PDF

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JP7128816B2
JP7128816B2 JP2019530500A JP2019530500A JP7128816B2 JP 7128816 B2 JP7128816 B2 JP 7128816B2 JP 2019530500 A JP2019530500 A JP 2019530500A JP 2019530500 A JP2019530500 A JP 2019530500A JP 7128816 B2 JP7128816 B2 JP 7128816B2
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ジェイ． ソス マイケル
リュー ギャング
リー カン
クロス ジェイソン
ジョーンズ フィリップ
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University of Texas System
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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  • Plural Heterocyclic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019530500A 2016-12-08 2017-12-08 疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤 Active JP7128816B2 (ja)

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US201662431504P 2016-12-08 2016-12-08
US62/431,504 2016-12-08
PCT/US2017/065385 WO2018107072A1 (en) 2016-12-08 2017-12-08 Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease

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JP2020502092A5 JP2020502092A5 (https=) 2021-01-21
JP7128816B2 true JP7128816B2 (ja) 2022-08-31

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US (3) US10093664B2 (https=)
EP (1) EP3551610B1 (https=)
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KR (1) KR20190087622A (https=)
CN (1) CN110191878B (https=)
AU (1) AU2017371084B2 (https=)
BR (1) BR112019011801A2 (https=)
CA (1) CA3045947A1 (https=)
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MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
IL291665B2 (en) * 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
CA3193736A1 (en) 2020-09-02 2022-03-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lzk-targeting degraders and methods of use
KR20240055041A (ko) 2021-09-01 2024-04-26 더 유나이티드 스테이츠 오브 아메리카, 애즈 레프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 혼합 계통 키나제 억제제 및 억제제의 사용 방법
CN115974795A (zh) * 2022-12-26 2023-04-18 杭州师范大学 一种含全氟烷基和n杂环二取代双环[1.1.1]戊烷及其合成方法
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MX2019006645A (es) 2019-08-26
AU2017371084B2 (en) 2022-04-28
AU2017371084A1 (en) 2019-06-20
US20190092764A1 (en) 2019-03-28
BR112019011801A2 (pt) 2019-10-29
ECSP19048477A (es) 2019-07-31
IL267121B (en) 2021-12-01
CO2019006785A2 (es) 2019-07-10
US10093664B2 (en) 2018-10-09
EP3551610A4 (en) 2020-04-22
KR20190087622A (ko) 2019-07-24
MX386838B (es) 2025-03-19
JP2020502092A (ja) 2020-01-23
CN110191878B (zh) 2023-05-26
IL267121A (en) 2019-08-29
US20220267311A1 (en) 2022-08-25
EA201991375A1 (ru) 2020-01-20
ES2895257T3 (es) 2022-02-18
US10428057B2 (en) 2019-10-01
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US20180186781A1 (en) 2018-07-05
ZA201904402B (en) 2020-12-23
EP3551610A1 (en) 2019-10-16
CL2019001539A1 (es) 2019-08-23
CA3045947A1 (en) 2018-06-14
CN110191878A (zh) 2019-08-30
WO2018107072A1 (en) 2018-06-14

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